Clinical trials: Pharyngeal Cancer
Oropharyngeal Neoplasms, Robotic Surgery and/or Radiotherapy
Phase II Randomized-registry Embedded Study of Lymphoscintigraphy for Oropharyngeal Neoplasms to Enable Risk-adapted Nodal Guidance for Robotic Surgery and/or Radiotherapy (LONE-RANGR2)
To test a new radiation treatment design based on where your cancer is located. Most participants with oropharyngeal cancer are treated with radiation to both sides of the neck.
- Conditions
- Oropharyngeal Neoplasms, Robotic Surgery and/or Radiotherapy, Lymphoscintigraphy
- Trial name
- NCT06167291
- Testing
- Arm 1- Ipsilateral
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- M.D. Anderson Cancer Center
Nasopharyngeal Carcinoma
Chemotherapy Combined With Radiotherapy vs Chemotherapy Alone for Distant Metastatic Nasopharyngeal Carcinoma
This is a randomized parallel control trial to evaluate whether radical loco-regional Radiotherapy can prolong survival time of initial untreated metastatic nasopharyngeal carcinoma.
- Trial name
- NCT02111460
- Testing
- Loco-regional Radiotherapy
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Sun Yat-sen University
Recurrent or Metastatic Nasopharyngeal Carcinoma
Combination Therapy for PD-1 Resistant Recurrent or Metastatic Nasopharyngeal Carcinoma: A Bayesian Adaptive Phase II Trial
This is a prospective, Bayesian adaptive, phase II clinical trial designed to evaluate the safety and efficacy of four treatment regimens in patients with recurrent (unamenable to local therapy) or metastatic nasopharyngeal…
- Trial name
- NCT07070479
- Testing
- Ivonescimab, Nimotuzumab, Irinotecan liposome
- Where
- 6 sites in China
- Volunteers
- 208 people
- Sponsor
- Ming-Yuan Chen
Nasopharynx Cancer
Photon/Proton Radiation Therapy for Carcinoma of the Nasopharynx
The purpose of this study is to collect outcomes information to see what effects photon/proton beam radiation has on nasopharynx cancer.
- Trial name
- NP01 (NCT00797290)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Florida
Nasopharyngeal Carcinoma, Chemotherapy
Toripalimab Plus Concurrent Chemo-radiotherapy for Unresectable Locally Recurrent Nasopharyngeal Carcinoma
Through multicenter, open-label, randomised clinical trials, we intend to demonstrate that concurrent and adjuvant PD-1 treatment added to concurrent chemo-radiotherapy could further decrease the rate of disease progression and…
- Conditions
- Nasopharyngeal Carcinoma, Chemotherapy, Radiotherapy, PD-1 Treatment
- Trial name
- NCT04453813
- Testing
- Toripalimab plus concurrent chemo-radiotherapy, Concurrent chemo-radiotherapy
- Where
- 6 sites in China
- Volunteers
- 226 people
- Sponsor
- Sun Yat-sen University
Nasopharyngeal Carcinoma (NPC)
RAIRI Model-Guided Adjuvant Therapy in Nasopharyngeal Carcinoma
This study aims to evaluate a personalized approach for treating patients with locoregionally advanced nasopharyngeal carcinoma (NPC).
- Trial name
- RAIRI-NPC (NCT07590024)
- Testing
- PD-1 inhibitor, Capecitabine
- Where
- China
- Volunteers
- 651 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Nasopharyngeal Carcinoma (NPC)
Effect of Nutritional Management on Patients With Concurrent Chemoradiotherapy for Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma (NPC) is a malignant tumor that develops in the nasopharyngeal mucosal epithelium. Due to the disease itself and the impact of anti-tumor therapy, malnutrition has become a common clinical complication in…
- Trial name
- NCT07085988
- Testing
- Rapid glitter
- Where
- China
- Volunteers
- 109 people
- Sponsor
- Jiangxi Provincial Cancer Hospital
Acinar Cell Carcinoma, Adenoid Cystic Carcinoma
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors
This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may…
- Conditions
- Acinar Cell Carcinoma, Adenoid Cystic Carcinoma, Adrenal Cortical Carcinoma, Adrenal Gland Pheochromocytoma
- Trial name
- NCT02834013
- Testing
- Biospecimen Collection, Computed Tomography, Echocardiography Test
- Where
- 1,007 sites in United States, Guam
- Volunteers
- 798 people
- Sponsor
- National Cancer Institute (NCI)
Human Papilloma Virus (HPV), Cervical Carcinoma
Transmission of Oncogenic HPV Infection Among Families
The goal of the Transmission of Oncogenic HPV Infection Among Families (TREVINO) study is to improve understanding of how high-risk human papillomavirus (HPV) infections are transmitted within families.
- Conditions
- Human Papilloma Virus (HPV), Cervical Carcinoma, Oropharyngeal Carcinoma, Transmission Vertical
- Trial name
- TREVINO (NCT07036211)
- Where
- 2 sites in Finland
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Recurrent Cutaneous Melanoma, Recurrent Lip and Oral Cavity Carcinoma
Donor Natural Killer Cells, Cyclophosphamide, and Etoposide in Treating Children and Young Adults With Relapsed or Refractory Solid Tumors
This phase I trial studies the side effects and best dose of cord blood-derived expanded allogeneic natural killer cells (donor natural killer [NK] cells) and how well they work when given together with cyclophosphamide and…
- Conditions
- Recurrent Cutaneous Melanoma, Recurrent Lip and Oral Cavity Carcinoma, Recurrent Malignant Endocrine Neoplasm, Recurrent Malignant Female Reproductive System Neoplasm
- Trial name
- NCT03420963
- Testing
- Cord Blood-derived Expanded Allogeneic Natural Killer Cells, Cyclophosphamide, Etoposide
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- M.D. Anderson Cancer Center
Nasopharyngeal Carcinoma
Phase Ⅱ Study of Neoadjuvant Chemotherapy Followed by Concurrent Chemoradiation for Stage ⅣAB Nasopharyngeal Carcinoma
The primary objective of this study is to determine the tolerance and overall survival in patients with stage ⅣAB NPC treated with neoadjuvant chemotherapy and concurrent chemoradiation.
