Clinical trials: Pessary
Bacterial Vaginosis
Clinical Performance and Safety of the Gedea Pessary in Adult Women With Bacterial Vaginosis
This is a randomised, double-blind placebo-controlled multi-centre study to evaluate clinical performance, safety and local tolerability of initial and preventive treatment with Gedea Pessary in adult women with confirmed BV.
- Trial name
- Nefertiti (NCT04640922)
- Testing
- Gedea Pessary pHyph
- Where
- 5 sites in Sweden, United Kingdom
- Volunteers
- 152 people
- Sponsor
- Gedea Biotech AB
Preterm Birth
Prevention of Preterm Birth Using Cervical Pessary in Pregnant Women With Short Cervix in Twins
Placement of a vaginal pessary reduces significantly the rate of spontaneous preterm birth in pregnant women with twins and a short cervical length at 18-22 weeks scan.
- Trial name
- PECEP-TWINS (NCT01242410)
- Testing
- Silicon ring (Arabin Cervical Pessary)
- Where
- Spain
- Volunteers
- 137 people
- Sponsor
- Maternal-Infantil Vall d´Hebron Hospital
Pelvic Organ Prolapse
Pelvic Ultrasound Pessary Study: Changes in Pelvic Anatomy After Placing a Pessary
In the past, the impact of pessaries was mostly assessed by questionnaires on Quality of Life (QoL) and sexual dysfunction. This research project primarily aims to objectify the effects of the currently available pessaries in a…
- Trial name
- PUPS (NCT04915664)
- Testing
- Pessary
- Where
- Belgium
- Volunteers
- 269 people
- Sponsor
- Universiteit Antwerpen
Preterm Birth
Mechanical Environment Pregnancy With Short Cervix
The objective of this study is to quantify the mechanical environment of pregnancies complicated by a short cervix and randomized in the Trial of Pessary in Singleton Pregnancies with a Short Cervix study with ultrasound imaging…
- Trial name
- ATOPS (NCT03865108)
- Testing
- Ultrasound imaging, Cervical speculum examination
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Columbia University
Vaginitis
Treatment for Aerobic Vaginitis by Using Bofukang Vaginal Suppository
Aerobic vaginitis was treated by using Baofukang Suppository 7 days group or Baofukang Suppository 14 days group.To evaluate the efficacy and safety after treatment.
- Trial name
- NCT04574089
- Testing
- Experimental: Baofukang Suppository 7 days, Experimental: Baofukang Suppository 14 days
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University Shenzhen Hospital
Candidal Vulvovaginitis (ICD-10 Code: B37.3), Vulvovaginal Candidiasis (VVC)
Efficacy and Safety of Clotrimazole+Lactulose Vaginal Suppositories Vs. Clotrimazole Monotherapy in Adult Women with Candidal Vaginitis/Vulvovaginitis
This study aims to compare the efficacy and safety of the combination drug Clotrimazole+Lactulose with the monocomponent product Canesten® (clotrimazole) in adult women diagnosed with candidal vulvovaginitis.
- Trial name
- NCT06835361
- Testing
- Clotrimazole+Lactulose., Canesten (Clotrimazole), Lactulose
- Where
- 7 sites in Belarus, Russia
- Volunteers
- 264 people
- Sponsor
- AVVA Pharmaceuticals Ltd.
Preterm Birth
Impact of Pessary Treatment on Cervical Stiffness Measurement and Birth Outcomes in Patients at Risk for Preterm Birth
Background: A preterm birth remain a worldwide important socioeconomic burden since prematurity has been consistently implicated in a wide range of health medical problems affecting newborn child and contributed in up to more…
- Trial name
- NCT05267717
- Testing
- Non-interventional study, all patients being tested with AG Pregnolia System to assess the values of the Cervical Stiffness
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Asklepios proresearch
External Genital Endometriosis
Study of the Efficacy and Safety of Longidaze® for the Treatment of Patients With External Genital Endometriosis
A study is being conducted to evaluate the efficacy and safety of Longidaze for the prevention and treatment of external genital endometriosis .
- Trial name
- NCT04962620
- Testing
- Bovhyaluronidase azoximer
- Where
- 6 sites in Russia
- Volunteers
- 149 people
- Sponsor
- NPO Petrovax
Pelvic Organ Prolapse, Inflammatory Response
Vaginal Probiotics and Pessaries and Their Impact on the Vaginal Microenvironment
In this study, the investigators are evaluating the effect of vaginal probiotics on the bothersome side effects of pessary use and the impact on the vaginal microenvironment (lactobacilli, anaerobic bacteria, mobiluncus bacteria…
- Conditions
- Pelvic Organ Prolapse, Inflammatory Response, Dysbiosis
- Trial name
- NCT04118049
- Testing
- BiopHreshTM vaginal probiotic supplement (Good Clean Love, Inc. Eugene, OR) and RestoreTM gel., Standard Care
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Hartford Hospital
Fissure in Ano, Diarrhea
The Efficacy of Asacol (Mesalazine) Suppository on the Treatment of Diarrhea-Induced Acute Fissure
Anal fissure define as a superficial tearing in mucosa on the anoderm surface distal to dentate line . The most important factor is hard stool passing with trauma to anal mucosa.
- Trial name
- NCT05091775
- Testing
- Asacol is used to treat and prevent mild to moderate acute fissure disease
- Where
- Iran
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Shiraz University of Medical Sciences
Interstitial Cystitis, Bladder Pain Syndrome
The CBD-IC Randomized Controlled Trial: Evaluation of Hemp Cannabidiol SuppositoRies for Pain and Urinary SymptOms in INterstitial Cystitis (CHRONIC)
This study seeks to exploit bladder cannabidiol receptors as a therapeutic drug target by conducting a double-masked, placebo-controlled randomized trial evaluating the effects of vaginal hemp cannabidiol (CBD) suppositories on…
- Trial name
- CHRONIC (NCT04349930)
- Testing
- Cannabidiol vaginal suppository
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of New Mexico
Pelvic Floor Dyssynergia
Baclofen/Diazepam Supps for Treatment of Pelvic Floor Myalgia
This study is a randomized, placebo controlled double blind cross over trial. Patients presenting with pelvic floor myalgia will be asked to complete a series of standardized questionnaires to assess their pain, quality of life…
- Trial name
- BDS (NCT03427216)
- Testing
- Baclofen/diazepam
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dr. John A. Thiel Medical Professional Corporation
Lower Urinary Tract Symptoms, Prostatic Hyperplasia
Efficacy and Safety of Longidaze in the Treatment of Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia
The goal of this clinical trial is to learn if Longidaze works to treat lower urinary tract symptoms in adult males with benign prostatic hyperplasia. It will also learn about the safety of Longidaze.
- Trial name
- ADAM (NCT06568718)
- Testing
- bovhyaluronidase azoximer, tamsulosin
- Where
- 3 sites in Russia
- Volunteers
- 229 people
- Sponsor
- NPO Petrovax
Cervix Cancer, Cervix Neoplasm
Artesunate Pessaries (Vaginal Inserts) for Cervical Precancer in Kenya
To investigate the use of self-administered artesunate vaginal pessaries as treatment for cervical precancer in low and middle-income countries (LMIC).
- Conditions
- Cervix Cancer, Cervix Neoplasm, Precancerous Conditions, Cervical Precancer
- Trial name
- NCT06165614
- Testing
- Artesunate pessary, Colposcopy
- Where
- Kenya
- Volunteers
- 17 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
IVF
Levofloxacin Plus Metronidazole Suppositories Versus Levofloxacin Co-administered with Metronidazole Tablets in Chronic Endometritis
This is a single randomised controlled trial. The investigators plan to randomise 800 participants to the levofloxacin plus metronidazole suppositories versus levofloxacin co-administered with metronidazole tablets for the…
- Trial name
- NCT06650540
- Testing
- Levofloxacin Plus Metronidazole Suppositories, Levofloxacin co-administered with Metronidazole tablets
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Peking University Third Hospital
Internal Hemorrhoids
Evaluate Safety and Efficacy of 25 mg Hydrocortisone Acetate Suppositories in Treatment of Internal Hemorrhoids
A randomized, double-blind, placebo-controlled, multicenter, parallel group study of the safety and efficacy of Hydrocortisone Acetate Suppositories, 25 mg compared to placebo suppositories in the treatment of symptomatic…
- Trial name
- NCT03335774
- Testing
- Hydrocortisone Acetate Suppository, 25 mg (Nivagen)
- Where
- 2 sites in United States, India
- Volunteers
- 103 people
- Sponsor
- Nivagen Pharmaceuticals Inc.
Pelvic Inflammatory Diseases
A Clinical Study on Kangfu Anti-inflammatory Suppository of Gynaecology Combined With Antibiotics for Pelvic Inflammatory Diseases (Evidence of Dampness and Heat Accumulation)
To evaluate the efficacy and safety of Kangfu Xiaoyan Suppository in the treatment of pelvic inflammatory diseases (dampness-heat accumulation syndrome) and its influence on the sequelae of pelvic inflammatory diseases, and to…
- Trial name
- NCT04035785
- Testing
- Kangfu Anti-inflammatory Suppository
- Volunteers
- 240 people
- Sponsor
- China Academy of Chinese Medical Sciences
Cervical Intraepithelial Neoplasia Grade 2/3, High-risk HPV (Any Strain)
Intravaginal Artesunate for the Treatment of HPV+ High Grade Cervical Intraepithelial Neoplasia (CIN2/3)
This phase I research protocol is designed to assess immunogenicity and clinical endpoints in patients with human papillomavirus (HPV) 16 cervical intraepithelial neoplasia (CIN)2/3.
- Trial name
- NCT02354534
- Testing
- Artesunate Suppositories
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Short Cervix, Preterm Delivery
A Randomized Trial of Pessary in Singleton Pregnancies With a Short Cervix
The purpose of the study is to determine whether the Arabin pessary is a useful intervention of preterm birth at less than 37 weeks in women with a singleton gestation and a short cervix.
- Trial name
- TOPS (NCT02901626)
- Testing
- Arabin Cervical Pessary
- Where
- 12 sites in United States
- Volunteers
- 544 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Pelvic Organ Prolapse, Vaginal Prolapse
The Impact of Long-term Pessary Use on Pelvic Organ Prolapse oìduring Covid-19 Pandemic in Patients Attending Surgery
Patients aged 45 to 80 years with a clinical diagnosis of stage III and IV genital prolapse involving the anterior and/or middle compartments and candidates for surgery will be considered.
- Trial name
- NCT06234449
- Testing
- Vaginal pessary before surgery for pelvic organ prolapse
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele