Clinical trials: Peroperative Complication
Systemic Inflammatory Response Syndrome, Sepsis
Impact of Vitamin D Supplementation on Hepcidin Levels and Transfusion Requirements in Surgical and Septic Patients
Acute inflammation induced by surgery and sepsis is complicated by the development of iron-restricted anemia due to the up-regulation of hepcidin.
- Conditions
- Systemic Inflammatory Response Syndrome, Sepsis, Surgical Injuries
- Trial name
- DEHEPTRA (NCT03001687)
- Testing
- enteral supplementation with vitamin D, blood collection 3mL
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Music Therapy, Cholecystitis/Cholelithiasis
Effect of Preoperative Music on Sterile Inflammation Induced by Laparoscopic Surgery
Surgery induced sterile inflammation leaves behind a biomolecular footprint measurable by various pro-inflammatory markers e.g. IL-6, CD(Cluster of differentiation)19B, HsCRP(High-sensitivity CRP) etc.
- Conditions
- Music Therapy, Cholecystitis/Cholelithiasis, Inflammatory Response, Surgical Injury
- Trial name
- NCT03429478
- Testing
- Preoperative application of a bluetooth enabled Headphones.
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Sir Ganga Ram Hospital
Intraoperative Bleeding, Hemorrhage, Surgical
GATT-Patch Versus TachoSil in Liver Surgery
This is a pre-market, prospective, randomized (2:1), multicenter, multi-national pivotal clinical investigation. The purpose of this investigation is to determine the clinical safety and performance of GATT-Patch as compared with…
- Conditions
- Intraoperative Bleeding, Hemorrhage, Surgical, Liver Diseases
- Trial name
- NCT05385952
- Testing
- GATT-Patch (currently named ETHIZIA), TachoSil
- Where
- 10 sites in United States, Germany and 1 more
- Volunteers
- 132 people
- Sponsor
- GATT Technologies BV
Intraoperative Bleeding
Effect of Topical and Systemic Tranexemic Acid on Bleeding During Ear Exploration Surgery
The effect of tranexamic acid (TXA) on bleeding and improvement of surgical field during ear exploration surgery is not clear yet. This study will conducted to answer this question.
- Trial name
- NCT03112135
- Testing
- Tranexamic Acid, Adrenalin
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Hypothermia Following Anesthesia, Intraoperative Complications
Goal-Directed Temperature Management During Prolonged Abdominal Surgery
During long operations on the abdomen, patients often get cold. Doctors call this perioperative hypothermia. Even a small drop in body temperature can cause problems, such as more bleeding, wound infection, and a longer stay in…
- Conditions
- Hypothermia Following Anesthesia, Intraoperative Complications, Body Temperature Changes, Anesthesia, General
- Trial name
- NCT07854704
- Testing
- Forced-air warming, Intravenous fluid warming, Unwarmed intravenous fluids
- Where
- Russia
- Volunteers
- 61 people
- Sponsor
- The Leningrad Regional Clinical Hospital
Blood Loss, Surgical
Effect of Equal Ratio Ventilation on Blood Loss During Posterior Lumbar Interbody Fusion Surgery
Ventilator mode change was associated with decrease in blood loss during posterior lumbar interbody fusion (PLIF) due to decrease in the peak inspiratory pressure (PIP).
- Trial name
- NCT03030963
- Testing
- Equal ratio ventilation(ERV), I:E Ratio "1:2
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Surgery-Complications, Anesthesia Complication
Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
The investigators will conduct a 13,000-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major…
- Conditions
- Surgery-Complications, Anesthesia Complication, Anesthesia Awareness, Anesthesia
- Trial name
- THRIVE (NCT05991453)
- Testing
- Anesthetic technique Propofol TIVA, Anesthetic technique inhaled agent
- Where
- 24 sites in United States
- Volunteers
- 13,000 people
- Sponsor
- Washington University School of Medicine
Cesarean Section
To Compare the Effects of Oxytocin and Carbetocin on Intraoperative Hemodynamic Changes in Cesarean Section Surgeries.
To compare the effects of oxytocin and carbetocin, used as uterotonics in elective caesarean section surgeries, in terms of intraoperative hemodynamic changes.
- Trial name
- NCT06956365
- Testing
- Group-C, Group-O
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Awareness, Anesthesia, Post Traumatic Stress Disorder
Psychological Effect of Explicit Recall After Sedation (PEERS)
Awareness, or explicit recall, under sedation is often intended and expected by anesthesiologists and is assumed that does not associate with any sequelae.
- Conditions
- Awareness, Anesthesia, Post Traumatic Stress Disorder, Depression
- Trial name
- PEERS (NCT04747379)
- Where
- Canada
- Volunteers
- 2,500 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Laparoscopic Pancreaticoduodenectomy
Analysis of Intraoperative Bleeding Characteristics in Laparoscopic Pancreaticoduodenectomy
In this study, we analyze the common bleeding characteristics in laparoscopic pancreaticoduodenectomy by reviewing and annotating bleeding information from previous surgical videos as well as surgical operation OSATS technique…
- Trial name
- NCT06128603
- Testing
- laparoscopic pancreaticoduodenectomy
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xinrui Zhu，MD
Anesthesia; Functional, Anesthesia Awareness
The Effect of Minimal Flow Sevoflurane Anesthesia
Our aim is to investigate the effect of minimal flow anesthesia with sevoflurane on hemodynamics and arterial blood gas parameters in laparoscopic cholecystectomy operations.
- Trial name
- NCT04813952
- Testing
- Sevoflurane inhalant product
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Hepatectomy, Transfusion Requirements
Reducing Red Blood Cell Transfusion Requirements for Adults Undergoing Surgical Resection of the Liver - A Quality Improvement Project
The goal of this clinical trial is to determine if implementing a controlled blood removal protocol (i.e. hypovolemic phlebotomy [HP] where approximately 10% of the patient's blood is removed and reinfused following hepatic…
- Conditions
- Hepatectomy, Transfusion Requirements, Intraoperative Bleeding, Intraoperative Monitoring
- Trial name
- NCT07629648
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Dr. Glenio Mizubuti (MD, PhD, FRCPC)
Blood Loss, Surgical
Can Trajectory Nor-epinephrine Infiltration Reduce Blood Loss During Percutaneous Nephrolithotomy (PCNL)?
during PCNL; A few milliliters of nor-epinephrine is injected into the intended tract after puncture of pelvicalyceal system and before its dilatation compared to injection of saline (placebo).
- Trial name
- NCT05035303
- Testing
- Nor-Epinephrine injection versus saline during PCNL
- Where
- 2 sites in Egypt
- Volunteers
- 140 people
- Sponsor
- Benha University
Hypothermia; Anesthesia, Peroperative Complication
Perioperative Hypothermia in Patients Submitted to Transurethral Resection
Hypothermia is a frequent perioperative complication. Its appearance can have deleterious effects such as myocardial ischemia or perioperative bleeding.
- Trial name
- NCT03527329
- Testing
- WarmTouch Model 5900, Covidien Ltd, Mansfield, USA
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
Intraoperative Complications, Postoperative Complications
Evaluating the Effect of Surgical Safety Checklists on Perioperative Complications in Children
The purpose of this study is to see if the surgical safety checklist is associated with a reduction in perioperative complications for children undergoing surgery in Ontario, Canada.
- Trial name
- NCT02419053
- Testing
- Surgical Safety Checklist
- Where
- Canada
- Volunteers
- 28,772 people
- Sponsor
- The Hospital for Sick Children
Surgical Blood Loss, Surgical Hemorrhage
TEG Use in Children Undergoing Procedures With High Anticipated Blood Loss
The research team proposes a prospective, observational study to better understand how TEG can be useful in guiding clinical practice in the Main OR for subject's undergoing high transfusion risk surgeries.
- Conditions
- Surgical Blood Loss, Surgical Hemorrhage, Post Operative Hemorrhage
- Trial name
- NCT05379530
- Testing
- Thromboelastography (TEG), Anesthesia Provider Survey
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Blood Loss, Postoperative, Blood Loss, Surgical
EFFECT OF TRANEXAMIC ACID ON PERIOPERATIVE BLOOD LOSS IN REAMED INTRAMEDULLARY NAILING OF DIAPHYSEAL FEMORAL AND TIBIAL FRACTURES: A PROSPECTIVE COMPARATIVE STUDY
Perioperative blood loss is one of the most frequently encountered and significant complications of spine surgery. Intraoperative and post-operative bleeding cause various complications and negatively affect patient outcomes.
- Conditions
- Blood Loss, Postoperative, Blood Loss, Surgical, Femoral Fracture, Tibial Fracture
- Trial name
- NCT07625709
- Testing
- Intervention with Tranexamic Acid, Control group (Normal Saline)
- Where
- Nepal
- Volunteers
- 54 people
- Sponsor
- Kathmandu University School of Medical Sciences
Misoprostol Allergy, Oxytocin Allergy
Methods Decreasing Bleeding in Open Myomectomy
Uterine leiomyomas (fibroids or myomas) are benign, smooth muscle tumors of the human uterus. Most myomas are asymptomatic (symptomless) and are discovered incidentally during a routine pelvic examination or imaging studies and…
- Conditions
- Misoprostol Allergy, Oxytocin Allergy, Tranexamic Acid Allergy, Ethamsylate Allergy
- Trial name
- NCT05806307
- Testing
- Misoprostol, Tourniquet, Carbetocin
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Cairo University
Blood Loss, Surgical, Blood Loss Requiring Transfusion
ROTEM-guided Transfusion Protocol in Attempt to Reduce Blood Transfusions in Major Oncological Surgery
Need for perioperative blood transfusion is still high in certain types of oncological abdominal surgery. Allogeneic blood transfusion may be detrimental in cancer patients undergoing a potentially curative resection of malignant…
- Conditions
- Blood Loss, Surgical, Blood Loss Requiring Transfusion, Coagulation Defect; Acquired
- Trial name
- ROTEM-SUR (NCT03993977)
- Testing
- Rotational thromboelastometry, Conventional treatment
- Where
- Finland
- Sponsor
- Tampere University Hospital
Anemia, Anemia, Iron-Deficiency
Patient Blood Management in Patients Scheduled for Cardiac Surgery
The ICARUS 2 study has the general objective of collecting data in patients undergoing cardiac surgery; in our centre, in order to optimize and improve hemoglobin values, a team of haematologists, assisted by cardio anesthetists…
- Conditions
- Anemia, Anemia, Iron-Deficiency, Iron Deficiency Anemia Treatment, Iron Deficiency Anemia (IDA)
- Trial name
- ICARUS-2 (NCT06637137)
- Testing
- Iron
- Where
- Italy
- Volunteers
- 464 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS