Clinical trials: Peroperative Complication
Blood Loss, Surgical
Comparison Between Low Dose and High Dose Intra-articular Tranexamic Acid in Total Knee Arthroplasty
The purpose of this study is to compare blood loss between using low dose (500 mg) and high dose (3 g) topical intra-articular tranexamic acid after total knee arthroplasty in double-blind RCT
- Trial name
- NCT03044041
- Testing
- Tranexamic Acid
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Thammasat University
Intraoperative Hypotension
Hypotension Decision Assist - Use, Safety and Efficacy
This clinical investigation will investigate whether Hypotension Decision Assist (HDA) is a feasible, safe and effective patient clinical decision support system to enhance an anaesthetist's ability to manage a patient's…
- Trial name
- HDA-USE (NCT05101590)
- Testing
- Monitored by HDA
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Directed Systems Limited
Acute Pain, Chronic Pain
ERECTOR SPINE PLANE BLOCK VERSUS LOCAL INFILTRATION ANAESTHESIA FOR TRANSFORAMINAL PERCUTANEOUS ENDOSCOPIC DISCECTOMY
The main aim of our study was to test the hypothesis that Erector spine plane block (ESP) with sedation will provide the similar employment of fentanyl and propofol during surgery as an infiltrative local anaesthesia with…
- Conditions
- Acute Pain, Chronic Pain, Postoperative Pain, Anesthesia
- Trial name
- NCT05483647
- Testing
- Local infiltrative anaesthesia, Erector spine plane block
- Where
- Ukraine
- Volunteers
- 52 people
- Sponsor
- Lviv National Medical University
Anesthesia Awareness
The Depth of Paediatric Anaesthesia: Observational Trial
Perioperative measurement of the Depth of anaesthesia is currently recommended part of daily anaesthesia good clinical practice. The optimal depth of anaesthesia measured by Bispectral index could be between 40-60.
- Trial name
- ANAPED (NCT05193747)
- Testing
- Anesthesia depth monitoring
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Brno University Hospital
Cerebral Palsy, Hip Surgery Corrective
Tranexamic Acid to Reduce Blood Loss After Varus Derotation Osteotomy
TABLO (Tranexamic Acid to reduce Blood Loss after varus derotation Osteotomy) is a clinical trial of postoperative tranexamic acid vs placebo in non-ambulatory children with cerebral palsy (CP) undergoing reconstructive hip…
- Conditions
- Cerebral Palsy, Hip Surgery Corrective, Tranexamic Acid Use, Blood Loss, Surgical
- Trial name
- TABLO (NCT07672158)
- Testing
- Tranexamic Acid (IV)
- Where
- Australia
- Volunteers
- 52 people
- Sponsor
- Murdoch Childrens Research Institute
Blood Loss, Surgical, Coagulation Disorder
Phase 3 Trial of Reltodecacog Alfa (VMX-C001) vs Usual Pharmacological Care in Patients Taking a FXa Direct Oral Anticoagulant Who Require Urgent Surgery With or Without Heparin.
The goal of this clinical trial is to learn if reltodecacog alfa (VMX-C001) works to to allow blood clotting control in participants who take FXa Direct Oral Anticoagulants (DOACs) during surgery or other invasive procedures that…
- Trial name
- EQUILIBRIX-S (NCT07288489)
- Testing
- Reltodecacog alfa, Usual Pharmacological Care
- Where
- 77 sites in United States, Australia and 16 more
- Volunteers
- 800 people
- Sponsor
- VarmX B.V.
Anesthesia, Emergence Delirium
The Effect of Anesthesia Depth Monitoring on Emergence Delirium in Pediatrics
Some changes in the patient's cognitive state are observed during the recovery period from general anesthesia. This period of behavioral dysregulation has been called emergence agitation (EA) and emergence delirium (ED).
- Conditions
- Anesthesia, Emergence Delirium, Anesthesia Awareness, Behavior Child Problems
- Trial name
- NCT06323616
- Testing
- MAC adjustment to PSI between 25 and 50
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Istanbul University
Remimazolam, Anesthesia Awareness
The Effect of Wavelet Index in Monitoring the Sedation Depth of Remimazolam Besylate
To explore the sedative effect of remimazolam in patients undergoing spinal anesthesia without pain stimulation. Both the Modified Observer's Assessment of Alertness/Sedation (MOAA/S) and the Wavelet index (WLi) were used to…
- Conditions
- Remimazolam, Anesthesia Awareness, Sedative, Hypnotic, or Anxiolytic Withdrawal
- Trial name
- NCT06427785
- Testing
- Remimazolam besylate
- Volunteers
- 30 people
- Sponsor
- Beijing Chao Yang Hospital
Surgical Blood Loss, Postoperative Pain
PVI vs ESP Block for Reducing Bleeding and Postoperative Pain in Lumbar Fusion Surgery.
This randomized controlled trial compares periarticular vasoconstrictor infiltration (PVI) versus erector spinae plane block (ESP) to reduce bleeding and postoperative pain in adults undergoing lumbar fusion surgery (up to 3…
- Conditions
- Surgical Blood Loss, Postoperative Pain, Lumbar Spinal Fusion Surgery
- Trial name
- NCT07550114
- Testing
- Periarticular vasoconstrictor infiltration (PVI), Erector Spinae Block (ESP)
- Where
- 2 sites in Spain
- Volunteers
- 62 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Gastric Emptying, Glucagon-Like Peptide-1 Receptor Agonists
Effect of Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RA) on Gastric Emptying
This study aims to assess the effect of using Glucagon-like peptide-1 receptor agonists (GLP-1) receptor agonists on gastric emptying on surgical patients and whether specific guidelines need to be established for these patients.
- Conditions
- Gastric Emptying, Glucagon-Like Peptide-1 Receptor Agonists, Intermittent Fasting, Intraoperative Complication Due to Anesthesia
- Trial name
- NCT07140289
- Testing
- Ultrasound of gastric contents
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wael Saasouh, MD
Kidney Stones, Surgical Blood Loss
Combined Intravenous and Irrigation Tranexamic Acid During Percutaneous Nephrolithotomy
Percutaneous nephrolithotomy is a minimally invasive surgical procedure used to remove large kidney stones. Although it is an effective treatment, bleeding during and after the procedure remains one of the main concerns and may…
- Conditions
- Kidney Stones, Surgical Blood Loss, Percutaneous Nephrolithotomy
- Trial name
- NCT07582341
- Testing
- Tranexamic acid, Normal Saline
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Benha University
Anesthesia
Decision Support System for Anesthetists
The balanced anesthesia process contains three main parts: the control of hypnosis, analgesia, and neuromuscular blockade. For the induction phase, the anesthesiologist performs protocols based on prior planning specific to each…
- Trial name
- Serenity (NCT04079036)
- Where
- Brazil
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Intraoperative Complications, Thermal Injury
Laparoscopic Cholecystectomy And Capacitive Coupling - Coag Versus Blend Mode Causing Thermal Injury at Port Site Skin
Monopolar radiofrequency energy is used to perform the laparoscopic cholecystectomy operation. The appearance of burns are common following laparoscopic cholecystectomy; particularly at the port site of the active electrode.
- Conditions
- Intraoperative Complications, Thermal Injury, Electrocoagulation
- Trial name
- NCT01664806
- Testing
- Covidien Triad monopolar generator
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Intraoperative Bleeding
The Effect of Adding Either Propofol or Ketamine to Magnesium and Lidocaine Infusions in Nasal Surgeries.
Nasal surgeries are common day case procedures. Although surgical complications are rare, bleeding decreases surgical field visibility and may cause vascular, orbital or intracranial complications in addition to failure of…
- Trial name
- NCT06427707
- Testing
- Intravenous Infusion of propofol, lidocaine, Magnesium sulfate, Intravenous infusion of ketamine, lidocaine, Magnesium sulfate, Intravenous infusion of dexmedetomidine, lidocaine, Magnesium sulfate
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Malignant Hyperthermia
Malignant Hyperthermia in Czech Republic: Description of the Biggest Slavonic Group of Patients Investigated for Risk of Malignant Hyperthermia
The Academic centre for Malignant Hyperthermia of Masaryk University (ACMHMU) was established in 2021 in Brno, Czech Republic and consists of four academic departments of Medical Faculty of Masaryk University in two tertiary…
- Trial name
- MHCZECH (NCT05036148)
- Testing
- Data analysis
- Where
- Czechia
- Volunteers
- 286 people
- Sponsor
- Brno University Hospital
Blood Loss, Surgical
Mediastinal Temperature and Post-operative Bleeding
This study will investigate how chest temperature relates to blood loss and blood clotting. Researchers will use infra-red thermometers to measure the temperature of the chest at the end of surgery see if this relates to the…
- Trial name
- NCT04933253
- Testing
- Saline irrigation
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Shoulder Joint Disease, Complications; Arthroplasty
Tranexamic Acid in Reverse Total Shoulder Arthroplasty
To the Investigators' knowledge, TXA has not been studied in the setting of reverse total shoulder arthroplasty. We propose a double-blinded, randomized, controlled trial comparing perioperative administration of TXA to placebo…
- Conditions
- Shoulder Joint Disease, Complications; Arthroplasty, Intraoperative Complications, Blood Loss, Surgical
- Trial name
- TXA (NCT02043132)
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Corewell Health East
Blood Loss, Surgical, Second Trimester Abortion
MisOpRostol Effect on Second Trimester Abortion Blood Loss
Although serious complications from second trimester abortion are rare hemorrhage is the most common cause of procedural abortion related morbidity and mortality.
- Trial name
- MORESTABL (NCT06078501)
- Testing
- Misoprostol 400mcg buccal
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Stanford University
Anxiety, Anesthesia Awareness
Fear and Anxiety in Anesthesia-Naïve Patients Pre-operatively vs Post-operatively
The goal of this observational study is to understand how fear and anxiety felt by anesthesia-naive patients compares before versus after their scheduled surgery.
- Trial name
- NCT07559461
- Testing
- Survey using a questionnaire.
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stony Brook University
Blood Loss, Surgical
Point of Care Coagulation Testing in Patients Undergoing Major Surgery
Bleeding is a frequent complication during surgery. The peri-operative administration of blood products, including packed red blood cells, thrombocytes and fresh frozen plasma (FFP), is often deemed necessary.
- Trial name
- POC-OP (NCT00656396)
- Testing
- Coagucheck XS Plus (Point of care monitor of coagulation intraoperative), Control Intervention
- Where
- Switzerland
- Volunteers
- 228 people
- Sponsor
- University of Bern