Clinical trials: Pharyngeal Diseases
Pharyngitis
Ambroxol Lozenges 20mg in Relieving the Pain of Sore Throat in Adolescent Patients With Acute Viral Pharyngitis
The purpose of this trial is to investigate efficacy and tolerability of lozenges containing 20mg am broxol hydrochloride relative to placebo in relieving pain of sore throat in adolescent patients suf fering from acute viral…
- Trial name
- NCT00144274
- Testing
- Ambroxol Lozenge
- Where
- 12 sites in South Africa
- Volunteers
- 220 people
- Sponsor
- Boehringer Ingelheim
Multi Drug Resistant, Dysphagia
Evaluation of the Variation of the Intestinal Microbiota and the Integrity of the Intestinal Barrier in Patients With M.D.R. Germ-induced Pneumonia Undergoing Enteral Nutrition
The study aims to evaluate the effects of enteral nutrition in subjects with MDR on the intestinal microbiota
- Trial name
- NCT06485791
- Volunteers
- 50 people
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Achalasia
Per-Oral Endoscopic Myotomy
This is a prospective chart review/data collection study of the per oral endoscopic myotomy (POEM) procedure, that will include questionnaires administered throughout the study.
- Trial name
- POEM (NCT01402518)
- Testing
- Per-oral enodscopic myotomy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Diego
Malocclusion, Angle Class II, Division 1
Pharyngeal Airway Dimensions With Twinblock Versus Myobrace Appliances in Developing Skeletal Class II Patients
The goal of this clinical trial is to compare the pharyngeal airway changes after treatment with Myobrace and after treatment with Twinblock in developing skeletal Class II patients.
- Trial name
- NCT05610150
- Testing
- Myobrace Functional Appliance, Twin Block
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Deglutition, Dysphagia
Movement of Epiglottis During Swallowing
This study will examine how the airway closes during swallowing to prevent food or liquid from entering the voice box or lungs while eating or drinking.
- Trial name
- NCT00475943
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Kaposi´s Sarcoma
Intralesional Bevacizumab for Treating AIDS-associated Kaposi´s Sarcoma of the Larynx, Pharynx and Oral Cavity
Kaposi sarcoma remains the most common malignancy among persons with HIV. Lesions localized to the airway may cause bleeding, pain and dyspnea. New therapeutic approaches for local disease are needed.
- Trial name
- NCT01296815
- Testing
- Bevacizumab
- Where
- Mexico
- Volunteers
- 14 people
- Sponsor
- Centro de Investigación en. Enfermedades Infecciosas, Mexico
Nasopharyngeal Carcinoma
Neoadjuvant and Adjuvant Tislelizumab for Nasopharyngeal Carcinoma
To estimate the efficacy and safety of tislelizumab for stage IVA locally advanced nasopharyngeal carcinoma combined with induction chemotherapy and concurrent chemoradiotherapy, followed by maintenance therapy
- Trial name
- NCT05448885
- Testing
- Tislelizumab
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Head and Neck Squamous Cell Carcinom, Nasopharyngeal Carcinoma
The Safety and Efficacy of Multiple-dose of JS004 in Subject With HNC
A phase I/II clinical study of JS004 in subjects with head and neck cancer in China, to evaluate the safety, tolerability, PK, immunogenicity, antitumor activity and biomarkers of JS004, define the RP2D.
- Trial name
- NCT04929080
- Testing
- JS004 , Recombinant humanized IgG4k monoclonal antibody specific to BTLA for injection Intravenous infusion, JS001 and JS004
- Where
- China
- Volunteers
- 149 people
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
Cardiac Rhythm Disorders, Urological Disorders
Product Surveillance Registry
The purpose of the Registry is to provide continuing evaluation and periodic reporting of safety and effectiveness of Medtronic market-released products.
- Conditions
- Cardiac Rhythm Disorders, Urological Disorders, Neurological Disorders, Cardiovascular Disorders
- Trial name
- PSR (NCT01524276)
- Where
- 402 sites in United States, Argentina and 39 more
- Volunteers
- 100,000 people
- Sponsor
- Medtronic
Nasopharyngeal Carcinoma
Valproic Acid in the Induction of EBV Lytic Cycle Antigen Expression in Nasopharyngeal Carcinoma
The proposed study will test the safety and efficacy of sodium valproate in the induction of Epstein-Barr virus (EBV) lytic cycle antigen expression in tumor tissue of patients undergoing primary therapy for nasopharyngeal…
- Trial name
- NCT00181220
- Testing
- valproic acid
- Where
- Singapore
- Sponsor
- Johns Hopkins University
Oropharyngeal Cancer, Hypopharyngeal Cancer
Safety and Efficacy Study of Nimotuzumab Plus Neoadjuvant and Concurrent Chemoradiotherapy to Treat Oropharynx and Hypopharynx Cancer
The purpose of this study is to evaluate the efficiency and safety of adding nimotuzumab to neoadjuvant and concurrent chemoradiotherapy in the treatment of patients with locoregionally advanced squamous cell carcinoma of the…
- Trial name
- NCT01516996
- Testing
- docetaxel and cisplatin, IMRT, Nimotuzumab
- Where
- 13 sites in China
- Volunteers
- 80 people
- Sponsor
- The Second People's Hospital of Sichuan
Injury; Temporal Region
Dose Constraints for the Temporal Lobes of Intensity-modulated Radiotherapy Treatment Plans for Nasopharyngeal Carcinoma
Radiation-induced temporal lobe injury (TLI) is usually devastating to patients; however, there is a poor understanding of TLI in nasopharyngeal carcinoma (NPC) patients treated with IMRT.
