Clinical trials: Periprosthetic Joint Infection
Osteoarthritis, Knee, Infection
Is Second Knee at Risk During Simultaneous Bilateral Total Knee Arthroplasty.
The effects of single-team simultaneous bilateral total knee arthroplasty on peri- and postoperative complications are clear. The investigators hypothesized that second knee at risk during single-team simultaneous bilateral total…
- Conditions
- Osteoarthritis, Knee, Infection, Periprosthetic Fracture Around Prosthetic Joint Implant
- Trial name
- NCT04367272
- Testing
- First Arthroplasty, Second Arthroplasty
- Volunteers
- 163 people
- Sponsor
- Bezmialem Vakif University
Prosthetic Joint Infections of Hip, Bacteriophage Therapy
Bacteriophage Therapy for Staphylococcus Lugdunensis Prosthetic Joint Infection
This is a single-patient, phase I/II clinical trial that aims to evaluate the potential of a bacteriophage drug product to treat and prevent the recurrence of a Staphylococcus lugdunensis prosthetic joint infection of the hip.
- Trial name
- NCT07461337
- Testing
- Five phage anti-Staphylococcus aureus bacteriophage cocktail
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Calgary
Infection
Prophylaxis of Periprosthetic Joint Infections With Calcium Sulfate Beads in Patients With Non-modifiable Risk Factors.
To demonstrate the prophylactic effect of calcium sulfate beads loaded with antibiotic in patients with non-modifiable risk factors that will undergo a hip or knee joint replacement, comparing with a control group.
- Trial name
- Stimulan (NCT03976466)
- Testing
- Antibiotic local prophylaxis with medicated calcium sulfate beads, Classical parenteral antibiotic prophylaxis
- Where
- Mexico
- Volunteers
- 87 people
- Sponsor
- Hospital Regional Tlalnepantla
Periprosthetic Joint Infection
Rifampin-combined Antibiotic Therapy for Staphylococcal PJI
This is a prospective, multicenter, randomized controlled study. Patients were evaluated through inclusion and exclusion criteria. Patients who meet the conditions will sign an informed consent form.
- Trial name
- NCT07313215
- Testing
- Rifampicin (R)
- Where
- China
- Volunteers
- 428 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Prosthetic-joint Infection
LE as a Marker for Periprosthetic Joint Infection
Testing and comparison of a novel point-of-care electrochemical assay to detect and help diagnose periprosthetic joint infection on the hip and knee to the standard of care test
- Trial name
- NCT05440032
- Testing
- Semi-quantitative electrochemical leukocyte esterse test strip, Roche Chemstrip
- Where
- 8 sites in United States
- Volunteers
- 160 people
- Sponsor
- Center for Innovation and Research Organization
Dihydrotestosterone, Periprosthetic Joint Infection (PJI)
Finasteride and Cutibacterium
High levels of Testosterone causes high amounts of skin bacteria (Cutibacterium Acnes) which can go into the skin during a shoulder replacement surgery and cause a terrible infection.
- Conditions
- Dihydrotestosterone, Periprosthetic Joint Infection (PJI), Cutibacterium Acnes
- Trial name
- NCT07731802
- Testing
- Finasteride 1 mg
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Washington
Infection Prosthesis Hip and Knee, Infection, Prosthesis Related
Results of Extended Versus Single Dose Antibiotic Prophylaxis In Orthopedic Revision Arthroplasty in Nijmegen.
The goal of this randomized control trial is to investigate the superiority of 5 days (extended) versus a single dose of cefazolin prophylaxis in revision arthroplasty of the hip and knee.
- Conditions
- Infection Prosthesis Hip and Knee, Infection, Prosthesis Related, Joint Infection, Infection, Surgical Site
- Trial name
- REViSION (NCT06402591)
- Testing
- Cefazolin
- Where
- Netherlands
- Volunteers
- 751 people
- Sponsor
- Radboud University Medical Center
Prosthesis-Related Infections, Arthroplasty, Replacement, Hip
Exploring Novel Diagnostic Tools for Periprosthetic Joint Infection
Joint replacement is a valuable surgical intervention that improves quality of life, provides pain relief, and restores function of patients.
- Conditions
- Prosthesis-Related Infections, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
- Trial name
- VECTOR-PJI (NCT05582460)
- Testing
- Reporter Gene Assay, Flow Cytometry
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Rijnstate Hospital
Prosthetic Joint Infection
The Utility of Next-generation Sequencing for the Diagnosis of Periprosthetic Joint Infection
This is a prospective multicenter study. All patients presenting for revision hip or knee arthroplasty for all indications under the respective surgeon's care may be eligible.
- Trial name
- NCT03200470
- Testing
- No intervention: sample collection study
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Rothman Institute Orthopaedics
Periprosthetic Joint Infection, PJI
Diagnosis and Bacterial Identification of Periprosthetic Joint Infection With Microbial-ID
The primary objective of this study is to demonstrate the validity of the Microbial- ID test to aid in diagnosis of periprosthetic joint infection (PJI) in terms of sensitivity and specificity.
- Trial name
- MID (NCT05320354)
- Testing
- Microbial ID test
- Where
- 6 sites in Germany, Netherlands and 4 more
- Volunteers
- 200 people
- Sponsor
- UMC Utrecht
Periprosthetic Joint Infection, Anti-Bacterial Agents
Prospective Cohort Study on Antibiotic Course and Efficacy After Two-stage Revision in PJI.
This is a multicenter prospective cohort study in which patients were evaluated by inclusion and exclusion criteria before phase II revision surgery.
- Trial name
- PACER-PJI (NCT05284318)
- Testing
- Antibiotics treatment
- Where
- China
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Hip Prosthesis Infection
Does the Type of Ventilation Affect the Risk for Infections After Hip Replacements?
Background: During hip replacement surgery, there is a risk that bacteria in the operating room can cause an infection. To try and reduce this risk, some operating rooms use a special system called laminar airflow (LAF), which…
- Trial name
- NCT05932823
- Testing
- Laminary airflow
- Volunteers
- 110,000 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Aseptic Loosening of Prosthetic Joint, Instability of Prosthetic Joint
The Use of CCK vs PS in Revision TKAs
This study aims to compare the clinical impact of Constrained Condylar versus Posterior Stabilized Knee (PS) bearings on patient satisfaction and surgical outcomes including mid-term survivorship among patients undergoing…
- Conditions
- Aseptic Loosening of Prosthetic Joint, Instability of Prosthetic Joint, Reimplantation for Periprosthetic Joint Infection, Femoral Revision Indicated
- Trial name
- NCT06782295
- Testing
- Constrained Condylar bearing, posterior stabilized bearing
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Rush University Medical Center
Prosthetic Joint Infection
Identification of Molecular Marker of Coagulase-negative Staphylococci for the Diagnosis of Prosthetic Joint Infections
One of the major causes of prosthetic joint failure is infection. Recently, coagulase-negative Staphylococci (CoNS) have been identified as emergent, nosocomial pathogens involved in subclinical prosthetic joint infections…
- Trial name
- NCT04661345
- Testing
- Proteomic analysis of synovial fluids, Proteomic analysis of the isolated coagulase-negative Staphylococci
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Direct Infection of Hip- and Knee Arthroplasty
Debridement, Antibiotics and Implant Retention in Early Periprosthetic Joint Infection: A Retrospective Cohort Study
Introduction: Periprosthetic joint infection (PJI) is a common cause for reoperation after knee and hip arthroplasty surgery. Debridement, antibiotics and implant retention (DAIR) is recommended in early infections (< 4 weeks)…
- Trial name
- DAIR (NCT02087020)
- Testing
- Debridement, antibiotics and implant retention
- Where
- Sweden
- Volunteers
- 51 people
- Sponsor
- Danderyd Hospital
Periprosthetic Joint Infection, Antibiotic Suppression
Proper Duration of Suppressive Antibiotic Therapy After Debridement, Antibiotics, and Implant Retention
Multiple studies have demonstrated oral suppressive antibiotic therapy (SAT), after intravenous antibiotics, maximizes reoperation-free survival of total joint arthroplasty (TJA) debridement, antibiotics, and implant retention…
- Trial name
- ProperSAT (NCT05495815)
- Testing
- 6 months of SAT, 12 months of SAT, Indefinite SAT
- Where
- United States
- Sponsor
- University of Maryland, Baltimore
Infections
Dose Optimization of Rivaroxaban Combined With Rifampicin
The goal of this observational study is to learn about exposure levels of rivaroxaban at different doses in patients with prosthetic joint infection combined with the use of rifampicin.
- Trial name
- NCT05658042
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Revision Hip Arthroplasty, Aseptic Loosening of Prosthetic Joint
Post-Market Clinical Follow-Up (PMCF) Study Evaluating the Safety and Efficacy of Tıpmed™ Revision Hip Prosthesis System
This is a multicenter, prospective, observational, post-market clinical follow-up (PMCF) study designed to evaluate the safety and clinical performance of the Tipmed™ Revision Hip Prosthesis System in adult participants…
- Conditions
- Revision Hip Arthroplasty, Aseptic Loosening of Prosthetic Joint, Prostheses-related Infections, Joint Instability
- Trial name
- NCT07653295
- Testing
- Tıpmed™ Revision Hip Prosthesis System
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- TIPMED Medical Device Manufacturing Ltd. Co.
Prosthetic Joint Infection, Prosthetic Infection
Susceptibility Testing of Biofilm to Guide Treatment of Periprosthetic Joint Infections
The overall purpose of this clinical treatment research project is to explore novel diagnostics that can guide the treatment of infections associated to orthopaedic implants, in order to improve patient outcomes and reduce the…
- Conditions
- Prosthetic Joint Infection, Prosthetic Infection, Hip Prosthesis Infection, Knee Prosthesis Infection
- Trial name
- NCT04488458
- Testing
- MIC or MBEC+MIC based treatment algorithm
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Vastra Gotaland Region
Prosthetic-joint Infection
Expanded Access to Cyclic Irrigation in Patients Undergoing Exchange Arthroplasty
The objective of the protocol is to provide access to the VT-X7 (Vancomycin, Tobramycin Exchanged in 7 Days) system for subjects with periprosthetic joint infection (PJI) of the hip or knee who lack therapeutic treatment…
- Trial name
- APEX-EAP (NCT06383611)
- Testing
- VT-X7 Treatment System
- Where
- 14 sites in United States
- Sponsor
- Osteal Therapeutics, Inc.