Clinical trials: Pessary
Healthy
Study to Compare Blood Levels of Ceftriaxone Given by Suppository or Injection.
Phase 1, three-way cross-over, randomised, open label comparison of intravenous versus two rectal dosage forms of ceftriaxone in 37 healthy Thai adults.
- Trial name
- CefREC (NCT03895567)
- Testing
- A. Ceftriaxone (Roche ®) 500mg (slow intravenous injection), B. Ceftriaxone rectal dosage form test formulation 1 (1 x 500mg), C. Ceftriaxone rectal dosage form test formulation 2 (1 x 500mg)
- Where
- Thailand
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Delivery Problem
Comparison Between Propess and Cook Double-balloon Catheter for Cervical Priming
The investigators aimed to compare efficacy and safety of Propess versus Cooks double-balloon catheter for cervical ripening with an unfavorable cervix in term pregnancy.
- Trial name
- NCT06438081
- Testing
- Cook double-balloon catheter
- Where
- Hong Kong
- Volunteers
- 28 people
- Sponsor
- The University of Hong Kong
Acute Hemorrhoids
Study to Find Out How Symptoms Severity Changes During the Standard Course of Treatment With the Cream Relief Pro and Suppositories Relief Pro (Active Ingredients Are Fluocortolone + Lidocaine) in Patients Suffering From Twisted and Bulging Veins in the Rectal Area (Acute Hemorrhoids)
In this study researcher wanted to learn more about the changes of biggest twisted and bulging veins in the rectal area (hemorrhoids) and changes of symptoms during a treatment period with the cream Relief Pro and suppositories…
- Trial name
- NCT03757078
- Testing
- Relief Pro cream, Relief Pro rectal suppositories
- Where
- Russia
- Volunteers
- 1,000 people
- Sponsor
- Bayer
Pelvic Organ Prolapse
PEssary Plus Physiotherapy for Pelvic Organ Prolapse (PEPPY)
1. To determine the feasibility of conducting a randomised controlled trial (RCT) of the effectiveness of a PFMT intervention in conjunction with vaginal pessary management versus vaginal pessary management alone for women with…
- Trial name
- PEPPY (NCT01136889)
- Testing
- PFMT
- Where
- 4 sites in United Kingdom
- Volunteers
- 16 people
- Sponsor
- Glasgow Caledonian University
Preterm Birth, Premature Birth
Cervical Pessary Treatment for Prevention of s PTB in Twin Pregnancies on Children's Long-Term Outcome
Preterm birth (PTB) complicates 13% of all pregnancies worldwide and is the most important cause of neonatal morbidity and mortality. Women with a twin pregnancy are at increased risk of preterm delivery.
- Trial name
- Impetus (NCT03418311)
- Testing
- Cervical Pessary-Group
- Where
- 10 sites in Australia, Germany and 2 more
- Volunteers
- 672 people
- Sponsor
- Bürgerhospital Frankfurt
Spinal Cord Injury, Neurogenic Bowel
Time Comparison of Interventions on Bowel Programs in Spinal Cord Injury
The goal of the study is to find out which of three different options (a suppository, a mini enema, or a transanal irrigation device) takes the least amount of time for completing bowel program amongst those who have spinal cord…
- Trial name
- NCT07817199
- Testing
- Suppository, Enemeez, Peristeen
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Pelvic Organ Prolapse, Pessary
Extended Pessary Interval for Care (EPIC Study)
Objectives: Pelvic organ prolapse (POP) is a common condition for which pessaries are commonly used in conservative treatment. Despite their prevalence, there is no literature to guide the management of pessaries.
- Trial name
- EPIC (NCT01644214)
- Testing
- 6 month follow up for pessary check in the clinic setting
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Unity Health Toronto
Fever
Oral Versus Rectal Ibuprofen for Fever in Young Children - a Randomized Control Study.
Fever is one of the most common symptoms in pediatrics and one of the most common reasons for visits in pediatricians' office and pediatric emergency departments. Many parents consider fever to be the most terrifying symptom.
- Trial name
- NCT00729976
- Testing
- Ibuprofen suppository, Ibuprofen Suspension
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Assaf-Harofeh Medical Center
Preterm Birth, Short Cervix
Cervical Pessary vs Vaginal Progesterone in Preventing Preterm Birth Among Women Presenting With Short Cervix: An Open-label Randomized Controlled Trial
The purpose of this randomized control trial is to determine whether cervical pessary plus vaginal progesterone is superior to vaginal progesterone alone in decreasing preterm delivery rate, and improving perinatal outcome, among…
- Trial name
- NCT02470676
- Testing
- Pessary, Progesterone
- Volunteers
- 430 people
- Sponsor
- Hillel Yaffe Medical Center
Preterm Birth
Prevention of Preterm Birth Using Cervical Pessary in Pregnant Women After Threatened Preterm Labor(PECEP-RETARD)
Placement of a vaginal pessary reduces significantly the rate of spontaneous preterm birth in pregnant women with short cervical length after an episode of threatened preterm labour.
- Trial name
- PECEP-RETARD (NCT01242384)
- Testing
- Device: Silicon ring (Arabin Pessary)
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Maternal-Infantil Vall d´Hebron Hospital
Labor Induction, Induced Delivery
Foley Catheter Versus PGE2 for Labor Induction at Term: a Pilot Study
Induction of labor is one of the most common interventions in obstetrics. In the past decade, the rates of labor induction at term have doubled from approximately 9% to 23% in the United States and from 10% to 20.4% in China.
- Trial name
- NCT04780269
- Testing
- Induction of labor with Foley catheter, Induction of labor with PGE2
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Premature Labour
Prevention and Treatment of Premature Labour for Asymptomatic Pregnant Women
State of the question and research objective: International trials have shown that ultrasound measurement of the cervix identifies a population at high risk of preterm delivery.
- Trial name
- Echo-col (NCT02598323)
- Testing
- ultrasound
- Where
- France
- Volunteers
- 3,500 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Fecal Incontinence
Safety, Tolerability, Pharmacodynamic and Pharmacokinetics of a Single Rectal Application of 10 mg NRL001 in Elderly Subjects
A total of 26 healthy elderly male and female subjects will receive both 10 mg NRL001 in a 2 g rectal suppository and placebo in this double-blind, cross-over study.
- Trial name
- NCT01099683
- Testing
- NRL001
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Norgine
Sexual Pain Disorders
Cannabis Suppositories and Mindful Compassion Online Groups for Sexual Functioning
Research aim: To determine how an online mindful-compassion intervention adjunct with cannabis suppositories might reduce vaginal pain during sexual intimacy among women post-gynaecological cancer treatment.
- Trial name
- NCT06607835
- Testing
- Mindful- compassion, Mindful-compassion and cannabis suppositories
- Where
- United Kingdom
- Volunteers
- 83 people
- Sponsor
- London Metropolitan University
Vaginal Atrophy
DHEA Bioavailability Following Administration of Vaginal Suppositories in Post-Menopausal Women With Vaginal Atrophy
The purpose of the study is to evaluate the systemic bioavailability of DHEA and its metabolites and the pharmacokinetics of vaginal suppositories at four different DHEA concentration.
- Trial name
- NCT00429806
- Testing
- DHEA
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- CHU de Quebec-Universite Laval
Short Cervical Length
A Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation With a Short Cervix
This protocol outlines a randomized trial of 630 women evaluating the use of micronized vaginal progesterone or pessary versus control (placebo) to prevent early preterm birth in women carrying twins and with a cervical length of…
- Trial name
- PROSPECT (NCT02518594)
- Testing
- Vaginal progesterone, Arabin Pessary
- Where
- 16 sites in United States
- Volunteers
- 1,311 people
- Sponsor
- The George Washington University Biostatistics Center
Pelvic Organ Prolapse
Patient Education in the Clinical Management of Pessary
This study is a prospective, randomized, controlled, single-blinded, multi-center clinical trial. Symptomatic patients with pelvic organ prolapse (POP) stage II, III or IV arranged to undergo pessary treatment will be randomized…
- Trial name
- NCT06432218
- Testing
- video education, conventional education
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Peking Union Medical College Hospital
Labor, Induced, Cervical Ripening
24-Hour Vaginal Dinoprostone Pessary Versus Gel for Labour Induction
The aim of induction of labour is to initiate labour when maternal and fetal conditions necessitate delivery before the onset of spontaneous contractions.
- Trial name
- NCT00843362
- Testing
- Dinoprostone vaginal pessary, Dinoprostone vaginal gel
- Where
- Italy
- Volunteers
- 133 people
- Sponsor
- Università degli Studi di Brescia
Anal High Grade Squamous Intraepithelial Lesion, Anal Precancerous Condition
Artesunate Suppositories for the Treatment of HIV-negative Patients With Intra-anal HSIL
This is a phase II double blind, placebo-controlled, randomized study of Artesunate suppositories for the treatment of HIV-negative men and women who have anal high grade squamous intraepithelial lesions (anal HSIL)
- Conditions
- Anal High Grade Squamous Intraepithelial Lesion, Anal Precancerous Condition, AIN 2/3, HPV Infection
- Trial name
- anal HSIL HIV- (NCT05555862)
- Testing
- Artesunate
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Frantz Viral Therapeutics, LLC
Cesarean Section Pain, Diclofenac
Intramuscular Versus Rectal Diclofenac for Pain Relief After Cesarean Section in Women
The goal of this clinical study is to find out which way of giving diclofenac sodium provides better pain relief after a planned cesarean section: an injection into the muscle or a suppository given through the rectum.
- Conditions
- Cesarean Section Pain, Diclofenac, Suppository, Postoperative Pain
- Trial name
- NCT07379762
- Testing
- Diclofenac 75mg, Diclofenac 50mg
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- CMH Multan Institute of Medical Sciences