Clinical trials: Persons With Psychiatric Disorders
Schizophrenia, Schizoaffective Disorder
Luteolin for the Treatment of People With Schizophrenia
Luteolin is a natural product found in foods such as celery, green pepper, parsley, and chamomile tea. It has been found to have anti-cancer, anti-oxidant, and anti-inflammatory properties.
- Trial name
- NCT05204407
- Testing
- Luteolin
- Where
- 2 sites in United States
- Volunteers
- 85 people
- Sponsor
- University of Maryland, Baltimore
Dementia
Effects and Costs of a Day Care Centre Program Designed for People With Dementia
Attending day care centres with programs specifically designed for patients with dementia is believed to postpone admittance to nursing home as well as increase quality of life and well-being for both patients and their family…
- Trial name
- ECOD (NCT01943071)
- Testing
- Day care for patients with dementia
- Where
- Norway
- Volunteers
- 261 people
- Sponsor
- Norwegian Centre for Ageing and Health
Posttraumatic Stress Disorder
Study of 3,4-Methylenedioxymethamphetamine-assisted Psychotherapy in People With Posttraumatic Stress Disorder
This study will examine MDMA-assisted psychotherapy in individuals aged 18 years or older diagnosed with PTSD, with PTSD symptoms not improving after trying at least one treatment.
- Trial name
- NCT00353938
- Testing
- 3,4-methylenedioxymethamphetamine (125 mg), 3,4-methyelendioxymethamphetamine (25 mg), Therapy
- Where
- Switzerland
- Volunteers
- 14 people
- Sponsor
- Resilient Pharmaceuticals
Tobacco Cessation
Pilot Testing a Digital Intervention to Improve Smoking Cessation in Persons With Serious Mental Illness
All patients with serious mental illness are abstinent while in the hospital for a psychiatric admission yet almost all return to smoking after discharge.
- Trial name
- NCT04367506
- Testing
- BecomeAnEX, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- University of Maryland, Baltimore
Cannabis Use Disorder, Repetitive Transcranial Magnetic Stimulation
Repetitive Transcranial Magnetic Stimulation to People With Cannabis Use Disorder (SToP-C-rTMS x CUD)
This study is to explore if repetitive transcrinal magnetic stimulation (rTMS) with different stimulation schedules will be equally effective in reducing carving, frequency of cannabis use, and the severity of cannabis use…
- Trial name
- NCT05292547
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- The University of Hong Kong
Cognitive Impairment, Cognitive Decline
Multicentre Study About the Effect of Individual Reminiscence Therapy
This study aims to evaluate the effect of individual reminiscence therapy (RT) on the global cognitive function of people with neurocognitive disorders attending social responses and to evaluate the ability of individually…
- Conditions
- Cognitive Impairment, Cognitive Decline, Dementia, Neurocognitive Disorders
- Trial name
- NCT04047238
- Testing
- Reminiscence Therapy
- Where
- 25 sites in Portugal
- Volunteers
- 251 people
- Sponsor
- Rsocialform - Geriatria, Lda
Generalized Anxiety Disorder (GAD), Major Depressive Disorder (MDD)
AI-Supported Therapy for Depression and Anxiety Compared With Standard CBT
This study is a pivotal, randomised, controlled, non-inferiority trial evaluating "Nook," an AI-delivered, neurosymbolic, clinician-supervised digital psychological intervention for depression and anxiety, compared with standard…
- Trial name
- NCT07620340
- Testing
- AI-Digital CBT, Cognitive Behavioural Therapy
- Volunteers
- 400 people
- Sponsor
- PsyScale
Anxiety, Depression
Evaluating Knowledge Insight Tools (KIT) for Reducing Anxiety and Low Mood in UK Secondary School Students
Background and Study Aims: Secondary school students are reporting unprecedented levels of anxiety and mood difficulties. To ensure that the needs of all young people are met, there is a need to evaluate more accessible forms of…
- Conditions
- Anxiety, Depression, Internalizing Problems, Low Mood
- Trial name
- NCT06188962
- Testing
- CBT-informed school-based counselling
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University College, London
Alzheimer's Disease and Related Dementias
OPTIMAL in NH Residents With Dementia
The purpose of this study is to develop and refine OPTIMAL and evaluate its feasibility, fidelity, and usefulness. The OPTIMAL is designed to teach staff to effectively engage residents in eating using individualized…
- Trial name
- NCT05255068
- Testing
- OPTIMAL
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- University of Iowa
Executive Dysfunction, Mild Cognitive Impairment (MCI)
Feasibility Study of Mixed Reality Exergame on Performance and Cortical Outcomes
The executive dysfunctions are a problem in individuals with MCI which predict conversion to dementia and is positively related to physical activity level.
- Trial name
- NCT06843733
- Testing
- Mixed reality exergame, Education
- Where
- Thailand
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Dementia
Improving Well-being and Health for People With Dementia
800,000 people in the United Kingdom (UK)have dementia, of which 250,000 are living in care homes. These individuals have complex mental health problems, disabilities and social needs, which if unmet will continue to adversely…
- Trial name
- WHELD (NCT01855152)
- Testing
- Optimised WHELD intervention, Treatment as usual
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- professor Clive Ballard
Alzheimer Disease, Dementia
MEMORI Corps: Activity-based Companion Care for Dementia
This project adapts a novel activity-based companion care model, the Making Engagement Meaningful through Organized Routine Interaction (MEMORI) Corps intervention, for a virtual delivery format, and then implements the…
- Trial name
- MEMORI Corps (NCT03896711)
- Testing
- MEMORI Corps program, Augmented Waitlist Control
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Dementia, Neuro-Degenerative Disease
Lived Experience Narratives in Dementia
The Lived Experience Narratives in Dementia (LEND) research programme involves five work packages (WP). WP1 explores how people living with dementia use narratives and how narratives can impact them.
- Conditions
- Dementia, Neuro-Degenerative Disease, Alzheimer Disease, Caregiver Burden
- Trial name
- LEND (NCT07757178)
- Testing
- Online LEND Intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Major Depressive Disorder, Mild Neurocognitive Disorder
Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV
A phase II, randomized, open-label, two-arm clinical trial evaluating the safety and efficacy of pramipexole extended release (ER) versus escitalopram for the treatment of major depressive disorder (MDD) and comorbid MDD with…
- Conditions
- Major Depressive Disorder, Mild Neurocognitive Disorder, HIV
- Trial name
- NCT06705478
- Testing
- Pramipexole ER, Escitalopram
- Where
- 41 sites in United States, Botswana and 12 more
- Volunteers
- 186 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Functional Neurological Disorder
Psychoeducation Group Intervention for FND
This study aims to assess the feasibility of running a brief psychoeducation group intervention in an outpatient setting to assess the practicalities and benefits of offering this type of intervention for both clinicians and…
- Trial name
- NCT03857347
- Testing
- Psychoeducation Group for FND
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Edinburgh
Depressive Disorder, Major
A Study to Test the Effect of Different Doses of BI 1358894 and Quetiapine in People With Depression
This study is open to adults with depression (major depressive disorder) for whom standard treatment with antidepressants alone does not work sufficiently.
- Trial name
- NCT04521478
- Testing
- BI 1358894, Quetiapine
- Where
- 120 sites in United States, Argentina and 12 more
- Volunteers
- 389 people
- Sponsor
- Boehringer Ingelheim
Mental Illness Persistent, Cardiovascular Prevention
Cardiac Rehabilitation for Cardiovascular Risk Reduction in People With Severe and Persistent Mental Illness
The goal of this prospective, randomized trial is to explore the link between cardiovascular disease and mortality in individuals with severe and persistent mental illness (SPMI).
- Trial name
- NCT05659498
- Testing
- Cardiac Rehabilitation Program
- Where
- Canada
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Lady Davis Institute
Schizophrenia, Schizotypal and Delusional Disorders, Bipolar Affective Disorder
Improving Work Outcome for People With Severe Mental Illness
The purpose of this study is to investigate the efficacy of IPS in Denmark and compare effects of 1. Individual Placement and Support (IPS) vs. 2. IPS + cognitive remediation and work-related social skills training vs. 3.
- Conditions
- Schizophrenia, Schizotypal and Delusional Disorders, Bipolar Affective Disorder, Recurrent Depressive Disorder
- Trial name
- NCT01722344
- Testing
- Individual Placement and support (IPS), IPS plus
- Where
- Denmark
- Volunteers
- 717 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Alcoholism, Alcohol Dependence
Alcoholism Assessment and Treatment
The purpose of this study is to gather information about people s drinking histories and to evaluate them for other research studies being conducted at the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
- Conditions
- Alcoholism, Alcohol Dependence, Alcohol Drinking Related Problems
- Trial name
- NCT00106093
- Where
- United States
- Volunteers
- 1,192 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Stroke, Aphasia
Study of the Participation of People With Aphasia Post Stroke and Their Caregivers in Valladolid Region (Spain)
The objective of this study is to determine the level of community participation of people with post-stroke aphasia and their caregivers, as well as the factors that facilitate or interfere with this participation in the…
- Trial name
- SPART-A (NCT06948721)
- Volunteers
- 50 people
- Sponsor
- Centro Integral de Rehabilitación
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