Clinical trials: Physical Dependence
Drug Abuse, Drug Dependence
Pharmacological, Clinical and Statistical Assessment of a New Tool Available for Pharmacodependence Report Evaluation
In France, the Afssaps is the body in charge of the evaluation of pharmacodependance. In order to fulfil its mission, the Afssaps has created a network of 11 Centres for Evaluation and Information on Pharmacodependance (CEIP)…
- Trial name
- NCT01052675
- Where
- 10 sites in France
- Volunteers
- 3,180 people
- Sponsor
- Nantes University Hospital
Pain, Chronic Pain
Developing rTMS Treatment Strategies for Pain in Opiate Dependence
The purpose of this study is to parametically evaluate two different types of repetitive Transcranial Magnetic Stimulation (rTMS) treatment strategies as a potential treatment for pain in individuals currently taking prescription…
- Conditions
- Pain, Chronic Pain, Opioid Dependence, Opioid Use
- Trial name
- NCT03576781
- Testing
- Real iTBS, Real cTBS
- Where
- 2 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cocaine Dependence
Study of Safety and Potential Efficacy of SYN117 in Cocaine Dependent Volunteers
This study will assess the potential interaction and subjective effects between intravenous cocaine and SYN117 in non-treatment seeking cocaine dependant subjects
- Trial name
- NCT00656357
- Testing
- SYN117 80 mg, SYN117 160 mg, Cocaine 10mg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Biotie Therapies Inc.
Nicotine Dependence
Assessment of a Teachable Moment for Smoking Cessation
A teachable moment (TM) refers to life events or transitions, such as physician visits, early detection screening feedback, pregnancy, and hospitalization for, and diagnosis of, disease, that inspire health behavior change.
- Trial name
- TM (NCT00596440)
- Testing
- Transdermal nicotine patch
- Where
- United States
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Self-identified Problematic Caffeine Use, DSM-IV Substance Dependence as Applied to Caffeine
Assessment and Treatment of Caffeine Dependence
Recent research has established that some individuals report that they are unable to cease caffeine use, despite feeling that caffeine is posing a health risk or causing significant impairment in their daily activities.
- Trial name
- NCT00338195
- Testing
- Individualized caffeine cessation instructions
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Alcohol Abuse or Dependence, Alcohol Use Disorder
Examination of Whether an Exercise Programme Reduces Alcohol Consumption Among Alcohol-Dependent Adults
This study is composed of two phases. Phase 1 will determine baseline demographic characteristics of participants, currently drinking harmful amounts of alcohol, who would be interested in an alternative treatment option to…
- Trial name
- AOA (NCT03848000)
- Testing
- Exercise Programme, NHS Standard Care
- Where
- United Kingdom
- Volunteers
- 53 people
- Sponsor
- Queen Mary University of London
Methamphetamine Dependence, Substance Abuse
Varenicline-Methamphetamine Interaction Study (2008)
The primary aim of the study is to determine the safety and tolerability of treatment with Varenicline in methamphetamine-dependent volunteers.
- Conditions
- Methamphetamine Dependence, Substance Abuse, Methamphetamine Abuse
- Trial name
- NCT00733967
- Testing
- Varenicline
- Sponsor
- Baylor College of Medicine
Cocaine-Related Disorders
Assessment of Potential Interactions Between Intravenous Cocaine and Atomoxetine - 1
The purpose of this study is to assess potential interactions between intravenous (i.v.) cocaine and atomoxetine (Strattera) administered orally in four escalating doses.
- Trial name
- NCT00265265
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Dependence
Behavioral Exercise Intervention for Smoking Cessation
The purpose of this study is to test the effect of a moderate-intensity aerobic exercise intervention for smokers interested in quitting smoking.
- Trial name
- NCT00713063
- Testing
- aerobic exercise, Health Education Control
- Volunteers
- 61 people
- Sponsor
- Butler Hospital
Alcohol Abuse/Dependence
Examining the Relationship Between Physical Activity Levels and Chronotype Tendencies in Individuals With Alcohol Dependence
Alcohol use disorders are characterized by excessive alcohol consumption and loss of control and are associated with high mortality and disease burden.
