Clinical trials: Peripheral Neuropathy Pain
Neuropathic Pain
The Use of Rechargeable Spinal Cord Stimulators for the Treatment of Neuropathic Pain
Neuropathic pain occurs due to one or several lesions of the central or peripheral nervous system. Spinal cord stimulation is now recommended in France by the Haute Autorité de Santé (HAS) to relieve chronic refractory…
- Trial name
- STIMREC (NCT05373654)
- Testing
- F-SUS Questionnaire, Interview (only for dissatisfied patients)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Elsan
Neuropathic Pain
Does Duloxetine Reduce Chronic Pain After Total Knee Arthroplasty?
Range from 24% to 44%, with a prevalence of neuropathic-type pain from 6% to 20%-cause impairment in quality of life and functional capacity after total knee arthroplasty(TKA).
- Trial name
- NCT02307305
- Testing
- Duloxetine, celecoxib, naproxen/esomeprazole, acetaminophen/tramadol, oxycodone/naloxone
- Where
- South Korea
- Volunteers
- 168 people
- Sponsor
- Hanyang University Seoul Hospital
Pain, Chronic, Lumbosacral Radiculopathy
Focal Microvibration and Chronic Lumbosacral Radicular Pain
The goal of this clinical trial is to investigate the effectiveness of focal microvibration on patients affected by chronic lumbosacral radicular pain.
- Conditions
- Pain, Chronic, Lumbosacral Radiculopathy, Radicular; Neuropathic
- Trial name
- NCT06301061
- Testing
- Equistasi®, Gabapentin; Pregabalin; Duloxetine; Amitriptyline
- Volunteers
- 150 people
- Sponsor
- Federico II University
Radiculopathy, Lumbosacral Region, Back Pain With Radiation
Ibuprofen With or Without Dexamethasone for Acute Radicular Low Back Pain.
This will be a placebo controlled, randomized, double-blind, comparative effectiveness study, in which we patients are enrolled during an emergency department (ED) visit for acute radicular low back pain (LBP) and followed by…
- Conditions
- Radiculopathy, Lumbosacral Region, Back Pain With Radiation, Low Back Pain
- Trial name
- NCT05721027
- Testing
- Ibuprofen 400 mg, Dexamethasone Oral, Educational Intervention
- Where
- 2 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Neuropathic Pain
Neural Exercises vs Surgery in Patients With Carpal Tunnel Syndrome
neural exercise in patients with carpal tunnel syndrome
- Trial name
- NCT04058041
- Testing
- Neural Mobilization, Surgery, Surgery and neural mobilization
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Universidad Rey Juan Carlos
Injuries, Spinal Cord, Pain
Levetiracetam in Chronic Neuropathic Pain Following Spinal Cord Injury
Purpose: To evaluate the efficacy and safety of levetiracetam on chronic neuropathic pain after spinal cord injury, and to examine its effect on spasms and evoked pain.
- Trial name
- NCT00252954
- Testing
- Levetiracetam
- Where
- 3 sites in Denmark
- Volunteers
- 36 people
- Sponsor
- Danish Pain Research Center
Postherpetic Neuralgia, Neuralgia
Evaluation of the Efficacy, Tolerability and Safety of Etoricoxib (Arcoxia) in Patients With Neuropathic Pain
The present study will aim to determine the safety, efficacy, and tolerability of etoricoxib, an NSAID pain reliever, in patients with Neuropathic pain.
- Trial name
- NCT01264237
- Testing
- Etoricoxib
- Where
- 2 sites in United Kingdom
- Volunteers
- 120 people
- Sponsor
- Analgesic Solutions
Fibromyalgia
Safety and Efficacy of Ketamine Intravenous Infusions in the Treatment of Fibromyalgia
Previous studies of intravenous ketamine, which is a non-competitive N-methyl-D aspartate receptor antagonist, for fibromyalgia pain relief are limited to three studies.
- Trial name
- NCT06916403
- Testing
- Intravenous Ketamine Infusions
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Wilderman Medical Clinic
Thoracic Outlet Syndrome
Effect of Osteopathic Technique on Respiratory Parameters and Pain in Thoracic Outlet Syndrome
Background: With regard to patients with thoracic outlet syndrome (GBS), it is important to improve inspiratory muscle strength and endurance, and pain perception in patients with TOS, so that patients are able to regain…
- Trial name
- NCT06446141
- Testing
- Osteopathic technique
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Horus University
Painful Peripheral Neuropathy, Diabetic Peripheral Neuropathic Pain (DPN)
SPENDD: Quantitative Sensory Testing and Analgesic Response for Painful Peripheral Neuropathy.
The goal of this clinical trial is to determine whether quantitative sensory testing (QST) can be used to classify participants into pain sub-groups and predict who will respond best to certain pain treatments in participants…
- Conditions
- Painful Peripheral Neuropathy, Diabetic Peripheral Neuropathic Pain (DPN), Chemotherapy Induced Peripheral Neuropathy (CIPN), Idiopathic Peripheral Neuropathy
- Trial name
- NCT06614322
- Testing
- Pregabalin, Duloxetine
- Where
- 7 sites in United States
- Volunteers
- 190 people
- Sponsor
- University of Rochester
Spinal Cord Injuries, Neuropathic Pain
Evaluation of Initiation Time on the Efficacy of Gabapentin in Treating Neuropathic Pain in SCI
Neuropathic pain is a common complaint in those with spinal cord injury (SCI) that has a significant negative effect on quality of life. Efficacy of various treatments, however, remains controversial.
