Clinical trials: Pessary
Preterm Birth, Twin Pregnancy
Pessary Versus Cerclage With or Without Progesterone in Twins
This study compares the effectiveness of cervical pessary and cervical cerclage with or without vaginal progesterone for prevention of preterm birth in women with a twin pregnancy and a cervix ≤28 mm.
- Conditions
- Preterm Birth, Twin Pregnancy, Short Cervix
- Trial name
- PCP-Twins (NCT03863613)
- Testing
- Pessary, Cervical cerclage, Vaginal progesterone
- Where
- Vietnam
- Volunteers
- 219 people
- Sponsor
- Mỹ Đức Hospital
Pelvic Organ Prolapse
Timing of Pessary Care
This is a prospective trial to investigate optimal timing of care for vaginal pessaries. A vaginal pessary is a silicone device that is placed in the vagina to support the pelvic organs of a woman who has pelvic organ prolapse.
- Trial name
- NCT02371083
- Testing
- Extended timing of pessary care
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Hartford Hospital
Vaginal Delivery, Cesarean Section
Open Label Comparative Trial of Dinoprostone Plus or Minus Oxytocin Versus Oxytocin Alone in Cervical Ripening for Labor Induction
This is a comparative trial between oxytocin alone and dinoprostone for cervical ripening in unfavorable cervix pregnant women with 38 or more weeks of gestational age.
- Trial name
- SOFTNES (NCT01190163)
- Testing
- Dinoprostone, Oxytocin
- Where
- 4 sites in Brazil
- Volunteers
- 170 people
- Sponsor
- Ferring Pharmaceuticals
Bacterial Vaginosis, Candidiasis
Topical Metronidazole and Miconazole Co-formulated Vaginal Suppositories for Preventing Vaginal Infections in HIV-seronegative Women
This research study is about vaginal infections such as bacterial vaginosis, yeast infections, and trichomoniasis. Usually, these infections can be treated with medication, but sometimes they come back after treatment.
- Conditions
- Bacterial Vaginosis, Candidiasis, Trichomoniasis
- Trial name
- NCT01230814
- Testing
- Neo-Penotran® Forte (active ingredient Metronidazole & Miconazole Nitrate)
- Where
- 4 sites in United States, Kenya
- Volunteers
- 234 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Vulvovaginal Atrophy
Investigation of Efficacy and Tolerability of a Lactic Acid Containing Vaginal Suppository in Post-menopausal Women With VVA
The aim of the study is to investigate the efficacy and tolerability of a lactic acid containing vaginal suppository with respect to the application in post-menopausal women with VVA.
- Trial name
- NCT04222647
- Testing
- WO533
- Where
- Germany
- Volunteers
- 43 people
- Sponsor
- Dr. August Wolff GmbH & Co. KG Arzneimittel
Healthy
Bioavailability of Prochlorperazine Suppositories, 25 mg
The purpose of this study is to compare prochlorperazine plasma concentrations produced after administration of the test formulation with those produced after administration of a marketed reference product.
- Trial name
- NCT00992472
- Testing
- Prochlorperazine suppositories, 25mg, Compazine® suppositories, 25mg
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Padagis LLC
Preterm Birth
Cervical Pessary for Prevention of Spontaneous Preterm Birth in Singleton Pregnancies With Arrested Preterm Labor
Preterm birth (PTB) is a major cause of perinatal morbidity and mortality. Worldwide, about 15 million babies are born too soon every year, causing 1.1 million deaths, as well as short- and long-term disability in countless…
- Trial name
- NCT03543475
- Testing
- arabin pessary, no pessary
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- Federico II University
Proctitis
Budesonide vs. Mesalazine vs. Budesonide/Mesalazine Suppository Combination Therapy in Acute Ulcerative Proctitis
The purpose of this study is to investigate the efficacy and safety of budesonide suppository for the treatment of acute ulcerative proctitis.
- Trial name
- NCT01966783
- Testing
- Budesonide 2 mg suppository, Budesonide 4 mg suppository, Mesalazine 1 g suppository
- Where
- 2 sites in Germany
- Volunteers
- 320 people
- Sponsor
- Dr. Falk Pharma GmbH
Pain;Sexual Intercourse;M
The Use of Mindful Compassion and Cannabis Suppositories for Anal Pain Among Men Who Have Sex With Men
Research aim: To determine how an online mindful-compassion intervention adjunct with cannabis suppositories might reduce anal pain during sexual intimacy among men who have sex with men.
- Trial name
- NCT06435650
- Testing
- Cannabis suppositories and mindful-compassion for anal pain, Mindful-compassion
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- London Metropolitan University
Failed Induction of Labor
Concurrent Oxytocin With Membrane Sweeping Versus Dinoprostone Pessary in Labor Induction of Nulliparas at Term
To compare concurrent oxytocin with membrane sweeping versus dinoprostone pessary in labor induction for nulliparas at term with an unfavorable cervix
- Trial name
- NCT02416583
- Testing
- Oxytocin, Dinoprostone, Membrane sweeping
- Where
- South Korea
- Volunteers
- 140 people
- Sponsor
- Seoul National University Hospital
Pelvic Organ Prolapse
Native Tissue Repair With Surgical Pelvic Organ Pessary - an RCT
This is an RCT looking at the primary outcome of composite success following anterior repair with native tissue at 6, 12, 24 months in two arms.
- Trial name
- NTRSPOP (NCT02808377)
- Testing
- Surgical Pelvic Organ Pessary
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Chronic Pelvic Pain Syndrome
Vaginal Baclofen Suppositories in Chronic Pelvic Pain
The purpose of this study is to evaluate if baclofen vaginal suppositories improve symptoms of Chronic Pelvic Pain (CPP). Participants in this study will take four short questionnaires prior to being randomized.
- Trial name
- NCT05968937
- Testing
- 20 mg baclofen vaginal suppository daily per vagina
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Focus: Prevent Preterm Delivery, Incidental Short Cervix at Mid-trimester
Arabin Pessary Combine With Vaginal Progesterone Compare With Vaginal Progesterone Alone to Prevent Preterm Delivery in Singleton Pregnancies
1. This will be a randomized prospective and open-label study with no placebo control or blinding of the participants and the research team members.
- Trial name
- NCT03052270
- Testing
- Arabin Pessary
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Illinois Chicago
Preterm Labor
Use of Pessary in Case of Cervical Insufficiency and Short Cervix
Prematurity is the most important cause of obstetric morbidity and mortality. Health centers and obstetricians are trying to reduce the preterm birth rate by taking into account the permanent effects of premature birth on human…
- Trial name
- NCT03096691
- Testing
- cervical pessary
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Faecal Incontinence
A Multi-centre, Phase II, Double-blind, Randomised, Placebo-controlled, Parallel Group, Dose-ranging Study in Patients With Faecal Incontinence; to Evaluate the Efficacy, Safety and Tolerability of Locally Applied NRL001 Over an 8 Week Treatment Period
The purpose of this study is to evaluate the safety, tolerability and efficacy of NRL001 in the treatment of faecal incontinence, compared against placebo
- Trial name
- NCT01656720
- Testing
- 1R, 2S-methoxamine hydrochloride
- Where
- 51 sites in Czechia, France and 7 more
- Volunteers
- 417 people
- Sponsor
- Norgine
Stress Urinary Incontinence, Pregnancy Related
Pessary Use for Stress Urinary Incontinence in Pregnancy
When women are pregnant they are more likely to leak urine which can severely affect their quality of life. This problem could be fixed by using a pessary.
- Trial name
- NCT04590092
- Testing
- Cooper Surgical Ring Pessary with Incontinence Knob
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Vulvovaginal Candidiasis
Arasertaconazole Nitrate Pessaries - Dose Finding Study for the Vulvovaginal Candidiasis (VVC) Treatment
In order to find an optimal dose of arasertaconazole nitrate in the treatment of vulvovaginal candidiasis, a multicenter, randomized, double-blind, parallel, placebo-controlled study will be conducted to compare the therapeutic…
- Trial name
- NCT01144286
- Testing
- arasertaconazole nitrate
- Where
- Spain
- Volunteers
- 229 people
- Sponsor
- Ferrer Internacional S.A.
Vaginal Surgery
Postoperative Belladonna and Morphine Suppositories in Vaginal Surgery
Our primary aim is to determine whether the routine use of belladonna and morphine suppositories will improve pain control following vaginal surgery.
- Trial name
- NCT01150474
- Testing
- Belladonna and Opium Suppositories
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Kristina A. Butler
Fecal Incontinence
Study to Investigate Safety and Response to 1 or 2 g Rectal Suppositories Containing 5 or 10 mg NRL001.
This is a healthy volunteer three-way crossover study. A total of 12 subjects will receive three single administrations of 1 g rectal suppositories (containing either 5 mg NRL001, 10 mg NRL001 or matching placebo), with a washout…
- Trial name
- NCT00857467
- Testing
- NRL001
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Norgine
Incontinence
Study to Examine the Effect of Coated Phenylephrine Suppositories on Anal Pressure in Healthy Subjects
This is an open label, dose-finding study. Approximately 8 healthy subjects will be participating in this study. A screening will be used to determine subject suitability for inclusion in the trial.
- Trial name
- NCT00972998
- Testing
- Phenyephrine
- Where
- Israel
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- RDD Pharma Ltd