Clinical trials: Peripheral Pulmonary Nodules
Lung Nodule
Tri-modality Sampling Using Radial Probe Endobronchial Ultrasound for the Diagnosis of Peripheral Pulmonary Lesions
As the former radial probe endobronchial ultrasound (RP-EBUS) guided transbronchial forceps biopsy of peripheral pulmonary nodules has some limitations, the purpose of this study is to investigate a novel biopsy technique that…
- Trial name
- NCT06123312
- Testing
- Tri-modality biopsy
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Pusan National University Hospital
Peripheral Pulmonary Nodules
RAB Versus Ultrathin Bronchoscopy With VBN in the Diagnosis of PPNs
The purpose of this study is to evaluate whether the diagnostic yield of robotic-assisted bronchoscopy is not inferior to that of the virtual bronchoscopic navigation combined with ultrathin bronchoscopy.
- Trial name
- NCT06962436
- Testing
- Robotic bronchoscopy system, Ultrathin bronchoscope combined with virtual bronchoscopic navigation
- Where
- 5 sites in China
- Volunteers
- 186 people
- Sponsor
- Shanghai Chest Hospital
Lung Cancer
Study Using Combined Virtual 4-D Electromagnetic (EM) Tip-Tracked Devices & EBUS in Diagnosis of Lung Nodules
The purpose of this study is to determine the safety and biopsy yield of EM Tip Tracked devices compared to standard bronchoscopy.
- Trial name
- NCT01947530
- Testing
- Navigational Bronchoscopy, Standard Bronchoscopy
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- University Health Network, Toronto
Solitary Pulmonary Nodule, Multiple Pulmonary Nodules
iNod™ Ultrasound-Guided Needle Biopsy System Study
The purpose of this study is to collect information on the iNod™ System's safety and ability to see the iNod™ biopsy needle in real-time in endobronchial lesions, peripheral lung nodules, or lung masses.
- Conditions
- Solitary Pulmonary Nodule, Multiple Pulmonary Nodules, Biopsy, Fine-Needle
- Trial name
- NCT05804435
- Testing
- iNod™ System
- Sponsor
- Boston Scientific Corporation
Peripheral Solitary Pulmonary Nodule or Tuberculoma
Comparative Study of Nonintubated Uniport Thoracoscopic Surgery Using Thoracic Paravertebral Nerve Block Versus Intercostal Nerve Block for Peripheral Solitary Pulmonary Nodule Patients
The aim of this study is to study the safety and effectiveness of the effects on the perioperative pain control comparing between the thoracic paravertebral nerve block using the camera guided and the intrathoracic intercostals…
- Trial name
- NCT03086213
- Testing
- Propofol, Sulfentanyl, Dexmedetomidine
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Shenzhen Third People's Hospital
Peripheral Pulmonary Lesions (PPLs), Lung Nodules
Shape-sensing Versus Electromagnetic Robotic Bronchoscopy for Evaluation of PulmoNary LEsions
This is an investigator-initiated, multicenter, non inferiority, cluster randomized controlled trial. The primary objective is to compare the diagnostic yield of the electromagnetic robotic assisted bronchoscopy with digital…
- Trial name
- SERENE (NCT07411989)
- Testing
- Bronchoscopy for peripheral pulmonary lesion biopsy
- Where
- 2 sites in United States
- Volunteers
- 346 people
- Sponsor
- The Cleveland Clinic
Pulmonary Nodule, Solitary, Lung Cancer
A Trial to Compare Robotic Assisted Bronchoscopy Ion's Clinical Utility for Peripheral Lung Nodule Access and Diagnosis to ENB
Multi-center randomized controlled study designed to compare the diagnostic yield of ION™ Endoluminal System with electromagnetic navigation bronchoscopy in patients undergoing transbronchial sampling procedure of peripheral…
- Trial name
- ARTICULAtE (NCT06308120)
- Testing
- Ion Endoluminal System, superDimension Navigation System and Accessories
- Where
- 3 sites in China
- Volunteers
- 354 people
- Sponsor
- Intuitive Surgical
Lung Cancers, Peripheral Pulmonary Nodules
General Anesthesia vs Conscious Sedation for Radial Endobronchial Ultrasound
The endoscopic investigation of lung lesions is experiencing significant growth with the increasing number of lung cancer screening programs.
- Trial name
- RESSOURCE (NCT06950515)
- Testing
- Peripheral EBUS under Concious sedation, Peripheral EBUS under General Anesthesia
- Where
- Canada
- Volunteers
- 306 people
- Sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Peripheral Pulmonary Nodules
Pilot Study of Navigational Bronchoscopy and Transthoracic Needle Biopsy
The goal of this study is to evaluate the feasibility and safety of navigation guided virtual transthoracic needle biopsy combined with navigational bronchoscopy for the diagnosis of peripheral pulmonary nodules (PPN).
- Trial name
- NCT02109458
- Testing
- Navigation guided bronchoscopy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Johns Hopkins University
Pulmonary Nodule Persistent, Malignant Neoplasm of the Respiratory System
Assessment of Probe Based Confocal Laser Endo-microscopy for In-vivo Diagnosis of Peripheral Lung Nodules and Masses.
