Clinical trials: Pharmacokinetic Profile
Pharmacokinetics
A Pharmacokinetic Study of Colchicine With an Oral Contraceptive
This study will evaluate the effect, if any, of twice daily dosing of colchicine 0.6 mg at steady state on the steady state pharmacokinetic profile of ethinyl estradiol and norethindrone (Ortho-Novum 1/35).
- Trial name
- NCT01040845
- Testing
- Norethindrone/Ethinyl Estradiol, Colchicine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mutual Pharmaceutical Company, Inc.
Healthy
Different Types of Fruits on Metabolic Function and Cognitive Performance
Primary objective is to assess the effect of the intake of different types of fruits on memory and attention. Secondary objective is to assess effect of intake of different types of fruits on metabolic markers, including glucose…
- Trial name
- WBB2 (NCT02736331)
- Testing
- Treatment 1, Treatment 2
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Healthy Volunteers
Pharmacokinetic Profile of OROS Hydromorphone in Healthy Taiwanese Participants With Different Genotypes for the UGT2B7 Gene
The purpose of this study is to investigate the pharmacokinetics of OROS hydromorphone in healthy adult Taiwanese participants after the oral administration of a single 16 mg dose.
- Trial name
- NCT01487564
- Testing
- Hydromorphone 16 mg
- Where
- Taiwan
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Ulcerative Colitis
Safety and Pharmacokinetic Study of LYC-30937 in Subjects With Active Ulcerative Colitis
The purpose of this study to assess the pharmacokinetic profile in patients with active ulcerative colitis and compare it to the experience in healthy volunteers.
- Trial name
- NCT02818543
- Testing
- LYC-30937
- Where
- 2 sites in Hungary
- Volunteers
- 6 people
- Sponsor
- Lycera Corp.
Formulation Finding
Study Evaluating the Pharmacokinetic Profile of Novel Formulations of RHUDEX®
The primary objectives of the study are: To compare the pharmacokinetic profiles of RhuDex administered as two novel oral formulations To identify the lead formulation and optimise the pharmacokinetic profile by modifying the…
- Trial name
- NCT01500122
- Testing
- RhuDex
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- MediGene
Alzheimer's Disease
Safety and Effect on Memory of PYM50028 in Mild Alzheimer's Disease
The purpose of this study is to assess the effect of PYM50028 administered once daily for up to 12 weeks on the memory and other faculties of subjects with dementia due to Alzheimer's disease.
- Trial name
- NCT00130429
- Testing
- PYM50028
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Phytopharm
Neuropathic Pain
Safety, Tolerability and Pharmacokinetics of Single Ascending Doses of REL-1017 (d-Methadone)
This study evaluated the safety, tolerance, and pharmacokinetics (PK) of d-methadone in a limited dose range, in single administrations in humans.
- Trial name
- NCT03637361
- Testing
- REL-1017
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Relmada Therapeutics, Inc.
Healthy Volunteers
To Evaluate the Safety, Tolerability and Pharmacokinetics of Oral NNZ-2591 in Healthy Volunteers
The purpose of this study is to assess the safety, tolerability and pharmacokinetics of NNZ-2591 when administered to healthy volunteers.
- Trial name
- NCT04379869
- Testing
- NNZ-2591
- Where
- 2 sites in Australia
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Neuren Pharmaceuticals Limited
Hypertension and Chronic Heart Failure
Safety, Tolerability, Pharmacokinetic, Including Food Interaction, and Pharmacodynamic Profile of BIA 5-1058.
The purpose of this study is to to assess the safety and tolerability of BIA 5 1058 after single and multiple oral doses
- Trial name
- NCT02151994
- Testing
- BIA 5-1058
- Where
- Netherlands
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Hepatitis B
Phase Ia/Ib Trial of SCTA02A Injection in Healthy Adults and Patients With Chronic Hepatitis B
Study SCTA02A-A101 is designed to assess the safety, tolerability and pharmacokinetics of SCTA02A in healthy volunteers and participants with chronic hepatitis B virus infection.
- Trial name
- NCT07903831
- Testing
- SCTA02A
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sinocelltech Ltd.
Healthy
Evaluating of Pharmacokinetic Profile of BCWP_C003 and Co-administration of Rosuvastatin and Metformin
The purpose of this study is to evaluate the pharmacokinetic Profile and Safety/Tolerability of BCWP_C003 compared to Co-Administration of Crestor 10mg and Glucophage XR 1000mg, and to evaluate the food effect of Pharmacokinetic…
- Trial name
- NCT01992211
- Testing
- Rosuvastatin, Metformin, BCWP_C003
- Where
- South Korea
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- BC World Pharm Co. Ltd.
Healthy Volunteers
QG101-23-0 Capsules SAD and MAD Study in Healthy Subjects
The study will consist of three parts: a single-dose ascending (SAD) phase (Part A) enrolling a total of five ~ six cohorts of healthy participants, a multiple-dose ascending (MAD) phase (Part B) enrolling 3 cohorts of healthy…
- Trial name
- NCT05650528
- Testing
- QG101-23-0 capsules
- Where
- Australia
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Amckaus PTY LTD.
Healthy
PK, Tolerability and Safety of the Co-administration of Sancuso® (Transdermal Granisetron) and IV Granisetron
This study has been designed to investigate the pharmacokinetic and safety profile of the co-administration of intravenous (IV) and transdermal granisetron, as well as characterise the pharmacokinetics of multiple transdermal…
- Trial name
- NCT00873197
- Testing
- granisetron
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Kyowa Kirin Co., Ltd.
Epilepsy
The Effect of BIA 2-093 on the Steady-state Pharmacokinetic Profile of Phenytoin in Patients
The purpose of this study is determine the interaction of eslicarbazepine acetate (ESL, BIA 2-093) on the steadystate pharmacokinetics of phenytoin in patients and to evaluate the tolerability and safety of ESL administered…
- Trial name
- NCT01878578
- Testing
- Eslicarbazepine acetate, phenytoin
- Where
- Portugal
- Volunteers
- 4 people
- Sponsor
- Bial - Portela C S.A.
Advanced Solid Tumors
A Study of KM501 in Patients With Solid Tumors
A single-arm, open, multicenter Phase I study to evaluate the safety, tolerability, pharmacokinetic profile, and efficacy of the KM501 double-antibody ADC in subjects with advanced solid tumors that express, amplify, or mutate…
- Trial name
- NCT05804864
- Testing
- KM501
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Xuanzhu Biopharmaceutical Co., Ltd.
Neoplasms Malignant
A Study of B1962, a PD-L1/VEGF Bispecific Antibody Fusion Protein, for Advanced Solid Tumors
This study is to characterize the safety, tolerability, pharmacokinetics (PK), and anti-tumor activity of B1962, a PD-L1/VEGF bispecific antibody fusion protein, as a single agent in adult subjects with advanced solid tumor…
- Trial name
- NCT05650385
- Testing
- B1962
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Tasly Biopharmaceuticals Co., Ltd.
Chronic Hepatitis C
A Study of the PK, Safety and Antiviral Activity of A-831 in HCV Carriers
The purposes of this study are: to determine the safety and tolerability of multiple doses of A-831 at various doses to determine how multiple doses of A-831 are distributed through the bloodstream to determine if A-831 reduces…
- Trial name
- CP104 (NCT00522808)
- Testing
- A-831
- Where
- 3 sites in New Zealand, United Kingdom
- Volunteers
- 36 people
- Sponsor
- Arrow Therapeutics
Healthy Volunteers
A Study to Compare the Safety, Tolerability, and Pharmacokinetics of CTP-692 Versus D-serine in Healthy Volunteers
This study will assess the safety, tolerability and pharmacokinetic (PK) profile of CTP-692 vs D serine.
- Trial name
- NCT03778320
- Testing
- CTP-692, D-Serine
- Where
- Australia
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Concert Pharmaceuticals