Clinical trials: Persons With Psychiatric Disorders
Schizophrenia, Schizoaffective Disorder
The Effects of Kynurenine Aminotransferase Inhibition in People With Schizophrenia
Kynurenic acid (KYNA) is a naturally occurring chemical in the brain. Studies with rodents indicate that levels of KYNA can impact levels of the neurotransmitters glutamate and dopamine.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder
- Trial name
- TrypNAC-II (NCT04013555)
- Testing
- N-acetylcysteine (NAC), Tryptophan
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Maryland, Baltimore
Mental Health Conditions, Developmental Disability
Evaluation of Telehealth Services on Mental Health Outcomes for People With Intellectual and Developmental Disabilities
Roughly 40% of those with intellectual and developmental disabilities (IDD) have mental health needs, which is twice the national average.
- Trial name
- NCT05336955
- Testing
- Intake and quarterly assessment:, Consultation & coping skills coaching:, 24-hour urgent crisis response and intervention:
- Where
- United States
- Volunteers
- 339 people
- Sponsor
- University of New Hampshire
Caregiver Burnout
Health enSuite Caregivers: an App-based Treatment for Distressed Caregivers of Persons With Moderate Dementia
Health enSuite Caregivers is an e-health program designed to meet some of the most common needs of caregivers of persons with dementia, including information about dementia and dementia care, caregivers' emotional health, formal…
- Trial name
- NCT04944420
- Testing
- Health enSuite Caregivers
- Volunteers
- 400 people
- Sponsor
- IWK Health Centre
Chronic Pain, Drug Dependence of Morphine Type
Novel Use of Probenecid to Alleviate Symptoms of Opioid Withdrawal
The proposed clinical trial will address the problem of opioid withdrawal. Opioids are essential for pain-relief in the short term, but their continued use is associated with a host of adverse effects.
- Conditions
- Chronic Pain, Drug Dependence of Morphine Type, Symptom, Withdrawal
- Trial name
- NCT04939623
- Testing
- Probenecid
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Geriatric İndividual Health
Group-based and Dual-task Focused Otago Exercises in Geriatric Individuals With Kinesiophobia
The aim of our study was to investigate the effects of group-based and dual-task focused otago exercises on kinesiophobia, musculoskeletal system and psychosocial status in geriatric individuals with kinesiophobia.
- Trial name
- NCT06577740
- Testing
- Otago Exercise, Dual Task Focused Otago Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Fibromyalgia
Cranial Electrical Stimulation Effects on Symptoms in Persons With Fibromyalgia
The purpose of this study is to determine the effects of mild cranial electrical stimulation on pain, fatigue, sleep disturbances, perceived stress, blood pressure, and functional status in persons with fibromyalgia.
- Trial name
- NCT00928720
- Testing
- CES device
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Virginia
Dementia
Compassion Pilot Intervention Study to Enhanced Integrated Care for People With Severe Memory Problems
The investigators developed the theory-driven 'Compassion Intervention', an integrated, interdisciplinary approach to address existing gaps in end-of-life care for people with advanced dementia.
- Trial name
- NCT02840318
- Testing
- Compassion Intervention
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- University College, London
Schizophrenia
Culturally Based Family Therapy for Improving Treatment Outcome for People With Schizophrenia
This study will evaluate the effectiveness of a culturally based family therapy intervention in improving treatment outcome in people with schizophrenia.
- Trial name
- NCT00356317
- Testing
- Culturally informed therapy for schizophrenia (CIT-S), Psychoeducation treatment as usual
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Miami
Depressive Disorder, Major
A Study to Test Different Doses of BI 1569912 in People With Depression Who Take Anti-depressive Medicine
This study is open to adults between 18 and 65 with a type of depression (major depressive disorder) for whom previous treatments for depression did not work.
- Trial name
- NCT06280235
- Testing
- BI 1569912
- Where
- 52 sites in United States, Belgium and 5 more
- Volunteers
- 243 people
- Sponsor
- Boehringer Ingelheim
Persons With Psychiatric Disorders
Perinatal Peer Support for Veterans With Serious Mental Illness
Veterans with serious mental illness (SMI) are at high risk of exacerbation of mental illness in pregnancy and postpartum, with consequences including poor pregnancy outcomes, decreased functioning, and impaired child…
- Trial name
- NCT07362576
- Testing
- Perinatal peer support
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- VA Office of Research and Development
Schizophrenia, Schizoaffective Disorder
Luteolin for the Treatment of People With Schizophrenia
Luteolin is a natural product found in foods such as celery, green pepper, parsley, and chamomile tea. It has been found to have anti-cancer, anti-oxidant, and anti-inflammatory properties.
- Trial name
- NCT05204407
- Testing
- Luteolin
- Where
- 2 sites in United States
- Volunteers
- 85 people
- Sponsor
- University of Maryland, Baltimore
Dementia
A Mobile Phone-based Intervention on Dementia Patients' Caregivers in Vietnam
Background: The growing number of older people with dementia increases demand on informal caregivers who lack information and skills, leading to a high psychological burden in care provision.
- Trial name
- NCT04958707
- Testing
- Information including knowledge and skills related to dementia patient care, Usual care
- Where
- 2 sites in Vietnam
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Autism Spectrum Disorder (ASD), Autism
Judo Training for People With Autism Spectrum Disorder, Physical Fitness and Psychological Indicators
Physical fitness and psychological indicators are key factors in healthy development. Individuals with autism spectrum disorder (ASD) tend to have lower levels of physical fitness and mental health than their neurotypical peers.
- Trial name
- JUDOASD/PA/PSY (NCT07419919)
- Testing
- Judo training for people with ASD - training in integration groups with non-ASD people
- Where
- Poland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Post Traumatic Stress Disorder (PTSD), HIV
Open Trial of Trauma-focused Psychodynamic Psychotherapy for People Living With HIV and PTSD
People living with HIV (PLWH) have a higher rate of post-traumatic stress disorder (PTSD) diagnosis than the general population. Comorbid PTSD is also associated with negative HIV-related health outcomes.
- Trial name
- TFPP-PLWH (NCT05929911)
- Testing
- Trauma-focused psychodynamic psychotherapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Montefiore Medical Center
Dementia, Behavioral and Psychiatric Symptoms of Dementia
Effects of Diffused Ylang-Ylang Essential Oil Amongst Older Persons With Dementia
Ylang-Ylang (Cananga Odorata) essential oil has been postulated to have calming effect, which may improve BPSD in persons with dementia.
- Trial name
- NCT05034107
- Testing
- Aromatherapy
- Where
- Malaysia
- Volunteers
- 28 people
- Sponsor
- Universiti Teknologi Mara
Frontotemporal Dementia, Alzheimer Disease
Young Onset Dementia - the Difficult Diagnosis and the Stressful Life for the Whole Family
People diagnosed with young onset dementia are today mostly assigned to the same healthcare services as people developing dementia at an older age.
- Trial name
- NCT02055092
- Where
- Norway
- Volunteers
- 250 people
- Sponsor
- Norwegian Centre for Ageing and Health
Mild Cognitive Impairment, Behavioral Symptoms
The Moderating Roles of Social Support, Coping Resources and Personality and Mediating Role of Self-esteem on the Impact of Cognitive Deficit on Neuropsychiatric Symptoms Among Persons With Mild Cognitive Impairment: A Mixed-method Sequential Explanatory Design
This is a sequential mixed study to test the hypothesized models with seven hypotheses of the relationship between cognitive deficit (subject and objective) and neuropsychiatric symptoms (NPS) among persons with mild cognitive…
- Trial name
- NCT04085107
- Testing
- Face-to-face interviews
- Where
- Hong Kong
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Dementia
Cognitive Rehabilitation for People With Mild-to-moderate Dementia
Cognitive Rehabilitation is an approach that teaches strategies to people with cognitive problems which helps them accomplish tasks which they find challenging.
- Trial name
- NCT06069882
- Testing
- Cognitive Rehabilitation
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Dementia, Med: Dementia
Can Value Champions Reduce Inappropriate Prescribing for People With Dementia?
The primary objective is to assess the effectiveness of training a clinician to be a 'value champion' within clinical settings to decrease the use of three classes of potentially inappropriate prescription medications (PIMs)…
- Trial name
- NCT05359679
- Testing
- Value Champion Training Program, No Intervention
- Where
- United States
- Volunteers
- 3,300 people
- Sponsor
- Kaiser Permanente
Opioid Use Disorder
Therapy for People With Opioid Use Disorder
The goal of this pilot clinical trial is to test the feasibility of a 12-week manualized cognitive-behavioral therapy treatment for opioid use disorder in reducing or stopping illicit opioid use in a community setting.
- Trial name
- NCT06008769
- Testing
- 12 Week Manualized Cognitive-Behavioral Therapy Intervention
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Philadelphia College of Osteopathic Medicine
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