Clinical trials: Pessary
Female Stress Incontinence
Continence Pessary Versus Disposable Intravaginal Device Trial
This is a multi-centered randomized controlled trial of women with stress urinary incontinence or stress predominant mixed urinary incontinence who desire non-surgical therapy.
- Trial name
- NCT03174431
- Testing
- Continence Pessary, Poise Impressa (Disposable Intravaginal Device)
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Ohio State University
Previous Mid Trimester Miscarriage, Previous Preterm Birth
Arabin Pessary in Singleton Pregnancy
This was a retrospective study sharing the experience of women high risk for spontaneous preterm birth managed by Arabin pessary.
- Conditions
- Previous Mid Trimester Miscarriage, Previous Preterm Birth, Previous Cervical Surgery, Short Cervix on Ultrasound
- Trial name
- NCT04638023
- Testing
- Arabin pessary
- Where
- Malaysia
- Volunteers
- 58 people
- Sponsor
- National University of Malaysia
Infant, Very Low Birth Weight
Efficacy of Prophylactic Glycerin Suppositories for Feeding Intolerance in Very Low Birth Weight Preterm Infants: a Randomized Trial
To evaluate the efficacy of prophylactic glycerin suppositories will accelerate the elimination of meconium from the large intestine and thus reduce the incidence of feeding intolerance in very low birth weight (VLBW) infants
- Trial name
- NCT01799629
- Testing
- Glycerin suppositories
- Where
- 3 sites in Saudi Arabia
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- King Faisal Specialist Hospital & Research Center
Placenta Previa
Vaginal Pessary Versus Expectant Management for Placenta Previa
The purpose of this study is to perform a large multi-center randomized trial comparing the role of vaginal pessary versus expectant management in women with placenta previa between 22w0d and 32w0d of gestation in prolonging…
- Trial name
- NCT01996345
- Testing
- Cervical Pessary Placement
- Where
- 10 sites in United States
- Volunteers
- 17 people
- Sponsor
- Pediatrix
Vaginal Personal Care
Randomized, Double-Blind Placebo-Controlled Trial to Assess Overall User Experience of a Synbiotic Vaginal Suppository
The purpose of this study is to assess the impact of a personal care product on vaginal health in individuals with a self-reported history of vaginal discomforts such as malodor, bothersome discharge, itching, irritation, and…
- Trial name
- NCT06236893
- Testing
- VH-01 vaginal suppository tablet
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Seed Health
Prostate Cancer (Post Prostatectomy), Perioperative Anesthetic
Effects of Rectal Indomethacin Suppository on Postoperative CRBD in Patients Undergoing LRP
The postoperative incidence of catheter-related bladder discomfort (CRBD) ranges from 47% to 95%. It increases postoperative pain and agitation, thus requiring early intervention.
- Conditions
- Prostate Cancer (Post Prostatectomy), Perioperative Anesthetic, Catheter-related Bladder Discomfort (CRBD)
- Trial name
- NCT07607990
- Testing
- Indomethacin suppository
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Zhejiang University
Preterm Birth, Short Cervix
Prevention of Preterm Birth With a Pessary in Singleton Gestations
Preterm birth (PTB) is associated with over one million infant deaths annually worldwide. The incidence of PTB in the United States is 11.5% with more than 500,000 deliveries occurring at less than 37 weeks gestation annually.
- Trial name
- PoPPS (NCT02056652)
- Testing
- Bioteque cup pessary
- Where
- 4 sites in United States
- Volunteers
- 122 people
- Sponsor
- University of Pennsylvania
Stress Urinary Incontinence, Prolapse
Host Response to Pessaries in Microbial Communities of the Postmenopausal Vagina
The ability to determine the postmenopausal vaginal environment and the impact of pessary use could help to maximize pessary therapy and non-surgical treatment for such a prevalent problem.
- Trial name
- NCT02605135
- Testing
- Continued Pessary Use
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Loyola University
Vaginal Prolapse
Prospective Observational Prolapse Study
The rationale of the study is to investigate the results of a prolapse treatment in adult women with a vaginal prolapse. The investigators will investigate this by taking questionnaires in women undergoing a surgical prolapse…
- Trial name
- NCT04701047
- Testing
- vaginal pessary, Vaginal prolapse surgery
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- University Hospital, Ghent
Atrophy of Vagina, Vaginal Ulceration
Vaginal Creams to Reduce Vaginal Erosion in Pessary Users
To compare the use of Estrace ® vaginal cream against a placebo vaginal cream in reducing symptomatic vaginal discharge and vaginal erosion in patients who are using the Gellhorn or Ring with support pessaries.
- Conditions
- Atrophy of Vagina, Vaginal Ulceration, Vaginitis
- Trial name
- NCT02316249
- Testing
- Estradiol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwell Health
Metastatic Castrate- Resistant Prostate Cancer
Idronoxil Suppository Combine With Radiotherapy for Metastatic Prostate Cancer
The aim of the study is to determine the toxicity of Idronoxil (NOX66) when used in combination with palliative radiotherapy for metastatic prostate cancer
- Trial name
- NCT03041285
- Testing
- idronoxil (NOX66) suppository, Stereotactic Body Radiation Therapy
- Where
- Australia
- Volunteers
- 1 people
- Sponsor
- Royal North Shore Hospital
Luteal Phase Defect
Progesterone Levels and Clinical Outcomes Using a Single Pessary of 400 mg of Vaginal Progesterone in Substitutive Cycles for Embryo Transfer.
This study aims to compare the efficacy, in terms of progesterone levels and clinical outcomes, of two different presentations of micronized vaginal progesterone (400 mg vs.
- Trial name
- CycloCT (NCT04722471)
- Testing
- Vaginally administered progesterone
- Where
- Spain
- Volunteers
- 347 people, healthy volunteers welcome
- Sponsor
- Instituto Bernabeu
Pelvic Organ Prolapse, Quality of Life
Conservative Management of Symptomatic Pelvic Organ Prolapse Using Vaginal Pessaries: Generation of a Standardized Management Protocol
Genital prolapse is a common condition (up 20%), affecting the quality of life. Treatment can be surgical or conservative using vaginal pessaries. These devices are introduced into the vagina aiming to reduces the prolapse.
- Trial name
- NCT02113969
- Testing
- Vaginal Pessary
- Where
- Chile
- Volunteers
- 294 people
- Sponsor
- Servicio de Salud Metropolitano Sur Oriente
Female Patients With High Tone Pelvic Floor Dysfunction
Diazepam Vaginal Suppositories for High Tone Pelvic Floor Dysfunction.
The purpose of this study is to determine whether vaginal diazepam suppositories are an effective treatment of high tone pelvic floor dysfunction.
- Trial name
- NCT01233791
- Testing
- Vaginal Diazepam Suppository
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- TriHealth Inc.
Anal Fissure
An Open Label Multi-Dose Study to Examine the Effect of Coated Nifedipine Suppository on Anal Fissure Pain and Healing
This is an open label study. The study will consist of 2 treatment group: coated Nifedipine suppository containing 12 mg of Nifedipine applied twice daily (group 1) and coated Nifedipine suppository containing 12 mg of Nifedipine…
- Trial name
- NCT02023047
- Testing
- Nifedipine 12 mg coated suppositories
- Where
- 4 sites in Israel
- Volunteers
- 33 people
- Sponsor
- RDD Pharma Ltd
Overactive Bladder, Urinary Urge Incontinence
Reduction of Bladder Injection Pain With Belladonna Opiate Suppository
The purpose of this study is to test whether using belladonna \& opiate suppositories (B\&Os) can improve patient discomfort during Onabotulinumtoxin A (BoNT) injection into the bladder for treatment of overactive bladder…
- Conditions
- Overactive Bladder, Urinary Urge Incontinence, Urinary Bladder, Neurogenic, Painful Bladder Syndrome
- Trial name
- ROBIN (NCT02600715)
- Testing
- Onabotulinumtoxin A (BoNT), belladonna, Morphine
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Edgar LeClaire, MD
High-risk HPV (Any Strain), LSIL, Low Grade Squamous Intraepithelial Lesion
Phase II Study of Dysplasix™ Intravaginal Suppositories in Patients Patients With High-Risk HPV and Mild Cervical Cytologic Abnormalities
The goal of this clinical trial is to learn if an investigational vaginal suppository therapy works to treat low-grade cervical lesions (ASC-US and LSIL) associated with high-risk human papillomavirus (hr-HPV) infection in women.
- Conditions
- High-risk HPV (Any Strain), LSIL, Low Grade Squamous Intraepithelial Lesion, ASC-US, HPV Infection
- Trial name
- NCT07572396
- Testing
- EGCG and Quinine Sulfate Vaginal Suppository
- Where
- Hong Kong
- Volunteers
- 45 people
- Sponsor
- Amplexd Therapeutics, Inc.
Urinary Incontinence
Ambulatory Pessary Trial
The purpose of this study is to compare two methods for assessing patients with pelvic organ prolapse for occult stress urinary incontinence.
- Trial name
- NCT02746913
- Testing
- Urodynamics, Pessary
- Where
- United States
- Sponsor
- NYU Langone Health
Pelvic Organ Prolapse
Attitude and Success Rate of Women With Pelvic Organ Prolapse on Self-management of Vaginal Pessary
This is a prospective cohort study aims at assessing patient's attitude towards self-management of vaginal pessary, and identifying factors that affect patient's level of acceptance towards self-management.
- Trial name
- NCT06246721
- Testing
- Self-management of vaginal pessary
- Where
- Hong Kong
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Cervical Insufficiency
Cerclage vs Cervical Pessary in Women With Cervical Incompetence
Cervical insufficiency (CI), responsible for 8% of preterm births (PB), is used to describe painless cervical dilation leading to recurrent second-trimester pregnancy losses/births of otherwise normal pregnancies.
- Trial name
- CEPEIC (NCT02405455)
- Testing
- Cerclage, Cervical pessary
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Maternal-Infantil Vall d´Hebron Hospital