- Trial name
- NCT00816816
- Testing
- docetaxel, cisplatin, fluorouracil
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Fudan University
Oropharyngeal Cancer
CompARE: Escalating Treatment of Intermediate and High-risk Oropharyngeal Cancer (OPC)
CompARE is a multicentre, phase III open-label randomised controlled trial using an adaptive, Multi-Arm, Multi-Stage (MAMS) design.
- Trial name
- CompARE (NCT04116047)
- Testing
- Cisplatin, Durvalumab, Radiotherapy
- Where
- 38 sites in Ireland, United Kingdom
- Volunteers
- 785 people
- Sponsor
- University of Birmingham
Hypopharyngeal Carcinoma, Immunotherapy
Induction Chemotherapy Combined With Immunotherapy for Locally Advanced Hypopharyngeal Carcinoma
This is a single-center, multidisciplinary, open-label, single-arm prospective clinical study.
- Conditions
- Hypopharyngeal Carcinoma, Immunotherapy, Chemotherapy
- Trial name
- NCT04156698
- Testing
- Docetaxel, Cisplatin, Capecitabine
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Nasopharyngeal Carcinoma
The Prognostic Value of Human Papilloma Virus in Nasopharyngeal Carcinoma
It is well established that HPV infection has a casual and is a prognostic factor in several cancer types, including oropharynx. We wish to examine if HPV infection has a prognostic significance in nasopharyngeal carcinoma.
- Trial name
- NCT04014738
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rambam Health Care Campus
HNSCC, Lip SCC
Pembrolizumab Combined With Cetuximab for Treatment of Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma
This is a prospective, multi-center, open-label, non-randomized, multi-arm phase II trial to evaluate the efficacy of combination therapy with pembrolizumab and cetuximab for patients with recurrent/metastatic HNSCC.
- Conditions
- HNSCC, Lip SCC, Oral Cavity Cancer, Oropharynx Cancer
- Trial name
- NCT03082534
- Testing
- Pembrolizumab, Cetuximab
- Where
- 4 sites in United States
- Volunteers
- 78 people
- Sponsor
- University of California, San Diego
Squamous Cell Carcinomas of the Head and Neck
Chromoendoscopy to Detect Early Synchronous Second Primary Esophageal Carcinoma
Patients with HNSCC represent a high-risk group for the development of SESCC. Thus, esophagogastrofibroscopy should be performed to detect possible synchronous esophageal carcinomas in these patients.
- Trial name
- HNSCC (NCT01783158)
- Testing
- Esophagoscopy and chromoendoscopy
- Where
- Czechia
- Volunteers
- 132 people
- Sponsor
- University Hospital Ostrava
Head and Neck Cancer, Dysphagia
Effect of Nutri-jelly on Quality of Life in Head and Neck Cancer Patients
The purpose of this study is to determine whether a novel edible nutritious gel for patients with chewing and swallowing difficulties, Nutri-jelly, is effective in improving the quality of life of head and neck cancer patients…
- Trial name
- NCT01871155
- Testing
- Nutri-jelly
- Where
- Thailand
- Volunteers
- 64 people
- Sponsor
- Dental Innovation Foundation Under Royal Patronage
Nasopharyngeal Carcinoma
Phase III Non-Inferiority Trial of Proton Versus Photon Therapy for Nasopharyngeal Carcinoma
This study is a prospective, open-label, multicenter, cohort, phase III non-inferiority clinical trial comparing proton therapy with photon radiotherapy for nasopharyngeal carcinoma.
- Trial name
- NCT07000643
- Testing
- Intensity-Modulated Proton Therapy (IMPT), Intensity-Modulated Radiotherapy (IMRT)
- Where
- China
- Volunteers
- 386 people
- Sponsor
- Man Hu
Nasopharyngeal Carcinoma (NPC)
Molecular Research on Predictive Efficacy and New Therapeutic Targets for Nasopharyngeal Carcinoma
To analyze the spatiotemporal dynamic evolution of nasopharyngeal carcinoma before and after immunotherapy and during tumor progression, 2~3 key cell subsets or node molecules were screened to predict the curative effect.
- Trial name
- NCT07198802
- Testing
- No Intervention
- Volunteers
- 600 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Recurrent / Metastatic Nasopharyngeal Cancer
To Evaluate the Safety and Efficacy of TQB2858 Injection to the Subjects With Recurrent/Metastatic Nasopharyngeal Cancer
This study is a single-arm, randomized, open-label, multi-cohort Phase Ib clinical trial. The experimental drug is TQB2858 Injection. The trial was divided into 3 cohorts.
- Trial name
- NCT05198531
- Testing
- TQB2858 Injection, Anlotinib Hydrochloride Capsule, Gemcitabine hydrochloride injection
- Where
- 7 sites in China
- Volunteers
- 90 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
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