Clinical trials: Persistent Atrial Fibrillation
Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
Comparison of Treatment Outcomes Between Convergent Procedure and Catheter Ablation for Persistent and Longstanding Persistent Atrial Fibrillation
In the last 20 years, atrial fibrillation has become one of the leading healthcare burden in Europe and other developed countries.
- Trial name
- NCT04509180
- Testing
- Catheter ablation, Convergent procedure
- Where
- Slovenia
- Sponsor
- University Medical Centre Ljubljana
Atrial Fibrillation (AF)
Low-VOLTage Area-Guided Catheter Ablation and SVC Isolation for Persistent Atrial Fibrillation Using a Balloon-in-Basket Pulsed Field Ablation Catheter
The primary objective of this study is to determine whether low-voltage areas (LVA)-guided catheter ablation combined with superior vena cava (SVC) isolation and pulmonary vein isolation (PVI), performed using the…
- Trial name
- LowVOLT-AF (NCT07587541)
- Testing
- Volt™ Pulsed Field Ablation System
- Volunteers
- 618 people
- Sponsor
- University of Luebeck
Paroxysmal Atrial Fibrillation (PAF), Persistent Atrial Fibrillation
A Prospective Clinical Study to Evaluate the Safety and Effectiveness of Pulmonary Vein Isolation Plus Box Isolation of Fibrotic Areas With the Globe® Pulsed Field System for Treating Patients With Symptomatic Paroxysmal or Persistent Atrial Fibrillation
The study will evaluate the safety and 12-month effectiveness of the Pulmonary Vein Isolation plus Box Isolation of Fibrotic Areas (BIFA) ablation strategy with the Globe Pulsed Field System (Globe PF System) for the treatment of…
- Trial name
- GLOBAL-PF (NCT06973031)
- Testing
- Globe Pulsed Field System
- Where
- Germany
- Volunteers
- 115 people
- Sponsor
- Kardium Inc.
Persistent Atrial Fibrillation
Modified Ablation Guided by Ibutilide Use in Chronic Atrial Fibrillation
Procedures for ablation of persistent or long lasting atrial fibrillation are frequently long and require extensive ablation. Some electrophysiologists administer the drug ibutilide during these procedures to help organize the…
- Trial name
- MAGIC-AF (NCT01014741)
- Testing
- Ibutilide
- Where
- 7 sites in United States, Canada and 1 more
- Volunteers
- 200 people
- Sponsor
- Vivek Reddy
Atrial Fibrillation
Study of Ablation Versus antiaRrhythmic Drugs in Persistent Atrial Fibrillation
The purpose of this study is to compare the effectivity and safety of atrial fibrillation ablation, in comparison to antiarrhythmic drug therapy in patients with refractory, persistent atrial fibrillation.
- Trial name
- SARA (NCT00863213)
- Testing
- Atrial fibrillation ablation, Antiarrhythmic drug
- Where
- 8 sites in Spain
- Volunteers
- 152 people
- Sponsor
- Hospital Clinic of Barcelona
Atrial Fibrillation
Vagal Nerve Stimulation for the Treatment of Persistent AF
The goal of this clinical trial is to answer the question whether a transcutaneous stimulation of a certain nerve (Nervus vagus) with a dedicated device reduces the recurrence of the heart rhythm disorder atrial fibrillation.
- Trial name
- VAST-AF (NCT05833373)
- Testing
- Vagal stimulation with the device tVNS from tVNS Technologies GmbH
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Krankenhaus Hetzelstift
Atrial Fibrillation, Atrial Flutter
Comparison of ATI-5923, a Novel Vitamin K Antagonist, With Warfarin in Patients Requiring Chronic Anticoagulation
The purpose of this research study is to test an experimental drug ATI-5923 vs Coumadin. The study is intended to demonstrate ATI-5923 is superior to Coumadin for keeping INR values in the desired therapeutic range.
- Conditions
- Atrial Fibrillation, Atrial Flutter, Venous Thromboembolic Disease, Myocardial Infarction
- Trial name
- EmbraceAC (NCT00691470)
- Testing
- ATI-5923, Coumadin (warfarin)
- Where
- 41 sites in United States
- Volunteers
- 600 people
- Sponsor
- ARYx Therapeutics
Persistant Atrial Fibrillation
Ablation With the PFA System With a Large-Area Focal Catheter for the Treatment of Persistent Atrial Fibrillation
The study evaluates the safety and effectiveness of the investigational QuickShot Nav configuration of the CardioWave System for focal catheter ablation of persistent atrial fibrillation (PerAF).
- Trial name
- Quick AF (NCT07281521)
- Testing
- pulsed field ablation
- Where
- 3 sites in Croatia, Czechia
- Volunteers
- 200 people
- Sponsor
- CardioFocus
Atrial Fibrillation Recurrent
Exploring P-Wave Duration in Arrhythmia Recurrence in Patients Undergoing AF Ablation
The aim of this study is to investigate whether P-wave duration in a baseline surface 12-lead ECGs correlates with recurrence of AF recurrence post successful ablation at the time of the procedure.
