Clinical trials: Phantom Sensation
Phantom Limb Pain
Sensory Retraining for Phantom Limb Pain
86-87% of people who have had an amputation still feel pain in the limb that has been amputated - Phantom limb pain (PLP). Sensory retraining is a form of treatment for PLP where a special form of electrical stimulation is…
- Trial name
- PHANTOM RELIEF (NCT04103983)
- Testing
- Sensory retraining device
- Where
- United Kingdom
- Volunteers
- 109 people
- Sponsor
- Teesside University
Amputation, Phantom Limb
Ambulatory Continuous Peripheral Nerve Blocks for Treatment of Post-Amputation Phantom Limb and Stump Pain
Research study to determine if putting local anesthetic-or numbing medication-through one or two tiny tube(s) placed next to the nerves that go to an amputated limb will decrease phantom limb and/or stump pain.
- Conditions
- Amputation, Phantom Limb, Stump Pain
- Trial name
- NCT00667264
- Testing
- perineural ropivacaine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of California, San Diego
Neuropathic Pain, Amputation, Traumatic
Postamputation Pain: Peripheral Mechanisms
Stump and phantom pain after amputation are common, but the responsible mechanisms are still not clarified. It has been suggested that phantom limb pain can be reduced by regional anaesthesia and in several recent studies, pain…
- Conditions
- Neuropathic Pain, Amputation, Traumatic, Nerve Block, Phantom Limb Pain
- Trial name
- NCT03317600
- Testing
- Lidocaine
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Danish Pain Research Center
Postoperative Pain
Preoperative (Pre-amputation) Cryoanalgesia to Improve Post-amputation Phantom Limb Pain
Investigators will evaluate preamputation cryoanalgesia on pain, mobility, opioid use and general physical and emotional disability using a pilot randomized trial design, to explore the amount and variability of improvement on…
- Trial name
- NCT06284109
- Testing
- Cryoanalgesia
- Where
- United States
- Sponsor
- The Cleveland Clinic
Phantom Limb Pain
Effects of Repetitive Transcranial Magnetic Stimulation in the Treatment of Phantom Limb Pain in Landmine Victims: ANTARES
Phantom Limb Pain (PLP) is a neuropathic chronic syndrome, characterized by a painful sensation in a body part that has been amputated.
- Trial name
- ANTARES (NCT01872481)
- Testing
- rTMS
- Where
- Colombia
- Volunteers
- 54 people
- Sponsor
- Fundación Cardiovascular de Colombia
Limb Pain, Phantom
A Study of Contralateral Limb Block
This research is being done to determine if an anesthetic like Lidocaine, may be effective when injected around the sciatic nerve of the intact limb in patients with limb loss pain on the contralateral side.
- Trial name
- NCT06045936
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Neuropathy, Phantom Limb Pain
Immersive Virtual Reality for Neuropathic Pain
Investigating how neuropathic limb pain, including phantom limb pain or complex regional pain syndrome, is affected by virtual reality.
- Conditions
- Neuropathy, Phantom Limb Pain, Complex Regional Pain Syndromes, Neuropathic Pain
- Trial name
- NCT03203772
- Testing
- Immersive Virtual Reality
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Loma Linda University
Phantom Limb Pain, Postoperative Pain
Postoperative Peripheral Nerve Stimulation for Management of Post-amputation Pain
Limb loss is frequently associated with postamputation pain that can be challenging to treat and often involves opioids. Advances in the field of neuromodulation has led to development of an intentionally reversible percutaneous…
- Conditions
- Phantom Limb Pain, Postoperative Pain, Neuroma, Acute Pain
- Trial name
- NCT03484429
- Testing
- Peripheral nerve stimulation, Standard Medical Therapy
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Complex Regional Pain Syndromes, Postherpetic Neuralgia
The Comparison of Sympathetic Blockade of Stellate Ganglion Block and Thoracic Paravertebral Block
The purpose of this study is to investigate the effect of ultrasound-guided thoracic paravertebral block (TPVB) when performing sympathetic block for upper limb pain control.
- Conditions
- Complex Regional Pain Syndromes, Postherpetic Neuralgia, Phantom Limb Pain, Chronic Post Surgical Pain
- Trial name
- NCT04876989
- Testing
- US-SGB, US-TPVB
- Where
- South Korea
- Volunteers
- 69 people
- Sponsor
- Seoul National University
Amputation, Chronic Pain
Efficacy of Opioids and Mexiletine for the Treatment of Postamputation Pain
Persistent pain occurs in 50-85 percent of patients who experience the amputation of an extremity. This study will compare the effectiveness of morphine and mexiletine to placebo in the treatment of postamputation pain.
- Trial name
- NCT00383682
- Testing
- morphine and mexiletine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Residual Limb Pain, Post-Traumatic Limb Pain
Kinematics-Based Prediction of Chronic Pain After Combat-Related Extremity Trauma
Combat-related extremity trauma frequently results in persistent pain, including neuropathic, residual limb, and phantom limb pain.
- Conditions
- Residual Limb Pain, Post-Traumatic Limb Pain, Extremity Trauma, Combat-Related Limb Injury
- Trial name
- KIN-LIMB (NCT07432685)
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
VTE (Venous Thromboembolism), Phantom Limb Pain After Amputation
Venous Thromboembolism and Chronic Pain After Major Limb Trauma
Major limb trauma is associated with a high risk of venous thromboembolism (VTE) due to systemic inflammation, endothelial injury, immobilization, and hypercoagulability.
- Conditions
- VTE (Venous Thromboembolism), Phantom Limb Pain After Amputation, Chronic Pain, Chronic Pain Due to Injury
- Trial name
- THROMBO-PAIN (NCT07475910)
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Tinnitus
Reversing Synchronized Brain Circuits With Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts
The goal of the study is to reduce tinnitus (ringing in the ear) loudness and improve the quality of life for those that are affected by tinnitus.
- Trial name
- NCT03621735
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Michigan
Targeted Sensory Reinervation, Amputation
Targeted Sensory Reinnervation (TSR) in Hand Amputation
If a person has to have a part of their body amputated, in this case their hand, the patient then lacks information about the missing limb, which in many cases leads to pain that severely restricts their quality of life and…
- Conditions
- Targeted Sensory Reinervation, Amputation, Phantom Pain
- Trial name
- NCT06249594
- Testing
- targeted sensory reinervation
- Where
- 2 sites in Austria, Italy
- Volunteers
- 3 people
- Sponsor
- Brixsana Private Clinic - Centro di Chirurgia Plastica, Estetica ed Ricostruttiva con Chirurgia dell
Phantom Limb Syndrome With Pain
Clinical Trial Exploring the Outpatient Treatment of Phantom Limb Pain With Ketamine Administration in a Six Month Study With a Minimum Remission Period of 7 Days Between Treatment Session. 25-30 Subjects With an Ongoing History of Significant PLP.--FDA and IRB Approved.
Must be living Within a 50 mile radius of our study sites: Bay Area, Los Angeles, Albuquerque, Sacramento, Los Angeles An anecdotal report with administration of ketamine in a non-clinical setting providing and sustained…
- Trial name
- PLP (NCT07276542)
- Testing
- IM ketamine in dose finding and then continuation
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- The Ketamine Research Foundation
Amputation, Phantom Limb Pain
Neuromodulation in Lower Limb Amputees
The goal of this study is to investigate the role of transcutaneous spinal cord stimulation on spinal cord excitability in lower limb amputees.
- Conditions
- Amputation, Phantom Limb Pain, Hoffman's Reflex
- Trial name
- NCT04543786
- Testing
- Transcutaneous spinal cord stimulation
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- University of Pittsburgh
Symptomatic Neuroma, Phantom Limb Pain After Amputation
Evaluation of RPNI for Symptomatic Neuromas in Lower Limb Amputees
This prospective, observational cohort study evaluates the long-term outcomes of Regenerative Peripheral Nerve Interface (RPNI) surgery in patients with major lower extremity amputations suffering from symptomatic neuromas.
- Conditions
- Symptomatic Neuroma, Phantom Limb Pain After Amputation, Residual Limb Pain, Neuropathic Pain
- Trial name
- RPNI-AMPUTEE (NCT07420192)
- Testing
- Regenerative Peripheral Nerve Interface (RPNI) Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Saglik Bilimleri Universitesi
Amputation, Phantom Limb Pain
Prevention of Phantom Limb and Stump Pain Using Ambulatory Continuous Peripheral Nerve Blocks: A Pilot Study
The purpose of this research study is to determine if putting local anesthetic through one or two percutaneous catheters placed next to the nerves that go to an amputated limb will decrease long-term pain in the amputated limb.
- Conditions
- Amputation, Phantom Limb Pain, Stump Pain
- Trial name
- NCT00771862
- Testing
- perineural ropivicaine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, San Diego
Pain, Phantom, Pain, Neuropathic
Valproic Acid for the Prevention of Post-Amputation Pain
The objectives of this study are, to test the effectiveness of Valproic Acid (VPA) in the prevention of chronic neuropathic and post-amputation pain, as well as to further define the underlying inflammatory and epigenetic…
- Trial name
- NCT01928849
- Testing
- Valproic Acid, Cherry Syrup
- Where
- 2 sites in United States
- Volunteers
- 128 people
- Sponsor
- Duke University
Phantom Limb Pain, Chronic Pain
Prevention of Phantom Limb Pain After Transtibial Amputation
Phantom limb pain following amputation is a major problem. Current evidence how to best prevent phantom limb pain is equivocal because previous trials have included small numbers of patients, and tested heterogeneous patient…
- Conditions
- Phantom Limb Pain, Chronic Pain, Prevention
- Trial name
- PLATA (NCT01626755)
- Testing
- Sciatic name block
- Where
- 9 sites in United States, Austria and 3 more
- Volunteers
- 12 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)