Clinical trials: Physical Exercise Condition
Hypertrophic Cardiomyopathy
Effect of Eleclazine (GS-6615) on Exercise Capacity in Subjects With Symptomatic Hypertrophic Cardiomyopathy
The primary objective of this study was to evaluate the effect of eleclazine (GS-6615) on exercise capacity as measured by Peak oxygen uptake (VO2) achieved during cardiopulmonary exercise testing (CPET), in participants with…
- Trial name
- LIBERTY-HCM (NCT02291237)
- Testing
- Eleclazine
- Where
- 46 sites in United States, Australia and 6 more
- Volunteers
- 172 people
- Sponsor
- Gilead Sciences
Cystic Fibrosis
A Study of the Effects of Lumacaftor/Ivacaftor (LUM/IVA) on Exercise Tolerance in Subjects With Cystic Fibrosis (CF), Homozygous for the F508del-CFTR Mutation
This is a Phase 4, randomized, double-blind, placebo-controlled, parallel-group study in subjects aged 12 years and older with CF who are homozygous for the F508del-CFTR mutation.
- Trial name
- NCT02875366
- Testing
- LUM/IVA
- Where
- 12 sites in Australia, United Kingdom
- Volunteers
- 70 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Pediatric Obesity, Weight Loss
Our Lifestyles Our Lives
The purpose of the study was to examine the influence of step goals with pedometers to improve children's weight loss, physical activity, and psychosocial health during behavioral treatment.
- Trial name
- OLOL (NCT02965729)
- Testing
- Family-based weight management, Pedometer, Individualized step goals
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Obesity
Phone Coaching and Internet-delivered Weight Loss
The purpose of this study is to examine whether adding phone coaching to an Internet-based weight loss program can improve weight loss outcomes at 4 months and 1 year.
- Trial name
- NCT03867981
- Testing
- Internet-based weight loss program, Brief phone coaching, Extended phone coaching
- Where
- United States
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
COPD Patients and Patients Recovering From COVID19
Increasing Physical Activity in COPD Through Rhythmically Enhanced Music
The VA cares for nearly one million Veterans with COPD at a cost of more than $5.5 billion annually. COPD profoundly impairs quality of life as it limits ability to work, to maintain physical exertion and to engage in social…
- Trial name
- NCT03655028
- Testing
- rhythmically auditory stimulation enhanced music, control
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- VA Office of Research and Development
Heart Failure
Restoration of Chronotropic Competence in Heart Failure Patients With Normal Ejection Fraction
This study will look at how pacing your heart may assist your daily activities and how you are feeling.
- Trial name
- RESET (NCT00670111)
- Testing
- Insignia Plus / Ultra (Guidant/Boston Scientific)
- Where
- 5 sites in United States
- Volunteers
- 32 people
- Sponsor
- Boston Scientific Corporation
Stem Cell Transplant
In Person and mHealth Coping Skills Training for Symptom Management and Steps in Stem Cell Transplant Patients
Hematopoietic stem cell transplant (HCT) is an aggressive treatment for life-threatening cancers. HCT improves survival, but most HCT patients experience significant physical disability, which is exacerbated by persistent…
- Trial name
- Symptoms-Steps (NCT03859765)
- Testing
- HCT Symptoms and Steps
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Shoulder Impingement Syndrome
Exercise Into Pain in Chronic Rotator Cuff Related Shoulder Pain: a Prospective Single-Group Feasibility Study
The purpose of this study is to evaluate a) the feasibility of applying a painful exercise program in the treatment of subacromial shoulder pain and b) the time needed to collect clinical outcomes for a future randomized…
- Trial name
- NCT04154345
- Testing
- Exercise therapy (exercising into pain)
- Where
- Belgium
- Volunteers
- 12 people
- Sponsor
- Universiteit Antwerpen
Pulmonary Arterial Hypertension
Clinical Study to Assess the Long-term Safety, Tolerability, and Efficacy of Macitentan in Subjects With Eisenmenger Syndrome
Long-term study to evaluate if macitentan is safe, tolerable and efficient enough to be used for treatment of Eisenmenger syndrome.
- Trial name
- MAESTRO-OL (NCT01739400)
- Testing
- Macitentan 10 mg tablet, once daily.
- Where
- 51 sites in United States, Austria and 17 more
- Volunteers
- 217 people
- Sponsor
- Actelion
Alzheimer's Disease Prevention
Exercise in Asymptomatic Pre-Alzheimer's Disease Pilot Study
Researchers are trying to determine if cognitively normal subjects undergoing a moderate aerobic exercise program will accumulate less amyloid-ß (Aβ) concentration in their brain than subjects undergoing a non-aerobic exercise…
- Trial name
- NCT01834716
- Testing
- Aerobic vs. Non-Aerobic exercise
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Flexible Flatfoot
Effectiveness of Core Stability Exercises on Foot Posture, Function and Limb Alignment in Flexible Flat Feet Patients
Flexible flat foot is a very common musculoskeletal disorder of lower limbs in general population. Studies have reported that a flexible flat foot causes an alteration in the human body structures and lower limb kinetics due to a…
- Trial name
- NCT06567509
- Testing
- Core stability exercises and Short foot exercises, Conventional foot exercises and short foot exercises
- Where
- Malaysia
- Volunteers
- 85 people
- Sponsor
- International Islamic University Malaysia
Spinal Cord Injuries
Long Duration Activity and Metabolic Control After Spinal Cord Injury
Skeletal muscle is the largest endocrine organ in the body, playing an indispensable role in glucose homeostasis. Spinal cord injury (SCI) prevents skeletal muscle from carrying out this important function.
