Clinical trials: Philadelphia Negative Myeloproliferative Neoplasms, active
Philadelphia Negative Myeloproliferative Neoplasms
Cardiovascular Manifestations in Ph-negative MPN
The primary aim of this research is to investigate the clinical and subclinical cardiovascular complications and its relationship with myeloproliferative neoplasms seeking to assess incidence, prevalence and severity in…
- Trial name
- NCT06615414
- Testing
- participants are not assigned an intervention as part of the study
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Myelofibrosis (MF), Polycythemia Vera
MPNdpoint. Single-center, Retrospective, Prospective Study of the Outcome of Patients With Philadelphia-negative Chronic Myeloproliferative Neoplasms
Chronic myeloproliferative neoplasms (MPNs) are hematologic disorders of the myeloid lineage characterized by clonal proliferation of hematopoietic stem cells, high risk of thrombotic-hemorrhagic complications, and transformation…
- Conditions
- Myelofibrosis (MF), Polycythemia Vera, Essential Thrombocythaemia
- Trial name
- NCT07863466
- Where
- Italy
- Volunteers
- 1,190 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Accelerated Phase Myeloproliferative Neoplasm, Blast Phase Myeloproliferative Neoplasm
A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs)
This phase II trial compares the effect of ASTX727 in combination with iadademstat to ASTX727 alone in treating patients with accelerated or blast phase Philadelphia chromosome negative myeloproliferative neoplasms (MPNs).
- Conditions
- Accelerated Phase Myeloproliferative Neoplasm, Blast Phase Myeloproliferative Neoplasm, Essential Thrombocythemia, Myelodysplastic/Myeloproliferative Neoplasm
- Trial name
- NCT06661915
- Testing
- Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy
- Where
- 32 sites in United States
- Volunteers
- 78 people
- Sponsor
- National Cancer Institute (NCI)
Philadelphia Chromosome Negative Chronic Myelogenous Leukemia
Metabolic Syndrome and Risk of Chronic Philadelphia Negative Myeloproliferative Neoplasms
Studying the role of metabolic syndrome in chronic Myeloproliferative neoplasms (MPNs)
- Trial name
- MetSaMyeloprof (NCT07814560)
- Volunteers
- 313 people
- Sponsor
- Assiut University
Myeloproliferative Neoplasm
Patient-Reported Outcomes in PHiladelphia-nEgative Cytogenetic mYeloproliferative Neoplasms (PROPHECY).
This study will ultimately aim at developing a GIMEMA platform for collecting HRQoL and symptom burden information on Italian patients with Philadelphia chromosome negative MPN.
- Trial name
- PROPHECY (NCT04378855)
- Testing
- Questionnaire
- Where
- 25 sites in Italy
- Volunteers
- 572 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Myelofibrosis，MF
Pacritinib For Bone Marrow Fibrosis In Patients With Myelofibrosis Who Have Thrombocytopenia
We hypothesize that pacritinib leads to modification of the myelofibrosis (MF) disease phenotype, especially related to BM fibrosis and cytopenias; due potentially to its dual effect as an inhibitor of the JAK and NFκB pathways…
- Trial name
- PACRIMYEL (NCT07394153)
- Testing
- Pacritinib
- Where
- 13 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Grupo Español de Enfermedades Mieloproliferativas Crónicas PH Negativas