Clinical trials: Peripheral Neuropathy Pain
Wrist-Drop
Wrist Splint and Occupational Therapy to Improve Pain, Mobility and Functional Status in Patients With Wrist Drop
To determine effectiveness of wrist splint and occupational therapy to improve pain, mobility and functional status in patients with wrist drop.
- Trial name
- NCT05875844
- Testing
- Wrist Splint, Occupational Therapy
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Superior University
Fabry Disease, Neuropathic Pain
Safety and Efficacy of Gabapentin for Neuropathic Pain in Fabry Disease
The purpose of this study is to determine efficacy of gabapentin vs. placebo at controlling peripheral neuropathic pain in patients with Fabry disease, and reducing their use of opioid analgesics.
- Trial name
- NCT01588314
- Testing
- Gabapentin
- Where
- United States
- Sponsor
- University of Minnesota
Acute Lymphoblastic Leukemia, Neuropathy
Therapeutic Interventions For Pain Induced By Vincristine Treatment For Childhood Acute Lymphoblastic Leukemia (ALL)
Neuropathic pain / peripheral neuropathy (NP/PN) is a known painful complication of vincristine (VCR) therapy; evidence supporting the best treatment plan for pediatric patients is limited.
- Conditions
- Acute Lymphoblastic Leukemia, Neuropathy, Neuropathic Pain
- Trial name
- TINALL (NCT01506453)
- Testing
- gabapentin
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- St. Jude Children's Research Hospital
Diabetes Mellitus, Peripheral Neuropathies
Effects of Pregabalin, Duloxetine & Amitriptyline on Pain & Sleep
The purpose of this study is to assess the effectiveness of pregabalin, duloxetine and amitriptyline compared with placebo in reducing pain in diabetic patients as assessed by Brief Pain Inventory (BPI).
- Trial name
- NCT00370656
- Testing
- Pregabalin, Duloxetine, Amitriptyline
- Where
- 3 sites in United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Surrey
Small Fiber Neuropathy
Intravenous Immunoglobulin Therapy for Small Fiber Neuropathy
Small fiber neuropathy (SFN) is the most common cause of neuropathic pain in peripheral neuropathies, with a prevalence of at least 53/100.000.
- Trial name
- IVIg-SFN (NCT02637700)
- Testing
- Intravenous Immunoglobulin
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Academisch Ziekenhuis Maastricht
Complex Regional Pain Syndrome, Type I
Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Complex Regional Pain Syndrome Type 1
The purpose of this multicenter, double-blind, placebo-controlled study is to evaluate the efficacy and safety of Lenalidomide in adult subjects with Complex Regional Pain Syndrome (CRPS) Type 1.
- Trial name
- CRPS-002 (NCT00109772)
- Testing
- lenalidomide
- Where
- 27 sites in United States
- Volunteers
- 184 people
- Sponsor
- Celgene Corporation
Reflex Sympathetic Dystrophy
Investigation of the Efficacy of tDCS in the Treatment of Complex Regional Pain Syndrome (CRPS) Type 1
The efficacy of the current standard non-pharmacological treatments for complex regional pain syndrome (CRPS), a painful syndrome mostly occurring after musculoskeletal trauma, is suboptimal.
- Trial name
- NCT01960400
- Testing
- Graded motor imagery (GMI)
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Université de Sherbrooke
Persistent Pain After Breast Cancer Surgery
Ultrasound Guided Pectoral Nerves Blockade for Persistent Pain After Breast Cancer Surgery
This is a pilot study of the pectoral nerves block (PECS) in patients with persistent pain after breast cancer surgery.
- Trial name
- PPBCS (NCT02349581)
- Testing
- PECS block, Bupivacaine
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Irritable Bowel Syndrome (IBS), Functional Abdominal Pain
Peer Mentorship: An Intervention To Promote Effective Pain Self-Management In Adolescents
This protocol matches child subjects with peer mentors of similar age who have learned to function successfully with a chronic pain disorder.
- Conditions
- Irritable Bowel Syndrome (IBS), Functional Abdominal Pain, Fibromyalgia, Complex Regional Pain Syndrome (CRPS)
- Trial name
- NCT01118988
- Testing
- Mentorship
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of California, Los Angeles
Neuralgia
Treatment of Upper Limb Chronic Neuropathic Pain by Electrical Stimulation of the Brachial Plexus Nerve Roots
Moderate to severe neuropathic pain has a prevalence of 5% in the French population, involving the upper limb (UL) in 47%. Invasive neuromodulation, mainly spinal cord stimulation (SCS) is recommended as a third line treatment in…
- Trial name
- SIMPLEX (NCT05817786)
- Testing
- electrical stimulation of the brachial plexus nerve roots
- Where
- 3 sites in France
- Volunteers
- 48 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Cannabis, HIV Neuropathy
Effect of Cannabis and Endocannabinoids on HIV Neuropathic Pain
Acute cannabis administration is reported to alleviate HIV neuropathic pain (HIV-NP), but there is limited knowledge about the effects of cannabis constituents (delta-9 tetrahydrocannabinol/THC and cannabidiol/CBD), the…
- Conditions
- Cannabis, HIV Neuropathy, Pain Syndrome
- Trial name
- NCT03099005
- Testing
- Cannabis
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of California, San Diego
HIV, Peripheral Nervous System Disorders
Safety and Efficacy Study of Prosaptide to Treat Neuropathic Pain in HIV-Positive Patients
This is a double-blind, placebo-controlled, parallel groups study to determine whether prosptide is effective in relieving pain in patients who have sensory neuropathic pain related to their HIV infection or the drugs used to…
- Trial name
- NCT00286377
- Testing
- prosaptide
- Volunteers
- 350 people
- Sponsor
- Savient Pharmaceuticals
Lumbosacral Radicular Pain
Corticosteroid Lumbar Epidural Analgesia for Radicular Pain 2
This is a research study of SP-102, an experimental medication designed to relieve pain in patients with moderate to severe sciatica (pain in the lower back, hips, buttocks and legs).
- Trial name
- CLEAR 2 (NCT07579351)
- Testing
- SP-102, Dexamethasone Sodium Phosphate 10 MG/ML
- Volunteers
- 755 people
- Sponsor
- Semnur Pharmaceuticals, Inc.
Diabetic Peripheral Neuropathy
Comparative Effects of Balance and Resisted Training in Diabetic Peripheral Neuropathy.
The aim of this study is to determine comparative effects of balance and resisted training on pain and balance in patients with daibetic peripheral neuropathy.
- Trial name
- NCT06303453
- Testing
- Balance exercises, Resisted exercises
- Where
- Pakistan
- Volunteers
- 58 people
- Sponsor
- Riphah International University
HIV, Sensory Neuropathy
Clinical Phenotyping and Genotyping of HIV-Associated Sensory Neuropathy: The HIV-POGO Study
This study aims to recruit a cohort of HIV patients with and without HIV-SN and to identify genetic risk factors for the development of HIV-SN and neuropathic pain.
- Conditions
- HIV, Sensory Neuropathy, Neuropathic Pain
- Trial name
- HIV-POGO (NCT02555930)
- Testing
- No Intervention
- Where
- United Kingdom
- Volunteers
- 148 people
- Sponsor
- Imperial College London
Painful Diabetic Neuropathy (PDN), Diabetic Neuropathy
Efficacy and Feasibility of BurstDR SCS in Painful Diabetic Neuropathy
This prospective, single-arm clinical study evaluates the therapeutic efficacy and feasibility of BurstDR spinal cord stimulation (SCS) using Abbott's Proclaim XR and Eterna systems in patients with painful diabetic neuropathy…
- Conditions
- Painful Diabetic Neuropathy (PDN), Diabetic Neuropathy, Neuropathic Pain, Chronic Pain
- Trial name
- ABBT DPN (NCT07250828)
- Testing
- BurstDR Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- TriCity Research Center
Complex Regional Pain Syndrome, Type I
Pain Exposure Physical Therapy (PEPT) Versus CBO in Patients With Complex Regional Pain Syndrome Type I (CRPS-1)
The current Dutch CBO guideline treatment of Complex Regional Pain Syndrome Type I (CRPS-1) is very disappointing with chronification, disability and subsequent high medical costs and personal suffering.
- Trial name
- PEPTOC (NCT00817128)
- Testing
- PEPT, CBO standard
- Where
- Netherlands
- Volunteers
- 62 people
- Sponsor
- Radboud University Medical Center
Plantar Fasciitis of Both Feet, Metatarsalgia
A Test of Efficacy and Foot Position Alteration in Patients Wearing Good Feet Arch Supports for the Treatment of Pain
This study is a single armed prospective case series designed to evaluate the efficacy of treating common structural-related foot ailments (i.e.
- Conditions
- Plantar Fasciitis of Both Feet, Metatarsalgia, Morton Neuroma, Hallux Valgus Deformity
- Trial name
- Good Feet (NCT07103070)
- Testing
- Arch supports
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Massachusetts General Hospital
Carpal Tunnel Syndrome
Nociceptive Gain Processing After Physical Therapy in Carpal Tunnel Syndrome
This randomized clinical trial will investigate changes in pain intensity and nociceptive gain processing after the application of either physical therapy or surgery in women with carpal tunnel syndrome (CTS).
- Trial name
- NCT02219919
- Testing
- Surgical Group, Physical Therapy Group
- Where
- 2 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Universidad Rey Juan Carlos
Complex Regional Pain Syndrome
Low-Dose Naltrexone for the Treatment of Complex Regional Pain Syndrome
The investigators are testing treatment with low-dose naltrexone (LDN) for symptom relief of complex regional pain syndrome (CRPS).
- Trial name
- LDN-CRPS (NCT02502162)
- Testing
- LDN
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Stanford University
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