Clinical trials: Persistent Physical Symptoms, open to volunteers
Inflammatory Bowel Diseases (IBD), Fatigue
Adapted Physical Activity for Persistent Fatigue in Patients With Inflammatory Bowel Disease in Remission
The cAPAble study aims to evaluate the impact of an adapted physical activity program on persistent fatigue in patients with inflammatory bowel disease in remission.
- Conditions
- Inflammatory Bowel Diseases (IBD), Fatigue, Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- cAPAble (NCT07804511)
- Testing
- Adapted Physical Activity, Usual Care
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Grenoble
Non-Small Cell Lung Cancer, Chronic Obstructive Lung Disease
Singing Training vs Usual Care 6-18 Months After Surgical Resection for Non-small Cell Lung Cancer (NSCLC)
People who have undergone curative surgery for non-small cell lung cancer (NSCLC) often experience reduced quality of life (QoL), a high burden of symptoms, and physical deconditioning.
- Trial name
- Sing-a-Lung 2 (NCT07460999)
- Testing
- Singing training (Singing for Lung Health (SLH)), Control group: Usual care
- Where
- 5 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Zealand University Hospital
Persistent Post-concussive Symptoms, Post Traumatic Headache
SPINEPASS: SPINE Self-management Techniques for Persistent Headache After Concussion: Physical Therapy Targeting Autonomic and Dura Mater Function.
This is a prospective randomized controlled trial comparing two different physical therapy approaches to the treatment of posttraumatic headache with autonomic symptoms.
- Trial name
- SPINEPASS (NCT06882239)
- Testing
- SPINEPASS Physical Therapy, Standard Physical Therapy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- The University of Queensland
Chronic Pain, Neuropathic Pain
Neuronal Activation Accuracy in Closed-loop Spinal Cord Stimulation
Observational, prospective, single-center to assess neuronal activation accuracy and stimulation sensation in patients with closed-loop spinal cord stimulation therapy.
- Conditions
- Chronic Pain, Neuropathic Pain, Persistent Spinal Pain Syndrome Type 2
- Trial name
- NAA (NCT06775535)
- Testing
- ECAP-controlled, closed-loop SCS
- Where
- Belgium
- Volunteers
- 12 people
- Sponsor
- Karel Hanssens
Obesity, Chronic Pain
Chronic Abdominal Pain After Laparoscopic Sleeve Gastrectomy
The study aims to evaluate the prevalence of postoperative chronic pain, defined as the persistence of abdominal pain for more than 3 months after laparoscopic sleeve gastrectomy.
- Conditions
- Obesity, Chronic Pain, Abdominal Pain
- Trial name
- Chron Pain LSG (NCT06686875)
- Testing
- Questionnaire
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Warsaw
Psychological Factors Affecting Other Medical Conditions, Somatic Symptom and Related Disorders
Exposure Therapy for Reactivity to Symptoms
It is unclear to what degree systematic exposure exercises contribute to the overall effects of exposure therapy (exposure and response prevention).
- Conditions
- Psychological Factors Affecting Other Medical Conditions, Somatic Symptom and Related Disorders, Bodily Distress Disorder
- Trial name
- SOMEX2 (NCT07757854)
- Testing
- Planned, systematic, exposure exercises, Response prevention
- Where
- Sweden
- Volunteers
- 360 people
- Sponsor
- Region Stockholm
Atrial Fibrillation (AF)
Smartphone Based-PPG Assessment of REconversion in Persistent Atrial Fibrillation
This study investigates whether a smartphone application that measures heart rhythm using light, a technique known as photoplethysmography or PPG, can accurately detect when the cardiac arrhythmia atrial fibrillation (AF)…
- Trial name
- SPARE-AF (NCT07752940)
- Testing
- Smartphone-based PPG monitoring
- Where
- 2 sites in Belgium
- Volunteers
- 200 people
- Sponsor
- Ziekenhuis Oost-Limburg
Atrial Fibrillation
A Study of VARIPULSE Catheter in Participants With Persistent Atrial Fibrillation Undergoing Pulmonary Vein and Superior Vena Cava Isolation
The purpose of this study is to assess how safe VARIPULSE catheter system is for treatment of a heart rhythm disease called persistent atrial fibrillation (PsAF) in participants who are having a catheter ablation procedure (treat…
- Trial name
- SPAA PFA (NCT07527299)
- Testing
- VARIPULSE Catheter System, LAAO Device
- Where
- 13 sites in United States
- Volunteers
- 1,070 people
- Sponsor
- Biosense Webster, Inc.
Consciousness Disorders, Persistent Vegetative State
Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)
After a severe brain injury some patients survive but cannot communicate, and deciding early which of them are likely to recover consciousness remains one of the hardest problems in neurocritical care.
- Conditions
- Consciousness Disorders, Persistent Vegetative State, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- CyDoC-MAP (NCT07736820)
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Nicosia General Hospital
Chronic Pain, Chronic Pain Due to Injury
Virtual Pain Education for Spinal Cord Stimulation Patients
Chronic pain is a leading cause of disability in the United States. When standard treatments fail, many patients develop treatment resistant pain and undergo Spinal Cord Stimulation (SCS) therapy.
- Conditions
- Chronic Pain, Chronic Pain Due to Injury, Failed Back Syndrome, Persistent Spinal Pain Syndrome
- Trial name
- SCS-PNE (NCT07743905)
- Testing
- SCS-PNE intervention
- Volunteers
- 50 people
- Sponsor
- University of Arkansas
Disorders of Consciousness Due to Severe Brain Injury, Minimally Conscious State
Assessment of Consciousness With CRS-R and SECONDs
Accurately determining the level of consciousness in patients with severe brain injury is essential for treatment planning, prognosis, and ethical decision-making.
- Conditions
- Disorders of Consciousness Due to Severe Brain Injury, Minimally Conscious State, Unresponsive Wakefulness Syndrome
- Trial name
- AssessConsc (NCT07456020)
- Testing
- Simplified Evaluation of CONsciousness Disorders (SECONDs), Coma Recovery Scale-Revised (CRS-R)
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- BDH-Klinik Hessisch Oldendorf
Persistent Atrial Fibrillation
PFLotus With the DePolar Mapping System in Patients With Persistent Atrial Fibrillation
This clinical trial aims to evaluate the safety and efficacy of pulmonary vein isolation (PVI), focal, and linear ablation in patients with persistent atrial fibrillation (PersAF) using a novel shape-adaptive pulsed field…
- Trial name
- NCT07321002
- Testing
- Ablation with the PFLotus catheter and Depolar system
- Volunteers
- 35 people
- Sponsor
- The Third People's Hospital of Chengdu
Obesity, Bariatric Surgery Candidate
Persistent Organic Pollutants and Mechanical Discharge: Limiting the Impact of Bariatric Surgery Through Personalized Adapted Physical Activity
For the most severe cases of obesity, recourse to bariatric surgery is the ultimate solution. Although highly beneficial to individual health, this massive loss of body mass could also have negative effects on metabolism and…
- Trial name
- PERSIST-APA (NCT06597617)
- Testing
- Adapted physical activity with aerobic training [GEA], Adapted physical activity with strength training [GRM]
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness
fNIRS for Disorders of Consciousness
The goal of this observational study is to learn whether functional near-infrared spectroscopy (fNIRS) can measure brain activity in healthy adults and in people with disorders of consciousness (DoC) in the neuro-intensive care…
- Conditions
- Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness, Coma, Minimally Conscious State
- Trial name
- NCT07485361
- Testing
- Functional Near-Infrared Spectroscopy Monitoring
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Persistent Physical Symptoms
My Symptoms: an eHealth and GP Assisted Programme for Persistent Symptoms in Primary Care
The project 'My Symptoms' is part of a large research programme: eHealth and GP-assisted self-help interventions for persistent physical symptoms (eASY). See www.mine-symptomer.dk.
- Trial name
- eASY (NCT06163014)
- Testing
- My Symptoms eHealth programme
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Aarhus University Hospital
Somatic Symptom Disorder (DSM-5), Impairment
An Ecological Momentary Intervention for the Reduction of Impairment in Somatic Symptom Disorder
Persistent somatic symptoms significantly impair the daily lives of individuals with Somatic Symptom Disorder (SSD). Negative psychological factors (NPFs), such as catastrophizing and negative affectivity, further compound this…
- Conditions
- Somatic Symptom Disorder (DSM-5), Impairment, Psychological Factors, Persistent Physical Symptoms
- Trial name
- NCT07646509
- Testing
- Music listening, Cognitive reappraisal, No intervention
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- University of Vienna
Immune Thrombocytopenia
Cognitive Dysfunction in Chronic and Persistent Immune Thrombocytopenia
Individuals with immune thrombocytopenia (ITP) frequently report difficulties with attention and memory. The main question this study seeks to answer is: Do patients with ITP have evidence of cognitive impairment as detected by a…
- Trial name
- COGFIT (NCT06817395)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Depressive Disorder, Major, Persistent Depressive Disorder
Effectiveness of an Ecological Momentary Emotion Regulation Intervention
This two-armed randomized controlled trial aims to investigate the effectiveness of an emotion regulation intervention in individuals with and without depressive disorders.
- Conditions
- Depressive Disorder, Major, Persistent Depressive Disorder, Healthy
- Trial name
- NCT06311136
- Testing
- Valence-Specific Ecological Momentary Intervention
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Brain Injury Traumatic Mild
Evaluation of the Impact of a Dietary and Nutritional Intervention on Persistent Post-concussive Symptoms
Concussions affect thousands of Canadians every year. Although the effects are usually temporary, 10-15% of adults experience persistent symptoms likely to last several weeks or even months.
- Trial name
- NCT05589064
- Testing
- Experimental: Dietetic counseling, Active Comparator: Omega-3, vitamin D3 and creatine monohydrate, Other : Physiotherapy treatment
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Universite de Moncton
Persistent Physical Symptoms (PPS), Bodily Distress Syndrome
My Symptoms Young - a New Internet-based Programme for Young People With Persistent Physical Symptoms in Primary Care: Exploration of Effect and Health Literacy Characteristics Among Users
The research programme is an ambitious effort aiming to improve overall functioning and quality of life for young people with bodily distress.
- Conditions
- Persistent Physical Symptoms (PPS), Bodily Distress Syndrome, Health Literacy, eHealth Literacy
- Trial name
- NCT07912515
- Testing
- My Symptoms Young - an internet-based self-help programme for young people with persistent physical symptoms
- Where
- Denmark
- Volunteers
- 62 people
- Sponsor
- Aarhus University Hospital