Clinical trials: Pharmacogenomics
Oral Surgeries
Evaluation of Pharmacogenomics Testing to Precision Prescriptions in Periodontal Patients
The different patients responses to medications vary from dose effectiveness to adverse drug reaction (ADRs). ADRs affect outpatient settings as it account for estimated 1 million emergency department visits and over 3.5 million…
- Trial name
- NCT05467436
- Testing
- Local anesthetics, IV sedation drugs and analgesics.
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Augusta University
Adverse Drug Event, Drug Drug Interaction
Implementation of a Pharmacist-led Pharmacogenomic Clinical Service
Tabula Rasa HealthCare (TRHC), doing business as CareKinesis, is the first national pharmacy that provides science-based medication risk identification and mitigation technologies and services.
- Conditions
- Adverse Drug Event, Drug Drug Interaction, Pharmacogenomics, Elderly
- Trial name
- NCT04984538
- Testing
- Pharmacogenomic Testing
- Where
- United States
- Sponsor
- Tabula Rasa HealthCare
Cardiovascular Diseases, Acute Coronary Syndrome
Pharmacogenomics of Anti-platelet Intervention-2 (PAPI-2) Study
It is standard treatment to take anti-platelet medication after cardiac catheterization and stent placement to help prevent the formation of blood clots that may cause heart attack or stroke.
- Trial name
- PAPI-2 (NCT01452152)
- Testing
- clopidogrel, prasugrel
- Where
- 5 sites in United States
- Volunteers
- 9 people
- Sponsor
- University of Maryland, Baltimore
Depression
Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support
The purpose of this study is to understand the effectiveness of pharmacogenomic testing in using antidepressants and to understand how EHR - driven clinical decision support system can be used to deliver PGx test results by…
- Trial name
- MyGenes (NCT03952494)
- Testing
- Genomind®Professional PGx Express TM
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Inflammatory Bowel Diseases, Ulcerative Colitis
Preemptive HLA Genotyping for the Safe Use of Infliximab-combination Therapy in Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a common disease in Canada, leading to significant morbidity as a result of remitting and relapsing intestinal inflammation.
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- INHERIT (NCT04109300)
- Testing
- HLADQA1*05A>G screening, Standard of Care
- Where
- Canada
- Volunteers
- 162 people
- Sponsor
- Western University, Canada
Leukemia, Lymphoma
iPSC Neurons From Adult Survivors of Childhood Cancer Who Have Persistent Vincristine-Induced Neuropathy
This observational study is designed to establish induced pluripotent stem cells (iPSCs) from childhood cancer survivors who did or did not develop persistent treatment-induced peripheral neuropathy, from which to make human…
- Trial name
- NCT02564484
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- St. Jude Children's Research Hospital
Breast Cancer
A Pharmacogenomics Study for Breast Cancer Patients Undergoing Adjuvant Chemotherapy With Doxorubicin (A)/Cyclophosphamide ©) and/or Weekly Paclitaxel
RATIONALE: Drugs used in chemotherapy, such as doxorubicin, cyclophosphamide, and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00131963
- Testing
- cyclophosphamide, doxorubicin, paclitaxel
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Duke University
Adverse Drug Reaction
PREemptive Pharmacogenomic Testing for Preventing Adverse Drug REactions
PREPARE is an international, prospective, multi-center, open, randomized, cross-over implementation study assessing the impact of pre-emptive pharmacogenomic testing, of a panel of actionable pharmacogenomic variants, on adverse…
- Trial name
- PREPARE (NCT03093818)
- Testing
- Pharmacogenomic testing
- Where
- 7 sites in Austria, Greece and 5 more
- Volunteers
- 6,950 people
- Sponsor
- J.J.Swen