Clinical trials: Philadelphia Chromosome Negative
- Condition Philadelphia Chromosome Negative
- Funder type Industry (pharma, biotech, devices)
- Accepts healthy volunteers yes
Myelofibrosis
Study to Evaluate the Effect of Rabeprazole Sodium Enteric-coated Tablets on the Pharmacokinetics of TQ05105 Tablets
Primary objective: To evaluate the effect of rabeprazole on the primary pharmacokinetics of TQ05105 tablets. Secondary objective: To assess the safety and tolerability of single oral administration of TQ05105 tablets alone and in…
- Trial name
- NCT07608666
- Testing
- TQ05105 tablets, Rabeprazole sodium enteric-coated tablets
- Where
- China
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Gastric pH Control
Magnesium Pantoprazole 20mg b.i.d. vs Magnesium Pantoprazole 40mg q.d. on Intragastric Acid Inhibition
The purpose of this study is to determine if magnesium pantoprazole 20 mg twice a day (b.i.d.), maintains gastric pH above 4 during a longer percentage of time than magnesium pantoprazole 40 mg once a day (qd).
- Trial name
- NCT01499693
- Testing
- Magnesium Pantoprazole 20 mg, Magnesium Pantoprazole 40 mg
- Where
- Mexico
- Volunteers
- healthy volunteers welcome
- Sponsor
- Takeda
Vaginal Health
Garden of Life Once Daily Women's Probiotic: Vaginal pH and Quality of Life Study
This decentralized observational study is designed to understand the effects of daily consumption of once daily woman's probiotic (ODWP) on vaginal pH levels in healthy female populations ages 19-70 years of age across the United…
- Trial name
- NCT05330091
- Testing
- Once Daily Women's Probiotic
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Garden of Life, LLC
Healthy
Study of 24-hour Intragastric pH Profiles of Esomeprazole 40 mg and Lansoprazole 30 mg in Healthy Volunteer Subjects
This study is intended to evaluate whether intravenous (iv) esomeprazole (Nexium® ) offers better intragastric acid suppression than iv lansoprazole (Prevacid ®
- Trial name
- NCT00230516
- Testing
- Nexium, Prevacid
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy Volunteers
A Study to Assess the Effect of Famotidine on the Drug Levels of Afimetoran in Healthy Participants
The purpose of this study is to confirm there is no significant effect of gastric pH changes of famotidine on the drug levels of afimetoran in healthy participants.
- Trial name
- NCT05866627
- Testing
- Famotidine, Afimetoran
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Physical Activity
Caminamos: A Smartphone App for Latinas to Connect With Walking Partners
Despite numerous interventions designed to increase physical activity, few are specifically tailored to Latinas, a population where higher rates of obesity, diabetes, and other chronic diseases are present.
- Trial name
- Caminemos (NCT03854916)
- Testing
- Caminemos Juntas App, World Walking App
- Where
- 2 sites in United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Klein Buendel, Inc.
Healthy
An Open-Label, Randomized, Comparative 3-Way Cross-Over Study to Evaluate the Effect of Food on the 24-Hour Intragastric pH at Day 5 After Twice Daily Oral Administration of PN 200 (Omeprazole/Naproxen) in Healthy Volunteers
Primary: To compare the pharmacodynamic efficacy of PN 200 in controlling intragastric pH (percent time pH> 4.0) following twice daily administration at different dosing times relative to food (30 or 60 minutes prior to food or…
- Trial name
- NCT00442208
- Testing
- PN 200
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- POZEN
GERD
Investigate Linaprazan Glurate/Linaprazan in Healthy Subjects
This is a Phase I, single-center, open label parallel-group, randomized study designed to evaluate the pharmacokinetics (PK), pharmacodynamics (PD, by continuous intragastric pH measurment), safety and tolerability of single and…
- Trial name
- NCT05742984
- Testing
- linaprazan glurate 25 mg QD, linaprazan glurate 50 mg QD, linaprazan glurate 75 mg QD
- Where
- Slovenia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Cinclus Pharma Holding AB
Overweight and Obesity, Health Behavior
Location-based Smartphone Technology to Guide College Students Healthy Choices Ph II
College students are in a newly independent phase of life; many of whom encounter unhealthy dietary decision- making, barriers to physical activity, and poor sleep behaviors.
- Conditions
- Overweight and Obesity, Health Behavior, Sleep Deprivation
- Trial name
- NCT02996864
- Testing
- Healthy Detours App, Fat Secret App
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Klein Buendel, Inc.
Aging Problems
Enhancing Care of the Aged and Dying in Prisons Ph II
The mission of corrections is to provide custody, control and care for incarcerated individuals. United States prisons are required by constitutional law to provide adequate care for growing numbers of older inmates who will…
- Trial name
- NCT03055429
- Testing
- Full Scale Unit
- Where
- 2 sites in United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Klein Buendel, Inc.
Healthy Volunteers
AZD4635 Relative Bioavailability Study
To investigate the pharmacokinetics and relative bioavailability of AZD4635 solid oral formulation and compare with the nano-suspension reference formulation with the option to assess food effect, pH effect and absolute…
- Trial name
- Rel Bio (NCT03710434)
- Testing
- AZD4635 50 mg nano-suspension (reference), AZD4635 solid oral formulation - fasted, AZD4635 solid oral formulation - fed
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
Bioavailability of Oral BIRB 796 BS Tablets With and Without Administration of Oral Pantoprazole in Healthy Male Volunteers
Study to assess the effect of gastric pH on the pharmacokinetics of BIRB 796 BS. Safety and tolerability were also assessed.
- Trial name
- NCT02209831
- Testing
- BIBR 796 BS, Pantoprazole
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Vaginal Microbiota, Microbiota
Effect of Hifas Intima Oral on Vaginal Microbiota in Healthy Women
The goal of this clinical trial was to learn whether the vaginal microbiota changed after healthy women aged 18 to 45 years took Hifas Intima, an oral food supplement, for 3 months.
- Conditions
- Vaginal Microbiota, Microbiota, Vaginal Microbiome
- Trial name
- NCT07715058
- Testing
- Hifas INTIMA Oral
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hifas da Terra S.L.
Healthy Participants
A Study Assessing the Drug Levels, Drug Effects, and Safety of BMS-986322 in Healthy Participants
A Study assessing the drug levels and drug effects of variable doses of BMS-986322 in Healthy Participants compared to a placebo. The study also assesses how BMS-986322 affects the body with food and its acidity levels.
- Trial name
- NCT04175925
- Testing
- BMS-986322, famotidine
- Where
- United States
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Driving While Intoxicated
WayToServePlus: Improving Responsible Alcohol Service Ph I
Responsible beverage service (RBS) training for alcohol servers is a promising intervention for reducing driving while intoxicated (DWI) by alcohol.
- Trial name
- NCT05146024
- Testing
- Way To Serve Plus: Improving Responsible Alcohol Service
- Where
- 2 sites in United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Klein Buendel, Inc.
Incontinence-associated Dermatitis
Reducing Skin Surface pH During Skin Occlusion: Changes to Skin Microbiome and Skin Parameters
The main aim of this exploratory research study is to investigate how exposure to a material with low pH affects the skin microbiome and skin parameters.
- Trial name
- NCT06363786
- Testing
- Test patches
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Essity Hygiene and Health AB
Healthy
Changes in the Renal Excretion of Neramexane by Acidification of Urinary pH Study With and Without Application of a Urinary pH Acidification Regimen
Primary: To assess the influence of acidified urinary pH on the renal excretion of Neramexane Secondary: To assess the influence of acidified urinary pH on the renal excretion of N-OH Neramexane To assess the steady state plasma…
- Trial name
- NCT00972127
- Testing
- Neramexane
- Volunteers
- healthy volunteers welcome
- Sponsor
- Merz Pharmaceuticals GmbH
Idiopathic Pulmonary Fibrosis (IPF)
TD-1058 First-In-Human Study in Healthy Subjects and Subjects With Idiopathic Pulmonary Fibrosis
This is a Phase 1, 4-part, randomized, double-blinded, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of TD-1058 inhaled solution.
- Trial name
- NCT04589260
- Testing
- TD-1058
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
Healthy
Study of Intragastric pH Profile After 5 Days Pantoprazole 40 mg iv Followed by Oral Esomeprazole 40 mg po or Oral Pantoprazole 40 mg po
This Phase IV study is intended to compare intragastric acid suppression of oral esomeprazole (NEXIUM ® Delayed-Release Capsules) with that of oral pantoprazole (PROTONIX ® Delayed Release Tablets ), in subjects who continue to…
- Trial name
- NCT00206050
- Testing
- Esomeprazole, pantoprazole
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
COVID - 19
PA-001 Ph.1 Study in Healthy and Elderly Subjects
This was a double blind, randomized, placebo controlled, single and multiple IV dose study conducted in 2 parts, single ascending dose and multiple ascending doses parts.
- Trial name
- NCT07518771
- Testing
- PA-001
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- PeptiDream Inc.