- Trial name
- NCT03539250
- Testing
- IMRT
- Volunteers
- 350 people
- Sponsor
- Jiangxi Provincial Cancer Hospital
Tonsillitis, Streptococcus Pharyngitis
Antimicrobial Stewardship Program (ASP) in Patients With a Sore Throat
The investigators have developed an antibiotic stewardship program (ASP) to increase adherence to the Swedish guidelines for managing patients with a sore throat.
- Conditions
- Tonsillitis, Streptococcus Pharyngitis, Sore Throat, Pharyngitis
- Trial name
- ASP-Throat (NCT03408704)
- Testing
- ASP
- Where
- Sweden
- Volunteers
- 49 people
- Sponsor
- Vastra Gotaland Region
Sore Throat, Postoperative Care
Benzydamine Hydrochloride and Post-operative Sore Throat
Postoperative sore throat (POST) after laryngeal mask airway (LMA) insertion is prevalent and unappealing. A significant cause of POST is mechanical injury to the airway mucosa during airway instrumentation, leading to mucosal…
- Trial name
- DIFFLAM (NCT06676748)
- Testing
- Benzydamine Hydrochloride
- Where
- Singapore
- Volunteers
- 106 people
- Sponsor
- KK Women's and Children's Hospital
Nasopharyngeal Carcinoma
Clinical Study on the EBV CAR-T /TCR-T Cells in the Treatment of Nasopharyngeal Carcinoma
This study was a single-arm, open-label, "3 + 3" dose-escalation Exploratory research. The patients were divided into two groups: EBV TCR-T-cell Group and EBV CAR-T-cell group.
- Trial name
- NCT05587543
- Testing
- PK Blood Collection, CAR, TCR
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Fudan University
Nasopharyngeal Carcinoma
GAPP Induction and Concurrent Chemoradiotherapy Followed by Toripalimab Maintenance for Nasopharyngeal Carcinoma.
In order to explore the efficacy and safety of targeted therapy and immunotherapy combined with GP chemotherapy in the treatment of high risk advanced nasopharyngeal carcinoma, the investigators design a single-arm, Phase II…
- Trial name
- NCT06851247
- Testing
- Toripalimab, Anlotinib, Gemcitabine
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Sun Yat-sen University
Nasopharyngeal Carcinoma
TPC vs PF as Induction Chemotherapy Combined With CCRT for Stage IVa-b Nasopharyngeal Carcinoma
The purpose of this study is to compare the survival and toxicity of TPC (TAXOL, DDP AND CAPECITABINE ) VS PF (cisplatin and 5-Fluorouracil) as induction chemotherapy combined with concurrent chemoradiotherapy (CCRT) for stage…
- Trial name
- NCT02940925
- Testing
- Drug: Taxol,cisplatin and capecitabine, Drug: Cisplatin and 5-Fluorouracil
- Where
- China
- Volunteers
- 241 people
- Sponsor
- Sun Yat-sen University
Postoperative Complications
Comparing the Effect of Ketamine and Magnesium Sulfate Gargling With Placebo on Post-operative Sore Throat
A prospective randomized double-blind study including patients ASA I-II, aged more than 18 years undergoing surgery under general anesthesia (GA) and endotracheal intubation.
- Trial name
- NCT04705948
- Testing
- Magnesium sulfate versus ketamine
- Where
- Tunisia
- Volunteers
- 60 people
- Sponsor
- University Tunis El Manar
Quality of Life (QOL), Tracheostomy
Feeding Difficulties and Quality of Life in Children With Tracheal Cannula
The over all goal of this observational study is to study if there is an association between the presence of feeding difficulties and self-assessed quality of life in children with tracheal cannula.
- Conditions
- Quality of Life (QOL), Tracheostomy, Children in the Pediatric Intensive Care Unit or General Pediatric Care Unit Requiring a Central Venous Catheter, Feeding Difficulties
- Trial name
- NCT06893458
- Where
- 2 sites in Sweden
- Volunteers
- 80 people
- Sponsor
- Karolinska Institutet
Dysphagia, Esophageal
Esophageal Impedance and Manometry Measurements and Dysphagia Symptom Scoring
Comparison of manometry measurements and EndoFlip Balloon measurements in patients with dysphagia and a known esophageal diagnosis
- Trial name
- NCT04503785
- Testing
- Manometry
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Indiana University
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