Clinical trials: Pessary
Vaginal Bleeding
Fitostimoline Vaginal Pessaries in Women With Hysterectomy. Randomized, Perspective, Monoscentric Study.
Clinical evaluation of Fitostimoline vaginal pessaries in the treatment of hysterectomy. An observational, randomized, perspective study performed on 60 women where 30 women are treated with fitostimoline pessaries and 30 women…
- Trial name
- NCT04612881
- Testing
- fitostimoline vaginal pessaries, standard of care
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Milan
Genital Prolapse, Pessary
Pessary Satisfaction Criteria for Urogenital Prolapse
Genital prolapse is a common pathology with a prevalence ranging from 2.9 to 11.4% or 31.8% to 97.7%, depending on whether a questionnaire or clinical examination is used.
- Conditions
- Genital Prolapse, Pessary, Satisfaction
- Trial name
- PeSaCUP (NCT03615872)
- Testing
- pessary use
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Caen
Prolapse
Evaluation of 3D Translabial Ultrasound Imaging for Pessary Size Estimation
Symptoms of female pelvic floor dysfunction, such as incontinence and pelvic organ prolapse, can be alleviated by using pessaries, which are passive medical devices that are inserted in the vagina to support the pelvic organs.
- Trial name
- NCT04099121
- Testing
- Ultrasound Imaging
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Western University, Canada
Pelvic Organ Prolapse (POP)
Evaluation of a Personalizable Pessary for Pelvic Organ Prolapse
Pelvic organ prolapse (POP) is a common health issue. It will impact about half of Canadian women over their lifetime. With POP, organs like the bladder, uterus, and bowel may push into the vagina.
- Trial name
- NPP-POP (NCT06954701)
- Testing
- Novel Personalizable Pessary
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- University of Alberta
Medication Palatability
Acceptability of Various Available Midazolam Formulations (Syrup, Rectal Suppository, Oro-dispersible Minitablet) in Clinical Practice
This observational study aims to gain knowledge on how the different midazolam formulations (oral syrup, rectal suppository, ODMT) are accepted by 2- to 10-year-old pediatric inpatients and outpatients at the University…
- Trial name
- NCT05894057
- Testing
- Data collection on acceptability of midazolam administration by 2- to 10-year-old pediatric patients at UKBB
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University Children's Hospital Basel
Preterm Birth
Comparison Between Vaginal Pessary and Progestogen in Twin Pregnancy With Short Cervical Length
A randomized clinical trial comparing vaginal progestogen and vaginal pessary as an intervention for twin pregnancies with short cervical length.
- Trial name
- NCT04342585
- Testing
- Micronised vaginal progesterone, Vaginal pessary
- Where
- Malaysia
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Pain, Hematuria
Diclofenac Suppository to Control Pain During Flexible Cystoscopy
Flexible cystoscopy has diagnostic as well as therapeutic role in many patients presenting in urology clinic with lower urinary tract symptoms (frequency, nocturia etc) and hematuria (blood in urine).
- Conditions
- Pain, Hematuria, Lower Urinary Tract Symptoms
- Trial name
- DUF (NCT01812928)
- Testing
- Diclofenac
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Pancreatitis, Cholangiopancreatography, Endoscopic Retrograde
The Optimal Dose of Indomethacin Suppository for Preventing Post-ERCP Pancreatitis
This study is a single-center, randomized, single-blind, parallel controlled clinical study to explore the optimal dose of postoperative indomethacin suppository for the prevention of post-ERCP pancreatitis.
- Conditions
- Pancreatitis, Cholangiopancreatography, Endoscopic Retrograde, Indomethacin
- Trial name
- NCT06031363
- Testing
- Indomethacin Suppository
- Where
- China
- Volunteers
- 192 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Vulvovaginal Atrophy
Efficacy and Safety of HYDEAL-D Vaginal Pessaries Application on the Treatment of Vaginal Atrophy in Post-menopause Women
This study evaluates the efficacy and safety of hyaluronic acid derivative based vaginal pessaries for the treatment of symptoms of vulvo-vaginal atrophy in post-menopausal women.
- Trial name
- NCT03557398
- Testing
- Hydeal-D vaginal pessaries
- Where
- 2 sites in Slovakia
- Volunteers
- 40 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Stress Urinary Incontinence
Pippa Pessary Study (Clinical Trial)
This is an open label, interventional, single arm, multi-clinic study where each adult female participant with stress urinary incontinence (SUI) serves as her own control (vaginal pessary use vs. no vaginal pessary).
- Trial name
- NCT05611970
- Testing
- Vaginal pessary
- Where
- 3 sites in United States
- Volunteers
- 7 people
- Sponsor
- Liv Labs Inc.
Failed Induction of Labor
Concurrent Oxytocin With Membrane Sweeping Versus Dinoprostone Pessary in Labor Induction of Multiparous Women at Term
The purpose of this study is to compare concurrent oxytocin with membrane sweeping versus dinoprostone pessary in labor induction for multiparas at term with an unfavorable cervix.
- Trial name
- NCT02618096
- Testing
- Oxytocin, Dinoprostone, Membrane sweeping
- Where
- South Korea
- Volunteers
- 154 people
- Sponsor
- Seoul National University Hospital
Healthy Women
Tolerability and Pharmacokinetic Study of Econazole Nitrate Plus Benzydamine HCl Vaginal Pessary
The primary objective of the study is to evaluate the local tolerability of the new Econazole/Benzydamine pessary, in comparison with Econazole and Benzydamine stand-alone products and placebo.
- Trial name
- NCT02720783
- Testing
- Econazole nitrate 150 mg plus Benzydamine HCl 6 mg vaginal pessary
- Where
- Switzerland
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Vaginal Vault Prolapse, Pelvic Organ Prolapse
Prediction of Postsurgical Symptomatic Outcomes With Preoperative Pessary Use
This is a single center, prospective trial of pessary use prior to reconstructive pelvic floor surgery for pelvic organ prolapse.
- Conditions
- Vaginal Vault Prolapse, Pelvic Organ Prolapse, Uterine Prolapse, Pelvic Floor Prolapse
- Trial name
- NCT02680145
- Testing
- Preoperative Pessary Use
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Mayo Clinic
Hysterosalpingography-Related Pain
Pain Control During Hysterosalpingography: A Three-Arm Randomized Trial
Hysterosalpingography (HSG) is commonly performed during infertility evaluation and may cause pain during cervical manipulation, uterine distension, and contrast-medium injection.
- Trial name
- HSG-PAIN (NCT07792668)
- Testing
- Indomethacin 100Mg Suppository, Lidocaine %2 ampoule
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Balikesir University
Pain
Assessing Maternal Post-partum Pain With Suppositories
This trial will evaluate whether the routine use of belladonna/opium (B\&O) suppositories improve patients' self-reported pain control in the first 24-hours after delivery.
- Trial name
- CRAMPS (NCT01271855)
- Testing
- Belladonna and opioid suppository, Glycerin Suppository
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Loyola University
Preterm Birth
Preventing Preterm Birth With a Pessary
The primary objective of this study, is to determine the effect of a Cup pessary, a device that is currently readily available in the USA and similar in design to the Arabin pessary, on the incidence of delivery prior to 37 weeks…
- Trial name
- PrePPy (NCT01380158)
- Testing
- Cup pessary (Bioteque America, Inc)
- Where
- 3 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute
Cervix Cancer, Cervix Intraepithelial Neoplasia Grade 3
Pharmacokinetics of Intravaginal, Self-administered Artesunate Vaginal Pessaries Among Women in Kenya
This study investigates the pharmacokinetics of Artesunate (AS) and dihydroartemisinin (DHA), the active metabolite of Artesunate, following intravaginal use at the dosing and frequency being studied for cervical precancer…
- Conditions
- Cervix Cancer, Cervix Intraepithelial Neoplasia Grade 3, Cervix; Intraepithelial Neoplasia, Grade I, Cervix; Intraepithelial Neoplasia, Grade II
- Trial name
- NCT06263582
- Testing
- Artesunate pessary, blood draws for pharmacokinetics of the study drug
- Where
- Kenya
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Vulvovaginal Candidiasis
Safety and Equivalence of a Terconazole Vaginal Suppository (Test Product) Compared to the Reference Terconazole Vaginal Suppository in the Treatment of Vulvovaginal Candidiasis
The objectives of this study were to demonstrate comparable safety and efficacy of Terconazole Vaginal Suppositories, 80 mg(Test Product) and Terconazole Vaginal Suppositories, 80 mg(Reference Product) in the treatment of…
- Trial name
- NCT00803738
- Testing
- Terconazole Vaginal Suppository, Terazol Vaginal Suppository
- Volunteers
- 572 people
- Sponsor
- Padagis LLC
Fever
Ibuprofen Suppositories Administration in Infants and Children
The study will evaluate the efficacy of Ibuprofen administered as suppositories in the treatment of fever in infants and children. Ibuprofen as suppositories is not yet registered in Israel, although widely used in Europe.
- Trial name
- NCT00938509
- Testing
- ibuprofen suppositories
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Soroka University Medical Center
Stress Urinary Incontinence (SUI)
A Clinical Study of the Effectiveness and Safety of a Disposable Intra-vaginal Device for Stress Urinary Incontinence (SUI)
This study will evaluate the effectiveness of the pessary device by assessing reduction in urine leakage in approximately 80 women with SUI.
- Trial name
- NCT02131311
- Testing
- disposable, single-use pessary
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- Procter and Gamble