- Trial name
- NCT04256603
- Testing
- Gabapentin, No gabapentin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- MetroHealth Medical Center
Diabetic Peripheral Neuropathy, Balance
Effects of Virtual Reality-Based Balance Training Compared to Conventional Balance Training to Reduce Risk of Fall in Patients With Diabetic Peripheral Neuropathy: A Randomized Control Trial
The objective of this study is to determine the effects of virtual reality based balance training compared to conventional balance training to reduce risk of fall in patients with diabetic peripheral neuropathy in terms of fall…
- Conditions
- Diabetic Peripheral Neuropathy, Balance, Fall Risk
- Trial name
- NCT06740227
- Testing
- Virtual Reality-Based Balance Training, Conventional Balance Training
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Foundation University Islamabad
Painful Diabetic Neuropathy
A Study of Single Dose Pain Therapy in Patients With Painful Diabetic Neuropathy (0000-115)
The purpose of this study is to determine if analgesic efficacy can be detected with single dose administration in patients with chronic neuropathic pain due to painful diabetic neuropathy.
- Trial name
- NCT00837941
- Testing
- Comparator: A: Pregabalin, Comparator: B: Duloxetine, Comparator: C: Diphenhydramine hydrochloride
- Sponsor
- Merck Sharp & Dohme LLC
Chemotherapy-induced Peripheral Neuropathy
Feasibility Study for Electroacupuncture for Chemotherapy- Induced Peripheral Neuropathy (CIPN)
The purpose of the study is to determine the validity of a point-of-care nerve conduction device (NeuroMetrix) and Rydel-Seiffer tuning fork in assessing the level of peripheral neuropathy in patients with chemotherapy-induced…
- Trial name
- NCT04092764
- Testing
- Electroacupuncture, NeuroMetrix, Rydel-Seiffer tuning fork
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Acute Sciatica
A Comparative Effectiveness Randomised Placebo Controlled Pilot Trial of the Management of Acute Lumbar Radicular Pain
Aim: In subjects with acute sciatica (≤ 4 weeks duration), this is a pilot comparative effectiveness study to evaluate feasibility and to determine final sample size for a future adequately powered randomised controlled trial of…
- Trial name
- SCIATICA (NCT03240783)
- Testing
- Betamethasone OR Dexamethasone Injectable, Normal Saline Flush, 0.9% Injectable Solution, Dexamethasone Oral Tablet
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- St George Hospital, Australia
Carpal Tunnel Syndrome
The Effect of High-intensity Laser Therapy in Patients With Carpal Tunnel Syndrome.
The aim of this study is to evaluate the effects of high intensity laser therapy (HILT) on pain, functional status, hand grip strength and median nerve cross-sectional area in ultrasonography in patients with carpal tunnel…
- Trial name
- NCT05678595
- Testing
- high-intensity laser therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Necmettin Erbakan University
Peripheral Neuropathy, Diabetes Mellitus
Oral Thiamine for the Treatment of Painful Diabetic Peripheral Neuropathy
This study will examine the effect of oral thiamine (Vitamin B1) supplementation on pain in patients with diabetic peripheral neuropathy.
- Conditions
- Peripheral Neuropathy, Diabetes Mellitus, Diabetes Complications
- Trial name
- NCT00279266
- Testing
- Thiamine
- Where
- United States
- Sponsor
- Loma Linda University
HIV Infections, Peripheral Nervous System Disease
A Phase II/III Double-Blind Study of Amitriptyline and Mexiletine for Painful Neuropathy in HIV Infection
To assess the efficacy, safety, and tolerability of amitriptyline hydrochloride versus mexiletine hydrochloride in reducing pain intensity in patients with HIV-related painful peripheral neuropathy.
- Trial name
- NCT00000793
- Testing
- Mexiletine hydrochloride, Benztropine mesylate, Amitriptyline hydrochloride
- Where
- 37 sites in United States, Tanzania
- Volunteers
- 240 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Neuropathic Pain
Neuropathic Pain in Patients With Cancer
The purpose of this study is to collect beginning information on whether intravenous (IV) administration of KRN5500 is safe and effective for treatment of neuropathic pain in patients with cancer.
- Trial name
- NCT00474916
- Testing
- KRN5500
- Where
- 12 sites in United States, Puerto Rico
- Volunteers
- 19 people
- Sponsor
- DARA Therapeutics
Neuralgia, Complex Regional Pain Syndromes
Novel Treatment Option for Neuropathic Pain
The purpose of this study is to determine whether the EGFR-inhibitor cetuximab is better than placebo for the treatment of neuropathic pain.
- Trial name
- NoTOPain (NCT02490436)
- Testing
- Cetuximab
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- Sorlandet Hospital HF
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