Clinical trials: Pessary
Labor Pain
Prostin and Propess in Induction of Labor
The purpose of the study was to compare the safety and efficacy of two agents used in induction of labor Propess (Controlled release dinoprostone, PGE2, pessary) and Prostin E2 (Dinoprostone vaginal Tablet).
- Trial name
- NCT01635439
- Testing
- Propess, Prostin E2
- Where
- Saudi Arabia
- Volunteers
- 200 people
- Sponsor
- Ain Shams University
Preterm Birth, Short Cervix
Canadian Study on the Association of Pessary With Progesterone
Prematurity is the leading cause of neonatal morbidity causing more than 1 million deaths worldwide per year. In 2012, a randomized controlled trial (RCT) testing "pessary" (silicone ring placed around the cervix) versus "no…
- Trial name
- CAPP (NCT03227705)
- Testing
- Prometrium, Dr. Arabin, cerclage pessary perforated
- Where
- 8 sites in Canada
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Preterm Birth
Prevention of Preterm Birth in Singletons Using Pessary After Resolutive Threatened Preterm Labor
In France, threatened preterm labour concerns 6.5% of pregnancies and is associated with a premature birth in 25.4% of cases. After 48 hours effective tocolysis, patients do not receive any further treatment while their risk of…
- Trial name
- PREMAPESSAIRE (NCT02484820)
- Testing
- Silicone pessary
- Where
- France
- Volunteers
- 168 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Spondylitis, Ankylosing
Evaluation of Efficacy and Safety of Meloxicam Suppository (15mg Daily) and Tablet (15 mg Daily) Compared to Indomethacin Suppository (50 mg Daily) in Patients With Ankylosing Spondylitis
Study to assess the efficacy and safety of meloxicam suppository 15 mg once daily, meloxicam tablet 15 mg once daily compared with Indomethacin suppository (50 mg daily) in patients with ankylosing spondylitis
- Trial name
- NCT02183168
- Testing
- Meloxicam suppository, Meloxicam tablet, Indomethacin
- Volunteers
- 192 people
- Sponsor
- Boehringer Ingelheim
Stress Urinary Incontinence, Urinary Incontinence
Incontinence Ring on Stress Urinary Incontinence
This study aims as defining success rate of the incontinence ring in women with test proven stress urinary incontinence and determining factors associated with successful use.
- Trial name
- NCT00427778
- Testing
- incontinence ring
- Where
- Canada
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Queen's University
Cough
Transpulmin Suppository and Guaiacol Compared to Transpulmin Syrup in Pediatric Participants With Productive Cough
This study evaluates the non-inferiority of Suppository Transpulmin and Suppository Guaiacol compared to Transpulmin Syrup in the treatment of cough with secretion of infectious origin in children between two and six years old.
- Trial name
- Transpulmin (NCT02581397)
- Testing
- Transpulmin suppository, Guaiacol suppository, Transpulmin syrup
- Where
- Brazil
- Volunteers
- 270 people
- Sponsor
- Ache Laboratorios Farmaceuticos S.A.
Preterm Birth
Pessary as Adjunctive Therapy to Cerclage for the Prevention of Preterm Birth
Cervical cerclage was devised in the 1950's for women with prior early preterm births (PTB) who developed a dilated cervix detected by manual exam in the second trimester.
- Trial name
- NCT02678026
- Testing
- Cervical pessary
- Where
- Italy
- Sponsor
- Federico II University
Placenta Previa
Effect of a Cervical Pessary on the Rate of Bleeding in Placenta Praevia
This study evaluates whether use of a cervical pessary can reduce vaginal bleeding and prolong pregnancy in women with placenta previa or a low-lying placenta.
- Trial name
- NCT07667777
- Testing
- Cervical pessary
- Where
- Germany
- Volunteers
- 190 people
- Sponsor
- Asklepios proresearch
Delivery Uterine
Comparison Between 25 µg Vaginal Misoprostol vs Slow Release Pessary PGE2
For about 10% of pregnancies, it is necessary to induce delivery for medical reasons. Prostaglandins alone can be used to perform cervical ripening in cases of immature cervix.
- Trial name
- CYTOPRO (NCT01765881)
- Testing
- Misoprostol, Dinoprostone
- Where
- 4 sites in France
- Volunteers
- 1,700 people
- Sponsor
- University Hospital, Toulouse
Healthy
Pharmacokinetics of 3 Formulations of Ibuprofen Suppositories
The purpose of this study is to compare the pharmacokinetic and bioavailability characteristics of two test formulations of ibuprofen for rectal administration with the profile of a marketed reference formulation of ibuprofen 200…
- Trial name
- NCT00921830
- Testing
- ibuprofen
- Where
- Ireland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Pregnancy
Cervical Pessary vs. Vaginal Progesterone for Preventing Premature Birth in IVF Twin Pregnancies
To compare the effectiveness of cervical pessary (Arabin) and vaginal progesterone for preventing premature birth in twin pregnancies after IVF
- Trial name
- NCT02623881
- Testing
- Cervical pessary, Vaginal progesterone
- Where
- Vietnam
- Volunteers
- 300 people
- Sponsor
- Vietnam National University
Urinary Incontinence, Stress
Canadian Experience With Contiform Intravaginal Device For The Treatment Of Stress Incontinence
Stress urinary incontinence (SUI) is a highly prevalent condition of involuntary urine leakage associated with coughing, sneezing or exertion.
- Trial name
- NCT03614611
- Testing
- Contiform pessary
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- CHU de Quebec-Universite Laval
Bladder Cancer
Efficacy of Diclofenac BCG Irrigations
This study is designed to test the effectiveness of diclofenac suppositories in the prophylaxis of side effects caused by BCG bladder irrigations in bladder cancer patients.
- Trial name
- DIC-2011 (NCT01542567)
- Testing
- Abitren
- Volunteers
- 100 people
- Sponsor
- Carmel Medical Center
Well-Being, Psychological, Quality of Life
The Use of Cannabidiol Suppositories for Sexual Pain
Research aim: To determine how cannabidiol suppositories might reduce sexual pain during intimacy. Outcomes are also hoped to increase sexual functioning, well-being, and quality of life.
- Conditions
- Well-Being, Psychological, Quality of Life, Sexual Behavior, Sexual Pain Disorder
- Trial name
- NCT07271030
- Testing
- Cannabidiol suppository intervention 1, Cannabidiol suppository intervention 2, Cannabidiol suppository intervention 3
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- London Metropolitan University
Pelvic Organ Prolapse
Self-management Pessary Project
The goal of this multicenter observational study is to study self-management of pessary therapy in patients with pelvic organ prolapse.
- Trial name
- ZPP (NCT05885711)
- Testing
- self-management
- Where
- Netherlands
- Volunteers
- 288 people
- Sponsor
- Zuyderland Medisch Centrum
Stress Urinary Incontinence
A Randomized Controlled Trial of the Uresta Continence Pessary
Stress urinary incontinence (SUI) is defined as the involuntary loss of urine with an increase in abdominal pressure, caused either by a loss of support under the bladder neck, or intrinsic urethral sphincter deficiency.
- Trial name
- SURE (NCT01284244)
- Testing
- Uresta pessary, Silastic ring
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Mount Sinai Hospital, Canada
Fecal Incontinence, Bowel Dysfunction
LIBERATE - PRO: Eclipse™ System Registry
A prospective, open label post market registry to collect Patient Reported Outcomes in an online data capture registry, maintained by Pelvalon, of women with fecal incontinence exiting the LIBERATE study (NCT02428595) continuing…
- Conditions
- Fecal Incontinence, Bowel Dysfunction, Bowel Incontinence, Accidental Bowel Leakage
- Trial name
- LIBERATEPRO (NCT03028636)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Pelvalon, Inc.
Vulvovaginal Candidiasis
Clinical Performance of the Gedea Pessary in Adult Women With Vulvovaginal Candidiasis
This is a multi-centre, multi-national study to evaluate the clinical performance and safety of treatment with Gedea Pessary in adult women with confirmed vulvovaginal candidiasis (VVC).
- Trial name
- EpHect (NCT05507333)
- Testing
- pHyph generation II
- Where
- 4 sites in Sweden
- Volunteers
- 26 people
- Sponsor
- Gedea Biotech AB
Bacterial Vaginosis, Recurrence
Oral Metronidazole With Lactobacillus Vaginal Suppositories to Prevent Recurrence of Bacterial Vaginosis
We are trying to determine if Oral Metronidazole with Lactobacillus Vaginal Suppositories is better than Oral Metronidazole in Preventing the Recurrence of Bacterial Vaginosis
- Trial name
- NCT03099408
- Testing
- Metronidazole Oral, "Metronidazole" and "Lactobacillus"
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Peking University Shenzhen Hospital
Premature Birth, Short Cervix
Prevention of Preterm Birth With a Pessary in Twin Gestations
Preterm birth (PTB) is a major health problem and contributes to more than 50% of the overall perinatal mortality. Twins are at increased risk for PTB.
- Trial name
- PoPPT (NCT02056639)
- Testing
- Bioteque cup pessary
- Where
- 3 sites in United States
- Volunteers
- 46 people
- Sponsor
- University of Pennsylvania