Clinical trials: Persistent Vegetative State
Disorder of Consciousness, MMN
Excitatory Prefrontal Weak Current Stimulation in Vegetative Patients
In response to "conscious" EEG findings related to detectable cognitive function that reliably denote awareness in vegetative state patients, in the current study, we will assess the covert conscious EEG activity (as well as…
- Conditions
- Disorder of Consciousness, MMN, Modification of Cognitive Status Indication, Anoxic Brain Damage
- Trial name
- VEG-TDCS (NCT04614792)
- Testing
- Transcranial direct current stimulation
- Where
- Israel
- Volunteers
- 16 people
- Sponsor
- Oded Meiron
Minimally Conscious State
Therapeutic Effects of Animal-assisted Therapy for Patients in a Minimally Conscious State
The aim of this study is to investigate the effects of animal-assisted occupational therapy on patient's consciousness, measured via the achievement of predefined, patient-specific goals.
- Trial name
- MCS Therapy (NCT03910959)
- Testing
- Animal-assisted therapy, Conventional therapy
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Basel
Vegetative State, Minimally Conscious State
Fronto-parietal tDCS in Severely Brain Injured Patients With Disorders of Consciousness
Previous studies showed that anodal transcranial direct current stimulation (tDCS) transiently improves performance of memory and attention.
- Conditions
- Vegetative State, Minimally Conscious State, Disorders of Consciousness
- Trial name
- NCT02626403
- Testing
- Anodal tDCS
- Where
- Belgium
- Volunteers
- 46 people
- Sponsor
- University of Liege
Vegetative State, Minimally Conscious State
Thalamic Stimulation of Patients in Vegetative or Minimally Conscious State
Rationale. The investigators hypothesize that bilateral electrical central thalamic stimulation of patients in Vegetative State and Minimally Conscious State from at least 6 months could improve the level of responsiveness. Aims.
- Trial name
- CATS\ (NCT01027572)
- Testing
- Implantable neurostimulation system (Medtronic)
- Where
- 3 sites in Italy
- Volunteers
- 5 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Disorder of Consciousness
Apomorphine in Severe Brain-injured Patients
Background: Patients who survive severe brain injury may develop chronic disorders of consciousness (DoC). Treating these patients to improve recovery is extremely challenging because of scarce and inefficient therapeutical…
- Trial name
- APODoC (NCT05213169)
- Testing
- Apomorphine Hydrochloride 5mg/ml, Sodium chloride 9mg/ml
- Where
- 4 sites in Belgium, Spain
- Volunteers
- 48 people
- Sponsor
- University of Liege
Brain Injuries, Minimally Conscious State
Effects of Whole-body Vibration Exercise in Brain Injury Patients With Minimally Conscious State
The purpose of this study is to investigate the effect of the whole body vibration exercise on cortical activity and consciousness Level in brain injury patients with minimally conscious state.
- Trial name
- NCT03389113
- Testing
- Whole body vibration, Exersice
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Samsung Medical Center
Disorder of Consciousness, Vegetative State
The Use of LIFUP in Chronic Disorders of Consciousness
When patients survive a severe brain injury but fail to fully recover, they often enter a Disorder of Consciousness (DoC) --that is, a set of related conditions of decreased awareness and arousal including the Vegetative State…
- Conditions
- Disorder of Consciousness, Vegetative State, Minimally Conscious State, Minimally Conscious State Plus
- Trial name
- NCT04921683
- Testing
- BX Pulsar 1002 (LIFUP) Low intensity Focused Ultrasound Pulsation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Failed Moderate Sedation During Procedure, Minimally Conscious State
Dexmedetomidine vs Midazolam for Intraoperative Sedation
This randomized, open clinical trial sought to compare the use of Midazolam and Dexmedetomidine during surgery in patients under regional anesthesia.
- Trial name
- NCT02878837
- Testing
- Dexmedetomidine, Midazolam
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Instituto de Assistencia Medica ao Servidor Publico Estadual, Sao Paulo
Persistent Vegetative State
18F-FDG PET/CT in Diagnostic Patients of Disorder of Consciousness
Clinical examinations are difficult to discriminate between vegetative state and minimally conscious state. the diagnostic and prognostic usefulness of neuroimaging methods has not been established in a clinical setting.
- Trial name
- NCT02999490
- Testing
- 18F-FDG
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Consciousness Disorders, Persistent Vegetative State
Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)
After a severe brain injury some patients survive but cannot communicate, and deciding early which of them are likely to recover consciousness remains one of the hardest problems in neurocritical care.
- Conditions
- Consciousness Disorders, Persistent Vegetative State, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- CyDoC-MAP (NCT07736820)
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Nicosia General Hospital
Minimally Conscious State, Vegetative State
The Initiation of Swallowing Can Indicate the Prognosis of DOC
This study is aimed to detect the initiation of swallowing act in DOC patients, to find if it is a good item as a stimulus and to detect the relationship between the initiation of swallowing act and the prognosis of DOC patients.
- Trial name
- NCT03508336
- Testing
- Coma Recovery Scale-Revised
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Hangzhou Normal University
Disorder of Consciousness, Minimally Conscious State
Target Behaviours to Identify Minimally Conscious State Patients
To analyse the frequency of the consciousness behaviour response for patients with minimally conscious state of Coma Recovery Scale-Revised items, as well as the necessary items for obtaining higher accuracy.
- Trial name
- NCT04471753
- Testing
- Coma Recovery Scale-Revised
- Where
- China
- Volunteers
- 215 people
- Sponsor
- Hangzhou Normal University
Chronic Vegetative State
The Impact of RPh201 on Chronic Vegetative State (CVS): fMRI Study
The aim is to evaluate the impact of RPh201 on brain activity in chronic vegetative state patients. The assessment will be done using clinical measurements and functional MRI studies.
- Trial name
- RPh-in-CVS (NCT01438684)
- Testing
- RPh201, Saline
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Hadassah Medical Organization
Consciousness Disorders
Validation of the Russian Version of Coma Recovery Scale-Revised (CRS-R)
The purpose of this study is to validate Russian version of Coma Recovery Scale - Revised and to assess its psychometric properties.
- Trial name
- NCT03060317
- Testing
- Examination with neurological scales.
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Research Center of Neurology, Russia
Postcomatose Unawareness State, Minimally Conscious State
Eye Tracking Technology in the Diagnosis of Neurological Patients
Demonstrating that diagnostics of the state of consciousness and cognitive functions of patients with consciousness disorders performed using C-Eye X (based on eye-tracking technology) allows a more objective assessment of state…
- Conditions
- Postcomatose Unawareness State, Minimally Conscious State, Vegetative State, Disorder of Consciousness
- Trial name
- NCT05536921
- Where
- 5 sites in Poland
- Volunteers
- 90 people
- Sponsor
- AssisTech Sp. z o.o.
Vegetative State, Stroke
Navigated Brain Stimulation in Diagnosis of Minimally Conscious State
It has already been demonstrated that mental imagining of the complex motor act, such as limb lifting, can evoke the activation of the involved motor centres even if it doesn't result in movement due to paresis.
- Conditions
- Vegetative State, Stroke, Brain Injury
- Trial name
- C-fMRI-NBS (NCT01467908)
- Testing
- Navigated transcranial magnetic brain stimulation
- Where
- Russia
- Volunteers
- 6 people
- Sponsor
- Clinical Institute of the Brain, Russia
Disorders of Consciousness
mindBEAGLE: Unlocking Functional Communication for Patients With Disorders of Consciousness
The goal of this clinical trial is to test how effective the mindBEAGLE device is in allowing people who are unconscious (due to a brain injury or other condition) to communicate using brain waves to answer Yes/No questions.
- Trial name
- NCT06426602
- Testing
- mindBEAGLE daily device use
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Amy Wagner
Consciousness Disorder
Multimodal Neuroprognostication in Disorders of Consciousness
Disorders of consciousness frequently occur at the acute phase of brain injuries. For the most severe cases, consciousness impairment can be prolonged.
- Trial name
- M-Neuro-DoC (NCT04534777)
- Testing
- repeated neurological, behavioral assessments and conventional, quantitative and functional brain imagery
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Brain Injuries
Validating the MATADOC Against Best Practice Standard External Reference Standard
The purpose of this project is to further develop a standardized music-based measure used in music therapy with adults who have emerged from coma following profound brain injury, but are not able to demonstrate responsiveness to…
- Trial name
- MATADOC (NCT02959736)
- Testing
- MATADOC and CRS-R
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Temple University
Consciousness Disorder
Detection of Arousal With Facial Micro-expression in Severe Brain-damaged Patient
Severe brain injuries lead to disorders of consciousness after coma. During this awakening period, detection of arousal is critical to the adaptation of medical strategy, but global paralysis, including facial expression, make…
- Trial name
- DAME (NCT03023657)
- Testing
- Detection of arousal
- Where
- 2 sites in France
- Volunteers
- 3 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne