Clinical trials: Pessary
Pelvic Organ Prolapse
Feasibility Study of the Reia Vaginal Pessary
The purpose of this study is to obtain preliminary data on the effectiveness, safety, function, comfort, and patient satisfaction with a novel vaginal pessary design for the use in women who suffer from symptoms of pelvic organ…
- Trial name
- NCT04508335
- Testing
- Reia Vaginal Pessary
- Where
- 7 sites in United States
- Volunteers
- 78 people
- Sponsor
- Reia, LLC
Incontinence
Study of Escalating Doses of NRL001 Given in Slow-release Rectal Suppositories of Different Weights
Studies investigating single doses of different NRL001 formulations showed formulation-dependent differences in exposure, even though they had similar effects on mean anal resting pressure (MARP).
- Trial name
- NCT00850590
- Testing
- NRL001
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Norgine
Fecal Incontinence
Safety, Tolerability, Pharmacodynamic and Pharmacokinetics of 7.5, 10, 12.5 or 15 mg NRL001 in a 2 g Suppository for 14 Days
Healthy subjects will receive NRL001 or placebo once daily for 14 days. The four treatment groups, shown below, will each consist of 12 subjects: Group 1; Nine subjects will receive a dose of 7.5 mg NRL001 in a 2 g suppository…
- Trial name
- NCT01099670
- Testing
- NRL001
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Norgine
BPH With Urinary Obstruction With Other Lower Urinary Tract Symptoms
Efficacy of Mictalase® After ThuLEP
In this single-center, prospective, randomized, open label, phase-III study, patients with indication to Thulium Laser Enucleation of Prostate were enrolled. The report conformed to CONSORT 2010 guidelines.
- Trial name
- NCT05130918
- Testing
- Phenolmicin P3 and Bosexil suppository
- Where
- Italy
- Volunteers
- 111 people
- Sponsor
- San Carlo di Nancy Hospital
Proctitis
Clinical Trial With Mesalamine 1g Suppositories
An Investigator-Blind, Randomized, Placebo-Controlled, Parallel-Group Study to Establish Therapeutic Equivalence of 1000 mg Mesalamine Rectal Suppositories and Canasa® Rectal Suppositories (1000 mg Mesalamine, USP) in the…
- Trial name
- NCT01172444
- Testing
- Mesalamine, Canasa
- Where
- 38 sites in India
- Volunteers
- 158 people
- Sponsor
- Sandoz
Pelvic Organ Prolapse, Stress Urinary Incontinence
Lidocaine for Pessary Check Pain Reduction
The primary objective of this study is to estimate the effect of lidocaine jelly on patient pain at the time of office pessary removal.
- Trial name
- NCT05493735
- Testing
- Lidocaine Hcl 2% Jelly
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Trichomonas Vaginitis
Neo-Penotran Forte Vaginal Suppository for Vaginal Trichomoniasis
The investigators are trying a combination vaginal product of higher dose metronidazole combined with miconazole to see if it is effective in treating vaginal trichomonas.
- Trial name
- NCT01361048
- Testing
- oral metronidazole, neo penotran forte, neo penotran forte once a day
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Stress Urinary Incontinence, Urinary Incontinence
ATLAS: Ambulatory Treatments for Leakage Associated With Stress
Stress urinary incontinence is the uncontrollable leakage of urine with physical effort or stress, such as coughing, sneezing, or exercise. Treatment for stress incontinence can be surgical or non-surgical.
- Trial name
- NCT00270998
- Testing
- Behavioral Therapy, Intravaginal Pessary, Pessary combined with behavioral therapy
- Where
- 8 sites in United States
- Volunteers
- 445 people
- Sponsor
- NICHD Pelvic Floor Disorders Network
Pain
Topical Anesthetic Use In Pessary Management
The purpose of this study is to evaluate if lidocaine-prilocaine (EMLA 5%) cream can reduce pain and discomfort at the time of vaginal pessary removal and insertion.
- Trial name
- NCT02380742
- Testing
- lidocaine-prilocaine cream
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Loyola University
Preterm Birth
Prevention of Preterm Birth With a Pessary in Triplet
The incidence of multiple gestations has increased over the past years, mostly because of increased use of assisted reproductive technologies.
- Trial name
- NCT02601443
- Testing
- Cervical Pessary
- Where
- Italy
- Sponsor
- Federico II University
All Patients Who Have Undergone a Pessary Fitting
Characteristics Predictive of Pessary Success
Pessaries are mechanical support devices worn vaginally to treat the symptoms of pelvic organ prolapse, such as vaginal pressure or a vaginal bulge.
