Clinical trials: Phase I
Phase Angle
Phase Angle as a Marker of Muscle Damage, Muscle Fatigue and Inflammation, After Eccentric Exercise
The purpose of this study will be to assess the effectiveness of bioimpedance device (BIA) as a safe, rapid, and non-invasive method of analyzing muscle damage induced by high intensity induced eccentric exercise as an…
- Trial name
- NCT05583500
- Testing
- Experimental: Single group: excentric exercise protocol
- Where
- Spain
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad Francisco de Vitoria
Chronic Myeloproliferative Disorders, Graft Versus Host Disease
Sargramostim in Reducing Graft-Versus-Host Disease in Patients Who Are Undergoing Donor Stem Cell Transplantation for Hematologic Cancer or Aplastic Anemia
RATIONALE: Colony-stimulating factors such as sargramostim may increase the number of immune cells found in bone marrow or peripheral blood and may help a person's immune system recover from the side effects of chemotherapy or…
- Conditions
- Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma
- Trial name
- NCT00053157
- Testing
- sargramostim
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Roswell Park Cancer Institute
Chronic Myeloid Leukemia, Chronic Phase
"Peripheral Blood Dipeptidylpeptidase IV (CD26) Positive Leukemic Stem Cells in Chronic Myeloid Leukemia as a Diagnostic Marker"
Chronic myeloid leukemia (CML) is a stem cell (SC) neoplasm which originates from an incomplete process of differentiation of the hematopoietic stem cells (HSCs) to the adult cells which lead to accumulation of their immature…
- Trial name
- NCT05543161
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Luteal Phase Progesterone Levels
The Effect of Luteal Blood Progesterone Levels on Ongoing Pregnancy Rates
Progesterone (P4) is essential for the secretory development of endometrium and the maintenance of early pregnancy. In the luteal phase following controlled ovarian stimulation in in vitro fertilization (IVF) treatment, P4…
- Trial name
- NCT04128436
- Testing
- Taking blood samples for analyzing progesterone levels
- Where
- 3 sites in Brazil, Denmark and 1 more
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Non-small Cell Lung Cancer Confirmed by Histopathology or Cytology, The TNM (8th) Phase is IV
the Efficacy and Safety of Dalpiciclib Combined With Third-generation EGFR-TKI in Patients With EGFR Mutation and Meningial Metastasis in Non-small Cell Lung Cancer Progressing Through Third-generation TKI and Platinum-containing Two-drug Chemotherapy
Efficacy and safety of Dalpiciclib combined with third-generation EGFR-TKI in patients with advanced EGFR-mutated non-small cell lung cancer with meningeal metastasis after third-generation TKI and platinum-containing chemotherapy
- Conditions
- Non-small Cell Lung Cancer Confirmed by Histopathology or Cytology, The TNM (8th) Phase is IV, With EGFR Mutations, Meningeal Progression Occurred After Previous Platinum-containing Two-drug Chemotherapy and Third-generation EGFR-TKI Treatment
- Trial name
- NCT05497076
- Volunteers
- 9 people
- Sponsor
- Fujian Cancer Hospital
Use of GnRH Agonist Alone for Luteal Phase Support in Fresh IVF Cycles
GnRH Agonist for Luteal Phase Support.
Objective To assess the the efficacy of luteal support with GnRH agonist in patients undergoing IVF in antagonist-based hcg triggered cycles compared with standard luteal support with progesterone.
- Trial name
- NCT05484193
- Testing
- GnRH agonist, Progesterone
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Olverembatinib, Chronic Myeloid Leukemia, Chronic Phase
Treatment With Olverembatinib in CML-CP Patients Who Failed to at Least Two Previously Administered Second-generation TKIs.
The purpose of this trial is to evaluate the efficacy and safety of olverembatinib(HQP1351) in patients with chronic myeloid leukemia in chronic phase (CML-CP) who are resistant and/or intolerant to at least two second-generation…
- Conditions
- Olverembatinib, Chronic Myeloid Leukemia, Chronic Phase, Tyrosine Kinase Inhibitors
- Trial name
- NCT05311943
- Testing
- olverembatinib
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shenzhen Second People's Hospital
Chronic Myeloid Leukemia in Chronic Phase
The Efficacy and Safety of Switching to Flumatinib Versus Dasatinib After Imatinib-related Low-grade Adverse Events in CML-CP Patients
The purpose of this study is to explore the efficacy and safety of switching to flumatinib versus dasatinib after imatinib-related low-grade adverse events in patients with chronic myeloid leukemia in chronic phase (CML-CP) in…
- Trial name
- NCT04933526
- Testing
- Flumatinib, Dasatinib
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Shenzhen Second People's Hospital
Chronic Myeloid Leukemia, Chronic Phase
Omega -3 Fatty Acid in Combination With Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia
This is a Phase I/II single site, open label clinical trial. The purpose of the Phase I portion is to determine the safety, tolerability, and recommended Phase II dose of Eicosapentaenoic Acid (EPA) when given daily in…
- Trial name
- NCT04006847
- Testing
- Eicosapentaenoic Acid, Tyrosine kinase inhibitor
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Milton S. Hershey Medical Center
Chronic Myeloid Leukemia
Studying First Line Treatment of Chronic Myeloid Leukemia (CML) in a Real-world Setting
The purpose of this study is to better understand the use of tyrosine kinase inhibitors (TKI) in patients newly diagnosed with CML and their quality of life in a real-world setting.
- Trial name
- SIMPLICITY (NCT01244750)
- Where
- 214 sites in United States, France and 6 more
- Volunteers
- 1,494 people
- Sponsor
- Bristol-Myers Squibb
Phase 1
Comparison of the Relative Oral Bioavailability of GKT137831 Formulated in Capsules or in Tablets
The study will be a comparative oral bioavailability study between GKT137831 capsules and tablets, together with an assessment of the impact of concomitant food intake on the relative bioavailability of GKT137831 tablets.
- Trial name
- NCT03740217
- Testing
- GKT137831
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Calliditas Therapeutics AB
Phase 1
Study to Evaluate the Pharmacokinetics and Drug-Drug Interactions of Setanaxib in Healthy Adult Male and Female Subjects
The study is a monocentric, open label, phase 1 study to evaluate the pharmacokinetics, and in particular the dose proportionality of setanaxib and its metabolites after a single oral dose (400 mg, 800 mg, 1200 mg, and 1600 mg)…
- Trial name
- NCT04327089
- Testing
- Setanaxib
- Where
- France
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Calliditas Therapeutics AB
Chronic Myeloid Leukemia, Philadelphia Chromosome
Study of Chinese Newly Diagnosed Participants With Philadelphia Chromosome-Positive (Ph+) Chronic Myeloid Leukemia in Chronic Phase (CML-CP)
Observational medical record review of newly diagnosed CML-CP participants in China
- Conditions
- Chronic Myeloid Leukemia, Philadelphia Chromosome, Chronic Myeloid Leukemia in Chronic Phase
- Trial name
- NCT03509896
- Testing
- Non-Interventional
- Where
- China
- Volunteers
- 463 people
- Sponsor
- Bristol-Myers Squibb
Natural Killer/T-Cell Lymphoma, Nasal and Nasal-Type, Early Stage
Combined Treatment of Sintilimab, Peg-aspargase Plus Anlotinib in NK/T Cell Lymphoma
This study aims to investigate the treatment of previously untreated stage I-II Extranodal NK/T Cell Lymphoma with sintilimab, peg-aspargase and anlotinib, "sandwich" with radiotherapy.
- Conditions
- Natural Killer/T-Cell Lymphoma, Nasal and Nasal-Type, Early Stage, Anlotinib, Peg-aspargase
- Trial name
- NCT03936452
- Testing
- Sintilimab
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Sun Yat-sen University
Progesterone, Luteal Phase Support
Patient's Preferences About Subcutaneous or Vaginal Progesterone Administration for Luteal Phase Support
Luteal phase support in "in vitro fertilization" (IVF) cycles has been shown to improve pregnancy rates and became a standard of treatment, and progesterone is the first choice considering its safety profile and effectiveness.
- Conditions
- Progesterone, Luteal Phase Support, In Vitro Fertilization
- Trial name
- PROPER-1 (NCT03734770)
- Testing
- Subcutaneous Progesterone, Vaginal progesterone
- Where
- Italy
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Effect of Adding GnRHa as Luteal Phase Support in Antagonist ART Cycles
Role of Triptorelin 0.1 mg as a Luteal Phase Support in Assisted Reproductive Technique After Embryo Transfer : a Randomized Controlled Trial
There is still controversy over the best LPS agent and protocol and its dose and duration as well as the time of initiation and cessation.
- Trial name
- NCT04087408
- Testing
- Effect of adding gonadotropins releasing hormone agonist to progesterone for luteal phase support in assisted reproductive technique )antagonist cycles(: a randomized controlled trial
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Moustafa Mohammed Abouelea
CML, Chronic Phase
A Real World Study of the Efficacy and Safety of Flumatinib Versus Imatinib in Patients With Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase
Flumatinib is an orally available TKI with high selectivity and potency against BCR-ABL1 kinase. It's a multi-center, open-label, real world study to explore the efficacy and safety of Flumatinib versus Imatinib as the first line…
- Trial name
- NCT05367765
- Testing
- Flumatinib, Imatinib
- Where
- China
- Volunteers
- 2,400 people
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.
Nodal Lymphoma, Lymphoma With Cutaneous Involvement
Panobinostat Biological Correlates Study
This study is looking at the effects of Panobinostat, an investigational treatment, on cancer cells in patients who have Hodgkin lymphoma (a cancer of the immune system with specific Hodgkin/Reed Sternberg Cells), T-cell lymphoma…
- Conditions
- Nodal Lymphoma, Lymphoma With Cutaneous Involvement, Lymphoma in Leukemic Phase, Marrow Involvement With Lymphoma
- Trial name
- VEG VCA1 (NCT01658241)
- Testing
- panobinostat
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
Phase 1
PK, Safety and Tolerability Study of AVT02 (Adalimumab) Pre-filled Syringe (PFS) vs, AVT02 Autoinjector (AI)
This study has been designed as a multicentre, randomised, open label study of AVT02 in healthy adult subjects. The study will assess the PK, safety and tolerability of AVT02 in Pre-Filled Syringe compared to AVT02 in…
- Trial name
- NCT03983876
- Testing
- Adalimumab
- Where
- 2 sites in New Zealand
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Alvotech Swiss AG
CML, Chronic Phase
A Study of the Efficacy and Safety of Flumatinib in Patients With Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase.
It's a double-blind , randomized ,multi-center study. The purpose of this study is to explore the efficacy and safety of flumatinib 400mg once daily (QD) versus 600mg QD as the first line therapy in patients with chronic myleiod…
- Trial name
- NCT05353205
- Testing
- Flumatinib mesylate tablets (400mg), Flumatinib mesylate tablets (600mg)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.