Solitary pulmonary nodule has become a major challenge in respiratory clinical practice. According to published guidelines, their management often requires close CT follow up, PET CT and invasive procedures to obtain a definite…
- Conditions
- Pulmonary Nodule Persistent, Malignant Neoplasm of the Respiratory System, Benign Neoplasms of the Respiratory System
- Trial name
- NODIVEM (NCT01931579)
- Testing
- confocal endo-microscopy
- Where
- 3 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Rouen
Peripheral Pulmonary Nodules, Ablation Techniques
Diagnosis and Treatment of Lung Lesions
To evaluate the safety and feasibility of a single-session "diagnose and treat" (one-stop) paradigm utilizing robotic-assisted bronchoscopy (RAB).
- Trial name
- NCT07642986
- Testing
- A single-session "diagnose and treat" (one-stop) paradigm utilizing robotic-assisted bronchoscopy (RAB)
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Jisong Zhang
Lung Cancer
CT-controlled Advanced Navigation Techniques for Transbronchial Pulmonary Lesion Access; Evaluation of Augmented Fluoroscopy Bronchoscopic Navigation Based Diagnostic Yield
In this exploratory adaptive clinical trial the investigators will examine the diagnostic yield of a combination of commercially available imaging and navigation techniques for reaching peripheral lung lesions.
- Trial name
- CONTROL-A (NCT03274609)
- Testing
- Augmented fluoroscopy
- Where
- Netherlands
- Volunteers
- 47 people
- Sponsor
- Radboud University Medical Center
Multiple Pulmonary Nodules
Single-Center CyTOF and Viral Imprinting Study in Postoperative Multiple Pulmonary Nodules
This multicenter prospective cohort study will enroll adults who have undergone resection of a primary pulmonary nodule and have residual multiple pulmonary nodules or require routine postoperative pulmonary nodule follow-up.
- Trial name
- NCT07647055
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Lung Nodule, Lung Mass
Cone Beam CT Guided Robotic Navigational Bronchoscopy
Navigational bronchoscopy (NB) is used to access peripheral and central parenchymal lung lesions via endobronchial and transbronchial approach.
- Conditions
- Lung Nodule, Lung Mass, Lung Cancer
- Trial name
- CBCTRNB (NCT05358041)
- Testing
- Robotic Bronchoscopy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Columbus Regional Health
Lung Cancer, Nodes, Lung
Confirmation of Accuracy of the Tool-in-lesion Technology (TiLT) of the Galaxy System With Integrated TOMO Technology
This study will evaluate the feasibility of performing robotic navigation of peripheral airways in human subjects for the purpose of biopsying peripheral lung lesions.
- Trial name
- TiLT (NCT06056128)
- Testing
- Robotic assisted bronchoscopy
- Where
- Hong Kong
- Volunteers
- 25 people
- Sponsor
- Noah Medical
Peripheral Pulmonary Nodules
ENB for the Diagnosis of PPNs:a Real World Study
The study is designed as a multi-center prospective trial of ENB for the diagnosis of peripheral pulmonary nodules in the real world. The purpose of the study is to identify the optimal method of using ENB.
- Trial name
- NCT03716284
- Testing
- Electromagnetic navigation bronchoscopy (ENB)
- Where
- China
- Volunteers
- 479 people
- Sponsor
- Shanghai Chest Hospital
Peripheral Pulmonary Lesions (PPLs), Pulmonary Nodules
Comparative Study of Rotational Cryobiopsy Needle and Automated Biopsy Needle in Transthoracic Biopsy Diagnosing Peripheral Pulmonary Lesions
This study aims to systematically compare the diagnostic efficacy, specimen quality, and complication rates of the cryobiopsy needle technique（CassiII rotational core biopsy） versus the automated biopsy technique in the biopsy of…
- Trial name
- NCT07772479
- Testing
- CassiII rotational core biopsy, Automated biopsy
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Beijing Chao Yang Hospital
Lung Nodule, Lung Mass
Cone Beam CT Guided Electromagnetic Navigational Bronchoscopy
Electromagnetic navigation bronchoscopy (ENB) is used to access peripheral and central parenchymal lung lesions via endobronchial and transbronchial approach.
- Conditions
- Lung Nodule, Lung Mass, Lesion of the Lung
- Trial name
- CBCTENB (NCT04194333)
- Testing
- Cone Beam CT with Embo Guide to creat 3D Overlay and CT Augmented Fluoroscopy to guide Electromagnetic Navigational Bronchoscopy instead of Standard Fluroscopic guidance using the C-Arm
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Columbus Regional Health
Lung Cancer, Lung Neoplasm Malignant
Confocal Laser Endomicroscopy VERification
The goal of this multi-center randomized clinical trial is to evaluate the added value of needle based confocal laser endomicroscopy (nCLE)-imaging to regular diagnostic bronchoscopic peripheral lung lesion analysis on the…
- Conditions
- Lung Cancer, Lung Neoplasm Malignant, Carcinoma, Non-Small-Cell Lung, Neoplasm of Lung
- Trial name
- CLEVER (NCT06079970)
- Testing
- Neelde Based Confocal Laser Endomicroscopy, Conventional diagnostic bronchoscopy
- Where
- 5 sites in United States, Austria and 3 more
- Volunteers
- 208 people
- Sponsor
- Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC)
Lung Cancer
Conventional vs Ultrathin Bronchoscopy for Peripheral Pulmonary Lesions
This study's purpose is to evaluate whether the use of an ultra-thin bronchoscope can improve sensitivity and diagnostic yield in peripheral pulmonary nodules.
- Trial name
- NCT04029155
- Testing
- Lung biopsy
- Volunteers
- 142 people
- Sponsor
- Stefano Gasparini