Clinical trials: Pharmaceutical Preparations
Insect Bites
Non-inferiority Clinical Trial of Dexchlorpheniramine (Cream Versus Lotion) in the Relief of Insect Bite Related Symptoms
Insect bite related symptoms (pruritus and papules) are caused by the release of histamine by mast cells in the skin. Topical anti-histaminics can be used to promote relief of these symptoms.
- Trial name
- NCT00995397
- Testing
- Dexchlorpheniramine 1% lotion, Dexchlorpheniramine 1% cream
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Mantecorp Industria Quimica e Farmaceutica Ltd.
Dry Eye, Dry Eye Syndromes
A Phase 3, Multi-Center Study Evaluating PL9643 in Patients with Dry Eye
This is a multi-center, double-masked, randomized, vehicle-controlled study testing PL9643, an ophthalmic solution to determine if safe and efficacious for dry eye patients.
- Trial name
- MELODY-1 (NCT05201170)
- Testing
- Vehicle Ophthalmic Solution, PL9643 Ophthalmic Solution
- Where
- 18 sites in United States
- Volunteers
- 575 people
- Sponsor
- Palatin Technologies, Inc
Bioavailability and Pharmacokinetics
Pharmacokinetic Study of Eicosapentaenoic Acid (EPA) and Calcium L-5-Methyltetrahydrofolate (L-5-MTHF) After Administration of CreNeuroS® CNS Fish Oil Plus Softgels in Healthy Subjects Under Fasting Conditions
Demographic data, medical and medication history, physical examination, 12-lead ECG, haematology, biochemistry, serology, urine routine analysis, additionally for females serum pregnancy test, hormone assay (FSH) will be done…
- Trial name
- NCT07461649
- Testing
- Eicosapentaenoic Acid (EPA) and Calcium L-5-Methyltetrahydrofolate (L-5-MTHF)
- Where
- India
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Sichuan Credit Pharmaceutical Co., Ltd.
Healthy
Bioequivalence Study of Torrent Pharmaceutical Ltd.'s Montelukast Sodium Chewable 5mg Tablet Under Fed Conditions
Objective: Primary objective of the present study was to compare the single dose bioavailability of Torrent's Montelukast Sodium chewable 5mg tablet and Innovator's(Merck)Singulair chewable 5mg tablet.
- Trial name
- NCT01931514
- Testing
- Torrent's Montelukast Sodium chewable Tablets 5mg, Singulair® (Montelukast Sodium) Chewable Tablets 5mg
- Where
- India
- Volunteers
- healthy volunteers welcome
- Sponsor
- Torrent Pharmaceuticals Limited
Pharmacokinetics
Evaluate Pharmacokinetics Of Two Different Pharmaceutical Oral Formulations Of Alprazolam And A Clonazepam Tablet In Mexican Healthy Population
To estimate the pharmacokinetics of single doses of benzodiazepines in Mexican adult healthy volunteers: a) alprazolam tablet extended release, b) alprazolam tablet immediate release, and clonazepam tablet.
- Trial name
- NCT00810316
- Testing
- Alprazolam, Alprazolam XR, Clonazepam
- Where
- Mexico
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Healthy
Bioequivalence Study of Mirabegron From Bladogra 25 mg Extended Release Tablets (Multi-Apex for Pharmaceutical Industries, Egypt) Versus Myrbetriq 25 mg Extended Release Tablets (Marketed by Astellas Pharma US, Inc, Product of Japan)
An open label randomized, single dose, three way three sequence two treatment partial replicate crossover study to determine the bioequivalence of Mirabegron from Bladogra 50 mg Extended Release film coated tablets (Man by…
- Trial name
- NCT04476966
- Testing
- Bladogra, Myrbetriq (first dosing), Myrbetriq (second dosing)
- Where
- Egypt
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Genuine Research Center, Egypt
Anesthesia, General
Clinical Practice of Inhalation Anesthesia With Sevoflurane in China
Until recently, there was a lack of understanding and consensus among Chinese anesthesiologists how they should practice general anesthesia with volatile anesthetics, since there was no standard of inhalation practice.
- Trial name
- NCT01715857
- Where
- 36 sites in China
- Volunteers
- 4,100 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
To Determine Bioequivalence Under Fasting Conditions
Bioequivalence Study of Doxycycline Monohydrate Tablets Under Fasting Conditions
The purpose of this study is to compare the single-dose bioequivalence of Par and Oclassen doxycycline monohydrate, 100 mg.
- Trial name
- NCT01380483
- Testing
- doxycycline monohydrate
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Par Pharmaceutical, Inc.
Healthy
Bioequivalence Study of Oxcarbazepine Oral Suspension 300 mg/5mL Under Fed Condition
The purpose of this study is to compare the single-dose oral bioavailability of oxcarbazepine 300 mg/5mL oral suspension of OHM Laboratories, USA (a subsidiary of Ranbaxy Pharmaceuticals Inc.) with Trileptal® 300 mg/5mL oral…
- Trial name
- NCT00951847
- Testing
- oxcarbazepine 300 mg/5 mL oral suspension
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited
Infertility
An Observational Study to Evaluate Efficacy, Safety and Clinical Outcomes of Currently Used Pharmaceutical Therapies for Controlled Ovarian Stimulation in Assisted Reproductive Techniques
Human gonadotrophins have been successfully used for the treatment of infertility for more than 30 years. This observational study is being conducted to evaluate the efficacy and safety of the gonadotropins used for controlled…
- Trial name
- ESCORT (NCT01149070)
- Where
- Hungary
- Volunteers
- 10,103 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility, Female
Biosimilarity Study of IM Injection of Human Chorionic Gonadotrophin After Parenteral Administration of Treatment A TEST Product Epifasi 5000 I.U. Ampoules (EIPICO PHARMA, EGYPT) and Treatment B REFERENCE Product Pregnyl 5000 I.U. Ampoules (Baxter Pharmaceutical Solutions for Organon, USA).
Comparative randomized, single dose, parallel, triple-blinded study in infertile females to evaluate biosimilarity of IM Injection of Human Chorionic Gonadotrophin (HCG) after Parenteral administration of Treatment A TEST Product…
- Trial name
- NCT04605107
- Testing
- Epifasi: Human chorionic gonadotrophin, Pregnyl: Human chorionic gonadotrophin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Genuine Research Center, Egypt
Healthy
Bioequivalence Study of Torrent Pharmaceutical Ltd's Esomeprazole Magnesium Delayed Release Capsules
Subjects to compare the single dose bioavailability of Torrent's Esomeprazole Delayed Release Capsule 1 × 40 mg and Nexium 1× 40 mg of AastraZeneca LP, USA. Dosing periods of studies were separated by a washout period of 7 days.
- Trial name
- NCT02680132
- Testing
- Nexium 40 mg DR Capsules of AstraZeneca LP, USA, Torrent's Esomeprazole Magnesium DR Capsules 40 mg
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Torrent Pharmaceuticals Limited
Healthy
A Relative Bioavailability Study of 20 mg Famotidine Tablets Under Fasting Condition
The study was conducted as an open-label, balanced, randomized, two-treatment, two-period, two-sequence, single-dose, crossover, bioavailability study comparing famotidine tablets, USP 20 mg manufactured by OHM Laboratories with…
- Trial name
- NCT01079065
- Testing
- Famotidine
- Where
- India
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited
Lennox-Gastaut Syndrome
Cannabidiol Oral Solution as an Adjunctive Therapy for Treatment of Participants With Inadequately Controlled Lennox-Gastaut Syndrome
This Phase 3 trial will enroll participants diagnosed with Lennox-Gastaut Syndrome (LGS) who are still experiencing at least 4 motor seizures involving the trunk or extremities per week, despite ongoing treatment with up to 3…
- Trial name
- NCT02318537
- Testing
- Cannabidiol Oral Solution
- Sponsor
- INSYS Therapeutics Inc
Meningitis, Cryptococcal, HIV Infections
Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome
To evaluate the safety, tolerance and efficacy of three different dosage regimens of Amphotericin B Lipid Complex (ABLC) compared to Fungizone (Amphotericin B) in patients with AIDS and cryptococcal meningitis.
- Trial name
- NCT00002019
- Testing
- Amphotericin B, Lipid-based, Amphotericin B
- Where
- 19 sites in United States
- Sponsor
- Liposome
Healthy Volunteers
Pharmacodynamic and Pharmacokinetic Study of PL-ASA
A randomized, open-label, 2-way crossover pharmacodynamic and pharmacokinetic study of a novel pharmaceutical lipid-aspirin complex formulation (PL-ASA) at an 81 mg dose
- Trial name
- NCT04811625
- Testing
- PL-ASA
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- PLx Pharma
Healthy Volunteers
Triazolam Trial In Healthy Subjects To Compare Bioavailability Between Formulations Of Triazolam To Determine Their Bioequivalence In Terms Of Rate And Magnitude Of Absorption
The purpose of this study is to compare the bioavailability of two oral formulations of Triazolam in healthy volunteers, in order to determine that they are bioequivalent.
- Trial name
- NCT01017926
- Testing
- Triazolam
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pfizer