Clinical trials: Pharmacokinetic Analysis
C.Delivery; Surgery (Previous), Gynecological
Effect of Laparoscopic Operation on Rocuronium and Cisatracurium: Pharmacokinetic and Pharmacodynamic Analysis
The investigators investigated whether laparoscopic versus open surgical approaches affected the pharmacokinetic and pharmacodynamic of a single bolus dose of rocuronium or cisatracurium.
- Trial name
- NCT02194855
- Testing
- rocuronium, cisatracurium
- Volunteers
- 100 people
- Sponsor
- Fudan University
Pulmonary Arterial Hypertension
Pharmacokinetic Study of Sub-q and IV Treprostinil in Kids With Pulmonary Arterial Hypertension (PAH)
Abstract This is a multi-center, open-label pharmacokinetic (PK) study examining the relationship between the steady-state plasma concentration and dose of treprostinil delivered intravenously or subcutaneously in children with…
- Trial name
- PKRemodulin (NCT02318186)
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Jeffrey A. Feinstein
Buruli Ulcer
Beta-Lactam Containing Regimen for the Shortening of Buruli Ulcer Disease Therapy
Buruli ulcer (BU) is a skin Neglected Tropical Disease (NTD) that is caused by Mycobacterium ulcerans. It affects skin, soft tissues and bones causing long-term morbidity, stigma and disability.
- Trial name
- BLMs4BU (NCT05169554)
- Testing
- Standard [RC8]: rifampicin plus clarithromycin (RC) therapy for 8 weeks., Investigational [RCA4]: standard (RC) plus amoxicillin/clavulanate (A) for 4 weeks.
- Where
- 3 sites in Benin
- Volunteers
- 140 people
- Sponsor
- Fundacion Agencia Aragonesa para la Investigacion y Desarrollo (ARAID)
Cesarean Section Complications, Pain
Intraabdominal Chloroprocaine During Cesarean Delivery for Pain Control
Objective The objective of this study is to test the hypothesis that instillation of intra-abdominal chloroprocaine during cesarean deliveries is associated with decreased postoperative pain and nausea compared to placebo…
- Trial name
- NCT03260972
- Testing
- Chloroprocaine Hcl 2% Inj, Normal saline
- Sponsor
- Johns Hopkins University
Healthy Subjects, Bioavailability
Bioavailability of Oleanolic Acid Formulated as Functional Olive Oil
The oral bioavailability of Oleanolic acid (OA) when formulated as functional olive oil, and its mechanisms of systemic transport, will be approached by mean of randomized and controlled trial with 20 healthy volunteers.
- Trial name
- BIO-OLTRAD (NCT05529953)
- Testing
- Oleanolic acid (CAS no. 598-02-1; PubChem CID 10494), Control commercial olive oil
- Where
- Spain
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Spanish National Research Council
Obesity, Mycoses
Effect of Weight and/or Obesity on Anidulafungin Drug Concentrations
This study will find how weight affects the dosing of a drug called anidulafungin. Currently, the amount of anidulafungin a patient receives is the same regardless of the patient's weight.
- Trial name
- NCT01307930
- Testing
- Anidulafungin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Postoperative Pain, Postoperative Analgesia
A Predictive Model for Postoperative Analgesic Requirements After Abdominal Surgery
Postoperative pain remains a common challenge after abdominal surgery despite the use of standard multimodal pain management strategies.
- Conditions
- Postoperative Pain, Postoperative Analgesia, Opioid Analgesic Requirement, Pain Management After Abdominal Surgery
- Trial name
- NCT07803575
- Testing
- Intravenous Morphine Patient-Controlled Analgesia
- Where
- Malaysia
- Volunteers
- 65 people
- Sponsor
- Chaw Sook Hui
Intensive Care Unit, Postoperative Care
Pharmacokinetics-pharmacodynamics and Safety of Dexmedetomidine in Children
This study evaluates pharmacokinetics and pharmacodynamics of dexmedetomidine for children under sedation at intensive care unit after surgery.
- Trial name
- NCT04027829
- Testing
- Dexmedetomidine Hydrochloride
- Where
- South Korea
- Volunteers
- 13 people
- Sponsor
- Seoul National University Hospital
Abiraterone Acetate, Gene Polymorphism
Effects of Metabolic Enzymes and Transporter Gene Polymorphisms on the Pharmacokinetics and Metabolism of Oral Abiraterone Acetate in Healthy Chinese Adults
1. To explore the relationship between the changes of plasma concentration of abiraterone acetate after taken orally on fasting or postprandial and gene polymorphism. 2.
- Conditions
- Abiraterone Acetate, Gene Polymorphism, Pharmacokinetic, Metabolic Analysis
- Trial name
- NCT04735913
- Testing
- Abiraterone acetate tablets
- Where
- China
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital