Clinical trials: Persistent Infection
HIV Infection
Structured Treatment Interruptions in Chronic HIV Infection
In the last years Structured Treatment Interruptions (STI) have been proposed to reduce HAART-related toxicity and to increase patients' compliance.
- Trial name
- NCT00324103
- Testing
- Structured Treatment Interruptions
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Istituto Superiore di Sanità
Adenovirus Infection, EBV Infection
Most Closely HLA Matched Allogeneic Virus Specific Cytotoxic T-Lymphocytes (CTL)
This trial is designed to evaluate the feasibility, safety and efficacy of most closely HLA-matched multivirus specific CTL lines (CHM-CTLs) in HSCT patients with EBV, CMV or adenovirus infections that are persistent despite…
- Trial name
- CHALLAH (NCT00711035)
- Testing
- Trivirus Specific CTLs for EBV, CMV and Adenovirus Infection
- Where
- 8 sites in United States
- Volunteers
- 50 people
- Sponsor
- Baylor College of Medicine
Sepsis
Kidney Response to Sepsis Affects Angiogenic Balance and Likelihood of CCI and PICS
This study investigates the mechanism by which kidney dysfunction perpetuates inflammation, immunosuppression, and catabolism (PICS) in chronic critical illness.
- Trial name
- NCT02276066
- Testing
- GFR by Iohexol, Urine Collection, Blood samples
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- University of Florida
Post-covid-19 Persistent Smell and Taste Disorders
Clinical Characteristics and Treatment of Anosmia and Ageusia Due to SARS-CoV2 Variants
The SARS-CoV-2 pandemic has consisted of multiple surges of infection because of continuous viral mutations. The WHO and CDC have defined the main SARS-CoV-2 variants based on international and national data for the circulation…
- Trial name
- NCT06208540
- Testing
- Cerebrolysin, olfactory and gustatory trainings
- Where
- 2 sites in Egypt
- Volunteers
- 160 people
- Sponsor
- Sherifa Ahmed Hamed
HIV-1-infection, ART
Ph1 Study of FT538 Alone and With Vorinostat for Persistent Low-Level HIV Viremia
This is a single center Phase I clinical trial of FT538 administered intravenously (IV) once every 14 days for 4 consecutive doses for the reduction of the HIV reservoir in lymphoid tissue of HIV-infected individuals receiving…
- Conditions
- HIV-1-infection, ART, Cd4+ Lymphocyte Deficiency, Lymphoid Tissue; Infection
- Trial name
- NCT05700630
- Testing
- FT538, Vorinostat
- Where
- United States
- Sponsor
- Masonic Cancer Center, University of Minnesota
Sepsis
Role of RNA Metabolism Alterations in Persistent Immune Dysfunction After Sepsis
This study includes adult ICU patients with sepsis (according to SEPSIS 3.0) or critically ill non-septic patients with severe non-infectious conditions at Louis Mourier Hospital.
- Trial name
- SEPSI-splice (NCT07418801)
- Where
- 2 sites in France
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Evaluate Response to Treatment Both Biochemically and Virologically to Determine the Safety and Effectiveness of Bulevirtide Therapy in HDV Patients
Assessment of Response and Safety of Bulevirtide Treatment in Patients With Chronic Delta Virus Infection
1. The study is non-interventional, multicenter, non-profit 2. The primary objective of the study is to evaluate the safety and efficacy in clinical practice of the drug Bulevirtide in the treatment of patients with chronic HDV…
- Trial name
- ARISTOTLE (NCT07116044)
- Testing
- virological tests diagnostic tests
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- University of Molise
Meningococcal Meningitis, Meningococcal Infections
Persistence of Protective Antibody Titers 12-24 Months After NmVac4-A/C/Y/W-135-DT Vaccination: Follow Up Study
To determine the persistence of protective antibody levels for subjects who seroconverted after vaccination with NmVac4-A/C/Y/W-135-DT™ Participants in trial # JN-NM-002, who seroconverted for serogroups A and C will be contacted…
- Trial name
- NCT02500511
- Testing
- NmVac4-A/C/Y/W-135-DT™
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- JN-International Medical Corporation
Obesity, Type2diabetes
Susceptibility to Infectious Diseases in Obesity
The role of intestinal microbiota is becoming ever more important in the context of obesity, type II diabetes (T2D), and infectious disorders as represented by the emerging discipline "therapeutic microbiology".
- Conditions
- Obesity, Type2diabetes, Gut Microbiota, Chronic Disease
- Trial name
- SIDERALE (NCT05975541)
- Testing
- Observational
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Cervical Intraepithelial Neoplasia (CIN), Human Papillovirus
Local Hyperthermia for the Treatment of Cervical Persistent High-risk Infection
Human papillomavirus(HPV) infect epithelial cells and have the capacity to stimulate cell abnormal hyperplasia, especially by those high-risk HPV types.
- Trial name
- NCT07059819
- Testing
- Local hyperthermia device
- Where
- China
- Volunteers
- 400 people
- Sponsor
- First Hospital of China Medical University
Systemic Inflammatory Response Syndrome, Sepsis
Persistent Multiorgan Failure in Intensive Care Units
Multiorgan failure (MOF) as a result of any critical condition is a complex set of immunological and biochemical interactions leading to death in patients who are effectively subjected to primary resuscitation (correction of…
- Conditions
- Systemic Inflammatory Response Syndrome, Sepsis, Multiorgan Failure
- Trial name
- PROPOSe (NCT03604731)
- Testing
- cytokine adsorbtion during extracorporeal circulation
- Volunteers
- 300 people
- Sponsor
- Research Institute for Complex Problems of Cardiovascular Diseases, Russia
Malaria,Falciparum, Malaria
CHILD (Child Health and Infection With Low Density) Malaria
This trial will assess the long-term health and socioeconomic impact of interventions targeting low-density malaria infection (LMI) among children in Tanzania
- Trial name
- NCT05567016
- Testing
- Active case detection using molecular testing (ACDm), Passive case detection using molecular testing (PCDm), Control (standard of care)
- Where
- Tanzania
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Fatigue Post Viral
Mechanisms of Persistent Fatigue
Persistent fatigue (PF) is a common symptom across countries and cultures, and an important cause of disability and reduced quality of life.
- Trial name
- MAP-FAT (NCT07394855)
- Where
- Norway
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
Post-COVID-19 Condition, Post-COVID-19 Syndrome
Vortioxetine for Post-COVID-19 Condition
A randomized, double-blinded, placebo-controlled trial will be conducted to evaluate vortioxetine, an antidepressant with established pro-cognitive properties, for the treatment of cognitive deficits which develop during or after…
- Conditions
- Post-COVID-19 Condition, Post-COVID-19 Syndrome, Cognitive Impairment
- Trial name
- NCT05047952
- Testing
- Vortioxetine
- Where
- Canada
- Volunteers
- 149 people
- Sponsor
- Brain and Cognition Discovery Foundation
Chronic Infection
Orange Juice Consumption in Patients With Hepatitis C
This study aimed to verify whether orange juice, source of citrus flavonoids and vitamin C, may contribute to the treatment of patients with chronic hepatitis C.
- Trial name
- NCT03026569
- Testing
- Orange juice (500 mL/d)
- Where
- Brazil
- Volunteers
- 43 people
- Sponsor
- São Paulo State University
Post-Treatment Lyme Disease Syndrome
Ceftriaxone for Post-Treatment Lyme Disease
Lyme disease is a public health crisis in the US. It is estimated that over 400,000 cases occur every year with 10-20% of those infected going on to develop Post-Treatment Lyme disease Syndrome (PTLDS).
- Trial name
- NCT06785402
- Testing
- Ceftriaxone treatment
- Where
- United States
- Sponsor
- Hackensack Meridian Health
Human Papillomavirus (HPV) Infection, Cervical Cancer
Cnidium Monnieri Detoxification Formula for Persistent High-risk Human Papillomavirus Infection of Cervix.
The purpose of this study is to evaluate the clinical efficacy and safety of Cnidium Monnieri Detoxification Formula in clearing HPV infection, improving clinical symptoms and quality of life in female patients with persistent…
- Trial name
- NCT06705322
- Testing
- Cnidium Monnieri Detoxification Formula
- Volunteers
- 79 people
- Sponsor
- Fudan University
Hip Prosthesis Infection
Single-stage Surgery With Antibiotic-loaded Hydrogel Coated Implants Versus Two Stage Surgery for Secondary Prevention of Complex Chronic Periprosthetic Hip Joint Infection
Each year, around 1500 infected Total Hip Arthroplasties (THA) need non-conservative surgery, remaining an issue for patients and healthcare units.
- Trial name
- SINBIOSE-H (NCT04251377)
- Testing
- Defensive Antiadhesive Coating DAC®, Novagenit SRL
- Where
- 14 sites in France
- Volunteers
- 39 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Xerostomia, COVID-19
The Use of Photobiomodulation in the Treatment of Oral Complaints of Long COVID-19.A Randomized Controlled Trial.
Coronavirus (COVID-19) is a newly emerging zoonotic agent that emerged in December 2019 in China (2019-nCoV) as a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV -2).
- Conditions
- Xerostomia, COVID-19, Long COVID, Persistent COVID-19
- Trial name
- NCT05760092
- Testing
- Institutional standard treatment for xerostomia and Long Covid, Photobiomodulation Therapy
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- University of Nove de Julho
Septic Shock
TIMP2*IGFBP7 and Transient AKI
Patients with septic shock in the intensive care unit have a high risk to develop acute kidney injury (AKI) and AKI is an independent risk factor of mortality.
- Trial name
- BIOCHECK (NCT03472079)
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens