Clinical trials: Persistent Post-surgical Pain
Breast Cancer, Pain
Long Term Follow-up of Persistent Pain, Sensory Disturbances and Lymphedema After Breast Cancer Treatment
Persistent pain, sensory disturbances, lymphedema and functional impairment are frequently occurring late effects of breast cancer treatment.
- Conditions
- Breast Cancer, Pain, Post Operative Pain, Lymphedema
- Trial name
- NCT01543711
- Where
- Denmark
- Volunteers
- 2,411 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Amputation; Lower Extremity, Pain, Persistent Postsurgical
Altius Peripheral Nerve Stimulation in Amputees After TMR/RPNI
This is a single-center, prospective, within-subject study. This study seeks to enroll a total of 32 prospective subjects who will undergo surgical implantation of the FDA-approved Altius® system.
- Trial name
- NCT07571239
- Testing
- Surgical Implantation
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- NYU Langone Health
Breast Cancer, Chronic Pain
Evaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery
Pre-existing pain and severe postoperative pain are predictors of persistent pain after surgery, but a complete understanding on the development of persistent pain is still lacking.
- Conditions
- Breast Cancer, Chronic Pain, Acute Pain, Depression, Anxiety
- Trial name
- B-CAPP (NCT03408717)
- Testing
- Questionnaires, Mechanical Temporal Summation assessment, Pain threshold assessment
- Where
- 2 sites in United States, Singapore
- Volunteers
- 220 people
- Sponsor
- KK Women's and Children's Hospital
Postoperative Pain, Postherniotomy Pain
Neurophysiological Characterization of Postherniotomy Pain
Sensory function is different in persistent postherniotomy pain patients than in operated controls, suggesting this to be a neuropathic pain syndrome.
- Conditions
- Postoperative Pain, Postherniotomy Pain, Neuropathic Pain
- Trial name
- NCT00719368
- Where
- 2 sites in Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Neuropathic Pain
Cryoneurolysis for Cutaneous Neuropathic Pain
Feasibility study with 25 patients investigating the effect of cryoneurolysis on persistent cutaneous neuropathic pain after surgery and trauma. All patients receive active treatment (cryoneurolysis).
- Trial name
- NCT04911569
- Testing
- Cryoneurolysis
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- Aarhus University Hospital
Chronic Post Operative Pain
Prevalence and Risk Factors for Postsurgical Pain After the Open Reduction and Internal Fixation of Lower Limbs.
The objective of this study is to specify the demographic and medical factors that most likely constitute a risk of developing CPSP in the patients with lower limb.
- Trial name
- NCT06136663
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Xuzhou Central Hospital
Lumbar Surgery
Study of PEMF (Pulsed Electromagnetic Field) Therapy in the Treatment of Persistent Post-Operative Pain Following Lumbar Surgery
To demonstrate the analgesic effectiveness of 2 modalities of PEMF treatment compared to sham treatment in patients with persistent pain following lumbar surgery when treatment is administered twice daily over a 60 day period.
- Trial name
- NCT02416973
- Testing
- Provant
- Where
- 8 sites in United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Regenesis Biomedical, Inc.
Chronic Postsurgical Pain
Vaginal or Laparoscopic Hysterectomy, Persistent Postsurgical Pain
Previous studies have shown that chronic pain after hysterectomy is common. The aim of this study is to investigate the incidence of chronic pain after vaginal or laparoscopic hysterectomy for benign reasons.
- Trial name
- NCT01537731
- Testing
- vaginal or laparoscopic hysterectomy
- Where
- Finland
- Volunteers
- 225 people
- Sponsor
- Tampere University Hospital
Mastectomy, Mastectomy Patient
A Study on Pain After Breast Reconstruction
The purpose of this study is to find out how common persistent postmastectomy pain (PPMP) is among people who have had a mastectomy and breast reconstruction surgery for their breast cancer.
- Conditions
- Mastectomy, Mastectomy Patient, Mastectomy and Breast Reconstruction, Breast Reconstruction
- Trial name
- NCT06627582
- Testing
- PROMIS Scale v2.0 - Pain Intensity 3a, PROMIS 29+2, PROMIS Scale v2.0 - Nociceptive Pain Quality 5a
- Where
- 7 sites in United States
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Osteoarthritis of the Knee
Effects of Perioperative Intravenous Dexamethasone on the Severity of Persistent Postsurgical Pain After Total Knee Arthroplasty : A Prospective, Randomized, Double-blind, Placebo-controlled Trial
To compare the effects of perioperative intravenous Dexamethasone with a placebo on the severity of persistent postsurgical pain after total knee arthroplasty.
- Trial name
- NCT02760459
- Testing
- Dexamethasone, Normal saline solution
- Where
- Thailand
- Volunteers
- 70 people
- Sponsor
- Chiang Mai University
Breast Cancer, Surgery
Analgesic Effect of Resistance Training for Breast Cancer Survivors
Persistent pain after treatment for breast cancer is a major clinical problem, affecting 25-60 % of the patients and is a source of considerable physical disability and psychological distress.
- Conditions
- Breast Cancer, Surgery, Chemotherapy Effect, Radiotherapy Side Effect
- Trial name
- (ANTRAC) (NCT04509284)
- Testing
- Training, Control
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Aalborg University
Pain, Neuropathic Pain
Nerveblocks for Persistent Pain After Breast Cancer Surgery
Persistent pain after breast cancer surgery (PPBCS) affects 25-60% of breast cancer survivors and nerve damage has been implicated as the cause of this neuropathic pain condition.
- Conditions
- Pain, Neuropathic Pain, Breast Cancer
- Trial name
- NCT02336529
- Testing
- Bupivacaine, NaCl
- Volunteers
- 48 people
- Sponsor
- Kenneth Geving Andersen
Cancer-related Pain, Chronic Post Cancer Surgery Pain
Exploring the Link Between Cancer Genetics and PPSP
Pain is common in cancer, affecting between 40 and 60% of patients depending on tumour type and stage of disease, and represents a major area of unmet need in cancer survivors.
- Conditions
- Cancer-related Pain, Chronic Post Cancer Surgery Pain, Breast Cancer
- Trial name
- NCT04007861
- Volunteers
- 104 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Mastectomy, Segmental, Regional Anesthesia
Post-discharge Pain After Breast-surgery Treated by Paravertebral Block
Breast surgery is known being associated to a high risk of persistent post-operative pain, which has been related, among other factors, to a poorly treated acute pain.
- Trial name
- NCT03618459
- Testing
- Phone questionnaire
- Where
- Switzerland
- Volunteers
- 244 people
- Sponsor
- Samuele Ceruti
Pain, Postoperative, Cognitive Function Abnormal
Perioperative Cognitive Training in Thoracic Surgery
More than 30% of patients undergoing thoracic surgical procedures develop persistent post-surgical pain (PPSP), which results in impaired functioning, diminished quality of life, and increased risk of chronic opioid use.
- Conditions
- Pain, Postoperative, Cognitive Function Abnormal, Lung Cancer
- Trial name
- COFLEX-T (NCT04563234)
- Testing
- COFLEX neurocognitive training, Crossword puzzles
- Sponsor
- Washington University School of Medicine
Post Surgical Pain
Characterization of PostOp Pain in Shoulder and Knee Arthroscopy
The purpose of this study is to describe the chronology of post operative pain in patients undergoing total knee arthroplasty and total hip arthroplasty.
- Trial name
- PurpleRain (NCT03047434)
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Defense and Veterans Center for Integrative Pain Management
Marginal Ulcer, Chronic Ulcer Disease
Chronic Marginal Ulcers After Gastric Bypass
The purpose of this study is to determine the feasibility, safety, and efficacy of revision gastroplasty along with other adjunct procedures in the treatment of intractable / chronic marginal ulcers after Roux-en-Y gastric…
- Conditions
- Marginal Ulcer, Chronic Ulcer Disease, Persistent Ulcer Disease, Recurrent Ulcer Disease
- Trial name
- ChronicMU (NCT01041079)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Lumbar Spine Pathology, Elective Spine Surgery
Neurocognitive and Genomic Predictors of Persistent Pain and Opioid Misuse After Spine Surgery
Having spine surgery and recovery is a vulnerable period when opioid naive patients may transition into long-term use of opioids, and when previously opioid tolerant patients may be at risk to continue towards long-term opioid…
- Trial name
- NCT06288256
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Persistent Postoperative Pain
Avoid With Locoregional Analgesia Persistant Postoperative Pain In Children
Persistent postoperative pain is a substantial pain (scores 4-10 using a 0-10 numeric scale) that develops 3 months after surgery. Persistent postoperative pain can be a problem even in ambulatory surgery.
- Trial name
- AWA3PASIC (NCT06271174)
- Testing
- Carbocaine, Profofol and/or Suxaméthonium and/or Sévoflurane
- Where
- France
- Volunteers
- 208 people
- Sponsor
- Nantes University Hospital
Cesarean Section Complications, Cesarean Section
Persistent Pain After Cesarean Delivery - A Danish Multicenter Cohort Study
In Denmark, around 12,700 patients undergo Cesarean delivery (CD) annually, constituting approximately 20% of all childbirths in the country.
- Conditions
- Cesarean Section Complications, Cesarean Section, Cesarean Delivery, Persistent Pain
- Trial name
- NCT06247852
- Where
- Denmark
- Volunteers
- 477 people
- Sponsor
- Nordsjaellands Hospital