Clinical trials: Pharmacological Action
Pre-diabetes
Resveratrol and First-degree Relatives of Type 2 Diabetic Patients
The main objective of the study is to investigate if resveratrol supplementation can improve overall and muscle-specific insulin sensitivity in first-degree relatives of type 2 diabetic patients.
- Trial name
- NCT02129595
- Testing
- resveratrol
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Maastricht University Medical Center
Pharmacological Action
"Corticoid-16" in Long Term When Administered Systemically in Patients in Routine Medical Practice
Evaluation of pharmacokinetic parameters of diprospan in long term when administered systemically in patients in routine medical practice. Applied research project. Design: open-comparative prospective cohort study.
- Trial name
- NCT03119454
- Testing
- Diprospan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Scientific Institution, Scientific Research Institute of Rheumatology
Coronary Artery Disease, Myocardial Infarction
Aspirin Response in High Risk Patients With Coronary Artery Disease
Previous studies indicate that patients with cardiovascular disease have a variable response to aspirin. Despite treatment with aspirin a large number of patients suffer a myocardial infarction.
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Diabetes Mellitus, Renal Insufficiency, Chronic
- Trial name
- NCT01383304
- Where
- Denmark
- Volunteers
- 906 people
- Sponsor
- University of Aarhus
Adult Diffuse Large Cell Lymphoma, Recurrent
DPX-Survivac and Checkpoint Inhibitor in DLBCL
This is a Phase 2 non-randomized, open label, uncontrolled, efficacy and safety study. Study participants will receive two priming doses of 0.5mL of DPX-Survivac 21 days apart and up to six 0.1ml maintenance injections every two…
- Conditions
- Adult Diffuse Large Cell Lymphoma, Recurrent, Adult Refractory Diffuse Large B-Cell Lymphoma
- Trial name
- SPiReL (NCT03349450)
- Testing
- DPX-Survivac, Pembrolizumab, Cyclophosphamide 50mg
- Where
- 6 sites in Canada
- Volunteers
- 25 people
- Sponsor
- Sunnybrook Health Sciences Centre
Neuromuscular Blockade
Effect of Magnesium on the Recovery Time of Neuromuscular Blockade With Sugammadex
The aim of this study is to determine the recovery time of moderate neuromuscular blockade with sugammadex in adults pretreated with magnesium sulfate.
- Trial name
- NCT01828385
- Testing
- Magnesium Sulfate, Saline
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Healthy
Effects of Psilocybin on Behavior, Psychology and Brain Function in Long-term Meditators
This is a double-blind placebo-controlled study investigating the acute and persisting effects of psilocybin on meditation, spirituality, health, well-being, prosocial attitudes, and brain functioning.
- Trial name
- NCT02145091
- Testing
- Moderately-high dose of psilocybin, Moderately-low dose of psilocybin, Very-low dose of psilocybin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Myelodysplastic Syndromes
Study of Azacitidine in Adult Taiwanese Subjects With Higher-Risk Myelodysplastic Syndromes (MDS)
The primary purpose of this study is to determine the effectiveness and safety of azacitidine in the treatment of Taiwanese subjects with higher-risk Myelodysplastic Syndrome (MDS).
- Trial name
- NCT01201811
- Testing
- Azacitidine
- Where
- 11 sites in Taiwan
- Volunteers
- 44 people
- Sponsor
- Celgene
Nicotine Withdrawal, Marijuana Dependence
Medications Development for the Treatment of Cannabis Related Disorders
The primary objective of this application is to test the neurobehavioral mechanisms and effects of aprepitant as a new cessation agent for cannabis, tobacco or both.
- Conditions
- Nicotine Withdrawal, Marijuana Dependence, Cannabis Dependence, Nicotine Dependence
- Trial name
- MTC (NCT01204723)
- Testing
- Active Aprepitant
- Where
- 2 sites in United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Chronic Hepatitis C Virus
Safety and Efficacy of Ledipasvir/Sofosbuvir Fixed-Dose Combination (FDC) With and Without Ribavirin for the Treatment of HCV
The purpose of this study is to evaluate the safety, tolerability, and antiviral efficacy of ledipasvir (LDV)/sofosbuvir (SOF) fixed-dose combination (FDC) tablets with or without ribavirin (RBV) administered for 12 and 24 weeks…
- Trial name
- NCT01701401
- Testing
- LDV/SOF, RBV
- Where
- 88 sites in United States, France and 5 more
- Volunteers
- 870 people
- Sponsor
- Gilead Sciences
Spinal Cord Injury, Spinal Cord Injuries
Testosterone Plus Finasteride Treatment After Spinal Cord Injury
The purpose of this study is to determine whether testosterone plus finasteride treatment will improve musculoskeletal health, neuromuscular function, body composition, and metabolic health in hypogonadal men who have experienced…
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Trauma, Nervous System, Wounds and Injuries
- Trial name
- NCT02248701
- Testing
- Testosterone Enanthate, Finasteride
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- VA Office of Research and Development
Obesity, Nutrition Disorders
Drug Concentration Analysis of Micafungin in Overweight, Obese, and Extremely Obese Volunteers
The purpose of this study is to assess the drug concentration of Micafungin amongst healthy volunteers having different weight groups.
- Conditions
- Obesity, Nutrition Disorders, Overweight
- Trial name
- Micafungin (NCT01090141)
- Testing
- Micafungin
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Pharmacological Action
Test of a New Gel-based Colon Cleansing Agent Compared to Moviprep
Crossover study comparing Moviprep (for bowel cleansing) with a new gel-based colon cleansing agent before colonoscopy
- Trial name
- NCT03904303
- Testing
- A 06 ad
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Major Depressive Disorder
A Study of LY03005 vs Pristiq
The objective of this study is to evaluate relative bioavailability between 80 mg LY03005 oral tablets and 50 mg Pristiq® oral tablets after a single dose of each drug in a cross-over 2-period design under fasting condition in…
- Trial name
- NCT03733574
- Testing
- LY03005, Pristiq
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Luye Pharma Group Ltd.
Stroke, Cerebrovascular Disorders
Propranolol on Post Stroke Immune Status and Infection
Stroke-associated pneumonia (SAP) is one of the important risk factors influencing poor outcomes and death in stroke patients. Over the past two decades, accumulating evidence suggests that post-stroke brain injury mobilizes the…
- Conditions
- Stroke, Cerebrovascular Disorders, Ischemic Stroke, Brain Diseases
- Trial name
- NCT05375240
- Testing
- Propranolol, Ceftriaxone
- Where
- 2 sites in China
- Volunteers
- 45 people
- Sponsor
- Tianjin Medical University General Hospital
Pharmacological Action
Pharmacokinetics and Excretion of Albendazole and Its Metabolites in Saliva
This project will develop and assess the feasibility and acceptability of a salive-based assay to monitor adherence to Mass Drug Administration (MDA) campaigns within Soil-transmitted helminthiasis (STH) control programs…
- Trial name
- NCT05453045
- Testing
- Albendazole
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Salta
Communicable Diseases, Infection
Probiotics to Promote Intestinal Health
The purpose of this study is to evaluate the effectiveness of bacteria called Lactobacillus GG, a Probiotic, in preventing the growth of resistant bacteria in the digestive tract in patients on broad spectrum antimicrobials.
- Conditions
- Communicable Diseases, Infection, Anti-Infective Agents, Therapeutic Uses
- Trial name
- NCT02046512
- Testing
- Probiotic
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Washington University School of Medicine
Pharmacological Action (PA)
The Effect Methylphenidate Hydrochloride on Pain and Auditory Sensitivity in Healthy Subjects
1. To examine whether Ritalin has analgesic properties in healthy subjects. 2. To examine if Ritalin analgesic effect is a pain specific phenomenon or a part of a broader, non-specific effect on high mental functions.
- Trial name
- NCT01914822
- Testing
- methylphenidate hydrochloride
- Where
- Israel
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Viral Infection
Safety and Pharmacokinetics of UV-4B Solution Administered Orally as Multiple Ascending Doses to Healthy Subjects
The purpose of this study is to evaluate the safety and pharmacokinetics of UV-4B oral solution when administered to healthy subjects three times a day (TID) for 7 days.
- Trial name
- NCT02696291
- Testing
- UV-4B 30 mg oral solution, UV-4B 75 mg oral solution, UV-4B 150 mg oral solution
- Where
- 2 sites in United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Open-angle Glaucoma, Ocular Hypertension
Efficacy of Changing to TRAVATAN® From Prior Therapy
The purpose of this study was to assess the efficacy and tolerability of TRAVATAN® solution without BAK (benzalkonium chloride) after changing from prior latanoprost 0.005% ophthalmic solution monotherapy in subjects with…
- Trial name
- NCT01510145
- Testing
- Travoprost 0.004% BAK-free
- Volunteers
- 191 people
- Sponsor
- Alcon Research
Pharmacological Action
Exploratory Pharmacokinetic Study of Virgin Coconut Oil (VCO)
This is a balanced, open-label, single- and multiple-dose pharmacokinetic (PK) study of virgin coconut oil (VCO) among healthy Filipino male adults 18-45 years of age in Dasmariñas, Cavite.
- Trial name
- NCT06324370
- Testing
- Virgin Coconut Oil
- Where
- Philippines
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Food and Nutrition Research Institute, Philippines