Clinical trials: Periprosthetic Knee Infection
Joint (Knee or Hip Replacement), Infection as Complication of Medical Care
Swiss Revision Cohort
This study follows patients with infections after a joint replacement over time. During follow-up, treatment outcomes are carefully measured to determine whether the infection can be cured.
- Trial name
- REVCO (NCT07473089)
- Testing
- Revision for periprosthetic joint infections of the hip, knee, shoulder, elbow or ankle
- Where
- 5 sites in Switzerland
- Volunteers
- 329 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Aseptic Loosening, Infection
Maxx Orthopedics' PCK Revision TKA Study of Component Survivorship
The objectives of this clinical investigation are to evaluate the safety and performance of the Freedom Total Knee® PCK System.
- Conditions
- Aseptic Loosening, Infection, Bone Loss, MCL - Medial Collateral Ligament Rupture of the Knee
- Trial name
- NCT03312088
- Testing
- Freedom Knee PCK Components
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Maxx Orthopedics Inc
Local Antibiotic Injection Catheter Acute Periprosthetic Infections Knee DAIR Randomized Controlled Trial
Efficacy of Local Antibiotic Injection Via a Catheter for Treating Acute Periprosthetic Infections After Knee DAIR Surgery
Prosthetic Joint Infection (PJI) is a severe complication following joint replacement surgery, imposing significant economic and health burdens on patients.
- Trial name
- YES (NCT06468163)
- Testing
- Drug infusion into joint through catheter.
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Xinjiang Medical University
Infection
The Effect of Oral Antibiotics on Synovial Fluid and Differential for the Diagnosis of Infection
Periprosthetic joint infection following total hip or knee arthroplasty is a rare but potentially devastating complication. Accurate diagnosis of these infections remains one of the most challenging undertakings in orthopaedics.
- Trial name
- NCT03551847
- Testing
- Antibiotic, No antibiotics
- Where
- United States
- Sponsor
- Rush University Medical Center
Direct Infection of Hip- and Knee Arthroplasty
Debridement, Antibiotics and Implant Retention in Early Periprosthetic Joint Infection: A Retrospective Cohort Study
Introduction: Periprosthetic joint infection (PJI) is a common cause for reoperation after knee and hip arthroplasty surgery. Debridement, antibiotics and implant retention (DAIR) is recommended in early infections (< 4 weeks)…
- Trial name
- DAIR (NCT02087020)
- Testing
- Debridement, antibiotics and implant retention
- Where
- Sweden
- Volunteers
- 51 people
- Sponsor
- Danderyd Hospital
Periprosthetic Fracture Around Prosthetic Joint Implant
Investigating Periprosthetic Fracture Cultures in Arthroplasty
This study aims to improve how doctors diagnose infections in patients with broken bones around joint replacements. Currently, there are no clear guidelines to help determine when an infection is present, making treatment…
- Trial name
- NCT06952738
- Testing
- Not applicable- observational study
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Chicago
Prosthetic Joint Infection of Knee
Sola2 AMF Knee System Added to Surgery and Antibiotics in Adults With Knee Implant Infection
The goal of this clinical trial is to learn whether the Sola2 AMF Knee System, when added to surgery and antibiotic treatment, can safely improve outcomes, knee function, and quality of life in adults with knee implant infection.
- Trial name
- AMPLIFY (NCT07700927)
- Testing
- Intervention 1: Alternating Magnetic Field Treatment, Debridement, Antibiotics, Implant Retention
- Where
- 2 sites in United States
- Volunteers
- 165 people
- Sponsor
- Solenic Medical, Inc.
Infection of Total Knee Joint Prosthesis
Comparison of Two Different Techniques of Synovial Biopsy and Resistances of Cutaneous Smears in Suspected PPI
The purpose of this study is to determine whether an undirected synovial biopsy technique has the same accuracy in detecting periprosthetic joint infection in the knee as an arthroscopic assisted directed synovial biopsy…
- Trial name
- COSPI (NCT02594930)
- Testing
- synovial biopsy of total knee arthroplasty
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Technical University of Munich
Periprosthetic Joint Infection (PJI)
Is the EBJIS Definition of Prosthetic Joint Infection Meaningful in Our Clinical Practice?
This retrospective multi-center, multi-national cohort study is to validate the European Bone and Joint Infection Society (EBJIS) Definition of Prosthetic Joint Infection.
- Trial name
- NCT05117671
- Testing
- data collection to classify infection status
- Where
- 2 sites in Portugal, Switzerland
- Volunteers
- 1,554 people
- Sponsor
- University Hospital, Basel, Switzerland
Prosthesis-Related Infections
Prospectively Observational Evaluation of Clinical Outcomes in Two-stage Revision for Periprosthetic Knee Infection
Total knee arthroplasty (TKA) infection is a complication requiring multiple hospitalizations, operations, and outpatient visits placing a significant burden on both patient and treating surgeons.
- Trial name
- NCT04622280
- Where
- Taiwan
- Volunteers
- 13 people
- Sponsor
- National Taiwan University Hospital
Osteoarthritis, Knee, Infection
Is Second Knee at Risk During Simultaneous Bilateral Total Knee Arthroplasty.
The effects of single-team simultaneous bilateral total knee arthroplasty on peri- and postoperative complications are clear. The investigators hypothesized that second knee at risk during single-team simultaneous bilateral total…
- Conditions
- Osteoarthritis, Knee, Infection, Periprosthetic Fracture Around Prosthetic Joint Implant
- Trial name
- NCT04367272
- Testing
- First Arthroplasty, Second Arthroplasty
- Volunteers
- 163 people
- Sponsor
- Bezmialem Vakif University
Periprosthetic Knee Infection
One-stage Versus Two-stage Revision of the Infected Knee Arthroplasty
This study investigates functional outcome and safety after one-stage versus two-stage revision of the infected knee arthroplasty.
- Trial name
- NCT03435679
- Testing
- one-stage, two-stage
- Where
- 9 sites in Denmark
- Volunteers
- 97 people
- Sponsor
- Odense University Hospital
Knee Arthropathy, PJI
Incidence and Microbial Profiles of Periprosthetic Joint Infection After Total Knee Arthroplasty in Obese vs Non-Obese Patients
Importance: After a primary total knee arthroplasty (TKA), we anticipate that obese individuals are more likely to experience a of periprosthetic joint infection (PJI).
- Trial name
- NCT07398742
- Where
- Denmark
- Volunteers
- 101,299 people
- Sponsor
- Bispebjerg Hospital
Prosthesis-Related Infections, Arthroplasty, Replacement, Hip
Exploring Novel Diagnostic Tools for Periprosthetic Joint Infection
Joint replacement is a valuable surgical intervention that improves quality of life, provides pain relief, and restores function of patients.
- Conditions
- Prosthesis-Related Infections, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
- Trial name
- VECTOR-PJI (NCT05582460)
- Testing
- Reporter Gene Assay, Flow Cytometry
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Rijnstate Hospital
Prosthetic Joint Infection, Prosthetic Infection
Susceptibility Testing of Biofilm to Guide Treatment of Periprosthetic Joint Infections
The overall purpose of this clinical treatment research project is to explore novel diagnostics that can guide the treatment of infections associated to orthopaedic implants, in order to improve patient outcomes and reduce the…
- Conditions
- Prosthetic Joint Infection, Prosthetic Infection, Hip Prosthesis Infection, Knee Prosthesis Infection
- Trial name
- NCT04488458
- Testing
- MIC or MBEC+MIC based treatment algorithm
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Vastra Gotaland Region
Knee Arthritis Osteoarthritis, Knee Replacement Arthroplasty
Is BMI Outdated in TKA Patient Selection? Assessment of the Impact of Pre-tubercular Subcutaneous Tissue Thickness and the Risk of Postoperative Infection Following Total Knee Arthroplasty
While Body Mass Index (BMI) is currently used as a primary tool for risk stratification in patients undergoing Total Knee Athroplasty(TKA), its limitations raise concerns regarding its accuracy and fairness in guiding surgical…
- Conditions
- Knee Arthritis Osteoarthritis, Knee Replacement Arthroplasty, BMI, Regional Body Composition
- Trial name
- BEYOND-BMI (NCT07763535)
- Volunteers
- 400 people
- Sponsor
- East Lancashire Hospitals NHS Trust
Periprosthetic Knee Infection
Antibiotic Elution After Two-stage Knee Revision
The goal of this observational study is to monitor the eluted antibiotic concentrations of gentamicin and vancomycin by a static knee cement spacer in patients being treated for periprosthetic infections of the knee.
- Trial name
- NCT06944184
- Testing
- Intraarticular microdialysis
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University Hospital, Bonn
Aseptic Loosening of Prosthetic Joint, Instability of Prosthetic Joint
The Use of CCK vs PS in Revision TKAs
This study aims to compare the clinical impact of Constrained Condylar versus Posterior Stabilized Knee (PS) bearings on patient satisfaction and surgical outcomes including mid-term survivorship among patients undergoing…
- Conditions
- Aseptic Loosening of Prosthetic Joint, Instability of Prosthetic Joint, Reimplantation for Periprosthetic Joint Infection, Femoral Revision Indicated
- Trial name
- NCT06782295
- Testing
- Constrained Condylar bearing, posterior stabilized bearing
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Rush University Medical Center
Infection Prosthesis Hip and Knee, Infection, Prosthesis Related
Results of Extended Versus Single Dose Antibiotic Prophylaxis In Orthopedic Revision Arthroplasty in Nijmegen.
The goal of this randomized control trial is to investigate the superiority of 5 days (extended) versus a single dose of cefazolin prophylaxis in revision arthroplasty of the hip and knee.
- Conditions
- Infection Prosthesis Hip and Knee, Infection, Prosthesis Related, Joint Infection, Infection, Surgical Site
- Trial name
- REViSION (NCT06402591)
- Testing
- Cefazolin
- Where
- Netherlands
- Volunteers
- 751 people
- Sponsor
- Radboud University Medical Center
Infection
Use of Antibiotic Carrier in Acute Periprosthetic Infections (APPI) of Total Knee Replacements
The purpose of the study is to gather information on the use of Stimulan, the surgery, and anitbiotics to whetether the APPI has decreased or shown improvement when compared to study participants who did not receive Stimulan…
- Trial name
- NCT02107924
- Testing
- APPI of TKR-Stimulan
- Where
- United States
- Sponsor
- Michael Muldoon, M.D.