Clinical trials: Pharmacogenetics
Inflammation
Systemic Immunomodulatory Effects and Pharmacogenetics of Atorvastatin in Early Atherosclerosis
The purpose of the study is to test whether atorvastatin (also known as Lipitor) has anti-inflammatory effects in people with no known heart disease or high cholesterol.
- Trial name
- NCT00361283
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Florida
Labor Pain, Post-cesarean Delivery
Mu-Opioid Receptor Genetic Polymorphism and Intrathecal Analgesia
Pharmacogenetics has allowed clinicians to identify associations between an individual's genetic profile and his/her response to drugs.
- Trial name
- NCT00418015
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 293 people, healthy volunteers welcome
- Sponsor
- Northwestern University
HIV
Effect of Gender and HIV Infection on Zidovudine and Lamivudine Pharmacokinetics
This study evaluated the blood and blood cell concentrations of zidovudine and lamivudine in men versus women and in those with versus without HIV infection.
- Trial name
- NCT01386970
- Testing
- zidovudine 300mg and lamivudine 150mg as Combivir
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Alcohol Related Disorders, Alcoholism
Pharmacogenetics of Alcohol: Treatment Implications
This study will explore the hypothesis that effects of alcohol are in part mediated by increased production of neuroactive steroids, which interact with GABAA-receptors.
- Conditions
- Alcohol Related Disorders, Alcoholism, Alcohol Abuse
- Trial name
- NCT00734656
- Testing
- dutasteride + ethanol
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- UConn Health
Heart Diseases, Coronary Disease
CES1 Carriers in the PAPI Study
This study builds, in part, upon preliminary results generated as part of the Pharmacogenomics Anti-Platelet Intervention (PAPI) Study (NCT00799396).
- Conditions
- Heart Diseases, Coronary Disease, Coronary Artery Disease, Cardiovascular Diseases
- Trial name
- NCT03188705
- Testing
- Clopidogrel, Aspirin
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Childhood Absence Epilepsy, Petit Mal Epilepsy
Childhood Absence Epilepsy Rx PK-PD-Pharmacogenetics Study
The purpose of this study is to determine the best initial treatment for childhood absence epilepsy.
- Conditions
- Childhood Absence Epilepsy, Petit Mal Epilepsy, Epilepsy, Seizures
- Trial name
- NCT00088452
- Testing
- Ethosuximide, Lamotrigine, Valproic acid
- Where
- 31 sites in United States
- Volunteers
- 453 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cocaine Dependence
Disulfiram for Cocaine Abuse
This study examines the influence of dopamine beta-hydroxylase enzyme activity on the clinical efficacy of the novel pharmacotherapy, disulfiram, for treating cocaine dependence in cocaine-dependent patients, some of whom are…
- Trial name
- NCT00395850
- Testing
- Disulfiram
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Cocaine Dependence
Pharmacogenetic Trial of Doxazosin for Treatment of Cocaine Abuse
Cocaine use disorders affect approximately 1.5 million Americans annually. Currently, there are no US Food and Drug Administration approved medications for treatment of cocaine dependence; however, both animal and human studies…
- Trial name
- NCT01953432
- Testing
- Doxazosin
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Hypogonadism
CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1) Gene and Pharmacogenetics of Response to Testosterone Therapy
Testosterone (T) replacement prevents bone loss and relieves symptoms associated with androgen deficiency in male patients with hypogonadism, but at the expense of an increase in prostate-related adverse events and in the…
- Trial name
- NCT01378299
- Testing
- Testosterone Cypionate
- Where
- 2 sites in United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Hypertension in Pregnancy, Preeclampsia
Response to Anti-hypertensives in Pregnant and Postpartum Patients
In this study, the investigators will evaluate the blood pressure response to nifedipine and labetalol in pregnant and postpartum patients, who present with hypertensive disease in pregnancy with severe range blood pressure…
- Trial name
- NCT03506724
- Testing
- Nifedipine, Labetalol
- Where
- 2 sites in United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
PTSD
Monoamine Transporters Genotypes: Risk of PTSD and Related Comorbidities
Dr. Wang's merit review is aimed at providing a better understanding of the relationship between SLC6A3/SLC6A4 and the mental health of veterans exposed to high levels of combat stress, specifically focusing on PTSD symptoms…
- Trial name
- MTG (NCT00403455)
- Testing
- Paroxetine
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Pain, Other Surgical Procedures
Influence of Genotype of CYP2C9 on Clinical Efficacy and Pharmacokinetics of Piroxicam After Lower Third Molar Surgery
Pharmacogenetics is an area of Pharmacology that studies the contribution of genetic factors to individual responses to drugs. This branch of science involves the variability in pharmacodynamics and pharmacokinetics through the…
- Conditions
- Pain, Other Surgical Procedures, Impacted Third Molar Tooth, Cytochrome P450 CYP2C9 Enzyme Deficiency
- Trial name
- NCT02450487
- Testing
- Piroxicam
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Schizophrenia, Memory Disorders
The Effects of Atomoxetine on Cognition and Brain Function Based on Catechol-O-methyltransferase(COMT) Genotype
This study will evaluate whether Atomoxetine improves cognition in healthy volunteers as well as patients with schizophrenia. Atomoxetine is a drug that has been Food and Drug Administration (FDA) approved for Attention Deficit…
- Conditions
- Schizophrenia, Memory Disorders, Cognition Disorders
- Trial name
- Atomoxetine (NCT00548327)
- Testing
- Atomoxetine, Functional magnetic resonance imaging, Neuropsychological Testing
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Diabetes Mellitus, Type 2
Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans
The SUGAR-MGH investigators are studying the influence of inherited gene variants on the response to two commonly prescribed type 2 diabetes medications, metformin and glipizide.
- Trial name
- SUGAR-MGH (NCT01762046)
- Testing
- Glipizide, Metformin, Oral Glucose Tolerance Test
- Where
- 3 sites in United States
- Volunteers
- 1,033 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Myocardial Infarction, Thrombosis
CES1 Crossover Trial of Clopidogrel and Ticagrelor
The purpose of this investigation is to evaluate when genetic variation in the carboxylesterase 1 (CES1) gene influences antiplatelet therapy response, as assessed by ex vivo platelet aggregometry, in healthy participants treated…
- Conditions
- Myocardial Infarction, Thrombosis, Platelet Dysfunction
- Trial name
- NCT03161678
- Testing
- Clopidogrel, Ticagrelor
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Hypertension, Diabetes Type 2
Pharmacogenetics of Ace Inhibitor-Associated Angioedema
The investigators would like to find out if sitagliptin (dipeptidyl peptidase-4 or DPP4 inhibition), a drug to treat diabetes, affects blood vessel relaxation in healthy people receiving enalapril (angiotensin converting enzyme…
- Trial name
- NCT01413542
- Testing
- Sitagliptin (DPP4 inhibitor), Substance P,, bradykinin
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Metabolism of Clopidogrel
Clopidogrel Pharmacogenetics (PGX) Bench to Bedside
Clopidogrel (also known as Plavix) is used commonly in patients to prevent heart attacks and conditions caused by blood clots. Although clopidogrel works in many individuals, some people do not respond as well to this drug.
- Trial name
- PGXB2B (NCT01341600)
- Testing
- Clopidogrel, Omeprazole/Clopidogrel
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Healthy
Pharmacogenetics of Warfarin Induction and Inhibition
This research study will help determine how a person's genetic makeup affects their response to drugs, the ability of the body to break down drugs, and their potential to experience an interaction between drugs.
- Trial name
- NCT01447511
- Testing
- Control - Warfarin only, Fluconazole - Warfarin, Rifampin - Warfarin
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Postoperative Nausea
Pharmacogenomics and Post-Operative Nausea and Vomiting
The Researchers overall goal is to evaluate the benefit and utility of preemptive genotypic data to guide post-operative nausea and vomiting treatment in the bariatric surgical population.
- Trial name
- NCT03503292
- Testing
- Granisetron, Ondansetron
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Efavirenz, Metabolism and Pharmacokinetics Changes
Determine the Effects of Gene Differences and Voriconazole on Enzyme CYP2B6 Activity in the Liver in Healthy Volunteers
The purpose of this study is to see if administration of medicines and genetic differences affects the activity of a liver enzyme called CYP2B6 in healthy volunteers.
- Trial name
- NCT01104376
- Testing
- Efavirenz, voriconazole
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Indiana University