Clinical trials: Photorefractive Keratectomy
Anisometropia, Hyperopia
Photorefractive Keratectomy for Severe Anisometropia and Isoametropia Associated With Amblyopia
Photorefractive keratectomy (PRK) with excimer laser has been used successfully to treat myopia, hyperopia, and astigmatism in adults for over 35 years.
- Conditions
- Anisometropia, Hyperopia, High Myopia, Amblyopia Isometropic
- Trial name
- NCT03610997
- Testing
- Photorefractive keratectomy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Baylor College of Medicine
Ocular Surface Symptom, Ocular Surface Disease
Efficacy and Safety of Topical Cyclosporine 0.05% and Lifitgrast on the Ocular Surface Symptom After Photorefractive Keratectomy in Feiz Hospital, Isfahan, 2024
The goal of this clinical trial is to compare the administration of 2 drugs, cyclosporine 0.05% (Restasis) and Lifitgrast (Xiidra) before PRK, in reducing the ocular surface symptom of patients after PRK.
- Conditions
- Ocular Surface Symptom, Ocular Surface Disease, Eye Pain, Eye Inflammation
- Trial name
- NCT06624384
- Testing
- Group 1 drug, Group 3: Drug and palcebo
- Where
- Iran
- Volunteers
- 150 people
- Sponsor
- Mohsen Pourazizi
Keratoconus
Impact of Keratoconus, Cross-linking and Cross-linking Combined With Topo-guided Photorefractive Keratectomy on Self-reported Quality of Life. A Three-year Update.
Study Hypothesis: Former investigators indicated that keratoconus has a negative impact on vision-specific quality of life. This study attempts to confirm this statement and assess whether cross-linking and cross-linking combined…
- Trial name
- NCT01845714
- Testing
- Corneal Cross Linking, Corneal Cross Linking combined with topoguided PRK
- Volunteers
- 28 people
- Sponsor
- Democritus University of Thrace
Ophthalmopathy, Myopia
Refractive Transepithelial Photo-keratectomy (T-PKR) in High Myopia
The aim of this study is to evaluate the anatomical and refractive parameters following a single-step transepithelial photo-refractive keratectomy (T-PRK) without the addition of mitomycin-C for the treatment of high myopia of 6…
- Conditions
- Ophthalmopathy, Myopia, Keratopathy
- Trial name
- TEPEHERKAHM (NCT04917562)
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Photorefractive Keratectomy
A Comparison of Topical Nepafenac to Placebo in Corneal Epithelial Healing Times and Postoperative Pain Relief
The purpose of this study is to compare healing times and subjective pain level responses of nepafenac to placebo after photo refractive keratomileusis (PRK) surgery.
- Trial name
- NCT00330798
- Testing
- nepafenac 0.1%, ketorolac 0.4%
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Alcon Research
Pupil Centroid Shift
Pupil Centroid Shift Compensation in Photorefractive Keratectomy Candidates
patients who are candidates of PRK will be recruited in this intrasubject randomized clinical trial. Inclusion criteria are myopia or myopic astigmatism with refractive cylinder.
- Trial name
- NCT03844178
- Testing
- The option for compensation of Pupil centroid shift was ON, The option for compensation of Pupil centroid shift was OFF, installation of Tetracaine 1%
- Where
- Iran
- Volunteers
- 104 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Photorefractive Keratectomy, Corneal De-epithelialization
Study to Evaluate the Efficacy of Lagricel® Ofteno PF Compared to Thealoz® Duo After Photorefractive Keratectomy
Phase IV comparative, controlled, parallel group, open, randomized multicenter study to evaluate the efficacy of Lagricel® Ofteno PF Compared to Thealoz® Duo.
- Trial name
- PRO-037 (NCT04704518)
- Testing
- Sodium Hyaluronate Ophthalmic 0.4%, Trehalose 3% / Sodium Hyaluronate Ophthalmic 0.15%
- Where
- Mexico
- Volunteers
- 96 people
- Sponsor
- Laboratorios Sophia S.A de C.V.
Keratoconus
Topography Versus Non-Topography-Guided PRK With CXL in Keratoconus
To our knowledge, this study is one of the first to compare the visual results of non-topography-guided and topography-guided photorefractive keratectomy (PRK) applying sequential and simultaneous corneal cross-linking (CXL)…
- Trial name
- keratoconus (NCT03890718)
- Testing
- Photorefractive keratectomy in mile keratoconus
- Where
- Iran
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Myopia, Astigmatism
Use of a Disk of Amniotic Membrane (Visio-AMTRIX) in Postoperative Care After PKR
The purpose of this open controlled multicenter trial is to assess the impact of use of an amniotic membrane on post PKR recovery.
- Conditions
- Myopia, Astigmatism, Hypermetropia
- Trial name
- NCT05247658
- Testing
- Therapeutic lens alone, Therapeutic lens + amniotic membrane (Visio-AMTRIX)
- Where
- 3 sites in France
- Volunteers
- 9 people
- Sponsor
- TBF Genie Tissulaire
Dry Eye
Investigator Initiated Study to Assess the Efficacy of OC-01 (Varenicline) Nasal Spray on Signs and Symptoms of Dry Eye Disease Following Photorefractive Keratectomy (PRK)
Evaluate the safety and effectiveness of OC-01 (varenicline) nasal spray among subjects suffering from dry eye following photorefractive keratectomy (PRK)
- Trial name
- NCT05045508
- Testing
- OC-01 (varenicline 0.6mg/ml) nasal spray
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brandon Baartman
Myopia
Effectiveness and Safety of the TENEO 317 Model 2 Excimer Laser to Treat Myopia With or Without Astigmatism by Transepithelial Photorefractive Keratectomy
A Study to Investigate the Effectiveness and Safety of the TENEO 317 Model 2 Excimer Laser to Treat Myopia with or without Astigmatism by Transepithelial Photorefractive Keratectomy
- Trial name
- NCT06618547
- Testing
- TENEO 317 Model 2 excimer laser
- Volunteers
- 140 people
- Sponsor
- Bausch & Lomb Incorporated
Corneal Epithelial Wound Healing
Effect of Topical Fluoroquinolones on Epithelial Wound Healing After PRK
The prescribed antibiotic for prophylaxis of infection following PRK should be effective at eradicating a potential infection. In addition, the antibiotic should have a rapid onset of action, effectively penetrate the target…
- Trial name
- NCT00569881
- Testing
- gatifloxacin and moxifloxacin
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Donnenfeld, Eric, M.D.
Corneal Wound Healing
Sutureless Cryopreserved Amniotic Membrane Graft (ProKera) and Wound Healing After Photorefractive Keratectomy
The purpose of this study is to evaluate the effect of ProKera on corneal wound healing after photorefractive keratectomy (PRK) in terms of re-epithelialization, pain, adverse effects, visual recovery, refractive accuracy, and…
- Trial name
- NCT00915759
- Testing
- ProKera, Bandage contact lens
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Ophthalmology, Photorefractive Keratectomy ("PRK")
Ocular Bandage Gel (OBG) Pivotal Trial in Patients Undergoing Photorefractive Keratectomy ("PRK")
Prospective, randomized, masked (reading center), controlled pivotal study of Ocular Bandage Gel (OBG) vs. a bandage contact lens (BCL) in subjects who have undergone bilateral photorefractive keratectomy (PRK).
- Conditions
- Ophthalmology, Photorefractive Keratectomy ("PRK"), Laser Assisted Surgery, Refractive Surgery
- Trial name
- NCT03938883
- Testing
- Ocular Bandage Gel (OBG), Bandage Contact Lens (BCL)
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Eyegate Pharmaceuticals, Inc.
Postoperative Pain
Oral Gabapentin Versus Placebo for Treatment of Postoperative Pain Following Photorefractive Keratectomy
The purpose of this study is to determine the effectiveness of an oral medication called gabapentin in reducing pain after Photorefractive Keratectomy (PRK) eye surgery and to assess the frequency of use of rescue medication…
- Trial name
- NCT00793910
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Myopia, Hypermetropia
Anesthetic Impregnated Bandage Soft Contact Lens (BSCL) in Pain Management After Photorefractive Keratectomy (PRK)
Compared to laser-assisted in situ keratomileusis (LASIK), Photorefractive Keratectomy (PRK) is associated with more discomfort and requires more downtime.
- Conditions
- Myopia, Hypermetropia, Refractive Errors, Astigmatism
- Trial name
- NCT04283331
- Testing
- Proparacaine Ophthalmic
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beeran Meghpara, MD
Photorefractive Keratectomy
A Double-masked, Randomized, Placebo-controlled,Pilot Study of Diquafosol Tetrasodium in Subjects Following Photorefractive Keratectomy (PRK)
The objectives of this trial are to: Assess the safety and tolerability of diquafosol tetrasodium ophthalmic solution versus placebo following one week of treatment in subjects undergoing photorefractive keratectomy (PRK).
- Trial name
- NCT01381731
- Testing
- diquafosol tetrasodium ophthalmic solution 2%
- Volunteers
- 14 people
- Sponsor
- Merck Sharp & Dohme LLC
Refractive Error
Epithelial Healing and Visual Outcomes Using Omega-3 Therapy Before and After Photorefractive Keratectomy (PRK) Surgery
The purpose of this study is to demonstrate that omega-3 supplement can be use as an adjunct therapy for PRK patients. The investigators believe that omega-3 supplement will reduce the size of persistent epithelial defects (PEDS)…
- Trial name
- Omega-3 (NCT01059019)
- Testing
- Omega-3 Fatty Acid Supplements
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Astigmatism
Comparison of Cross-cylinder and Conventional Photorefractive Keratectomy(PRK) in Correcting Medium-high Astigmatism
The purpose of this study is to determine whether cross-cylinder approach is more effective than routine method in laser correction of astigmatism.
- Trial name
- PRK (NCT00663923)
- Testing
- photorefractive keratectomy (PRK)
- Where
- Iran
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tabriz University
Myopia
Comparison of Conventional and Custom Photorefractive Keratectomy (PRK)
The study objective is to compare the clinical outcomes using wavefront guided PRK with iris registration and conventional laser PRK using FDA-approved laser technology on the same patient.
- Trial name
- NCT00713856
- Testing
- Custom PRK with iris registration, Conventional PRK
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Utah