Clinical trials: Periprosthetic Infection
PJI
Results of Silver-coated Resection Prostheses in the Treatment of Periprosthetic Knee Infections with Bone Deficiency
The goal of this observational study is to evaluate the infection control and mid-term survival of silver-coated articulated megaprosthetic and knee arthrodesis implants in PJI patients with bone stock deficiency and treated with…
- Trial name
- MEGAPJI (NCT06806449)
- Where
- 3 sites in Italy
- Volunteers
- 45 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Candida Infection
One-stage Exchange in Candida Periprosthetic Infection a Suitable Way to go
Accounting for only 0.7% to 3% of joint prosthesis infections, yeast infections are considered particularly difficult to treat. They are primarily caused by Candida yeasts, representing over 90% of cases.
- Trial name
- CPCI (NCT07303101)
- Where
- France
- Volunteers
- 16 people
- Sponsor
- University Hospital, Strasbourg, France
Femoral Neck Fractures, Prosthetic Infection
Dual vs. Single-Antibiotic Impregnated Cement in Hemiarthroplasty for Femoral Neck Fracture
Rational for conducting the study: Periprosthetic joint infection (PJI) is the most feared complication following prosthetic replacement of the hip joint and is associated with increased mortality, morbidity and economic burden.
- Trial name
- DAICY (NCT05164081)
- Testing
- antibiotic loaded bone cement (gentamicin+clindamycin) COPAL G+C (Heraeus)., antibiotic loaded bone cement (gentamicin) Paladins R+G (Heraeus) or Refobacin (Biomet).
- Where
- Sweden
- Volunteers
- 7,000 people
- Sponsor
- Umeå University
Infections
Dose Optimization of Rivaroxaban Combined With Rifampicin
The goal of this observational study is to learn about exposure levels of rivaroxaban at different doses in patients with prosthetic joint infection combined with the use of rifampicin.
- Trial name
- NCT05658042
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
PJI
Infection Consortium Study#1
In this study, the Sponsor wants to evaluate the performance and accuracy of the PJI Panel compared to the currently used multiple-criterion scoring systems for the diagnosis of PJI.
- Trial name
- NCT06153446
- Testing
- Synovasure® Comprehensive Infection Panel
- Where
- United States
- Volunteers
- 810 people
- Sponsor
- Zimmer Biomet
Femoral Neck Fracture, Infection
Early Periprosthetic Joint Infection and Outcome Debridement, Antibiotics and Implant Retention
Introduction Periprosthetic joint infection (PJI) is a severe complication to hip arthroplasty for femoral neck fractures (FNF).
- Trial name
- DAIR (NCT02771639)
- Testing
- Hip arthroplasty
- Volunteers
- 736 people
- Sponsor
- Sundsvall Hospital
Total Joint Arthroplasty, Periprosthetic Joint Infections
Genetic Susceptibility to Periprosthetic Joint Infections
The investigators primary objective is to identify genetic factors that may increase the risk of patients developing a periprosthetic joint infections (PJI) following total joint arthroplasty (TJA).
- Trial name
- NCT05159739
- Testing
- Blood Draw or Saliva/Cheek Cell Sample:
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Utah
SARS CoV 2 Infection
Using Vibroacoustic Therapy in a Patient With Co-infection and COVID-19
This article describes a case of successful treatment of a 59-year-old man with sepsis as a result of periprosthetic infection against the background of severe SARS-CoV-2-19, who was hospitalized for 59 days, 57 of which were in…
- Trial name
- NCT05188482
- Testing
- vibroacoustic therapy
- Where
- Kazakhstan
- Volunteers
- 1 people
- Sponsor
- Astana Medical University
Periprosthetic Joint Infection
Preoperative Daptomycin Prophylaxis in Two-Stage Exchange Arthroplasty: A Prospective, Randomized, Double-Blinded Trial
The gold standard for treating prosthetic joint infection (PJI) is two-stage exchange arthroplasty. This includes the first stage of debridement and removal of the artificial joint, and the second stage of reimplantation of the…
- Trial name
- NCT06189885
- Testing
- Cefazolin with Daptomycin, Cefazolin with vancomycin
- Where
- Taiwan
- Volunteers
- 184 people
- Sponsor
- Chang Gung Memorial Hospital
Streptococcus Infection
Clindamycin as Antimicrobial Treatment for Streptococcus Spp. PeRiprosthetic Infection
Clindamycin is an antibiotic with several advantages: high oral bioavailability and good bone and joint penetration. In France, it is a recommended drug for other types of Streptococcus spp.