- Trial name
- NCT06850428
- Where
- Turkey (Türkiye)
- Volunteers
- 207 people
- Sponsor
- Gulhane School of Medicine
Dependency
Comprehensive Geriatric Assessment for Frail Older People
The study "Comprehensive Geriatric Assessment for frail older people in Swedish acute care settings - a randomized controlled study" comprised two study arms: one intervention and one control group.
- Trial name
- NCT02773914
- Testing
- Comprehensive Geriatric Assessment
- Where
- Sweden
- Volunteers
- 155 people
- Sponsor
- Göteborg University
Stroke
Trunk Restraint Therapy in Post-stroke Patients.
The aim of this study was to evaluate the long-term effects of the task-specific training with trunk restraint comparing to the free one in post-stroke reaching movements.
- Trial name
- NCT02364141
- Testing
- Trunk restraint therapy, Trunk unrestraint therapy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Nicotine Dependence
Measuring Smoking Behaviors While Using Varenicline
This study will demonstrate the behavioral responses to varenicline, helping to better understand its mechanisms. Hypotheses for the study are to observe decreases in smoking topography and nicotine cigarette choice on…
- Trial name
- NCT00948155
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Opioid-Related Disorders
Opioid Agonist and Antagonist Effects on Opioid Dependence
The purpose of this study is to examine the acute agonist and antagonist effects of a full opioid agonist medication, an opioid antagonist medication, and a partial opioid agonist medication in individuals who have different…
- Trial name
- NCT00142727
- Testing
- Methadone, Full opioid agonist, Partial opioid agonist
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Dependence
Lifestyle Physical Activity Intervention for Depressed Alcohol Dependent Women
Building on the large body of evidence for the effect of exercise in decreasing depressive symptoms and the few preliminary findings of its effect on craving and drinking outcomes, the purpose of this study is to develop a…
- Trial name
- NCT02705898
- Testing
- LPA+Fitbit, HEC
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Butler Hospital
Substance-Related Disorders, Drug Abuse
Structured Physical Exercise in Short-term Inpatient Treatment of Substance Use Disorder
In 2017, structured physical exercise with high intensity was implemented as a part of the treatment program at St. Olav Hospital Clinic of Substance Use and Addiction Medicine.
- Conditions
- Substance-Related Disorders, Drug Abuse, Drug Dependence
- Trial name
- NCT04141202
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- St. Olavs Hospital
People 60 Years of Age or Over 55 Years of Age With a Diagnosed Pathology and Preferably With a Recognized Physical and/or Cognitive Dependency
A Randomized Controlled Trial to Address a Multimodal Intervention in the Elderly
The study is a quantitative randomized control trial (RCT) with a longitudinal pre-test, mid-test and post-test within and between subject design. It was conducted between July 2023 and December 2024.
- Trial name
- CAMINN (NCT07362381)
- Testing
- Multimodal intervention in the elderly
- Where
- Spain
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
Opioid Withdrawal, Physical Dependence
5HT3 Antagonists to Treat Opioid Withdrawal and to Prevent the Progression of Physical Dependence
Opioid medications are commonly used for pain relief. When given over time, physical dependence can occur. This results in unpleasant side effects (such as agitation and nausea) if opioid medications are suddenly stopped.
- Trial name
- NCT01549652
- Testing
- Ondansetron, Morphine, Naloxone 0.4 mg/70 kg
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- Stanford University
Respiratory Infections in Old Age
Functional Impact of Acute Respiratory Viral Infections in Older Adults
The prevention of infectious diseases in older adults remains a major public health challenge, as acute respiratory infections are a leading cause of hospitalisation, mortality, and functional decline worldwide.
- Trial name
- AFIRI (NCT07388173)
- Where
- 24 sites in United States, France and 3 more
- Volunteers
- 1,600 people
- Sponsor
- University Hospital, Grenoble
Frailty Syndrome, HIV Infections
Effectiveness of a Multifactorial Intervention in Frailty Individuals With HIV Infection: HIDRA360
The goal of this quasi-experimental before/after study without equivalent control group is to to describe the prevalence of frail, pre-fragile and robust individuals in the study group before and after a multifactorial…
- Trial name
- HIDRA360 (NCT05832164)
- Testing
- Multifactorial intervention
- Where
- Spain
- Volunteers
- 61 people
- Sponsor
- Hospital Costa del Sol