Clinical trials: Peripheral Pulmonary Nodules, open to volunteers
Peripheral Pulmonary Lesions (PPLs), Pulmonary Nodules
Comparative Study of Rotational Cryobiopsy Needle and Automated Biopsy Needle in Transthoracic Biopsy Diagnosing Peripheral Pulmonary Lesions
This study aims to systematically compare the diagnostic efficacy, specimen quality, and complication rates of the cryobiopsy needle technique（CassiII rotational core biopsy） versus the automated biopsy technique in the biopsy of…
- Trial name
- NCT07772479
- Testing
- CassiII rotational core biopsy, Automated biopsy
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Beijing Chao Yang Hospital
Lung Cancers, Peripheral Pulmonary Nodules
General Anesthesia vs Conscious Sedation for Radial Endobronchial Ultrasound
The endoscopic investigation of lung lesions is experiencing significant growth with the increasing number of lung cancer screening programs.
- Trial name
- RESSOURCE (NCT06950515)
- Testing
- Peripheral EBUS under Concious sedation, Peripheral EBUS under General Anesthesia
- Where
- Canada
- Volunteers
- 306 people
- Sponsor
- Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Pulmonary Nodule, Solitary, Peripheral Pulmonary Nodules
Intraoperative Longitude-Latitude-Depth Localization Versus Preoperative CT-Guided Percutaneous Lung Puncture Localization for 0.8-2 cm Peripheral Pulmonary Nodules
The goal of this clinical trial is to learn whether intraoperative longitude-latitude-depth three-dimensional localization (LLD localization) is non-inferior to preoperative CT-guided percutaneous lung puncture localization for…
- Conditions
- Pulmonary Nodule, Solitary, Peripheral Pulmonary Nodules, Pulmonary Nodules
- Trial name
- NCT07675889
- Testing
- Longitude-Latitude-Depth Localization, CT-Guided Percutaneous Lung Puncture Localization
- Where
- 4 sites in China
- Volunteers
- 274 people
- Sponsor
- Qilu Hospital of Shandong University
Diagnosis
The Study of ENB With Ultra-thin Cryobiopsy in the Diagnosis of Peripheral Pulmonary Nodules
To investigate the safety and efficacy of ultrafine cryoprobe biopsy by electromagnetic navigation bronchoscopy compared with biopsy forceps in the diagnosis of peripheral pulmonary nodules in a national multicenter randomized…
- Trial name
- NCT07326072
- Testing
- Cryobiopsy, Forceps biopsy
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Beijing Chao Yang Hospital
Lung Cancer (Diagnosis)
Novel Thin Bronchoscope Versus Ultrathin Bronchoscope for the Diagnosis of Peripheral Pulmonary Nodules
This is a prospective, randomised, non-inferior, multicenter study in consecutive patients with solid or sub-solid PPLs 8 to 30 mm in diameter.The subjects will be randomly assigned in a 1:1:1 ratio to the 3.0mm outer…
- Trial name
- NCT07135297
- Testing
- Ultrathin bronchoscope (UTB), Thin bronchoscope (TB1), Thin bronchoscope (TB2)
- Where
- 5 sites in China
- Volunteers
- 465 people
- Sponsor
- Shanghai Chest Hospital
Peripheral Pulmonary Nodules
RAB Versus Ultrathin Bronchoscopy With VBN in the Diagnosis of PPNs
The purpose of this study is to evaluate whether the diagnostic yield of robotic-assisted bronchoscopy is not inferior to that of the virtual bronchoscopic navigation combined with ultrathin bronchoscopy.
- Trial name
- NCT06962436
- Testing
- Robotic bronchoscopy system, Ultrathin bronchoscope combined with virtual bronchoscopic navigation
- Where
- 5 sites in China
- Volunteers
- 186 people
- Sponsor
- Shanghai Chest Hospital
Pulmonary Nodules
The SEQUENCE Trial
This study will randomize participants undergoing a bronchoscopic biopsy of a peripheral pulmonary nodule for their standard of care to receive robotic-assisted bronchoscopy (RaB) and then staging linear endobronchial ultrasounnd…
- Trial name
- SEQUENCE (NCT06676956)
- Testing
- Linear EBUS first, Robotic-assisted bronchoscopy first
- Where
- 5 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Peripheral Pulmonary Nodules
Diagnostic Efficiency Comparasion of Hand-Drawn Navigation and Virtual Navigation for Peripheral Pulmonary Nodules
Peripheral pulmonary lesions (PPLs) refer to isolated or localized lesions located in the outer one-third of the lung field. Their qualitative diagnosis is a key link in the early screening and precise treatment of lung cancer.
- Trial name
- NCT07053124
- Testing
- Hand-drawn navigation, Virtual bronchoscopy navigation
- Volunteers
- 500 people
- Sponsor
- Guangzhou Medical University
Lung Nodule, Solitary, Lung Nodule
Iriscope for the Diagnosis of Peripheral Pulmonary Lesions: a Multicentre Randomised Controlled Trial
A pulmonary nodule is a small mass detected in your lungs during a scan. When a nodule is suspicious, we need to determine its nature (benign or malignant). To do this, a bronchoscopy is performed.
