Clinical trials: Persistent Atrial Fibrillation
Persistent Atrial Fibrillation
Hybrid Characterization of Driver Sites During Atrial Fibrillation and Sinus Rhythm
The primary objective of this study is twofold, first we aim to identify rotors in atrial fibrillation (AF) and analyze their relationship with the left atrium-left atrial appendage (LA-LAA) connections.
- Trial name
- Hybrid-AFMAP (NCT05077670)
- Testing
- Pulmonary vein electrical isolation, Atrial substrate mapping
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundacion para la Innovacion en Biomedicina (FIBMED)
Persistent Atrial Fibrillation
PerAF: AF Termination vs Prespecified Ablation
The design of this study is an intervention, randomized, controlled study and contains two randomized groups：（1）AF-termination group；（2）Prespecified-ablation group.
- Trial name
- NCT06837441
- Testing
- Atrial Fibrillation Termination, Prespecified Ablation
- Where
- China
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Persistent Atrial Fibrillation
EGM Guided PFA for PerAF
Pulse field ablation (PFA) has shown safety and efficacy in paroxysmal atrial fibrillation (AF), while the application in persistent atrial fibrillation (PerAF) is still under investigation.
- Trial name
- EGM-PFA (NCT06729866)
- Testing
- electrogram guided pulse field ablation
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Xu Liu
Long Standing Persistent Atrial Fibrillation
Long-term Outcomes in Long Standing Persistent Atrial Fibrillation
Atrial fibrillation (AF) is a condition detected as an irregular heartbeat. It is the most common rhythm disturbance worldwide which can lead to significant symptoms and serious health problems (stroke and heart failure).
- Trial name
- LoTO_CASA_AF (NCT04280042)
- Where
- United Kingdom
- Volunteers
- 104 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Atrial Fibrillation
Safety and Efficacy Study of The Combined Ablation Procedure To Treat Longstanding Persistent Atrial Fibrillation
This is a multi-center, prospective open label, feasibility study evaluating the safety and efficacy of the combined ablation procedure for the treatment of longstanding persistent atrial fibrillation.
- Trial name
- CAPstopsLSPAF (NCT01103661)
- Testing
- Numeris®-AF Guided Coagulation System with VisiTrax®
- Where
- 4 sites in United States
- Volunteers
- 7 people
- Sponsor
- nContact Surgical Inc.
Atrial Fibrillation (AF)
Exercise-induced Cardioversion in Persistent Atrial Fibrillation
This study aims to to evaluate the feasibility of conducting a larger randomized controlled trial (RCT) to assess whether an exercise stress test on an ergometer bicycle could induce sinus rhythm in patients with persistent AF…
- Trial name
- ExPAF (NCT07008066)
- Testing
- Bicycle ergometer excercise, Standard care with electrical cardioversion
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Uppsala University
Atrial Fibrillation
Atrial Ganglionated Plexi Ablation Guided by the SUMO Technology With and Without Conventional Pulmonary Vein Isolation in Patients With Persistent AF
Although circumferential pulmonary vein isolation (PVI) has been considered as the cornerstone for atrial fibrillation ablation, there has been a substantial recurrence rate.
- Trial name
- NCT02492256
- Testing
- Pulmonary vein isolation, GP ablation guided by SUMO technology, ILR implantation
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Persistent Atrial Fibrillation
Pulsed Field Ablation (PFA) vs Anti-Arrhythmic Drug (AAD) Therapy as a First Line Treatment for Persistent Atrial Fibrillation
The purpose of this study is to establish the safety and effectiveness of pulsed field ablation as a first-line ablation treatment for subjects with persistent atrial fibrillation as compared to subjects who received an initial…
- Trial name
- AVANT GUARD (NCT06096337)
- Testing
- FARAPULSE™ Pulsed Field Ablation (PFA) System, Anti-Arrhythmic Drug (AAD): Flecainide, Sotalol, Propafenone, Dofetilide, and Dronedarone
- Where
- 61 sites in United States, Australia and 11 more
- Volunteers
- 484 people
- Sponsor
- Boston Scientific Corporation
Atrial Tachycardia
Identification, Electro-mechanical Characterisation and Ablation of Driver Regions in Persistent Atrial Fibrillation
Atrial fibrillation (AF) is the most common sustained heart rhythm abnormality. Its incidence is increasing partly due to the aging population and it has been referred to as a growing epidemic.
- Trial name
- NCT06335446
- Testing
- Novel mapping algorithm
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Barts & The London NHS Trust
Atrial Fibrillation, Persistent
Waveform Periodicity Analysis of Complex Fractionated Electrograms in Patients With Persistent Atrial Fibrillation
Atrial fibrillation (AF) has been the most frequently occurring, sustained arrhythmia, which causes significant morbidity and mortality. AF may not always be a totally random process.
- Trial name
- NCT05426603
- Testing
- Pulmonary vein isolation, Substrate ablation(PRISM based)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation
A Feasibility Study to Evaluate the Effect of Concomitant Renal Denervation and Cardiac Ablation on AF Recurrence
The purpose of this post market clinical investigation is to complete preliminary evaluation on whether or not concomitant renal denervation with the EnligHTN™ Renal Denervation System and cardiac ablation will result in improved…
- Conditions
- Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation, Hypertension
- Trial name
- RDN+AF (NCT01907828)
- Testing
- Renal Artery Ablation, Cardiac Ablation
- Where
- 2 sites in Germany
- Volunteers
- 61 people
- Sponsor
- Abbott Medical Devices
Atrial Fibrillation
Marshall Ethanolization, Pulmonary Vein Isolation and Line Completion for Ablation of Persistent Atrial Fibrillation
In ablation strategy for persistent Atrial Fibrillation (PsAF), ablation limited to Pulmonary Vein (PV) isolation is the most straightforward approach but the result give only 50% of arrhythmia free follow-up.
- Trial name
- MARSHALL-PLAN (NCT04681872)
- Testing
- Destruction of Marshall bundles, Pulmonary veins isolation, Linear ablation in the left and right atria
- Where
- 9 sites in Belgium, France
- Volunteers
- 262 people
- Sponsor
- University Hospital, Bordeaux
Atrial Fibrillation, Persistent
Effect of taVNS on Heart Rate in Persistent Atrial Fibrillation
The goal of this clinical trial is to investigate the effects of non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) in patients with persistent atrial fibrillation.
- Trial name
- NCT05944575
- Testing
- active taVNS
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Burrell College of Health Sciences
Paroxysmal Atrial Fibrillation (PAF), Persistent Atrial Fibrillation
Evaluation of the FARAFLEX Mapping and Pulsed Field Ablation System in Subjects With Atrial Fibrillation
The goal of this clinical trial is to learn if the FARAFLEX™ Mapping and pulsed field ablation (PFA) System can safely and effectively treat symptomatic, drug-refractory Paroxysmal atrial fibrillation (PAF) and Persistent atrial…
- Trial name
- FARADIGM (NCT07575269)
- Testing
- FARAFLEX Mapping and Pulsed Field Ablation (PFA) System
- Where
- 13 sites in United States, Belgium and 2 more
- Volunteers
- 571 people
- Sponsor
- Boston Scientific Corporation
Atrial Fibrillation
Ablation of Fibrotic Areas in Patients With Persistent Atrial Fibrillation.
Brief summary: The objective of this study is to compare two different ablation strategies in participants with persistent atrial fibrillation and fibrotic areas in the left atrium.
- Trial name
- IDEAL-AF (NCT04377594)
- Testing
- Radio frequency ablation
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska University Hospital
Persistent Atrial Fibrillation
Observational Study to Examine the Procedural and Outcomes of AF Ablation Assisted by STAR Apollo™ Mapping System
STAR Apollo Mapping System is an FDA cleared mapping technology that can analyze the signals collected during the ablation procedure on the 3D mapping system and give the physician further insight into the AF activation patterns…
- Trial name
- NCT05826665
- Testing
- Persistent AF ablation assisted with the STAR Apollo Mapping System
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Atrial Fibrillation
Persistent AF Catheter Ablation: Re-PVI Vs. Re-PVI + Continuous Complex Activity Mapping and Ablation - AF-CAM
Major objective is to compare the efficacy of adding additional ablation step (targeting areas of complex, continuous electrical activity in LA) beyond Re-PVI during catheter ablation of Atrial Fibrillation (AF) in patients…
- Trial name
- AF-CAM (NCT05496088)
- Testing
- Re-PVI only, Re-PVI + substrate ablation
- Where
- 3 sites in Germany
- Volunteers
- 56 people
- Sponsor
- Asklepios proresearch
Atrial Fibrillation, Paroxysmal, Atrial Fibrillation, Persistent
MultiPulse Therapy (MPT) for AF
Assess the clinical safety and feasibility of MultiPulse Therapy (MPT) electrical stimulation waveform sequence in terminating paroxysmal and persistent atrial fibrillation.
- Conditions
- Atrial Fibrillation, Paroxysmal, Atrial Fibrillation, Persistent, Atrial Fibrillation
- Trial name
- NCT04206917
- Testing
- Multi Pulse Therapy
- Where
- 6 sites in Australia
- Volunteers
- 30 people
- Sponsor
- Cardialen, Inc.
Persistent Atrial Fibrillation
Irbesartan and Adhesion Molecules in AF
Experimental data suggest that angiotensin II-antagonists reduce the atrial expression of prothrombotic adhesion molecules and oxidative stress parameters.
- Trial name
- CREATIVE-AF (NCT00613496)
- Testing
- irbesartan
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Magdeburg
Persistent Atrial Fibrillation
Atrial Fibrillation Trial to Evade Recurrence: effectS of Hiit Before electrO-Cardioversion for 3-weeKs
This is a study looking at the feasibility of conducting a larger definitive research trial looking at the effectiveness of high intensity interval training in individuals who are scheduled for electro-cardioversion.
- Trial name
- AFTERSHOCK (NCT03467633)
- Testing
- High-intensity interval training
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Ottawa Heart Institute Research Corporation