Clinical trials: Photon Radiotherapy
Nasopharynx Cancer
Photon/Proton Radiation Therapy for Carcinoma of the Nasopharynx
The purpose of this study is to collect outcomes information to see what effects photon/proton beam radiation has on nasopharynx cancer.
- Trial name
- NP01 (NCT00797290)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Florida
Head and Neck Neoplasms
ROCOCO - Adaptive IMRT Versus IMPT in Head and Neck Cancer
Given the lack of evidence for the benefit of particle therapy in relevant cases, he investigators proposed an in silico trial to investigate the dosimetric effect of contour changes for OAR as well as tumor during chemoradiation…
- Trial name
- ROCOCO (NCT02908386)
- Where
- United States
- Sponsor
- Maastricht Radiation Oncology
Sinonasal Tumors
Multidisciplinary Approach for Poor Prognosis Sinonasal Tumors in Operable Patients
Sinonasal tumors are rare diseases, so no standard treatment for such aggressive tumors has been reported, given rarity, absence of prospective study and heterogeneity of histologies and stages of diseases.
- Trial name
- NCT02099175
- Testing
- Cisplatin, Docetaxel, 5-fluorouracil
- Where
- 5 sites in Italy
- Volunteers
- 41 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Meningioma
Proton Dose Escalation for Patients With Atypical or Anaplastic Meningiomas
The trial evaluates the effect of a moderately increased radiation dose in patients with atypical (grade II) and anaplastic (grade III) meningioma after incomplete or no surgery. Endpoint is recurrence-free survival after 5 years.
- Trial name
- PANAMA (NCT02978677)
- Testing
- Radiotherapy 68 Gy(RBE), Radiotherapy 72 Gy(RBE), Radiotherapy 60 Gy(RBE)
- Volunteers
- 90 people
- Sponsor
- Technische Universität Dresden
Gynaecologic Cancer, Cervical Cancer
GCCC 2578 Randomized Photon vs Proton RT for Newly Diagnosed Gynecologic Primaries
The purpose of study is to compare the side effects of two different forms of radiation for endometrial and cervical cancer. If you decide to enroll in this study, you will be randomized to one of two treatment groups.
- Conditions
- Gynaecologic Cancer, Cervical Cancer, Radiation Therapy
- Trial name
- NCT07415681
- Testing
- Volume Modulated Arc Therapy (VMAT), Intensity Modulated Proton Therapy (IMPT)
- Where
- 5 sites in United States
- Volunteers
- 116 people
- Sponsor
- University of Maryland, Baltimore
Head and Neck Cancer
Study of Proton Versus Photon Beam Radiotherapy in the Treatment of Head and Neck Cancer
Compared to IMRT, PBRT is thought to give less radiation exposure to the surrounding healthy tissues. It is possible that side effect rates with PBRT will be lower or the same compared to IMRT, but this has not been well studied…
- Trial name
- NCT02923570
- Testing
- Photon intensity modulated radiation therapy (IMRT), Proton beam radiotherapy (PBRT)
- Where
- 9 sites in United States
- Volunteers
- 108 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Early Breast Cancer, Radiation Associated Cardiac Failure
The DBCG Proton Trial: Photon Versus Proton Radiation Therapy for Early Breast Cancer
The majority of early breast cancer patients are treated with adjuvant radiation therapy (RT) as part of their multimodal therapy.
- Trial name
- NCT04291378
- Testing
- Proton versus photon radiation therapy
- Where
- 8 sites in Denmark
- Volunteers
- 1,502 people
- Sponsor
- Danish Breast Cancer Cooperative Group
Clinical Stage I Esophageal Adenocarcinoma AJCC v8, Clinical Stage I Esophageal Squamous Cell Carcinoma AJCC v8
Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer
This trial studies how well proton beam radiation therapy compared with intensity modulated photon radiotherapy works in treating patients with stage I-IVA esophageal cancer.
- Conditions
- Clinical Stage I Esophageal Adenocarcinoma AJCC v8, Clinical Stage I Esophageal Squamous Cell Carcinoma AJCC v8, Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8, Clinical Stage II Esophageal Adenocarcinoma AJCC v8
- Trial name
- NCT03801876
- Testing
- Biospecimen Collection, Capecitabine, Carboplatin
- Where
- 96 sites in United States
- Volunteers
- 300 people
- Sponsor
- NRG Oncology
Cancer of the Prostate
Proton Boost in Prostate Cancer
This study uses photon radiation with a proton boost to treat prostate cancer. The purpose of this study is to determine if proton therapy as a boost following photon intensity modulated radiation therapy (IMRT) produces…
- Trial name
- NCT03564275
- Testing
- Proton Boost
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Cincinnati
Nasopharyngeal Carcinoma
Proton Versus Photon Radiotherapy for Nasopharyngeal Carcinoma
The purpose of this study is to compare the toxicity and therapeutic efficacy of proton or photon combined with carbon ion radiotherapy for newly diagnosed nasopharyngeal carcinoma.Participants will be randomized to 2 arms.
- Trial name
- NCT04528394
- Testing
- Photon, Proton, Carbon ion
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Shanghai Proton and Heavy Ion Center
Oligodendroglioma, Oligodendroglioma, Anaplastic
PRO-GLIO: PROton Versus Photon Therapy in IDH-mutated Diffuse Grade II and III GLIOmas
Proton therapy is a powerful tool enabling oncologists to spare normal tissue around the target for irradiation much better than what can be achieved with photon irradiation.
- Conditions
- Oligodendroglioma, Oligodendroglioma, Anaplastic, Diffuse Astrocytoma, IDH-Mutant
- Trial name
- PRO-GLIO (NCT05190172)
- Testing
- Radiation therapy
- Where
- Norway
- Volunteers
- 225 people
- Sponsor
- Oslo University Hospital
Lung Neoplasm
Ventilation Using Radiographic Examination: Functional Lung Imaging Techniques for the Reduction of Toxicity in Functional Avoidance Radiation Therapy
The goal of this observational validation study is to determine the best implementation of fluoroscopic and CT ventilation imaging in patients having non-stereotactic ablative body radiotherapy (non-SABR) radiotherapy for stages…
- Trial name
- VENTURE (NCT06159660)
- Where
- Australia
- Volunteers
- 15 people
- Sponsor
- University of Sydney
Brain Tumor
Neurobehavioral Outcomes and Quality of Life in Pediatric Patients With Brain or Head/Neck Tumors Receiving Proton or Photon Radiotherapy
Background: Neurobehavioral functions and quality of life (QoL) are the important outcome measurements after radiotherapy in patients with brain tumors and even head/neck cancers.
- Trial name
- NCT02608762
- Testing
- standard adjuvant local radiation therapy or cranial radiation therapy
- Where
- Taiwan
- Volunteers
- 72 people
- Sponsor
- Chang Gung Memorial Hospital
Anaplastic Astrocytoma, Anaplastic Oligoastrocytoma
Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma
This randomized phase II clinical trial studies the side effects and how well proton beam or intensity-modulated radiation therapy works in preserving brain function in patients with IDH mutant grade II or III glioma.
- Conditions
- Anaplastic Astrocytoma, Anaplastic Oligoastrocytoma, Anaplastic Oligodendroglioma, Diffuse Astrocytoma
- Trial name
- NCT03180502
- Testing
- Biospecimen Collection, Intensity-Modulated Radiation Therapy, Laboratory Biomarker Analysis
- Where
- 34 sites in United States
- Volunteers
- 120 people
- Sponsor
- NRG Oncology
Glioblastoma
Proton and Heavy Ion Beam Radiation vs. Photon Beam Radiation for Newly Diagnosed Glioblastoma.
This is a multi-center prospective phase 3 clinical trial to explore the efficacy and side effects of standard-dose photon radiation versus standard-dose proton radiation versus carbon ion boost plus standard proton radiation for…
- Trial name
- NCT04536649
- Testing
- Radiotherapy
- Where
- China
- Volunteers
- 369 people
- Sponsor
- Shanghai Proton and Heavy Ion Center
Cancer
Exploring Photon-Counting CT for Enhanced Target Delineation and Dose Accuracy in Personalized Radiotherapy - ANTHEM
Radiotherapy remains a cornerstone of oncology care, particularly for rare or orphan cancers and chronic oncologic and rare non oncologic conditions, where precision and individualized treatment planning are necessary.
- Trial name
- RAD4/RT_ANTHEM (NCT07098247)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Istituto Clinico Humanitas
Pancreatic Cancer
Proton Therapy for Unresectable Cancer (CA) of Pancreas
The purpose of this study is to find out what effects, good and/or bad, proton radiation and chemotherapy has on you and your pancreatic cancer.
- Trial name
- PC01 (NCT00685763)
- Testing
- Proton radiation and chemotherapy
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Florida
Breast Cancer
Shortening Adjuvant Photon and Proton Irradiation (SAPPHIRe-II): A 4 Cohort, Randomized, Phase II Multi-center Trial Evaluating Shorter Schedules of Adjuvant Regional Nodal Irradiation Among Women and Men With Node-positive and High-risk Node-negative Invasive Breast Cancer
To learn about the effects of shorter RNI regimens in patients with breast cance who have had a lumpectomy or mastectomy and who are at higher risk for lower risk for the disease returning.
- Trial name
- NCT07076485
- Testing
- Ultrahypofractionated Radiation, Moderately Hypofractionated Radiation
- Where
- 5 sites in United States
- Volunteers
- 768 people
- Sponsor
- M.D. Anderson Cancer Center
Unresectable Malignant Neoplasm, Bulky Tumor
Proton and Proton-Photon Hybrid Partial Stereotactic Ablative Boost Radiotherapy (P-SABR) for Unresectable Large Tumors
This prospective, multicenter, observational cohort study will enroll 60 adults with unresectable larege tumors (longest diameter > 5 cm) who receive one of two treatment modes: (A) proton P-SABR, in which both the proton…
- Conditions
- Unresectable Malignant Neoplasm, Bulky Tumor, Solid Tumor
- Trial name
- LARGE-Proton (NCT07818798)
- Testing
- Proton P-SABR, Proton-Photon Hybrid P-SABR
- Volunteers
- 60 people
- Sponsor
- Peking University First Hospital
Rectal Cancer
Preoperative Short-Course Radiation Therapy With PROtons Compared to Photons In High-Risk RECTal Cancer (PRORECT)
To investigate a potential toxicity benefit of preoperative radiation therapy with protons compared to conventional photon beam radiation therapy in patients with locally advanced rectal cancer.
- Trial name
- PRORECT (NCT04525989)
- Testing
- Radiation therapy
- Where
- 9 sites in Sweden
- Volunteers
- 254 people
- Sponsor
- Alexander Valdman