- Trial name
- NCT04968678
- Testing
- P-wave duration measurement on 12 lead ECG with standard parameters
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Nik Spinthakis
Atrial Fibrillation, Persistent
Comparison Between Extended Cryoablation, Standard Cryoablation, and Radiofrequency Ablation
The objective of this study is to test the efficacy hypothesis that extended cryoballoon ablation is superior to either standard cryoballoon ablation or radiofrequency ablation
- Trial name
- EXCAPE-AF (NCT07034378)
- Testing
- Radiofrequency ablation, Extended cryoballoon ablation, Standard cryoballoon ablation
- Where
- 3 sites in South Korea
- Volunteers
- 288 people
- Sponsor
- Asan Medical Center
Atrial Fibrillation, Persistent, Atrial Fibrillation Chronic
Lenient Rate Control Versus Strict Rate Control for Atrial Fibrillation. The Danish Atrial Fibrillation Randomised Clinical Trial
Atrial fibrillation is the most common heart arrhythmia with a prevalence of approximately 2% in the western world. Atrial fibrillation is associated with an increased risk of death and morbidity.
- Conditions
- Atrial Fibrillation, Persistent, Atrial Fibrillation Chronic, Atrial Fibrillation
- Trial name
- DanAF (NCT04542785)
- Testing
- Rate control
- Where
- 4 sites in Denmark
- Volunteers
- 350 people
- Sponsor
- Holbaek Sygehus
Recurrent Persistent Atrial Fibrillation
Recurrent Persistent Atrial Fibrillation:In-situ Ablation Vs Extensive Ablation
This is an open label, randomized parallel control clinical trial, to compare extra-PV extensive ablation with in-situ ablation as two strategies for the treatment of PerAF to identify the mechanisms of PerAF recurrence.
- Trial name
- NCT06829446
- Testing
- Extra-PV extensive ablation, Repeat same PVI and linear ablation as the first procedure
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Shanghai Chest Hospital
Paroxysmal Atrial Fibrillation (PAF), Persistent Atrial Fibrillation
Outcomes of an Optimized Workflow With PulseSelect Pulsed Field Ablation (PFA) System in Paroxysmal and Persistent Atrial Fibrillation
The NEXT PULSE study is a pre-market, prospective, multi-center, non-randomized, interventional clinical study. Adult subjects with symptomatic paroxysmal or persistent AF who provided consent will be enrolled and treated with…
- Trial name
- NEXT PULSE (NCT07575828)
- Testing
- PulseSelect Pulse Field Ablation (PFA) System
- Volunteers
- 320 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Atrial Fibrillation
Genetically Determined Response to Atenolol in Patients With Persistent Atrial Fibrillation
Atrial fibrillation (AF), the most common sustained heart rhythm disorder, is becoming increasingly prevalent in the Western world.
- Trial name
- NCT01719367
- Testing
- Atenolol
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Vanderbilt University Medical Center
Atrial Fibrillation, Anticoagulants and Bleeding Disorders
Safety and Efficacy of Edoxaban in Thoracoscopic Ablation
The aim of this study is to compare the safety and efficacy of edoxaban and warfarin for prevention of stroke during a 6-month follow up after total thoracoscopic ablation.
- Trial name
- NCT04121767
- Testing
- Edoxaban, Warfarin
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Heart Failure With Reduced Ejection Fraction, Atrial Fibrillation, Persistent
Pulmonary Artery Pressure and Right Heart Evaluation for Patients Requiring Physiological Pacing Treatment
With the aging of society, the use of cardiac pacing in patients with irreversible bradycardia is increasingly widespread. As early as the 1950s, right ventricular pacing (RVP) began to be used in patients with atrioventricular…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Atrial Fibrillation, Persistent, Sick Sinus Syndrome, Atrioventricular Block
- Trial name
- NCT05575557
- Testing
- Right heart catheterization
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai 10th People's Hospital
Atrial Fibrillation (AF), Atrial Fibrillation (Paroxysmal)
PREACTIVE: Preconditioning Exercise Intervention to Improve Symptoms and Quality of Life in Comorbid Atrial Fibrillation and HFpEF
Atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF) are very common conditions that often occur together and result in worsening symptoms and reduced quality of life (QoL).
- Conditions
- Atrial Fibrillation (AF), Atrial Fibrillation (Paroxysmal), Persistent Atrial Fibrillation, Heart Failure With Preserved Ejection Fraction (HFPEF)
- Trial name
- PREACTIVE (NCT07324772)
- Testing
- progressive resistance training, combined aerobic + resistance training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwestern University
Persistent Atrial Fibrillation
FIND CAN Trial: "CF-172"
The purpose of this feasibility study is to further explore characteristics of ablation targets identified by CARTOFINDER 4D LAT Algorithm in subjects with persistent atrial fibrillation and to assess the acute outcome of…
- Trial name
- FIND CAN (NCT03033641)
- Testing
- Ablation procedure
- Volunteers
- 25 people
- Sponsor
- Biosense Webster, Inc.
Atrial Fibrillation
Atrial Fibrillation Characterization on Paroxysmal and Persistent Patients
Background and Hypothesis: Atrial Fibrillation (AF) treatment strategies have limitations. The efficacy of the procedure depends in several factors such as age, AF duration, atrial diameter and atrial electrophysiological…
- Trial name
- PAPER-AF (NCT05343923)
- Where
- Spain
- Volunteers
- 55 people
- Sponsor
- Felipe Atienza
Atrial Fibrillation
aMAZE Study: LAA Ligation Adjunctive to PVI for Persistent or Longstanding Persistent Atrial Fibrillation
This study is a prospective, multicenter, randomized (2:1) controlled study to evaluate the safety and effectiveness of the LARIAT System to percutaneously isolate and ligate the Left Atrial Appendage from the left atrium as an…
- Trial name
- aMAZE (NCT02513797)
- Testing
- LARIAT + PVI, Pulmonary Vein Isolation
- Where
- 53 sites in United States
- Volunteers
- 600 people
- Sponsor
- AtriCure, Inc.