- Trial name
- NCT03139344
- Testing
- Low-frequency Exercise, High-frequency Exercise
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Richard K Shields
Burnout, Professional, Burnout Syndrome
Evaluation of a Daily Brief Exercise Intervention on Resident Physician Personal Resiliency and Burnout
This study seeks to evaluate the prevalence and characterize predictors of physician burnout in the anesthesia residency at Vanderbilt University Medical Center.
- Trial name
- NCT03489720
- Testing
- Prescribed Exercise Program, Usual Exercise Program
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Type 1 Diabetes
Two Way Crossover Closed Loop Study MPC vs FMPD
An artificial pancreas (AP) is a control system for automatic insulin delivery. Our group has implemented a fading memory proportional derivative controller (FMPD) for use within an AP control system which has been evaluated in…
- Trial name
- NCT04771403
- Testing
- FMPD AP algorithm, MPC AP system, Dexcom G6 Continuous Glucose Monitoring (CGM) System
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Oregon Health and Science University
Pulmonary Disease, Chronic Obstructive
An Exercise Endurance Study to Evaluate the Effects of Treatment of Chronic Obstructive Pulmonary Disease (COPD) Patients With a Dual Bronchodilator: GSK573719/GW642444.Study B
This is a phase III multicenter, randomized, double-blind, placebo-controlled, combination and component, two-period, incomplete block design cross-over study using GSK573719/GW642444.
- Trial name
- COPD (NCT01323660)
- Testing
- GSK573719/GW642444 125/25, GSK573719/GW642444 62.5/25, GSK573719 125
- Where
- 53 sites in United States, Canada and 5 more
- Volunteers
- 307 people
- Sponsor
- GlaxoSmithKline
Sarcopenia, Aging
Immune Function and Muscle Adaptations to Resistance Exercise in Older Adults
The loss of muscle mass and strength due to aging leads to serious health problems for older adults. Muscle health can be improved by exercise training, but some people improve their strength substantially, whereas others improve…
- Conditions
- Sarcopenia, Aging, Immune Function
- Trial name
- TDAP2 (NCT02261961)
- Testing
- TDAP, Acute Resistance Exercise, Resistance Exercise Training
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Intermittent Claudication, Peripheral Vascular Disease
Adjuvant Benefit of NMES to Supervised Exercise in Patients With IC
This study will assess the adjuvant benefit of a neuromuscular electrical stimulation device to standard treatment of supervised exercise in patients suffering from symptoms and effects of lower limb Intermittent Claudication.
- Conditions
- Intermittent Claudication, Peripheral Vascular Disease, Lower Limb Arterial Disease
- Trial name
- AdjIC (NCT02429310)
- Testing
- Revitive IX
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- Imperial College London
Osteoarthritis, Knee, Osteoarthritis, Hip
Increasing Physical Activity in Older Adults With Osteoarthritis Pain: Examining a Brief Behavioral Intervention
The purpose of this study is to evaluate how older adults might benefit from sessions that teach behavioral coping skills for increasing physical activity and reducing interference from arthritis pain.
- Trial name
- NCT04490395
- Testing
- Engage PA, Treatment as Usual plus (TAU+)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Hypoxia, Altitude
Effects of Nebivolol Versus Carvedilol on Cardiopulmonary Function at High Altitude in Healthy Subjects.
Exposure of healthy subjects to high altitude hypoxia elicits changes in cardiovascular, respiratory and metabolic features as weel as in exercise performance similar, for some aspects, to those observed in chronic heart failure.
- Conditions
- Hypoxia, Altitude, Heart Failure
- Trial name
- NCT00924833
- Testing
- Carvedilol, Nebivolol
- Where
- Italy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Heart Failure
This Study Tests Empagliflozin in Patients With Chronic Heart Failure With Preserved Ejection Fraction (HFpEF). The Study Looks at How Far Patients Can Walk in 6 Minutes and at Their Heart Failure Symptoms.
The primary objective of the study is to evaluate the effect of empagliflozin 10 mg versus placebo on exercise ability using the 6 minute walk test (6MWT) in patients with chronic heart failure (CHF) with preserved ejection…
- Trial name
- NCT03448406
- Testing
- Empagliflozin
- Where
- 108 sites in United States, Australia and 9 more
- Volunteers
- 315 people
- Sponsor
- Boehringer Ingelheim
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