- Conditions
- Lung Nodule, Solitary, Lung Nodule, Lung Cancer (Diagnosis)
- Trial name
- NCT07798362
- Testing
- Use of Iriscope via guide sheath to guide biopsies, Bronchoscopy
- Volunteers
- 140 people
- Sponsor
- Erasme University Hospital
Lung Cancer (Diagnosis), Pulmonary Nodule Persistent
Multi-omics Detection Techniques for Differentiating Benign and Malignant Pulmonary Nodules
Research objective: To explore the clinical application effect of multi-omics detection based on flow cytometry analysis, single-cell data and images combined with clinical features in differentiating the benign and malignant…
- Trial name
- NCT07047573
- Testing
- PBMCS were isolated from the peripheral blood of hospitalized patients with pulmonary nodules and incubated with nanoparticles loaded with tumor antigens for a specific period of time to detect cancer
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Zhao Jun
Peripheral Pulmonary Nodules
Sd-RAB for the Diagnosis of PPNs
This is a single-center, prospective, and single-arm study. The purpose of this study is to evaluate the feasibility and safety of a new self-driving robotic-assisted bronchoscopic system for the diagnosis of peripheral pulmonary…
- Trial name
- NCT06719687
- Testing
- Self-driving robotic-assisted bronchoscope
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Chest Hospital
Peripheral Pulmonary Lesions (PPLs), Lung Nodules
Shape-sensing Versus Electromagnetic Robotic Bronchoscopy for Evaluation of PulmoNary LEsions
This is an investigator-initiated, multicenter, non inferiority, cluster randomized controlled trial. The primary objective is to compare the diagnostic yield of the electromagnetic robotic assisted bronchoscopy with digital…
- Trial name
- SERENE (NCT07411989)
- Testing
- Bronchoscopy for peripheral pulmonary lesion biopsy
- Where
- 2 sites in United States
- Volunteers
- 346 people
- Sponsor
- The Cleveland Clinic
Stage I - II Primary Lung Cancer, Stage I Lung Cancer
Avecure Flexible Microwave Ablation Probe For Lung Nodules
This research study to determine the effectiveness of the AveCure Flexible Microwave Ablation Probe to destroy cancerous lung nodules up to 3 c m in size. This research study involves microwave ablation (MWA)
- Conditions
- Stage I - II Primary Lung Cancer, Stage I Lung Cancer, Stage II Lung Cancer, Lung Cancer Stage I
- Trial name
- NCT05281237
- Testing
- AveCure 16 Gauge Flexible Microwave Ablation Probe
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Beth Israel Deaconess Medical Center
Multiple Pulmonary Nodules
Single-Center CyTOF and Viral Imprinting Study in Postoperative Multiple Pulmonary Nodules
This multicenter prospective cohort study will enroll adults who have undergone resection of a primary pulmonary nodule and have residual multiple pulmonary nodules or require routine postoperative pulmonary nodule follow-up.
- Trial name
- NCT07647055
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Multiple Pulmonary Nodules
Peripheral Blood CyTOF and Viral Imprinting in Postoperative Multiple Pulmonary Nodules
This multicenter prospective cohort study will enroll adults who have undergone resection of a primary pulmonary nodule and have residual multiple pulmonary nodules or require routine postoperative pulmonary nodule follow-up.
- Trial name
- NCT07647484
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Lung Cancer, Non-Small Cell, Lung Cancer, Small Cell
The Diagnostic Value of Bronchoscopic Needle-based Confocal Laser Endomicroscopy (nCLE) As a Real-time Detection Tool for Diagnosing Peripheral Lung Cancer: a Multi-centre Randomised Controlled Trial
The goal of this prospective, multi-centre, randomised controlled clinical study is to evaluate the diagnostic efficacy and safety of nCLE guided lung biopsy in patients with for peripheral lung nodules under the assistance of…
- Trial name
- NCT06739421
- Testing
- nCLE-NB-rEBUS-forcep biopsy, nCLE-NB-rEBUS-TBCB, NB-rEBUS-forcep biopsy
- Where
- China
- Volunteers
- 1,040 people
- Sponsor
- China-Japan Friendship Hospital
Lung Nodules, Peripheral Lung Lesions
Shape-Sensing Robotic-Assisted Bronchoscopy for Diagnosis of Peripheral Pulmonary Nodules in Korea
What is this study about? This study tests a new robotic technology to take tissue samples from lung nodules (small spots in the lungs). Some lung nodules are cancer, but doctors need a tissue sample to know for sure.
- Conditions
- Lung Nodules, Peripheral Lung Lesions, Pulmonary Nodules, Lung Cancers
- Trial name
- ULSAN-ION (NCT07057648)
- Testing
- Shape-sensing Robotic-assisted Bronchoscopy (ssRAB)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Ulsan University Hospital
Lung Cancer, Lung Neoplasm Malignant
Confocal Laser Endomicroscopy VERification
The goal of this multi-center randomized clinical trial is to evaluate the added value of needle based confocal laser endomicroscopy (nCLE)-imaging to regular diagnostic bronchoscopic peripheral lung lesion analysis on the…
- Conditions
- Lung Cancer, Lung Neoplasm Malignant, Carcinoma, Non-Small-Cell Lung, Neoplasm of Lung
- Trial name
- CLEVER (NCT06079970)
- Testing
- Neelde Based Confocal Laser Endomicroscopy, Conventional diagnostic bronchoscopy
- Where
- 5 sites in United States, Austria and 3 more
- Volunteers
- 208 people
- Sponsor
- Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC)