Clinical trials: Persistent Infection
Allergic Rhinitis
The Effect of Early Radiofrequency Turbinate Reduction on Persistent Allergic Rhinitis
The primary outcome of this study is to evaluate the effect of radiofrequency turbinate reduction as an initial treatment on clinical improvement (using visual analogue scale based on total nasal symptoms score, peak nasal…
- Trial name
- NCT05276336
- Testing
- Radiofrequency turbinate reduction, Pharmacology treatment
- Where
- Indonesia
- Volunteers
- 32 people
- Sponsor
- Universitas Indonesia
Covid19
Enhancing COVID Rehabilitation With Technology
In March 2020, the World Health Organization (WHO) declared the novel coronavirus (COVID-19) a global pandemic. Ontario has confirmed more than 547,000 cases of COVID-19 since testing began.
- Trial name
- ECORT (NCT05019963)
- Testing
- NexJ Connected Wellness, Usual Care
- Where
- Canada
- Volunteers
- 106 people
- Sponsor
- University of Ottawa
Sepsis
A Clinical Trial of Procalcitonin-guided Antimicrobial Therapy in Sepsis
The aim of the study is to demonstrate if using one procalcitonin (PCT)-guided rule of stop of antimicrobials, the incidence of infections by C.difficile and by Multi-Drug-Resistant (MDR) bacteria during the next six months may…
- Trial name
- PROGRESS (NCT03333304)
- Testing
- Procalcitonin measurement
- Where
- 7 sites in Greece
- Volunteers
- 266 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
COVID-19, SARS-CoV-2
Extended Remdesivir Infusion Combined With Nirmatrelvir/Ritonavir for Persistent SARS-CoV-2 Infection in Immunocompromised Patients
To evaluate the safety and efficacy of extended remdesivir infusion, targeting on immunocompromised individuals who had positive SARS-CoV-2 PCR despite an oral antiviral agent prescription.
- Conditions
- COVID-19, SARS-CoV-2, Immunocompromised
- Trial name
- SARS-CoV-2 (NCT06610643)
- Testing
- combination therapy, SOC
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Persistent Infection, Cystic Fibrosis
A Study To Evaluate The Safety Of CMTX-101 In People With Cystic Fibrosis
CMTX-101 is a bacterial biofilm disrupting monoclonal antibody being developed as an adjunctive therapy to standard of care antibiotics.
- Trial name
- NCT06159725
- Testing
- CMTX-101
- Where
- 23 sites in United States
- Volunteers
- 43 people
- Sponsor
- Clarametyx Biosciences, Inc.
Persistent COVID-19, Quality of Life
Vascular Structure, Vascular Function and Vascular Aging in Adults Diagnosed With Persistent COVID
The ICOPER study aims to analyze the structure, vascular function, vascular aging and determining factors in 300 adults diagnosed with Persistent Covid in the field of Primary Health Care.
- Conditions
- Persistent COVID-19, Quality of Life, Lifestyles, Arterial Stiffness
- Trial name
- ICOPER (NCT05819840)
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
HIV Infections
Alternative Dosing Strategy for Anti-HIV Drugs
Anti-HIV drugs are usually given to patients at fixed, standardized doses. This study will investigate alternative ways of dosing anti-HIV drugs to improve viral control.
- Trial name
- NCT00059384
- Testing
- Concentration-controlled therapy
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Post COVID-19 Condition, Long COVID Syndrome
Study to Evaluate the Efficacy and Safety of Plitidepsin in Adults With Post-COVID-19 Condition (PCC)
The study aims to prove that plitidepsin could be an efficacious, safe, and well-tolerated therapy for PCC. To this end, we will perform a randomized, double-blind study comparing the clinical and laboratory benefits of…
- Conditions
- Post COVID-19 Condition, Long COVID Syndrome, Persistent COVID-19, Persistent COVID Condition
- Trial name
- THALASSA (NCT06766825)
- Testing
- Plitidepsin 1.5 mg/day
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
COVID-19
Pulmonary Rehabilitation Post-COVID-19
The main objective of this pilot study was to evaluate the feasibility, safety, and satisfaction of a remote interdisciplinary PR program delivered using two exercise approaches (video conference and self-directed) on the…
- Trial name
- NCT05003271
- Testing
- Exercise program (virtual/remote)
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University of Manitoba
Persistent COVID-19
Efficacy of Two Therapeutic Exercise Modalities for Patients With Persistent COVID
Symptoms of long-standing sequelae and complications of COVID-19, termed Long COVID19 or persistent COVID, have been reported worldwide.
- Trial name
- NCT06142240
- Testing
- exercise programe
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Facultat de ciencies de la Salut Universitat Ramon Llull
Covid19, Dyspnea
Prospective Study of Persistent Dyspnea in Recovered COVID-19 Patients
We conducted a national, single center (Hospital Clínico Universitario de Valladolid, Spain, Valladolid), prospective study of patients with prior hospitalization because of COVID-19 who were admitted between March 1st, 2020, and…
- Trial name
- DISCOVID19 (NCT04689490)
- Testing
- Cardiopulmonary exercise test
- Where
- Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hospital Clínico Universitario de Valladolid
Cervical Intraepithelial Neoplasia, Cervical Cancer
The Durability of Protection Study of a Recombinant HPV 16/18 Bivalent Vaccine in Female
The primary objective of this study is to evaluate the durability of protection of Recombinant Human Papillomavirus Bivalent (Types 16,18) Vaccine administered in females aged 18-45 years.
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Cancer, Vaginal Intraepithelial Neoplasia, Vulvar Intraepithelial Neoplasia
- Trial name
- NCT04969445
- Testing
- Recombinant Human Papillomavirus Bivalent (Types 16, 18) Vaccine (Escherichia coli)
- Where
- China
- Volunteers
- 647 people
- Sponsor
- Jun Zhang
HPV Infection, LSIL, Low-Grade Squamous Intraepithelial Lesions
Research About Impact of HPV Integration on the Prognosis of Women With Persistent HR-HPV Infection
Clinically, patients with persistent HR-HPV infection for more than 18 months or HR-HPV infection with CIN2 + need regular colposcopic biopsy to assess the outcome and progression of the disease.
- Conditions
- HPV Infection, LSIL, Low-Grade Squamous Intraepithelial Lesions, HSIL, High-Grade Squamous Intraepithelial Lesions, Virus Integration
- Trial name
- NCT05283239
- Testing
- Follow up
- Where
- 11 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Fujian Maternity and Child Health Hospital
Pain, Postoperative, Root Resorption
Evaluation of Different Medicaments in the Management of Necrotic Primary Molars by Lesion Sterilization and Tissue Repair
Management of non-vital primary molars is challenging due to the natural anatomy of primary teeth, patients' young age, and their behavior toward dental treatment.
- Conditions
- Pain, Postoperative, Root Resorption, Persistent Infection, Necrotic Pulp
- Trial name
- NCT06926322
- Testing
- Conventional double antibiotic paste of Metronidazole 500 mg plus Ciprofloxacin 500 mg mixed with propylene glycol, Double antibiotic paste of Metronidazole and Ciprofloxacin loaded chitosan-coated silver nanoparticles, chitosan-coated silver nanoparticles
- Where
- Egypt
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Perennial Rhinitis, Seasonal Rhinitis
Efficacy, Safety & Tolerability of Ciclesonide 200mcg Spray 4 Weeks Treatment for Intermittent & Persistent Rhinitis
To assess the efficacy, safety and tolerability of ciclesonide 200 mcg once daily, applied as a nasal spray for four weeks. The main outcome will be the improvement on global and individual typical and associated symptoms of…
- Trial name
- SISRIP (NCT01369563)
- Where
- Mexico
- Volunteers
- 1,630 people
- Sponsor
- AstraZeneca
Long COVID, Sars-CoV-2 Infection
Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID
The overarching goal of this study is to determine if baricitinib, as compared to placebo, will improve neurocognitive function, along with measures of physical function, quality of life, post-exertional malaise, effect of…
- Conditions
- Long COVID, Sars-CoV-2 Infection, Coronavirus Infections, COVID-19
- Trial name
- REVERSE-LC (NCT06631287)
- Testing
- Baricitinib
- Where
- 17 sites in United States
- Volunteers
- 550 people
- Sponsor
- Wes Ely
Sepsis
Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS): A New Horizon for Surgical Critical Care and Induced Frailty
The purpose of this study is to define the natural history and causes of chronic critical illness (CCI) in surgical intensive care patients who have had sepsis.
- Trial name
- NCT02711709
- Testing
- Frailty Measurements, Modified Minnesota Leisure Time Activities, Computed tomography morphometrics
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Florida
Immune Senescence
Influence of Persistent CMV-infection on Immune Senescence
Recent studies indicate that persistent viral infections particularly with Cytomegalovirus (CMV) might have a negative impact on immune senescence (i.e. immunocompetence of elderly individuals).
- Trial name
- NCT00461695
- Testing
- Vaccination against TBEV (FSME Immun CC)
- Where
- Switzerland
- Volunteers
- 183 people
- Sponsor
- University of Zurich
Visceral Leishmaniasis, Human African Trypanosomiasis
Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever)
Tropical fevers have been a diagnostic challenge from the antiquity. Nowadays, despite the availability of good diagnostic capacities, undifferentiated febrile illnesses continue to be a thorny problem for travel physicians.
- Conditions
- Visceral Leishmaniasis, Human African Trypanosomiasis, Enteric Fever, Melioidosis
- Trial name
- NCT01766830
- Testing
- rk28 ICT, IT LEISH (rK39), Immunochromatographic HAT test
- Where
- 7 sites in Cambodia, Democratic Republic of the Congo and 2 more
- Volunteers
- 1,927 people
- Sponsor
- University Hospital, Geneva
Hepatitis C Infection, Thrombocytopenia
Romiplostim in Treating Hepatitis C-Infected Patients With Thrombocytopenia
RATIONALE: Romiplostim may cause the body to make platelets. PURPOSE: This randomized phase II trial is studying how well romiplostim works in treating hepatitis C-infected patients with thrombocytopenia.
- Trial name
- NCT01153919
- Testing
- romiplostim, ribavirin, PEG-interferon alfa-2a
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Southern California