Clinical trials: Photorefractive Keratectomy
Myopia
Bromday Versus Nevanac Eye Drops to Control Pain Following Photorefractive Keratectomy
This study will compare the effect of two topical non-steroidal antiinflammatory agents to control pain after photorefractive keratectomy (PRK) eye surgery.
- Trial name
- NCT01475877
- Testing
- Bromfenac
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Virdi Eye Clinic
Postoperative Ocular Pain After PRK Surgery
Study of SAF312 as an Eye Drop for Treatment of Eye Pain Following Photorefractive Keratectomy (PRK) Surgery
The purpose of this study is to determine if SAF312 eye drops have an adequate safety and efficacy profile to justify further clinical development for the treatment of ocular pain associated with corneal epithelial defect such as…
- Trial name
- NCT02961062
- Testing
- SAF312
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Novartis Pharmaceuticals
Myopia, Astigmatism
Use of a Disk of Amniotic Membrane (Visio-AMTRIX) in Postoperative Care After PKR
The purpose of this open controlled multicenter trial is to assess the impact of use of an amniotic membrane on post PKR recovery.
- Conditions
- Myopia, Astigmatism, Hypermetropia
- Trial name
- NCT05247658
- Testing
- Therapeutic lens alone, Therapeutic lens + amniotic membrane (Visio-AMTRIX)
- Where
- 3 sites in France
- Volunteers
- 9 people
- Sponsor
- TBF Genie Tissulaire
Ophthalmopathy, Myopia
Refractive Transepithelial Photo-keratectomy (T-PKR) in High Myopia
The aim of this study is to evaluate the anatomical and refractive parameters following a single-step transepithelial photo-refractive keratectomy (T-PRK) without the addition of mitomycin-C for the treatment of high myopia of 6…
- Conditions
- Ophthalmopathy, Myopia, Keratopathy
- Trial name
- TEPEHERKAHM (NCT04917562)
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Corneal re-Epithelialization
A Study to Assess the Safety, Tolerability and Effect of Nexagon™ Applied to the Eye After PRK Laser Eye Surgery for Nearsightedness
Phase 1 randomized, prospective, double-masked, vehicle-controlled, dose-escalation study to evaluate the safety, tolerability and clinical effect of Nexagon™ in subjects following bilateral PRK for the correction of mild to…
- Trial name
- NCT00654550
- Testing
- Nexagon™ or Nexagon™ vehicle
- Where
- New Zealand
- Volunteers
- 24 people
- Sponsor
- OcuNexus Therapeutics, Inc.
Epithelium, Corneal
Comparison of the Effect of 4th Generation Fluoroquinolones, Gatifloxacin and Moxifloxacin, on Epithelial Healing Following Photorefractive Keratectomy (PRK), A Substudy of: Initial Evaluation of Excimer Laser Keratorefractive Surgery in U.S. Army Personnel (WU # 2335-99)
The purpose of this study is a prospective,double-blinded, randomized trial to compare the rate of healing following PRK after the use of two commercially available 4th generation fluoroquinolones, moxifloxacin and gatifloxacin.
- Trial name
- NCT00414011
- Testing
- Moxifloxacin, Gatifloxacin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Refractive Errors
The Effect of Gabapentin (Neurentin) and Pregabalin (Lyrica) in Pain Reduction After Photorefractive Keratectomy
The studied patients will be given randomly one of three following drugs1:Gabapentin2: Pregabalin or placebo for 3 days after Photorefractive keratectomy surgery.
- Trial name
- PRK (NCT01122004)
- Testing
- Pregabalin
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Keratoconjunctivitis Sicca
Goblet Cell Response and Dry Eye Symptoms After PRK and LASIK
Purpose: To develop a screening metric by examining both the characteristics of the preoperative tear film and the intracellular signaling pathways of conjunctival goblet cells in order to determine if there are certain…
- Trial name
- NCT00411827
- Testing
- PRK with conjunctival impression cytology before and after surgery, LASIK with conjunctival impression cytology before and after surgery
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Myopia
Base Curves of Bandage Contact Lenses and Their Effects on Post Trans-PRK Vision and Pain
The objective of this study was to investigate the impact of employing bandage contact lenses with a base curve of 8.4 mm versus 8.8 mm on visual recovery following Trans-PRK in patients characterized by steep corneas and high…
- Trial name
- NCT06393855
- Testing
- single-step Trans-PRK, Placing a bandage contact lens on the cornea, with an 8.4-mm base curve in right eye and one with an 8.8-mm base curve in the left eye., Placing a bandage contact lens on the cornea,A contact lens placed on the cornea, with an 8.8-mm base curve in right eye and one with an 8.4-mm base curve in the left eye.
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Dongyang People's Hospital
Anisometropia, Hyperopia
Photorefractive Keratectomy for Severe Anisometropia and Isoametropia Associated With Amblyopia
Photorefractive keratectomy (PRK) with excimer laser has been used successfully to treat myopia, hyperopia, and astigmatism in adults for over 35 years.
- Conditions
- Anisometropia, Hyperopia, High Myopia, Amblyopia Isometropic
- Trial name
- NCT03610997
- Testing
- Photorefractive keratectomy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Baylor College of Medicine
Postoperative Pain
Oral Gabapentin Versus Placebo for Treatment of Postoperative Pain Following Photorefractive Keratectomy
The purpose of this study is to determine the effectiveness of an oral medication called gabapentin in reducing pain after Photorefractive Keratectomy (PRK) eye surgery and to assess the frequency of use of rescue medication…
- Trial name
- NCT00793910
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Pain After Photorefractive Keratectomy, VAS Will be Used to Assess Pain Postoperative
Assessment of Safety and Efficacy of Gabapentin After Surface Ablation, a Case Control Experimental Study
The current study aims at assessing the efficacy and safety of oral Gabapentin alone versus Diclofenac Potassium drugs for postoperative analgesia in patients undergoing surface ablation.
- Trial name
- NCT06752486
- Testing
- Giving post photorefractive keratectomy for pain relief
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Research Institute of Ophthalmology, Egypt
Intraocular Pressure, Corneal Opacity
Loteprednol vs. Prednisolone and Fluorometholone
Corneal haze, in which the cornea becomes cloudy, is a well-known and a potentially vision-threatening postoperative complication of photorefractive keratectomy (PRK).
- Trial name
- NCT03123614
- Testing
- Loteprednol Etabonate 0.5% Oph Gel, Prednisolone Acetate 1% Oph Susp
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- University of Utah
Keratoconus
Blurring Strength & Aberrometric Changes Following Corneal Cross-linking (CxL) and CxL Combined With Photorefractive Keratectomy (PRK) in Keratoconus
Primary objective of this study was to assess the impact of the two prevalent therapeutic options, CxL and CxL combined with topography-guided photorefractive keratectomy (t-PRK), on both anterior and posterior corneal High order…
- Trial name
- NCT01527721
- Testing
- Corneal Collagen Cross-Linking (CxL), Corneal Collagen Cross-Linking combined with t-PRK
- Where
- Greece
- Volunteers
- 32 people
- Sponsor
- Democritus University of Thrace
Photorefractive Keratectomy, Corneal Haze
Effect of Ectoine After Photorefractive Keratectomy (PRK).
This is a comparative, open label, parallel group, non interventional study aims to assess the effect of Ectoine containing eye drops on stromal haze, pain and epithelial healing after Photorefractive keratectomy (PRK).
- Trial name
- NCT05313425
- Testing
- Ectohylo (R) eye drops
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Tanta University
Surgical Procedure, Unspecified
Corneal Cross-linking and Refractive Surface Ablation in Patients With Asymmetric Corneas
The purpose of this study is to evaluate safety and efficacy of corneal cross-linking and photorefractive keratectomy for refractive correction in patients with bilateral asymmetric topography.
- Trial name
- NCT02943967
- Testing
- CXL + PRK group, PRK group
- Where
- Brazil
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Refractive Disorders
Anterior Stromal Changes After PRK by Using Intraoperative Mitomicin C
To evaluate the confocal microscopy changes in keratocyte density at the anterior stromal after Photorefractive keratectomy (PRK) surgery, using intraoperative mitomycin C(Mitolem, LEMERY, S.A. de C.V. Mexico D.F. Reg.
- Trial name
- NCT00599950
- Testing
- Mitomycin C and Photorefractive keratectomy (PRK)
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Myopes Who Have Undergone PRK.
Time Serial Analysis on Preemptive Analgesia of Preoperative Topical Diclofenac and Ketorolac in Photorefractive Keratectomy(PRK)
The investigators performed this study to investigate pain prevention of preoperative topical nonsteroidal anti-inflammatory drug (NSAID) in photorefractive keratectomy(PRK) using time serial pain scoring.
- Trial name
- NCT01761071
- Testing
- topical ketorolac 0.5% (Acular®, Allergan Inc, Irvine, CA), topical diclofenac 0.1% (Voltaren®, Novartis, Bern, Switzerland)
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Yonsei University
Dry Eye, Dry Eye After LASIK-Laser in Situ Keratomileusis
Combined Treatment With Pulsed Light and Photobiomodulation Before Laser Refractive Surgery
Laser corneal refractive surgery is a widely adopted approach for correcting refractive errors, but postoperative dry eye remains a common side effect.
- Trial name
- TEBELID (NCT05803798)
- Testing
- IPL+LLLT
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Corneal Epithelial Wound Healing
Effect of Topical Fluoroquinolones on Epithelial Wound Healing After PRK
The prescribed antibiotic for prophylaxis of infection following PRK should be effective at eradicating a potential infection. In addition, the antibiotic should have a rapid onset of action, effectively penetrate the target…
- Trial name
- NCT00569881
- Testing
- gatifloxacin and moxifloxacin
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Donnenfeld, Eric, M.D.