Clinical trials: Persistent
Healthy, Primary Immune Thrombocytopenia
A First in HumanTrial to Evaluate The Safety, Tolerability, And Pharmacokinetics Of PF-06755347
This phase 1 single ascending dose study will provide a first in human assessment of safety and tolerability of PF-06755347 in healthy adult males as well as adult males and females with Immune Thrombocytopenia (ITP).
- Conditions
- Healthy, Primary Immune Thrombocytopenia, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
- Trial name
- NCT03275740
- Testing
- PF-06755347 intravenous healthy participant, PF-06755347 subcutaneous healthy participant, PF-06755347 subcutaneous ITP
- Where
- 6 sites in United States, Belgium and 3 more
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Pfizer
Fatigue, Lupus Erythematosus, Systemic
Acupressure for Fatigue in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by involvement of multiple organs with a female to male ratio of 12:1 with the highest incidence reported in women of child bearing age (15-44…
- Conditions
- Fatigue, Lupus Erythematosus, Systemic, Pain, Chronic, Quality of Life
- Trial name
- AcuSLE (NCT03200548)
- Testing
- Relaxing acupressure plus usual care, Usual care, Stimulating acupressure plus usual care
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Suzanna Zick
Hyperlipidemia, Diabetes
Point-of-Care Testing (POCT) Detection and Management of Metabolic Syndrome in Patients With Mental Illness
The study was a 12-month, multi-centered, quasi-experimental design to assess point-of-care (POCT) screening/monitoring of subjects on antipsychotic agents for metabolic syndrome.
- Conditions
- Hyperlipidemia, Diabetes, Hypertension
- Trial name
- NCT02029989
- Testing
- Glucose and lipids, Glycosylated Hemoglobin A1c, Blood Pressure and Heart Rate
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Asthma
Effect of Flovent Discus vs QVAR vs Pulmicort Flexhaler on Short Term Growth
Children with mild persistent asthma that have asthma symptoms once or twice a week and use a daily controller, while children with mild intermittent asthma rarely have asthma symptoms and do not use a daily controller.
- Trial name
- NCT01520688
- Testing
- Fluticasone, Budesonide, Beclomethasone, Fluticasone, Beclomethasone, Budesonide, Budesonide, Fluticasone, Beclomethasone
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- West Penn Allegheny Health System
Hydromorphone Use, Acute Postoperative Pain
Methadone and Hydromorphone For Spinal Surgery
Patients undergoing major spinal surgery continue to experience moderate-to-severe pain during the first 2-3 days following the operative procedure.
- Conditions
- Hydromorphone Use, Acute Postoperative Pain, Patient Satisfaction, Chronic Persistent Surgical Pain
- Trial name
- NCT02107339
- Testing
- Methadone, Hydromorphone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Lumbar Surgery
Study of PEMF (Pulsed Electromagnetic Field) Therapy in the Treatment of Persistent Post-Operative Pain Following Lumbar Surgery
To demonstrate the analgesic effectiveness of 2 modalities of PEMF treatment compared to sham treatment in patients with persistent pain following lumbar surgery when treatment is administered twice daily over a 60 day period.
- Trial name
- NCT02416973
- Testing
- Provant
- Where
- 8 sites in United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Regenesis Biomedical, Inc.
Age Related Macular Degeneration
A Pilot Study to Evaluate the Role of High-dose Ranibizumab (2.0mg) in the Management of AMD in Patients With Persistent/Recurrent Macular Fluid Less Than 30 Days Following Treatment With Intravitreal Anti-VEGF Therapy (the LAST Study)
This is a single-masked study to compare intravitreally administered 0.5 mg ranibizumab to 2.0 mg ranibizumab in subjects who manifest persistent or recurrent macular fluid less than 30 days following treatment with intravitreal…
- Trial name
- LAST (NCT01115556)
- Testing
- Ranibizumab
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Vitreous -Retina- Macula Consultants of New York
Hepatitis B
Pilot Study: Gene Expression Profiling of Immune Response to HBV Vaccination in Healthy Volunteers
Vaccines have been responsible for preventing millions of deaths and extending the average human lifespan. Effective vaccines stimulate the cells of the immune system to activate genes and associated functions that bring about…
- Trial name
- NCT02055365
- Testing
- Hepatitis B Vaccine (Recombinant)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Hepatitis C Infection
Effects of Persistent Innate Immune Activation on Vaccine Efficacy
This study will investigate the effects of chronic HCV infection and corresponding innate immune activation on the immune response to HBV vaccination.
- Trial name
- NCT02429583
- Testing
- Recombivax
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Infections, Papillomavirus
Human Papilloma Virus (HPV) Vaccine Efficacy Trial Against Cervical Pre-cancer in Young Adults With GlaxoSmithKline (GSK) Biologicals HPV-16/18
Human Papilloma virus (HPV) are viruses that cause a common infection of the skin and genitals in men and women. Several types of HPV infection are transmitted by sexual activity and, in women, can infect the cervix (part of the…
- Trial name
- NCT00122681
- Testing
- Cervarix™, Havrix™-based investigational formulation
- Where
- 138 sites in United States, Australia and 12 more
- Volunteers
- 18,729 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Colorectal Cancer
Improving Colorectal Cancer Screening in Racially Diverse Zip Codes Using Navigation and Machine Learning (PCSNaP)
The overarching goal of the "PCSNaP" Research Study is to support the Abramson Cancer Center (ACC) of the University of Pennsylvania in carrying out its mission to increase colorectal cancer (CRC) screening completion among…
- Trial name
- PCSNaP (NCT05383976)
- Testing
- Machine Learning Algorithm with Existing Penn Medicine CRC Patient Navigation Program
- Where
- United States
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
New Daily Persistent Headache (NDPH)
Endogenous Modulation and Central Sensitization in New Daily Persistent Headache ( NDPH ) in Children
New daily persistent headache (NDPH) is a primary headache disorder characterized by the daily and unremitting headache pain patients experience with a distinct onset.
- Trial name
- EMCS-NDPH (NCT03447782)
- Testing
- Naltrexone HCl (Bulk) Powder
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
HIV
SEARCH CAB LA Dynamic Choice HIV Prevention Study Extension
The overall purpose of this SEARCH CAB-LA (Cabotegravir Injectable Suspension) randomized extension study is to determine if adding the option of CAB-LA as a prevention choice using a person-centered dynamic choice HIV (human…
- Trial name
- NCT05549726
- Testing
- Cabotegravir Injectable Suspension, Dynamic Choice Delivery Model, Standard of Care
- Where
- 2 sites in Kenya, Uganda
- Volunteers
- 984 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cigarette Smoking, Nicotine Dependence
Incentives for Oklahoma Tobacco Helpline Engagement in Persistent Poverty Counties
The proposed pilot project is designed to evaluate the feasibility and potential efficacy of offering small financial incentives for the completion of smoking cessation counseling and self-reported abstinence at follow-up among…
- Trial name
- CLIMB (NCT05095779)
- Testing
- Coaching calls, Nicotine replacement therapy, Financial Incentives
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Preeclampsia
Angiotensin II and Chronic Inflammation in Persistent Microvascular Dysfunction Following Preeclampsia
Women who develop preeclampsia during pregnancy are more likely to develop cardiovascular disease later in life, even if they are otherwise healthy.
- Trial name
- NCT03482440
- Testing
- Salsalate Oral Tablet
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Apical Periodontitis
Bone Regenerative Techniques in Endodontic Microsurgery
The purpose of this randomized controlled clinical trial was to evaluate two dimensionally and 3-dimensionally the effect of resorbable collagen-based bone filling material on periapical healing following endodontic microsurgery…
- Trial name
- NCT04514991
- Testing
- Foundation
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Diabetic Macular Edema
IAI for Persistent DME After Treatment With Bevacizumab And Ranibizumab
This is a phase 4 prospective, nonrandomized, open label, interventional clinical trial. Study eyes will receive 5 required initial monthly Intravitreal Aflibercept (IAI) doses of 2 mg followed by 2q8 IAI for a total of 52 weeks…
- Trial name
- ROTATED (NCT03340610)
- Testing
- Alflibercept
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Southeast Retina Center, Georgia
Rosacea
A Clinical Endpoint Bioequivalence Study of "Oxymetazoline Hydrochloride Cream"
A Randomized, Double-blind, Parallel-group, Three-arm, Placebo-controlled, Multi-Site Therapeutic Equivalence Study with Clinical End-points Comparing Test Product "Oxymetazoline hydrochloride Cream, 1%" to Reference Product…
- Trial name
- NCT03954444
- Testing
- Oxymetazoline Hydrochloride, Rhofade Cream, 1%
- Where
- United States
- Volunteers
- 1,105 people, healthy volunteers welcome
- Sponsor
- Actavis Inc.
Mental Disorders
Efficacy of the Recovery Workbook as a Psychoeducational Tool for Facilitating Recovery
The present study will determine if Spaniol and colleague's (1994) Recovery Workbook group intervention is an effective clinical tool to move a person with SMI along in their journey of recovery.
- Trial name
- NCT00375167
- Testing
- Recovery Workbook Training (psychoeducational training), ACT as usual
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Queen's University
HIV, Hypertension
SEARCH SAPPHIRE Phase A: A Multisectoral Strategy to Address Persistent Drivers of the HIV Epidemic in East Africa
The randomized trials in this record will assess effectiveness, fidelity and cost of prevention and treatment interventions for HIV and hypertension with the objective of informing a population-based study of multi-sectored…
- Conditions
- HIV, Hypertension, Alcohol Drinking, Maternal Child Health
- Trial name
- SAPPHIRE PhA (NCT04810650)
- Testing
- Mobility Dynamic Treatment Intervention, Health Living Intervention for Heavy Alcohol Users, Hypertension Linkage
- Where
- 2 sites in Kenya, Uganda
- Volunteers
- 2,233 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco