Clinical trials: Pharmacokinetics of Methotrexate
Arthritis, Rheumatoid
Evaluation of Pharmacokinetics and Safety of GSK3196165 in Combination With Methotrexate in Japanese Subjects With Rheumatoid Arthritis
This is a randomized, double-blind, parallel group, 3 dosage level, placebo-controlled, Phase 1/2 study designed to evaluate the pharmacokinetics, safety, tolerability, and efficacy of the monoclonal antibody GSK3196165, in…
- Trial name
- NCT03028467
- Testing
- GSK3196165 Dose 1, GSK3196165 Dose 2, GSK3196165 Dose 3
- Where
- 32 sites in Japan
- Volunteers
- 15 people
- Sponsor
- GlaxoSmithKline
Rheumatoid Arthritis
Safety, Tolerance, Pharmacokinetics and Activity of HE3286 in Patients With Rheumatoid Arthritis
The purpose of this pilot, exploratory study is to evaluate the safety, tolerance, pharmacokinetics and potential anti-inflammatory activity of an investigational agent, HE3286, when administered orally for 29 days to patients…
- Trial name
- NCT00712114
- Testing
- HE3286
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Harbor Therapeutics
Drug Interaction
A Drug-drug Interaction Study to Evaluate the Effect of Rifampicin and Febuxostat on the Pharmacokinetics of Methotrexate in Healthy Subjects
To investigate the effect of rifampicin and febuxostat on pharmacokinetics of methotrexate in healthy volunteers
- Trial name
- NCT05575297
- Testing
- Methotrexate Sodium, Rifampicin Sodium, Febuxostat Tablets
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Rheumatoid Arthritis
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics/Pharmacodynamics (PK/PD) of Ocrelizumab in Patients With Rheumatoid Arthritis
This study will evaluate the efficacy, safety and PK/PD of ocrelizumab at each dose in combination with methotrexate（MTX）in patients with active rheumatoid arthritis (RA).
- Trial name
- NCT00779220
- Testing
- methotrexate, ocrelizumabu 50mg, ocrelizumabu 200mg
- Where
- 7 sites in Japan
- Volunteers
- 152 people
- Sponsor
- Chugai Pharmaceutical
Rheumatoid Arthritis
A Trial to Evaluate the Safety and Tolerability of Namilumab (MT203) in Patients With Mild to Moderate Rheumatoid Arthritis
The purpose of this trial is primarily to investigate the safety and tolerability of repeated subcutaneous injections of MT203 in patients with mild to moderate rheumatoid arthritis.
- Trial name
- PRIORA (NCT01317797)
- Testing
- namilumab (MT203)
- Where
- 2 sites in Bulgaria, Netherlands
- Volunteers
- 24 people
- Sponsor
- Takeda
Rheumatoid Arthritis
Dose Optimisation Study of ART621 in Subjects Diagnosed With Rheumatoid Arthritis Taking Methotrexate
The purpose of this clinical trial is to establish what dose level and dosing frequency is optimal in the treatment of rheumatoid arthritis patients with ART621.
- Trial name
- NCT00854685
- Testing
- ART621
- Where
- Sri Lanka
- Volunteers
- 27 people
- Sponsor
- Arana Therapeutics Ltd
Rheumatoid Arthritis
A Drug Interaction Study to Evaluate the Pharmacokinetics of ASP015K and Methotrexate in Patients With Rheumatoid Arthritis
A drug interaction study to evaluate the effect of ASP015K (twice daily) on the pharmacokinetics (PK) of once weekly oral methotrexate (MTX).
- Trial name
- NCT01754805
- Testing
- peficitinib, methotrexate
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Astellas Pharma Inc
Rheumatoid Arthritis
A Study of the Pharmacokinetics and Safety of MK-8808 (MK-8808-002)
This is a study of the overall safety, tolerability, and pharmacokinetics (PK) of MK-8808 versus rituximab (MabThera® and Rituxan®) in participants with moderate to severe RA with an inadequate response or intolerance to…
- Trial name
- NCT01390441
- Testing
- MK-8808, MabThera® (rituximab), Methotrexate
- Volunteers
- 100 people
- Sponsor
- Merck Sharp & Dohme LLC