- Trial name
- NCT01123213
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- University of California, Irvine
Pelvic Organ Prolapse, Vaginal Prolapse
Cross-Shaped Vaginal Pessary for Pelvic Organ Prolapse
This prospective multicenter single-arm study evaluates the effectiveness and safety of a novel volumetric cross-shaped vaginal pessary in women with pelvic organ prolapse who had prior experience using a traditional vaginal…
- Trial name
- CROSS-PES (NCT07554651)
- Testing
- Volumetric Cross-Shaped Vaginal Pessary
- Where
- 5 sites in Ukraine
- Volunteers
- 51 people
- Sponsor
- Dnipro State Medical University
CIN 2/3, HPV Infection
Artesunate Vaginal Inserts for the Treatment of Cervical Intraepithelial Neoplasia (CIN2/3)
This is a phase II double blind, placebo-controlled, randomized study of Artesunate vaginal inserts for the treatment of women who have cervical high grade intraepithelial neoplasia (CIN2/3).
- Conditions
- CIN 2/3, HPV Infection, Pre-Cancerous Dysplasia, Cervical Dysplasia
- Trial name
- ART-CIN_IIB (NCT04098744)
- Testing
- Artesunate vaginal insert
- Where
- 7 sites in United States
- Volunteers
- 78 people
- Sponsor
- Frantz Viral Therapeutics, LLC
Preterm Birth
Pessary in Singleton Gestations With Short Cervix Without Prior Preterm Birth
Spontaneous preterm birth (SPTB) remains the number one cause of perinatal mortality in many countries, including the United States.
- Trial name
- NCT02716909
- Testing
- Cervical pessary
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Federico II University
Preterm Birth
Does Cervical Pessary Prevent Spontaneous Preterm Birth in Twin Pregnancies With Short Cervical Length?
Spontaneous preterm birth (SPTB) remains the number one cause of perinatal mortality in many countries, including the United States. Multiple gestations are at increased risk of SPTB.
- Trial name
- NCT02708264
- Testing
- Cervical pessary
- Where
- Italy
- Volunteers
- 242 people
- Sponsor
- Federico II University
Overactive Bladder
Timing of B and O Suppositories to Help Relieve Post-operative Bladder Spasms
Ureteroscopy is a common procedure in Urology that patients undergo daily to deal with a variety of ailments. These procedures often require that the bladder be filled and emptied with sterile water or saline several times during…
- Trial name
- NCT02865395
- Testing
- Belladonna and Opium Suppository, Rectal Exam
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Campbell Grant
Preterm Birth
Cervical Pessary to Prevent Preterm Singleton Birth in High Risk Population
DESIGN: Observational prospective study. INCLUSION CRITERIA: All women are 18 years old of age or older with high risk for preterm birth, based on clinical history, and between 18.0 weeks and 23.6 weeks of pregnancy.
- Trial name
- NCT04147117
- Testing
- Cervical pessary
- Where
- Spain
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Hospital Sant Joan de Deu
Preterm Birth
Randomized Study of Pessary Versus Standard Management in Women With Increased Chance of Premature Birth
The aim of the study is to determine the effect of cerclage pessary on the incidence of spontaneous delivery between randomization (at 20-24+6 weeks) and 33+6 weeks in asymptomatic women with singleton pregnancies found at…
- Trial name
- NCT00735137
- Testing
- Vaginal pessary (CE0482, MED/CERT ISO 9003 / EN 46003)
- Where
- 24 sites in Austria, Brazil and 10 more
- Volunteers
- 2,109 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Rectal Cancer, Radiotherapy, Anal Pain
Mepilex Lite Dressings for the Treatment of Acute Radiation Dermatitis of Anal Canal Skin
Background: According to GLOBOCAN 2022 statistics, colorectal cancer has become the third most common cancer disease worldwide, and also the second leading cause of death.
- Conditions
- Rectal Cancer, Radiotherapy, Anal Pain, Acute Radiation Dermatitis, Anal Canal
- Trial name
- NCT06837831
- Testing
- Control group, Experimental group
- Where
- China
- Volunteers
- 274 people
- Sponsor
- Qianfoshan Hospital
Endometriosis, Endometriosis Ovary
Safety, Tolerability and Efficacy of Vaginal Suppositories for Treatment of the Endometriosis
Background: Endometriosis is a chronic gynecological disease with the growth of endometrial tissue outside the endometrium. In all its properties, this tissue is similar to the mucous membrane of the uterus.
- Conditions
- Endometriosis, Endometriosis Ovary, Endometriosis Externa, Endometriosis, Rectum
- Trial name
- ELTA (NCT03481842)
- Testing
- Linifanib, BIBW2992, Axitinib
- Where
- Switzerland
- Sponsor
- BioGene Pharmaceutical Ltd.