Clinical trials: Physical Decline
Cognitive Decline
Physical and Cognitive Training System for Neurocognitive Protection and Enhancement in Older Adults
Neurocognitive decline is a health issue that is associated with ageing. It is often irreversible from the onset. The concomitant costs of neurocognitive decline could be potentially exponential if left unchecked.
- Trial name
- NCT05163769
- Testing
- NeeuroCycle Physical and Cognitive Training System, NeeuroCycle Cognitive Training System
- Where
- Singapore
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- Duke-NUS Graduate Medical School
Cognitive Decline, Cardiovascular Diseases
Lifestyle Physical Activity and Cognitive Training Interventions
Older women with cardiovascular disease (CVD) are at greater risk for memory loss, an important public health issue due to the negative effects to quality of life and health care costs.
- Conditions
- Cognitive Decline, Cardiovascular Diseases, Cognitive Dysfunction, Cognitive Impairment
- Trial name
- MindMoves (NCT04556305)
- Testing
- Mind, Move
- Where
- United States
- Volunteers
- 253 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Frail Elderly Subjects
Omega-3 Fatty Acids and/or Multi-domain Intervention in the Prevention of Age-related Cognitive Decline
Epidemiological and fundamental research carried out in recent years has highlighted the role played by omega-3 fatty acids in the process of cognitive decline that accompanies advancing age and Alzheimer's disease.
- Trial name
- MAPT (NCT00672685)
- Testing
- omega-3, multi-domain intervention
- Where
- 13 sites in France, Monaco
- Volunteers
- 1,680 people
- Sponsor
- University Hospital, Toulouse
Sedentary Time, Insomnia
mPATH for Low-income Older Adults
Although empirical research suggests that physical activity interventions benefit cognition and sleep in older adults in general, the possible benefit of physical activity is understudied in low-income older adults.
- Conditions
- Sedentary Time, Insomnia, Cognitive Decline
- Trial name
- NCT05935241
- Testing
- mPATH, Attention Control
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Healthy
Effects of Vitamin D3 Supplementation on Cognitive Function in Community Dwelling Older Adults
Ireland is predicted to have the highest older adult population growth of any European Union country. A substantial economic and social challenge of this projected growth is the increased incidence of cognitive impairment and the…
- Trial name
- NCT02804841
- Testing
- Cholecalciferol -Vitamin D3
- Where
- Ireland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Vestibular Dysfunction, Dizziness
Vestibular Balance-Cognition Dual-Task Digital System: Development of a Smart Rehabilitation Platform for the Elderly and Prediction of Balance Function Risks
This study is being done to better understand how vestibular problems and thinking abilities (such as attention and mental flexibility) are related in older adults, and how doing a balance task and a thinking task at the same…
- Conditions
- Vestibular Dysfunction, Dizziness, Falls (Accidents) in Old Age, Balance Assessment
- Trial name
- NCT07735078
- Testing
- Instrumented balance and gait assessment using wearable inertial sensors, Questionnaires and paper-based cognitive tests
- Where
- Taiwan
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Dementia, Cognitive Assessment
Study Protocol: The Efficacy of Mushroom to Reduce Cognitive Decline in At-Risk Middle-aged Adults and Young-olds Living in the Community
The investigator's objective is to explore the definitive evidence of mushroom on cognitive functions among at-risk middle-aged and young-olds.
- Trial name
- NCT07775833
- Testing
- Golden oyster mushroom powder
- Where
- Singapore
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Prostate Cancer
Digitally Captured Activity Data and PROs to Monitor Physical Function in Prostate Cancer Patients
Prospective observational research study to evaluate the role of wearable activity monitors to predict physical function decline among prostate cancer survivors receiving ADT.
- Trial name
- DigiPRO (NCT04575402)
- Testing
- Wearable Activity Monitor
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Cedars-Sinai Medical Center
Frailty, Cognitive Decline
The Effectiveness of a Dual-task Training Program
The purpose of this study is to explore the effect of a dual-task training intervention on cognitive function,physical function, depression symptoms and quality of life in middle-aged and elderly people with cognitive impairment.
- Trial name
- NCT06450119
- Testing
- walking training, cognition training
- Volunteers
- 196 people
- Sponsor
- Taipei Medical University
Liver Cirrhosis, Cognitive Dysfunction
The Liver Cirrhosis Cognitive Decline Scale (LiCCoS)
The goal of this observational study is to develop and test a new questionnaire called the Liver Cirrhosis Cognitive Decline Scale (LiCCoS) for adults with liver cirrhosis.
- Conditions
- Liver Cirrhosis, Cognitive Dysfunction, Hepatic Encephalopathy, Neurocognitive Disorders
- Trial name
- LiCCoS (NCT07418008)
- Where
- India
- Volunteers
- 230 people
- Sponsor
- University of Malaya
Depression, Depressive Disorder
Beyond Ageing Project: A Study for the Prevention of Depression
The purpose of this study is to determine whether folate and vitamin B12, physical activity and mental health literacy can prevent depression, and folate and vitamin B12 and physical activity can prevent cognitive impairment in…
- Trial name
- NCT00214682
- Testing
- Folate (400mcg) and Vitamin B12 (100 mcg), mediated physical activity promotion, Mental health literacy
- Where
- Australia
- Volunteers
- 909 people
- Sponsor
- Australian National University
Prostate Cancer, Physical Function
RESIST-ADT (Androgen Deprivation Therapy)
The overall goal of this study is to determine if implementing structured exercises prevent decline in muscle mass, muscle strength and physical function in men with prostate cancer undergoing androgen deprivation therapy (ADT).
- Trial name
- NCT04485767
- Testing
- Progressive Resistance Training Exercise, Flexibility and Balance Exercise
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Dana-Farber Cancer Institute
Geriatric Assessment, Health Services for the Aged
Geriatric-CO-mAnagement for Cardiology Patients in the Hospital
The primary objective of the evaluation study is to determine if geriatric co-management is superior to standard of care in preventing functional decline in older patients admitted for acute heart disease or Transcatheter Aortic…
- Conditions
- Geriatric Assessment, Health Services for the Aged, Cardiovascular Diseases, Activities of Daily Living
- Trial name
- G-COACH (NCT02890927)
- Testing
- Cardio-geriatric co-management
- Where
- Belgium
- Volunteers
- 454 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Diabetes, Diabetes Mellitus, Type 1
The Effect of Exercise on Blood Glucose Levels in Patients With Type 1 Diabetes: A Comparison of 3 Long-acting Insulins
This trial is conducted in Europe. The aim of this research is to assess the impact of three basal (long-acting) insulin treatments on blood glucose levels in people with type 1 diabetes when performing physical exercise.
- Trial name
- NCT00313742
- Testing
- insulin detemir, insulin glargine, insulin NPH
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 51 people
- Sponsor
- Novo Nordisk A/S
Dementia, Dementia Alzheimers
On Site Sensors Monitoring Impacts of Cognitive Decline on ADLs
The purpose of this research is to compare the effectiveness of a continuous monitoring system to assess Activities of Daily Living (ADLs) over time compared to the traditional assessments used by medical professionals as…
- Trial name
- NCT04871698
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- National Institute on Aging (NIA)
Frailty, Disability Physical
Functional Decline and QoL in People Aging with HIV in Asia
This is a multi-center prospective cross-sectional study to determine the burden of decline in intrinsic capacity and functional ability, and the prevalence of geriatric syndromes, such as frailty, and disability in adult people…
- Conditions
- Frailty, Disability Physical, HIV/AIDS
- Trial name
- NCT04212884
- Where
- 2 sites in Hong Kong
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Memory Disorders, Mild Cognitive Impairment
Physical Exercise for Prevention of Dementia
The principal aim of this study is to verify whether a program of supervised, multimodal physical exercise improves cognitive function and/or reduces the rate of cognitive decline in older adults
- Conditions
- Memory Disorders, Mild Cognitive Impairment, Aging
- Trial name
- EPD (NCT02236416)
- Testing
- Intervention group, Control group
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Molise
Chronic Pain, Pain
Classifying and Predicting Long-term Pain and Function in Older Adults
This project will use novel methods to detect clinically meaningful subgroups of older adults based on long-term trajectories of bothersome pain and function.
- Trial name
- NCT04864223
- Where
- United States
- Volunteers
- 6,783 people, healthy volunteers welcome
- Sponsor
- University of Washington
Old Age
Inspiring Seniors Towards Exercise Promotion - 2
Older adults' low adherence to the national physical activity guidelines may stem from a failure to increase positive affective responses to exercise (e.g., enjoyment).
- Trial name
- iSTEP-2 (NCT07629739)
- Testing
- Exercise intervention with RAS (EX+RAS), Exercise intervention without RAS (EX)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Emory University
Post-Operative Cognitive Decline in Older Adults, Post-operative Cognitive Decline
Post-operative Cognitive Decline After Ambulatory Cataract Surgery in the Elderly Population
Postoperative cognitive decline is a recognized complication following anesthesia and surgery in older adults; however, its incidence after ambulatory cataract surgery performed under sedation is not well understood.
- Conditions
- Post-Operative Cognitive Decline in Older Adults, Post-operative Cognitive Decline, Perioperative Neurocognitive Disorders, Cataract Surgery Anesthesia
- Trial name
- NCT07714174
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital