Clinical trials: Persistent Asthma
Asthma
Asthma Control Among Patients Receiving Inhaled Corticosteroids in Thailand
The purpose of this study is to determine the percentage of patients who has reached the GINA guideline of asthma treatment after receiving any inhaled corticosteroid for 3 months or longer in actual clinical practice.
- Trial name
- NCT00800904
- Where
- 26 sites in Thailand
- Volunteers
- 1,210 people
- Sponsor
- AstraZeneca
Asthma
Comparison of the Efficacy/Safety of Symbicort® Turbuhaler®,Seretide™ Diskus™ 50/500 µg & Terbutaline Turbuhaler® 0.4 mg
The purpose of this study is to compare the efficacy and safety of a variable dose of Symbicort with a high fixed maintenance dose of another asthma medication, Seretide, in the treatment of asthma.
- Trial name
- NCT00242775
- Testing
- Budesonide/formoterol Turbuhaler, Salmeterol/fluticasone Diskus
- Where
- 143 sites in Argentina, Australia and 15 more
- Volunteers
- 2,100 people
- Sponsor
- AstraZeneca
Moderate Persistent Asthma, Severe Persistent Asthma
Expressions of TRPV1 in Airway of Asthmatics
The purpose of this study is to measure the density of a temperature-sensitive protein, named TRPV1, in the airway mucosa tissue of both non-asthmatic and moderate to severe persistent asthmatic patients.
- Conditions
- Moderate Persistent Asthma, Severe Persistent Asthma, Nodule Solitary Pulmonary, Pulmonary Atelectasis
- Trial name
- TRPV1 (NCT02952066)
- Testing
- Bronchial biopsy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Lu Yuan Lee
Asthma
Efficacy and Safety of Mometasone Furoate for Persistent Asthma Previously Treated With Low-Dose Inhaled Glucocorticosteroids (ICS) (Study P06115)
Mometasone furoate (MF) is a synthetic glucocorticosteroid that, when administered to asthma patients with a dry powder inhaler (Asmanex® Twisthaler®) at dosages of 100 to 400 mcg twice daily, has been shown to improve lung…
- Trial name
- NCT01026870
- Testing
- SCH 32088 mometasone furoate (MF) metered-dose inhaler
- Sponsor
- Organon and Co
Mild Persistent Asthma
Knemometry Study to Compare the Systemic Safety of Flutiform pMDI, Fluticasone pMDI and Beclometasone Autohaler in Paediatric Subjects Aged 5 to Less Than 12 Years.
Aim of the study is to investigate the short-term growth in children with asthma aged 5-11 years in treatment with fluticasone propionate / formoterol spray (flutiform®) 200/20 micrograms per day
- Trial name
- NCT02063139
- Testing
- Flutiform 50/5 ug (2 puffs bid) pMDI, Fluticasone 50 ug (2puffs bid) pMDI, Beclometasone Autohaler 50 ug (2 puffs bid)
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Mundipharma Research Limited
Asthma
Omalizumab in Adult and Adolescent Patients With Severe Persistent Allergic Asthma
Omalizumab will be given as add-on treatment to optimized asthma therapy in patients with severe persistent asthma, who demonstrate inadequate asthma symptom control.
- Trial name
- NCT00264849
- Testing
- Omalizumab, Optimized asthma therapy
- Where
- 17 sites in Belgium, Canada and 15 more
- Volunteers
- 406 people
- Sponsor
- Novartis
Asthma
Evaluation of Tiotropium 5 µg/Day Delivered Via the Respimat® Inhaler Over 48 Weeks in Patients With Severe Persistent Asthma on Top of Usual Care (Study II)
The trial is a randomised, double-blind, placebo-controlled, parallel-group trial to evaluate the efficacy and safety of 5 µg tiotropium over a 48-week treatment period as compared to placebo.
- Trial name
- NCT00776984
- Testing
- tiotropium 5mcg/day
- Where
- 75 sites in United States, Australia and 13 more
- Volunteers
- 453 people
- Sponsor
- Boehringer Ingelheim
Asthma
TC-6987 for the Treatment of Mild to Moderate Asthma
This study is designed to determine whether TC-6987 improves respiratory function in subjects with asthma by reducing airway hyper-responsiveness and inflammation.
- Trial name
- NCT01296087
- Testing
- TC-6987
- Where
- 21 sites in United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Targacept Inc.
Asthma
AZISAST Study: AZIthromycin in Severe ASThma Study
The purpose of this study is to evaluate the efficacy, safety and cost-effectiveness of azithromycin as add-on therapy in adult subjects with severe persistent asthma, who remain inadequately controlled despite GINA (2006) step 4…
- Trial name
- AZISAST (NCT00760838)
- Testing
- Azithromycin 250 mg
- Where
- 7 sites in Belgium
- Volunteers
- 109 people
- Sponsor
- University Hospital, Ghent
Persistent Asthma
Cockroach Immunotherapy in Children and Adolescents
Scientific evidence has shown that, over the past two decades, the combination of cockroach allergy and cockroach exposure is one of the most important factors contributing to the dramatic increase in asthma morbidity seen in…
- Trial name
- CRITICAL (NCT03541187)
- Testing
- German cockroach allergenic extract
- Where
- 11 sites in United States
- Volunteers
- 82 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Mild, Moderate and Severe Persistent Asthma as Defined by NHLBI-2 Guidelines
Asthma In-Home Monitoring (AIM) Trial
OBJECTIVE: Determine whether home asthma telemonitoring using store-and-forward technology improves outcomes when compared to in-person, office-based visits.
- Trial name
- NCT00282516
- Testing
- In-home telemonitoring of pediatric patients with persistent asthma
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Tripler Army Medical Center
Asthma
Efficacy of Ciclesonide vs Fixed Combination of Fluticasone Propionate/Salmeterol vs Placebo in Patients With Mild Persistent Asthma (12 to 75 y) (BY9010/M1-132)
The aim of the study is to compare the efficacy of ciclesonide versus fixed combination of fluticasone propionate/salmeterol versus placebo, on long-term asthma control in patients with mild persistent asthma.
- Trial name
- NCT00163358
- Testing
- Ciclesonide
- Where
- 111 sites in Australia, Canada and 5 more
- Volunteers
- 630 people
- Sponsor
- AstraZeneca
Asthma
A Study of Safety and Efficacy of CNTO 148 in Patients With Severe Persistent Asthma
The purpose of this study is to evaluate the effectiveness and safety of CNTO 148 (golimumab) in patients with severe persistent asthma.
- Trial name
- NCT00207740
- Testing
- CNTO148
- Where
- 57 sites in United States, Belgium and 9 more
- Volunteers
- 309 people
- Sponsor
- Centocor, Inc.
Asthma
Efficacy and Safety of Fexofenadine in Mild to Moderate Persistent Asthma
The purpose of this study is to investigate the efficacy and safety of fexofenadine 120mg BID compared to placebo in the treatment of subjects with mild to moderate persistent asthma
- Trial name
- NCT00044824
- Testing
- Fexofenadine
- Where
- 7 sites in United States, Costa Rica and 5 more
- Volunteers
- 1,000 people
- Sponsor
- Sanofi
Asthma
Study of JNJ-39758979 in Symptomatic Adult Patients With Uncontrolled Asthma
The purpose of this study is to evaluate the efficacy, safety and tolerability of JNJ-39758979 compared with placebo in patients with uncontrolled asthma despite current treatment with inhaled corticosteroids and/or long-acting…
- Trial name
- NCT01493882
- Testing
- JNJ-39758979 30 mg/d, JNJ-39758979 100 mg/d, JNJ-39758979 300 mg/d
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Asthma
A Study to Compare the Efficacy and Safety of Different Dosings of Olodaterol Administered With the Respimat® Inhaler in Patients With Moderate to Severe Asthma
This study will compare efficacy and safety of different regimens of olodaterol administration in asthma (once daily, twice daily) with placebo in a complete cross-over design each within one of the two daily dose groups (medium…
- Trial name
- NCT01311661
- Testing
- Olodaterol low daily dose twice daily, Olodaterol medium daily dose twice daily
- Where
- 36 sites in United States, Austria and 4 more
- Volunteers
- 206 people
- Sponsor
- Boehringer Ingelheim
Asthma
Study of the Effect of Mometasone Furoate/Formoterol (MF/F), Montelukast and Beclomethasone Dipropionate (BDP) on Plasma Cortisol Levels of Children 5-11 Years Old With Persistent Asthma (P05574)
The purpose of this study is to assess the effect of one of five possible study medications used in the treatment of asthma on blood plasma cortisol levels in children aged 5-11 years with persistent asthma.
- Trial name
- NCT01615874
- Testing
- MF/F Metered Dose Inhaler (MDI) 25/5 mcg, MF/F MDI 50/5 mcg, MF/F MDI 100/5 mcg
- Sponsor
- Organon and Co
Persistent Asthma
Efficacy, Safety and Pharmacokinetics of Different Regimens of Indacaterol
This study assessed the bronchodilator efficacy of three different regimens of indacaterol in patients with asthma
- Trial name
- NCT01156844
- Testing
- Indacaterol
- Where
- 30 sites in United States, France and 4 more
- Volunteers
- 191 people
- Sponsor
- Novartis Pharmaceuticals
Asthma
SYMPHONIE - A Comparison of Symbicort Single Inhaler and Conventional Best Practice for the Treatment of Persistent Asthma in Adolescents and Adults
The purpose of the study is to compare the efficacy of a flexible dose of Symbicort with conventional stepwise treatment according to asthma treatment guidelines in patients with persistent asthma.
- Trial name
- NCT00259792
- Testing
- Budesonide/formoterol Turbuhaler
- Where
- 82 sites in France
- Volunteers
- 1,000 people
- Sponsor
- AstraZeneca
Asthma
Study to Evaluate the Inflammatory Cells Activity in Patients With Persistent Asthma Treated With Montelukast (0476-403)(COMPLETED)
Verify if the quantitative parameters of the eosinophils activation and phagocyte system function show a predictive value for clinical response and prognostic in patients with persistent asthma treated with montelukast
- Trial name
- NCT00770900
- Testing
- montelukast sodium
- Volunteers
- 83 people
- Sponsor
- University of Brasilia