Clinical trials: Persons With Psychiatric Disorders
Severe Mental Disorder
Independent Housing and Support for People With Severe Mental Illness
Background: Adequate and stable housing conditions are fundamental for the psychiatric rehabilitation of individuals with severe mental illness (SMI).
- Trial name
- NCT03815604
- Testing
- Independent Housing and Support (IHS), Residential Care Settings and other Treatment as Usual (RCS/TAU)
- Where
- 2 sites in Switzerland
- Volunteers
- 143 people
- Sponsor
- University of Bern
Caregiver Burden, Stress
Evaluation of Mobile Apps for Informal Caregivers of People Living With Dementia
The purpose of this study is to evaluate the effectiveness of two currently available apps for unpaid caregivers of people living with dementia.
- Conditions
- Caregiver Burden, Stress, Dementia
- Trial name
- NCT05217004
- Testing
- Dementia Talk mobile application, CLEAR Dementia Care mobile application
- Where
- Canada
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University of Regina
Speech Sound Disorder
Visual-acoustic Intervention With Service Delivery In-person and Via Telepractice Trial
Children with speech sound disorder show diminished intelligibility in spoken communication and may thus be perceived as less capable than peers, with negative consequences for both socioemotional and socioeconomic outcomes.
- Trial name
- VISIT (NCT06517225)
- Testing
- Visual-acoustic biofeedback
- Where
- 3 sites in United States
- Volunteers
- 76 people
- Sponsor
- New York University
Alzheimer's Disease
3-month Study of MSDC-0160 Effects on Brain Glucose Utilization, Cognition & Safety in Subjects With Alzheimer's Disease
This study will evaluate the effect of 150 mg MSDC-0160 taken daily for 90 days compared to the effect of placebo on changes in brain glucose utilization using FDG-PET and cognition in older persons with mild Alzheimer's disease.
- Trial name
- NCT01374438
- Testing
- MSDC-0160
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Metabolic Solutions Development Company
Mild Cognitive Impairment (MCI)
Cognitive-motor Training in Community-dwelling Older People With Mild Cognitive Impairment
As the global population ages, the prevalence of mild cognitive impairment (MCI) among older adults, which ranges from 5% to 40%, is expected to rise.
- Trial name
- NCT07241598
- Testing
- Smart±step cognitive-motor training
- Where
- Thailand
- Volunteers
- 70 people
- Sponsor
- Mahidol University
Schizophrenia, Cognition
Cognitive and Balance Dual Task Training for People With Schizophrenia
After developing and pilot testing the training program, including the CogBals software, a 3-arm, single-blinded, randomized controlled trial is used to recruit 84 participants and then randomly allocated to the cognitive and…
- Conditions
- Schizophrenia, Cognition, Balance, Dual Task
- Trial name
- NCT05341804
- Testing
- cognitive and balance dual task training, balance training
- Where
- Taiwan
- Volunteers
- 84 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Schizophrenia Spectrum and Other Psychotic Disorders
Mindfulness, Empathy and the Oxytocinergic System in Persons With Schizophrenia
Recent studies indicated positive effects of mindfulness-based interventions (MBI) for schizophrenia (SCZ), but also on oxytocin (OXT) levels in healthy persons.
- Trial name
- OXYGEN (NCT05491486)
- Testing
- Mindfulness-based Group Therapy
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
Severe Mental Disorder, Severe Mental Illness
"Pilot Study of Music Intervention for Recovery of People With Severe Mental Disorder in the Community"
The aim of this study was to analyze the effect of music therapy on hope, quality of life, and social functioning in individuals with Severe Mental Disorder in the community.
- Trial name
- NCT07379996
- Testing
- Passive music therapy in an individual format
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Alejando Vargas Rubio
TBI, Insomnia
Cognitive Behavior Therapy for Insomnia (CBT-I) in Persons With Traumatic Brain Injury (TBI)
The current study seeks to evaluate cognitive behavior therapy for insomnia (CBT-I), a non-medication treatment, in recent TBI patients compared to a sleep education control intervention.
- Trial name
- NCT02709980
- Testing
- Sleep Education, Cognitive Behavior Therapy for Insomnia
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Johns Hopkins University
Depression, Anxiety
Identity-Based Transdiagnostic Therapy for Young People With Anxiety and Depression
Depression and anxiety are the most prevalent mental disorders among both the general population and young adults, and transdiagnostic treatments for these patients are mostly based on cognitive-behavioral therapy (CBT).
- Trial name
- IBTTYOUNG (NCT06384196)
- Testing
- Identity-Based Transdiagnostic Therapy (IBTT), Unified Protocol
- Where
- 2 sites in Spain
- Volunteers
- 138 people
- Sponsor
- University of Barcelona
Psychotic Disorder
Speech-based Assessment of Relapse Risk in People With Psychosis
This observational, multinational study assesses the feasibility of speech and self-report data collection across six languages for Artificial Intelligence (AI)-driven relapse risk estimation in psychosis.
- Trial name
- TRUSTING-WP4 (NCT07397975)
- Testing
- Weekly online speech assessments via a smartphone app collect speech and self-report data. Recordings are securely transferred and analyzed by an AI-based backend to calculate relapse risk scores.
- Where
- 7 sites in Czechia, Ireland and 4 more
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Philipp Homan
Dementia, Alzheimer's Disease
Evaluating the Effects of Music Interventions on Hospitalised People With Dementia
Dementing syndromes are, for the most part, incurable. People with dementia become highly dependent and frequently have to move from their homes into residential aged care facilities.
- Conditions
- Dementia, Alzheimer's Disease, Dementia, Vascular, Lewy Body Disease
- Trial name
- NCT00448318
- Testing
- Music Therapy
- Where
- Australia
- Volunteers
- 180 people
- Sponsor
- National Ageing Research Institute, Australia
Developmental Disability, Intellectual Disability
Online Learning Module to Advance Research Related to People With Disabilities
This study will measure the effects of a brief one-time eLearning intervention on researcher Knowledge, Attitudes, and Perceptions (KAP) of including people with disabilities (PWDs) in biomedical \& behavioral research.
- Conditions
- Developmental Disability, Intellectual Disability, Disability
- Trial name
- D2/R3 (NCT07220837)
- Testing
- eLearning module, Control
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Executive Dysfunction, Mild Cognitive Impairment (MCI)
Feasibility Study of Mixed Reality Exergame on Performance and Cortical Outcomes
The executive dysfunctions are a problem in individuals with MCI which predict conversion to dementia and is positively related to physical activity level.
- Trial name
- NCT06843733
- Testing
- Mixed reality exergame, Education
- Where
- Thailand
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Parkinson Disease, Anxiety
MBCT for People With Parkinson's Disease and Caregivers
This study aims to explore the feasibility and effectiveness of mindfulness-based cognitive therapy (MBCT) in reducing anxiety and/or depressive symptoms in people with Parkinson's disease (PD) and caregivers of people with PD.
- Conditions
- Parkinson Disease, Anxiety, Depression
- Trial name
- MBCT-PD-2 (NCT04469049)
- Testing
- Mindfulness-based cognitive therapy (MBCT)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
PTSD
Primary Care Intervention for PTSD in Ethiopia
Mixed methods (qualitative and quantitative) cluster randomized pilot feasibility trial (n=40) to refine the the Brief Relaxation, Education and Trauma Healing (BREATHE) Ethiopia intervention and explore effectiveness and…
- Trial name
- NCT04385498
- Testing
- BREATHE Intervention, Waitlist Treatment as Usual
- Where
- Ethiopia
- Volunteers
- 14 people
- Sponsor
- University of California, Los Angeles
Paranoia in People With Schizophrenia-spectrum Diagnosis
Computerised Interventions for Thinking and Anxiety in Delusions (CITADEL) Trial
People with a schizophrenia spectrum diagnosis often experience distressing worries or beliefs about others intending to cause them harm (also known as paranoia).
- Trial name
- CITADEL (NCT01920685)
- Testing
- Anxiety intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 25 people
- Sponsor
- King's College London
Post-COVID-19 Condition, Post-COVID-19 Syndrome
Vortioxetine for Post-COVID-19 Condition
A randomized, double-blinded, placebo-controlled trial will be conducted to evaluate vortioxetine, an antidepressant with established pro-cognitive properties, for the treatment of cognitive deficits which develop during or after…
- Conditions
- Post-COVID-19 Condition, Post-COVID-19 Syndrome, Cognitive Impairment
- Trial name
- NCT05047952
- Testing
- Vortioxetine
- Where
- Canada
- Volunteers
- 149 people
- Sponsor
- Brain and Cognition Discovery Foundation
Alzheimer's Disease
An Investigation Into the Feasibility of Beetroot Juice Supplementation in People Living With Alzheimer's Disease.
The goal of this clinical trial is to learn if taking a beetroot juice supplement will work in people living with Alzheimer's disease.
- Trial name
- OMNI (NCT07258004)
- Testing
- Beetroot juice
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of the West of Scotland
Alzheimer Disease
Wearables-and Blood-based Biomarkers-incorporated Modernisation of Circadian Rhythm Disruption Management in People Living With Alzheimer's Dementia: A Stepwise Study From Digital Inclusivity, Digital Therapy, to Digital Phenotyping and Biomarker Exploration
By 2025, Taiwan will become a super-aged society, with the number of Alzheimer's disease patients continuing to rise. However, the vast majority of dementia patients experience "behavioral and psychological symptoms of dementia"…
- Trial name
- NCT07222449
- Testing
- Photobiomodulation
- Where
- Taiwan
- Volunteers
- 162 people
- Sponsor
- China Medical University Hospital
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