Clinical trials: Photorefractive Keratectomy
Fruste Keratoconus, Risk of Ectasia
Combined CXL//UV and PRK or LASIK in Forme Fruste Keratoconus or Eyes With Potential Risk of Ectasia
This study is being performed to evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) in strengthening and optimizing the biomechanical and biochemical stability of the cornea in patients…
- Trial name
- NCT01726283
- Testing
- Corneal Cross-Linking, Riboflavin
- Where
- 8 sites in United States
- Volunteers
- 22 people
- Sponsor
- Cxlusa
Dry Eye Syndromes
Efficacy of Cyclosporine for the Prevention and Treatment of Dry Eye Symptoms Following LASIK or Photorefractive Keratectomy
The purpose of this study is to evaluate the effect of topical cyclosporine ophthalmic solution 0.05% (Restasis, Allergan) on the signs and symptoms of dry eye in patients undergoing LASIK or photorefractive keratectomy (PRK).
- Trial name
- NCT00349440
- Testing
- Cyclosporine, Refresh Plus
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Innovative Medical
Ophthalmology, Photorefractive Keratectomy ("PRK")
Ocular Bandage Gel (OBG) Pivotal Trial in Patients Undergoing Photorefractive Keratectomy ("PRK")
Prospective, randomized, masked (reading center), controlled pivotal study of Ocular Bandage Gel (OBG) vs. a bandage contact lens (BCL) in subjects who have undergone bilateral photorefractive keratectomy (PRK).
- Conditions
- Ophthalmology, Photorefractive Keratectomy ("PRK"), Laser Assisted Surgery, Refractive Surgery
- Trial name
- NCT03938883
- Testing
- Ocular Bandage Gel (OBG), Bandage Contact Lens (BCL)
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Eyegate Pharmaceuticals, Inc.
Photorefractive Keratectomy, Corneal De-epithelialization
Study to Evaluate the Efficacy of Lagricel® Ofteno PF Compared to Thealoz® Duo After Photorefractive Keratectomy
Phase IV comparative, controlled, parallel group, open, randomized multicenter study to evaluate the efficacy of Lagricel® Ofteno PF Compared to Thealoz® Duo.
- Trial name
- PRO-037 (NCT04704518)
- Testing
- Sodium Hyaluronate Ophthalmic 0.4%, Trehalose 3% / Sodium Hyaluronate Ophthalmic 0.15%
- Where
- Mexico
- Volunteers
- 96 people
- Sponsor
- Laboratorios Sophia S.A de C.V.
Chronic Ocular Pain
Study of Efficacy and Safety of SAF312 Eye Drops in Subjects With Post-operative Corneal Induced Chronic Pain (CICP)
The study was designed to demonstrate the safety and efficacy of two dose concentrations of SAF312 eye drops (5 mg/mL and 15 mg/mL) in subjects with CICP persisting at least for 4 months after refractive or cataract surgery and…
- Trial name
- NCT04630158
- Testing
- SAF312
- Where
- 28 sites in United States, Japan and 1 more
- Volunteers
- 153 people
- Sponsor
- Novartis Pharmaceuticals
Photorefractive Keratectomy
A Comparison of Topical Nepafenac to Placebo in Corneal Epithelial Healing Times and Postoperative Pain Relief
The purpose of this study is to compare healing times and subjective pain level responses of nepafenac to placebo after photo refractive keratomileusis (PRK) surgery.
- Trial name
- NCT00330798
- Testing
- nepafenac 0.1%, ketorolac 0.4%
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Alcon Research
Corneal Epithelial Wound
Safety and Effectiveness of OBG vs.a Bandage Contact Lens for Large Corneal Epithelial Defects in Patients Post-PRK.
This is a prospective, randomized (Reading Center), masked, controlled study in up to 45 subjects who have undergone bilateral PRK with epithelial removal using alcohol in a 9.0 mm well or trephine at the time of surgery to…
- Trial name
- NCT03163641
- Testing
- Acuvue Oasys, Ocular Bandage Gel
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Eyegate Pharmaceuticals, Inc.
Myopia
Effectiveness and Safety of the TENEO 317 Model 2 Excimer Laser to Treat Myopia With or Without Astigmatism by Transepithelial Photorefractive Keratectomy
A Study to Investigate the Effectiveness and Safety of the TENEO 317 Model 2 Excimer Laser to Treat Myopia with or without Astigmatism by Transepithelial Photorefractive Keratectomy
- Trial name
- NCT06618547
- Testing
- TENEO 317 Model 2 excimer laser
- Volunteers
- 140 people
- Sponsor
- Bausch & Lomb Incorporated
Ametropia
Safety and Efficacy of a New Transepithelial Photorefractive Keratectomy Treatment
This is a prospective, comparative, randomized, controlled, single-blind, single-surgeon, single-center PMCF clinical study whereby participants undergoing refractive surgery for correction of ametropia will receive a…
- Trial name
- NCT04698174
- Testing
- Transepithelial Photorefractive keratectomy (tPRK) without laser polishing, Transepithelial Photorefractive keratectomy (tPRK) with laser polishing, Standard Photorefractive keratectomy (PRK)
- Where
- Philippines
- Volunteers
- 39 people
- Sponsor
- Bausch & Lomb Incorporated
Postoperative Ocular Pain After PRK Surgery
Study of SAF312 as an Eye Drop for Treatment of Eye Pain Following Photorefractive Keratectomy (PRK) Surgery
The purpose of this study is to determine if SAF312 eye drops have an adequate safety and efficacy profile to justify further clinical development for the treatment of ocular pain associated with corneal epithelial defect such as…
- Trial name
- NCT02961062
- Testing
- SAF312
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Novartis Pharmaceuticals
Myopia, Astigmatism
Use of a Disk of Amniotic Membrane (Visio-AMTRIX) in Postoperative Care After PKR
The purpose of this open controlled multicenter trial is to assess the impact of use of an amniotic membrane on post PKR recovery.
- Conditions
- Myopia, Astigmatism, Hypermetropia
- Trial name
- NCT05247658
- Testing
- Therapeutic lens alone, Therapeutic lens + amniotic membrane (Visio-AMTRIX)
- Where
- 3 sites in France
- Volunteers
- 9 people
- Sponsor
- TBF Genie Tissulaire
Corneal re-Epithelialization
A Study to Assess the Safety, Tolerability and Effect of Nexagon™ Applied to the Eye After PRK Laser Eye Surgery for Nearsightedness
Phase 1 randomized, prospective, double-masked, vehicle-controlled, dose-escalation study to evaluate the safety, tolerability and clinical effect of Nexagon™ in subjects following bilateral PRK for the correction of mild to…
- Trial name
- NCT00654550
- Testing
- Nexagon™ or Nexagon™ vehicle
- Where
- New Zealand
- Volunteers
- 24 people
- Sponsor
- OcuNexus Therapeutics, Inc.
Photorefractive Keratectomy
A Double-masked, Randomized, Placebo-controlled,Pilot Study of Diquafosol Tetrasodium in Subjects Following Photorefractive Keratectomy (PRK)
The objectives of this trial are to: Assess the safety and tolerability of diquafosol tetrasodium ophthalmic solution versus placebo following one week of treatment in subjects undergoing photorefractive keratectomy (PRK).
- Trial name
- NCT01381731
- Testing
- diquafosol tetrasodium ophthalmic solution 2%
- Volunteers
- 14 people
- Sponsor
- Merck Sharp & Dohme LLC
Pain, Postoperative
A Study to Evaluate the Use of Topical Ocular BL1332 for the Management of Postoperative Ocular Pain Following Photorefractive Keratectomy
This is a multicenter, double-masked study to evaluate the use of Topical Ocular BL1332 for the management of post-operative pain after Photorefractive Keratectomy (PRK) surgery.
- Trial name
- NCT07412496
- Testing
- Topical Ocular BL1332 low dose, Topical Ocular BL1332 high dose, BL1332 Vehicle ophthalmic vehicle
- Where
- 15 sites in United States
- Volunteers
- 130 people
- Sponsor
- Bausch & Lomb Incorporated