Clinical trials: Pharmacokinetics
Not Applicable as This is a Mass Balance/Pharmacokinetic Study Performed in Healthy Subjects, Apathy
Phase I Trial Evaluating the Pharmacokinetics of Single Ascending Oral Doses of IRL757 in Healthy Elderly Volunteers
This is a phase I trial evaluating the pharmacokinetics of single ascending oral doses of IRL757 in healthy elderly volunteers.
- Trial name
- NCT06699628
- Testing
- IRL757
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Integrative Research Laboratories AB
Pharmacokinetics
Safety and Pharmacokinetics of Cannabidiol in Healthy Volunteers
The purpose of this study is to assess the pharmacokinetics, safety, tolerability and food effect of investigational drug MRX1 in healthy adults.
- Trial name
- NCT06854783
- Testing
- Cannabidiol
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tiamat Australia Pty Ltd
Pharmacokinetics, Safety
Study in Healthy Subjects to Investigate the Relative Bioavailability and Safety of Pasireotide After Single Subcutaneous Dose Administration Using a Reusable ServoPen With Cartridge as Compared to Administration Using a Syringe Drawn From an Ampule
This single-center Phase 1 study in healthy male and female subjects of 18 to 55 years (inclusive) will follow an open-label, randomized, single-dose, crossover design with 2 intervention periods.
- Trial name
- PASIPHY_PEN (NCT07312643)
- Testing
- Pasireotide cartridge with reusable ServoPen, Pasireotide ampule with syringe
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- RECORDATI GROUP
Pharmacokinetics
Multiple Ascending Dose Noribogaine PK/PD in Healthy Volunteers
This trial will be a randomised, double-blind, sequential-group, multiple-dose, placebo-controlled, dose escalation trial to characterise the pharmacokinetics (PK), pharmacodynamics (PD) and safety of noribogaine in healthy adult…
- Trial name
- NCT06480981
- Testing
- Noribogaine
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- DemeRx NB
Pharmacokinetic, Olverembatinib
Pharmacokinetics of Olverembatinib in Participants With Hepatic Impairment
This is a non-randomized, open-label, parallel, single-dose study to evaluate the pharmacokinetic profile of olverembatinib in participants with normal or impaired liver function.
- Trial name
- NCT07282093
- Testing
- Olverembatinib 20mg
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ascentage Pharma Group Inc.
Safety, Tolerability
A Phase 1 Study of Y-3 in US Healthy Volunteers.
The goal of this clinical trial is to assess the safety, tolerability, and pharmacokinetic profiles of Y-3 in healthy adult volunteers in the United States.
- Conditions
- Safety, Tolerability, Pharmacokinetic Study in Healthy Volunteers
- Trial name
- NCT06770491
- Testing
- Y-3 for injection
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Neurodawn Pharmaceutical Co., Ltd.
Pharmacokinetics
Ceftibuten/VNRX-7145 in Participants With Varying Degrees of Renal Function
This is an open-label, multicenter, parallel-group study in participants with normal renal function, mild, moderate, or severe renal impairment, or end stage renal disease (ESRD) undergoing standard intermittent dialysis.
- Trial name
- NCT05488678
- Testing
- VNRX-7145, Ceftibuten
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Basilea Pharmaceutica
Pharmacokinetics
Food Effect on Ceftibuten/VNRX-7145 in Healthy Participants
This is an open label, two period (fasted and fed), crossover study in up to 3 cohorts of 12 healthy adult participants per cohort (up to 36 participants in total).
- Trial name
- NCT05527834
- Testing
- VNRX-7145, Ceftibuten
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Basilea Pharmaceutica
Pharmacokinetics in Healthy Volunteers
A Study to Evaluate the Relative Bioavailability of Pimicotinib Capsules Containing Free Base in Different Proportions in Healthy Subjects
This is an open-label, randomized, two-treatment, single-dose, two-way crossover study to evaluate the relative bioavailability and tolerability of Pimicotinib capsules containing free base in different proportions in healthy…
- Trial name
- NCT07210996
- Testing
- pimicotinib capsules
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Abbisko Therapeutics Co, Ltd
Similarity of Pharmacokinetics and Safety
Comparison of Pharmacokinetics and Safety of HS632 and Xolair® With a Single Injection
To evaluate the bioequivalence of HS632 and Omalizumab (Xolair®) in a single subcutaneous administration in healthy subjects.
- Trial name
- NCT04361812
- Testing
- HS632, Omalizumab (Xolair®)
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- BioRay Pharmaceutical Co., Ltd.
Healthy Volunteers - Male and Female, Pharmacokinetic Study in Healthy Volunteers
OEA and LipiSperse Metabolic Study
A placebo controlled, single blind, cross-over study evaluating the short-term effect of oleoylethanolamide (OEA) with LipiSperse supplementation on metabolic pathways in healthy participants.
- Trial name
- NCT06840080
- Testing
- 125mg OEA with LipiSperse, 250mg OEA with LipiSperse
- Where
- Australia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- RDC Clinical Pty Ltd
Pharmacokinetics, Solid Tumor
Study of Boserolimab (MK-5890) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Adults With Advanced Solid Tumors (MK-5890-001)
The purpose of this study is to assess the safety and pharmacokinetics of boserolimab (MK-5890) when administered alone and in combination with pembrolizumab (MK-3475) in adults.
- Conditions
- Pharmacokinetics, Solid Tumor, Carcinoma, Non-Small-Cell Lung, Triple Negative Breast Neoplasms
- Trial name
- NCT03396445
- Testing
- Boserolimab, Pembrolizumab, Pemetrexed
- Where
- 18 sites in United States, Chile and 5 more
- Volunteers
- 182 people
- Sponsor
- Merck Sharp & Dohme LLC
Pharmacokinetics Study on Healthy Volunteers Adults
Evaluation of the Concentration of ANT3310 and Meropenem in the Lung in Healthy Adult Participants
This is an open-label, non-randomized, single-center, repeated i.v. doses, Phase 1 trial to evaluate the pharmacokinetics, safety, and tolerability of a combination of MEM-ANT3310 in healthy adult female and male participants who…
- Trial name
- NCT06916156
- Testing
- ANT3310, Meropenem
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Antabio
Safety, Pharmacokinetics
Single Ascending Doses of Kratom in Healthy Nondependent Adults With Opioid Experience
Kratom (Mitragyna speciosa) is a plant often used to self-treat conditions such as pain, coughing, diarrhea, anxiety and depression, opioid use disorder, and opioid withdrawal.
- Conditions
- Safety, Pharmacokinetics, Pharmacodynamics
- Trial name
- NCT06072170
- Testing
- Kratom
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Altasciences Company Inc.
Pharmacokinetics
A Study to Evaluate the the Bioequivalence of Two Different Pimicotinib Capsules in Healthy Subjects
This is a study to evaluate bioequivalence and tolerability of two different pimicotinib capsules in healthy subjects under fasting condition.
- Trial name
- NCT07126249
- Testing
- pimicotinib capsules
- Where
- China
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Abbisko Therapeutics Co, Ltd
Pharmacokinetic Differences, Y-3
Y-3 for Injection in Patients With Hepatic Insufficiency and Healthy Subjects
The goal of this clinical trial is to assess the pharmacokinetic profiles and safety of Y-3 in subjects with mild hepatic insufficiency (Child-Pugh: grade A), moderate hepatic insufficiency (Child-Pugh: grade B) and gender, age…
- Conditions
- Pharmacokinetic Differences, Y-3, Saftey, Mild Hepatic Insufficiency
- Trial name
- NCT07055412
- Testing
- Y-3 for injection（40mg）
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Neurodawn Pharmaceutical Co., Ltd.
Safety, Pharmacokinetics
Single and Multiple Intravenous Administrations of Estetrol (E4) in Healthy Adult Volunteers
The Sponsor intends to develop an intravenous (i.v.) formulation of E4 for the treatment of neonatal hypoxic-ischemic encephalopathy (NHIE). E4 has not been administered intravenously to humans yet.
- Trial name
- NCT05460065
- Testing
- single E4 28.3 mg, single E4 94.4 mg, multiple E4 94.4 mg
- Where
- Bulgaria
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- NEURALIS s.a.
Advanced Solid Malignancy, Safety and Tolerability
Safety, Tolerability & Potential Anti-cancer Activity of Increasing Doses of AZD5363 in Different Treatment Schedules
This study is designed to investigate the safety and tolerability of a new drug, AZD5363, in patients with advanced cancer - and to identify a dose and schedule that can be used in the future.
- Conditions
- Advanced Solid Malignancy, Safety and Tolerability, Pharmacokinetics, Pharmacodynamics
- Trial name
- NCT01226316
- Testing
- AZD5363
- Where
- 34 sites in United States, Canada and 8 more
- Volunteers
- 285 people
- Sponsor
- AstraZeneca
The Effects of Clarithromycin or Cyclosporine on Pharmacokinetics of Deuterium Hydrobromide Ramidvir Tablets in Healthy Chinese Subjects
Effect of Pharmacokinetics in Healthy Chinese Subjects
This study is a single-center, open label, self-controlled phase I clinical study, to evaluate the effects of clarithromycin or cyclosporine on pharmacokinetics of deuterium hydrobromide ramidvir tablets in healthy Chinese…
- Trial name
- NCT06005714
- Testing
- Mindeudesivir hydrobromide tablets and Clarithromycin tablets, Mindeudesivir hydrobromide tablets and Cyclosporine softgels
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Shanghai Vinnerna Biosciences Co., Ltd.
Pharmacokinetics
To Evaluate the Safety, Tolerability and Pharmacokinetic of SAL0133 Tablets in Chinese Adult Healthy Subjects
To evaluate the safety and tolerance of single and multiple administrations of SAL0133 tablets in adult healthy subjects in China receptivity.
- Trial name
- NCT07030504
- Testing
- SAL0133
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Shenzhen Salubris Pharmaceuticals Co., Ltd.