- Trial name
- CASPR (NCT07335627)
- Where
- France
- Volunteers
- 260 people
- Sponsor
- University Hospital, Strasbourg, France
Hip Osteoarthritis, Hip Arthritis
Evaluating XPERIENCE™ Advanced Surgical Irrigation
A prospective, multi-center, double-arm, parallel, interventional, randomized, controlled clinical trial to assess the rate of periprosthetic joint infection (PJI) in patients undergoing primary total knee arthroplasty (TKA)…
- Conditions
- Hip Osteoarthritis, Hip Arthritis, Knee Osteoarthritis, Knee Arthritis
- Trial name
- XPERIENCE (NCT05543941)
- Testing
- XPERIENCE Advanced Surgical Irrigation, Dilute Betadine
- Where
- 8 sites in Canada
- Volunteers
- 7,600 people
- Sponsor
- Ottawa Hospital Research Institute
Periprosthetic Joint Infection (PJI)
Preop Biomarkers as Outcome Predictors in 2 Stage Revision Surgery for PJI
With the progressive ageing of the population, a significant increase in the incidence of skeletal fractures-particularly of the proximal femur-as well as degenerative conditions such as osteoarthritis has been observed, for…
- Trial name
- ARKO-PJI (NCT07358455)
- Volunteers
- 200 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Periprosthetic Joint Infection (PJI)
Efficacy of Serum ESR, CRP, Synovial Leucocyte Esterase Dipstick Test in The Diagnosis of Chronic Infection in Total Joint Arthroplasty
aim of this study was to determine accuracy of using leucocyte esterase (LE),Erythroscyte sedimentation rates (ESR) and C- Reactive protein (CRP) for diagnosing periprosthetic joint infections (PJI)
- Trial name
- ESR/CRP/LE pji (NCT07718386)
- Testing
- CRP, ESR, Leukocyte esterase dipstick test
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Prosthetic Joint Infection
Abbreviated Protocol for Two-Stage Exchange
Study Type: A multi-site, parallel group, randomized trial. Study Objectives: The objective is to evaluate safety and determine preliminary efficacy of VT-X7 (Vancomycin and Tobramycin Exchanged over 7 Days).
- Trial name
- APEX (NCT04662632)
- Testing
- VT-X7 Treatment System with Tobramycin Sulfate, Standard of Care, Two-stage exchange arthroplasty
- Where
- 17 sites in United States
- Volunteers
- 76 people
- Sponsor
- Osteal Therapeutics, Inc.
Periprosthetic Joint Infection
Treatment of Acute Periprosthetic Joint Infection Comparing Single and Planned Double-Debridement Antibiotics and Implant Retention Followed by Chronic Antibiotic Suppression
The purpose of this research is to evaluate two different standard of care surgeries in treating periprosthetic joint infection (PJI) after total hip and knee arthroplasty.
- Trial name
- NCT05640336
- Testing
- Single Debridement, Antibiotics and Implant Retention, Planned Double Debridement, Antibiotics and Implant Retention
- Where
- 2 sites in United States
- Volunteers
- 490 people
- Sponsor
- Mayo Clinic
Total Knee Arthroplasty, Reinfection
Reinfection and Re-revision Rates of Periprosthetic Knee Infection Under Four Different Surgical Strategies
A single-center retrospective cohort study was conducted in the Department of Orthopedics, the First Affiliated Hospital of Fujian Medical University.
- Conditions
- Total Knee Arthroplasty, Reinfection, Aseptic Loosening, Revision
- Trial name
- NCT07232771
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Knee; Infection, Joint
Clinical Evaluation of Infection Control to Knee Periprosthetic Joint Infection (PJI) -United Cellbrick Knee Spacer
A novel polyethylene-based knee spacer (United Cellbrick Knee Spacer), for the purpose of infection control, was developed to enhance biomechanical safety and surgical convenience of articulating knee spacers.
- Trial name
- NCT06042062
- Testing
- Novel spacer, Spacer
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Chang Gung Memorial Hospital
Periprosthetic Joint Infection
Phage Therapy for the Treatment of a Chronic Enterococcus Faecium Periprosthetic Joint Infection
This purpose of this clinical trial is to evaluate the safety, tolerability and efficacy of a bacteriophage therapy in a patient with a methicillin-susceptible Enterococcus faecium (E.
- Trial name
- NCT06942624
- Testing
- Phage Therapy
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Orthopaedic Innovation Centre
Femur Fracture, Periprosthetic Fracture of Hip
Dose-Response Association Between Cerclage Wire Number and Infection Risk
The purpose of this dual-center retrospective study is to investigate the relationship between the number of metallic cerclage wires used in femoral fracture surgery and the risk of developing deep infections.
- Conditions
- Femur Fracture, Periprosthetic Fracture of Hip, Periprosthetic Fracture of the Femur, Surgical Site Infection (SSI)
- Trial name
- C-INFECT (NCT07434258)
- Testing
- 1 Metallic Cerclage Wiring, 2 metalic cerclage wire, 3 metalic cerclage wire
- Volunteers
- 148 people
- Sponsor
- Istanbul University
Periprosthetic Joint Infection
Rifampin-combined Antibiotic Therapy for Staphylococcal PJI
This is a prospective, multicenter, randomized controlled study. Patients were evaluated through inclusion and exclusion criteria. Patients who meet the conditions will sign an informed consent form.
- Trial name
- NCT07313215
- Testing
- Rifampicin (R)
- Where
- China
- Volunteers
- 428 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University