Clinical trials: Pharyngeal Cancer
Xerostomia, Hyposalivation, Saliva Substitute, Radiation-induced Toxicity, Nasopharyngeal Cancer
Saliva Substitute Mouthwash in NPC Survivors With Xerostomia: A Randomized Controlled Trial
Nasopharyngeal carcinoma (NPC) is the highest reported otorhinolaryngological malignancy reported in Malaysia affecting predominantly male adults between 40-60 years old [1, 2].
- Trial name
- NCT04491435
- Testing
- Summated Xerostomia Inventory, Sialometry
- Where
- Malaysia
- Volunteers
- 94 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Nasopharyngeal Carcinoma (NPC)
Proton vs Photon IMRT in Locally Advanced Nasopharyngeal Carcinoma: A Phase III Trial
This multicenter, open-label, randomized Phase III trial evaluates intensity-modulated proton therapy (IMPT) versus intensity-modulated photon radiotherapy (IMRT) in patients with newly diagnosed, high-risk, locoregionally…
- Trial name
- NCT07340515
- Testing
- Intensity-Modulated Proton Therapy (IMPT), Intensity-Modulated Radiation Therapy (IMRT), Cisplatin
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Man Hu
Head and Neck Cancers, Head and Neck Cancers - Nasopharyngeal
Predictive Tools in Head and Neck Cancer Patients Undergoing Radiotherapy
The ITHACA study aims to improve the treatment of head and neck cancer by developing a predictive tool that helps doctors personalize care for each patient.
- Conditions
- Head and Neck Cancers, Head and Neck Cancers - Nasopharyngeal, Oral Cavity Cancer, Oropharyngeal Cancers
- Trial name
- ITHACA (NCT06806683)
- Testing
- intensity modulated radiotherapy
- Where
- Italy
- Volunteers
- 915 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Precancerous Conditions, Leukoplakia
Natural History of Oro-pharyngeal Cancer Precursors
Oro-pharyngeal cancers can develop from squamous dysplastic precursor lesions, which occur in a subset of common white (leukoplakia), red (erythroplasia), or mixed oro-pharyngeal plaques.
- Conditions
- Precancerous Conditions, Leukoplakia, Erythroplasia, Oral Papillomas
- Trial name
- NCT00179361
- Where
- United States
- Volunteers
- 374 people
- Sponsor
- Albert Einstein College of Medicine
Nasopharyngeal Carcinoma
Induction Chemotherapy Plus Radiotherapy Alone in Patients With Locoregionally Advanced Nasopharyngeal Carcinoma
The purpose of this study is to compare induction chemotherapy (TPF or GP) plus radiotherapy alone with induction chemotherapy plus concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma…
- Trial name
- NCT04414566
- Testing
- gemcitabine and cisplatin; docetaxel, cisplatin and fluorouracil, IMRT, IMRT and concurrent cisplatin
- Where
- China
- Volunteers
- 562 people
- Sponsor
- West China Hospital
Nasopharyngeal Carcinoma, Immune Checkpoint Inhibitors
Cadonilimab in the Treatment of Recurrent/Metastatic Nasopharyngeal Carcinoma
This study is a single-arm, multicenter clinical study to evaluate the efficacy and safety of Cadonilimab in combination with gemcitabine/cisplatin as a first-line treatment for recurrent or metastatic nasopharyngeal carcinoma.
- Trial name
- NCT05898256
- Testing
- Cadonilimab, Gemcitabine, Cisplatin
- Volunteers
- 20 people
- Sponsor
- Guangxi Medical University
Nasopharyngeal Carcinoma
A Multicenter Trial Comparing Induction C/T Followed by CCRT v.s. CCRT Alone in Stage IV Nasopharyngeal Carcinoma
Investigate the effect of induction MEPFL chemotherapy followed by concurrent chemoradiotherapy (CCRT) on the disease control and survival in treatment of patients with advanced NPC.
- Trial name
- NCT00201396
- Testing
- CCRT, Mitomycin C,Epirubicin,Cisplatin,5-Fluorouracil,Leucovorin
- Where
- 4 sites in Taiwan
- Volunteers
- 480 people
- Sponsor
- National Health Research Institutes, Taiwan
Oropharyngeal Cancer, HPV-Related Squamous Cell Carcinoma
PROGRESS Trial - Prophylactic Gabapentin for Relief of Symptoms and Improved Swallowing
Enrollment is only available to patients enrolled on the Optima II study (NCT03107182). The purpose of this trial is to compare rates of opioid use at completion of radiation for patients with Common Terminology Criteria for…
- Trial name
- NCT03423264
- Testing
- Gabapentin
- Where
- United States
- Sponsor
- University of Chicago
Head and Neck Cancer
Combination Chemotherapy in Treating Patients With Stage IIB, Stage III, or Stage IV Cancer of the Nasopharynx
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Trial name
- NCT00004164
- Testing
- filgrastim, cisplatin, docetaxel
- Where
- 2 sites in United States
- Sponsor
- Dana-Farber Cancer Institute
Nasopharyngeal Carcinoma
Nimotuzumab Combined With VMAT in Elderly Patients With Nasopharyngeal Carcinoma
To evaluate the efficacy and toxicity of Nimotuzumab combined with VMAT in the treatment of elderly patients with nasopharyngeal carcinoma (> 70 years old), and to provide high-level clinical evidence for the optimal treatment of…
- Trial name
- NCT03915132
- Testing
- Nimotuzumab, VMAT
- Where
- China
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences
Head and Neck Squamous Cell Carcinoma, HPV-Negative Squamous Cell Carcinoma
Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC)
The study is an open-label phase I/II clinical trial. The study will enroll patients to receive neoadjuvant SBRT plus 1 or 2 doses of neoadjuvant pembrolizumab with concurrent ficerafusp alfa (4 doses) prior to definitive…
- Trial name
- NCT07552558
- Testing
- Hypofractionated Stereotactic Body Radiotherapy (SBRT), Pembrolizumab, Ficerafusp alfa
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Washington University School of Medicine
Head and Neck Cancer, Dysphagia
Effect of Nutri-jelly on Quality of Life in Head and Neck Cancer Patients
The purpose of this study is to determine whether a novel edible nutritious gel for patients with chewing and swallowing difficulties, Nutri-jelly, is effective in improving the quality of life of head and neck cancer patients…
- Trial name
- NCT01871155
- Testing
- Nutri-jelly
- Where
- Thailand
- Volunteers
- 64 people
- Sponsor
- Dental Innovation Foundation Under Royal Patronage
Nasopharyngeal Cancer
Assessment of Treatment Response of Nasopharyngeal Cancer Using Simultaneous 18F-FDG-PET and MRI
The overarching goal of this study is to develop PET/MR techniques for accurate assessment of treatment response during and immediately after chemoradiation therapy.
- Trial name
- NCT03656250
- Testing
- PET/CT scans
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- NYU Langone Health
Nasopharyngeal Carcinoma
Study of Concurrent Chemotherapy and Radiotherapy for Stage II Nasopharyngeal Carcinoma
The primary objective of this study is to determine the overall survival in patients with stage II (T1-2N1M0) NPC treated with concurrent chemotherapy and radiotherapy.
- Trial name
- NCT00817258
- Testing
- cisplatin, 3D-CRT (three-dimensional conformal radiation therapy) or IMRT (intensity-modulated radiation therapy)
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Fudan University
Cervical Cancer, Ovarian Clear Cell Carcinoma
Asian Multicenter Prospective Study of ctDNA Sequencing
This study is a genetic analysis of aberrations in circulating tumor DNA (ctDNA) in patients in Asian countries. This study protocol is divided into parts describing several subanalyses that differ in terms of cancer types…
- Conditions
- Cervical Cancer, Ovarian Clear Cell Carcinoma, Nasopharyngeal Carcinoma, Ovarian Cancer
- Trial name
- A-TRAIN (NCT05099978)
- Testing
- NGS analysis of ctDNA
- Where
- 19 sites in Japan, Malaysia and 6 more
- Volunteers
- 506 people
- Sponsor
- National Cancer Center, Japan
Nasopharyngeal Cancer
Nivolumab in Nasopharyngeal Cancer With Progression During or After Platinum-based Treatment
Multicentre , non-randomized, prospective clinical trial to assess efficacy of Nivolumab in treatment of nasopharyngeal cancer who progressed during or after platinum-based chemotherapy .
- Trial name
- NIVONASO-21 (NCT04875611)
- Testing
- Opdivo
- Where
- 4 sites in Poland
- Volunteers
- 32 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Nasopharyngeal Carcinoma (NPC)
Dynamic Risk-adapted EBV-DNA and MRI-guided De-concurrent Chemotherapy in Nasopharyngeal Carcinoma
This study aims to explore the efficacy and safety of risk-adapted adjuvant therapy based on dynamic EBV-DNA changes and MRI in nasopharyngeal carcinoma patients.
- Trial name
- NCT07762976
- Testing
- Observation, Adjuvant therapy
- Where
- China
- Volunteers
- 148 people
- Sponsor
- Fudan University
Nasopharyngeal Carcinoma
Comparison the Effects of Different Neoadjuvant Chemotherapy Regimen on Acute Toxicity, Tumor Response, and Survival in Patients With Advanced Nasopharyngeal Carcinoma
The purpose of this study is to investigate the impact of different neoadjuvant chemotherapy schedules of cisplatin and 5-FU on acute toxicity, tumor response, and long-term survival in patients with advanced nasopharyngeal…
- Trial name
- NCT02500940
- Testing
- Cisplatin, Fluorouracil, Radiation therapy
- Where
- Taiwan
- Volunteers
- 54 people
- Sponsor
- Taichung Veterans General Hospital
Nasopharangeal Cancer, Recurrent Nasopharynx Carcinoma
PD-1 Inhibitor Plus Chemotherapy Followed by Immediate Versus Selective Re-irradiation for Locally Advanced Recurrent NPC
This phase II randomized trial evaluates PD-1 inhibitor plus chemotherapy followed by immediate versus selective re-irradiation in locally advanced recurrent nasopharyngeal carcinoma.
- Trial name
- NCT07332247
- Testing
- Selective re-irradiation, Immediate re-irradiation
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Sun Yat-sen University
Nasopharyngeal Carcinoma
Fosaprepitant for the Prevention of Nausea and Emesis During Concurrent Chemoradiotherapy for Nasopharyngeal Carcinoma
This is an opene-label, single center, randomized prospective pilot study to compare the efficacy of weekly versus triweekly fosaprepitant regimens for the prevention of nausea and emesis during concurrent chemoradiotherapy for…
- Trial name
- NCT04636632
- Testing
- fosaprepitant
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sun Yat-sen University
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